Advanced search
Publication Cover
Autoimmunity Volume 55, 2022 - Issue 7
Submit an article Journal homepage
503
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Abnormal lower expression of GPR183 in peripheral blood T and B cell subsets of systemic lupus erythematosus patients

Mingming Zhaoa Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, ChinaView further author information
,
Yang Meia Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, ChinaView further author information
,
Zhidan Zhaoa Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, ChinaView further author information
,
Pengpeng Caoa Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, ChinaView further author information
,
Yue Xina Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, ChinaView further author information
,
Yunkai Guob Department of Otolaryngology Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, ChinaView further author information
,
Ming Yanga Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Haijing Wua Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Central South University, Changsha, Hunan, ChinaCorrespondence[email protected] [email protected]
View further author information
 show all
Pages 429-442 | Received 04 Feb 2022, Accepted 06 Jul 2022, Published online: 25 Jul 2022

References

  • Richardson B. The interaction between environmental triggers and epigenetics in autoimmunity. Clin Immunol. 2018;192:1–5. Jul
  • Canny SP, Jackson SW. B cells in systemic lupus erythematosus: from disease mechanisms to targeted therapies. Rheum Dis Clin North Am. 2021;47(3):395–413. Aug
  • Ma K, Du W, Wang X, et al. Multiple functions of B cells in the pathogenesis of systemic lupus erythematosus. Int J Mol Sci. 2019;20(23):6021.
  • Yoshikawa M, Nakayamada S, Kubo S, et al. Type I and II interferons commit to abnormal expression of chemokine receptor on B cells in patients with systemic lupus erythematosus. Clin Immunol. 2019;200:1–9. Mar
  • Lu E, Cyster JG. G-protein coupled receptors and ligands that organize humoral immune responses. Immunol Rev. 2019;289(1):158–172.
  • Hannedouche S, Zhang J, Yi T, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011;475(7357):524–527. Jul 27
  • Liu C, Yang XV, Wu J, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011;475(7357):519–523.
  • Sun S, Liu C. 7alpha, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases. Front Pharmacol. 2015;6:60.
  • Barington L, Wanke F, Niss Arfelt K, et al. EBI2 in splenic and local immune responses and in autoimmunity. J Leukoc Biol. 2018;104(2):313–322. Aug
  • Gatto D, Wood K, Caminschi I, et al. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol. 2013;14(5):446–453.
  • Li J, Lu E, Yi T, et al. EBI2 augments tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016;533(7601):110–114. 5
  • Suan D, Nguyen A, Moran I, et al. T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses. Immunity. 2015;42(4):704–718.
  • Preuss I, Ludwig MG, Baumgarten B, et al. Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages. Biochem Biophys Res Commun. 2014;446(3):663–668. 11
  • Baptista AP, Gola A, Huang Y, et al. The chemoattractant receptor Ebi2 drives intranodal naive CD4(+) T cell peripheralization to promote effective adaptive immunity. Immunity. 2019;50(5):1188–1201 e6.
  • Ruiz F, Wyss A, Rossel JB, Swiss IBD Cohort Study Group, et al. A single nucleotide polymorphism in the gene for GPR183 increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease. Br J Pharmacol. 2021;178(16):3157–3175.
  • Misselwitz B, Wyss A, Raselli T, et al. The oxysterol receptor GPR183 in inflammatory bowel diseases. Br J Pharmacol. 2021;178(16):3140–3156. Aug
  • Heinig M, Petretto E, Wallace C, Cardiogenics Consortium, et al. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature. 2010;467(7314):460–464. Sep 23
  • Clottu AS, Mathias A, Sailer AW, et al. EBI2 expression and function: Robust in memory lymphocytes and increased by natalizumab in multiple sclerosis. Cell Rep. 2017;18(1):213–224. Jan3
  • Nevius E, Gomes AC, Pereira JP. Inflammatory cell migration in rheumatoid arthritis: a comprehensive review. Clin Rev Allergy Immunol. 2016;51(1):59–78. Aug
  • Wanke F, Moos S, Croxford AL, et al. EBI2 is highly expressed in multiple sclerosis lesions and promotes early CNS migration of encephalitogenic CD4 T cells. Cell Rep. 2017;18(5):1270–1284.
  • Choi C, Finlay DK. Diverse immunoregulatory roles of Oxysterols-The oxidized cholesterol metabolites. Metabolites. 2020;10(10):384.
  • Gatto D, Brink R. B cell localization: regulation by EBI2 and its oxysterol ligand. Trends Immunol. 2013;34(7):336–341. Jul
  • Yi T, Wang X, Kelly LM, et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012;37(3):535–548.
  • Gatto D, Wood K, Brink R. EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J Immunol. 2011;187(9):4621–4628.
  • Pereira JP, Kelly LM, Cyster JG. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int Immunol. 2010;22(6):413–419.
  • Wu H, Deng Y, Zhao M, et al. Molecular control of follicular helper T cell development and differentiation. Front Immunol. 2018;9(2470):2470.
  • Daugvilaite V, Arfelt KN, Benned-Jensen T, et al. Oxysterol-EBI2 signaling in immune regulation and viral infection. Eur J Immunol. 2014;44(7):1904–1912. Jul
  • Gessier F, Preuss I, Yin H, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014;57(8):3358–3368.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.