Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression

References

• Chen C, Zhang H, Ge M, et al. LncRNA NEAT1 acts as a key regulator of cell apoptosis and inflammatory response by the miR-944/TRIM37 axis in acute lung injury. J Pharmacol Sci. 2021;145(2):202–212.
   PubMed Web of Science ®Google Scholar
• Qu L, Chen C, Chen Y, et al. High-Mobility group box 1 (HMGB1) and autophagy in acute lung injury (ALI): a review. Med Sci Monit. 2019;25:1828–1837.
   PubMed Web of Science ®Google Scholar
• Li Y, Li H, Liu S, et al. Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation. Mol Immunol. 2018;99:134–144.
   PubMed Web of Science ®Google Scholar
• Fan EKY, Fan J. Regulation of alveolar macrophage death in acute lung inflammation. Respir Res. 2018;19(1):50.
   PubMed Web of Science ®Google Scholar
• Wu P, Yan H, Qi J, et al. L6H9 attenuates LPS-induced acute lung injury in rats through targeting MD2. Drug Dev Res. 2020;81(1):85–92.
   PubMed Web of Science ®Google Scholar
• Lei J, Wei Y, Song P, et al. Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol. 2018;818:110–114.
   PubMed Web of Science ®Google Scholar
• Li J, Zeng X, Wang W. miR-122-5p downregulation attenuates lipopolysaccharide-induced acute lung injury by targeting IL1RN. Exp Ther Med. 2021;22(5):1278.
   PubMed Web of Science ®Google Scholar
• Zhong Z, Zhou F, Wang D, et al. Expression of KLF9 in pancreatic cancer and its effects on the invasion, migration, apoptosis, cell cycle distribution, and proliferation of pancreatic cancer cell lines. Oncol Rep. 2018;40(6):3852–3860.
   PubMed Web of Science ®Google Scholar
• Bagati A, Moparthy S, Fink EE, et al. KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene. 2019;38(19):3585–3597.
   PubMed Web of Science ®Google Scholar
• Ai F, Zhao G, Lv W, et al. Dexamethasone induces aberrant macrophage immune function and apoptosis. Oncol Rep. 2020;43(2):427–436.
   PubMed Web of Science ®Google Scholar
• Cui A, Fan H, Zhang Y, et al. Dexamethasone-induced krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. J Clin Invest. 2019;129(6):2266–2278.
   PubMed Web of Science ®Google Scholar
• Bai X, Jiang X, Liu Y, et al. Krüppel-like factor 9 upregulates E-cadherin transcription and represses breast cancer invasion and metastasis. Am J Cancer Res. 2021;11(7):3660–3673.
   PubMed Web of Science ®Google Scholar
• Yi TW, Lv XX, Fan H, et al. LncRNA SNHG15 promotes the proliferation of nasopharyngeal carcinoma via sponging miR-141-3p to upregulate KLF9. Eur Rev Med Pharmacol Sci. 2020;24(12):6744–6751.
   PubMed Web of Science ®Google Scholar
• Fang QY, Deng QF, Luo J, et al. MiRNA-20a-5p accelerates the proliferation and invasion of non-small cell lung cancer by targeting and downregulating KLF9. Eur Rev Med Pharmacol Sci. 2020;24(5):2548–2556.
   PubMed Web of Science ®Google Scholar
• Qiaoli S, Yi S, Jie Z, et al. KLF2 and caveolin-1 as early indicators of acute lung injury induced by paraquat. Eur Rev Med Pharmacol Sci. 2016;20(1):138–145.
   PubMed Web of Science ®Google Scholar
• Ma C, Yang D, Wang B, et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci Adv. 2020;6(21):eaaz6717.
   PubMed Web of Science ®Google Scholar
• Pandeya A, Li L, Li Z, et al. Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm. 2019;10(5):660–667.
   PubMed Web of Science ®Google Scholar
• Lieberman J, Wu H. Gasdermin D activity in inflammation and host defense. Sci Immunol. 2019;4(39):eaav1447.
   PubMed Web of Science ®Google Scholar
• Chen KW, Monteleone M. Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps. Sci Immunol. 2018;3(26):eaar6676.
   PubMed Web of Science ®Google Scholar
• Silva CMS, Wanderley CWS, Veras FP, et al. Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation. Blood. 2021;138(25):2702–2713.
   PubMed Web of Science ®Google Scholar
• Wu J, Zhang J, Zhao J, et al. Treatment of severe acute pancreatitis and related lung injury by targeting gasdermin D-Mediated pyroptosis. Front Cell Dev Biol. 2021;9:780142.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhu X, Yuan S, et al. TLR4/NF-κB signaling induces GSDMD-related pyroptosis in tubular cells in diabetic kidney disease. Front Endocrinol (Lausanne). 2019;10:603.
   PubMed Web of Science ®Google Scholar
• Cao Q, Feng D, He J, et al. Involvement of TFAP2A in the activation of GSDMD gene promoter in hyperoxia-induced ALI. Exp Cell Res. 2021;401(1):112521.
   PubMed Web of Science ®Google Scholar
• Ju M, Liu B, He H, et al. MicroRNA-27a alleviates LPS-induced acute lung injury in mice via inhibiting inflammation and apoptosis through modulating TLR4/MyD88/NF-κB pathway. Cell Cycle. 2018;17(16):2001–2018.
   PubMed Web of Science ®Google Scholar
• Hiroshima Y, Hsu K, Tedla N, et al. S100A8/A9 and S100A9 reduce acute lung injury. Immunol Cell Biol. 2017;95(5):461–472.
   PubMed Web of Science ®Google Scholar
• Xie W, Lu Q, Wang K, et al. miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin. J Cell Physiol. 2018;233(9):6615–6631.
   PubMed Web of Science ®Google Scholar
• He YQ, Zhou CC, Yu LY, et al. Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms. Pharmacol Res. 2021;163:105224.
   PubMed Web of Science ®Google Scholar
• Palioura D, Lazou A, Drosatos K. Krüppel-like factor (KLF)5: an emerging foe of cardiovascular health. J Mol Cell Cardiol. 2021;163:56–66.
   PubMed Web of Science ®Google Scholar
• Khamphikham P, Jearawiriyapaisarn N, Tangprasittipap A, et al. Downregulation of KLF4 activates embryonic and fetal globin mRNA expression in human erythroid progenitor cells. Exp Ther Med. 2021;22(4):1105.
   PubMed Web of Science ®Google Scholar
• Parga JA, Rodriguez-Perez AI, Garcia-Garrote M, et al. NRF2 activation and downstream effects: focus on parkinson's disease and brain angiotensin. Antioxidants (Basel). 2021;10(11):1649.
   PubMedGoogle Scholar
• Lopez Gavilanez E, Johansson H, McCloskey E, et al. Assessing the risk of osteoporotic fractures: the ecuadorian FRAX model. Arch Osteoporos. 2019;14(1):93.
   PubMed Web of Science ®Google Scholar
• Sun G-R, Zhang M, Sun J-W, et al. Krüppel-like factor KLF9 inhibits chicken intramuscular preadipocyte differentiation. Br Poult Sci. 2019;60(6):790–797.
   PubMed Web of Science ®Google Scholar
• Yan Q, He B, Hao G, et al. KLF9 aggravates ischemic injury in cardiomyocytes through augmenting oxidative stress. Life Sci. 2019;233:116641.
   PubMed Web of Science ®Google Scholar
• Qiu J, Ma C, Dai W, et al. Ghrelin attenuates transforming growth factor-β1-induced pulmonary fibrosis via the miR-125a-5p/kruppel-like factor 13 axis. Arch Biochem Biophys. 2021;715:109082.
   PubMed Web of Science ®Google Scholar
• Li T, Wu YN, Wang H, et al. Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway. Mol Immunol. 2020;120:13–22.
   PubMed Web of Science ®Google Scholar
• Zhu J, Feng B, Xu Y, et al. Mesenchymal stem cells alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of Ly6C(+) CD8(+) T cells. Cell Death Dis. 2020;11(10):829.
   PubMed Web of Science ®Google Scholar
• Peng Y, Wu Q, Tang H, et al. NLRP3 regulated CXCL12 expression in acute neutrophilic lung injury. J Inflamm Res. 2020;13:377–386.
   PubMed Web of Science ®Google Scholar
• Blázquez-Prieto J, López-Alonso I, Huidobro C, et al. The emerging role of neutrophils in repair after acute lung injury. Am J Respir Cell Mol Biol. 2018;59(3):289–294.
   PubMed Web of Science ®Google Scholar
• Kurdowska AK, Florence JM. Promoting neutrophil apoptosis to treat acute lung injury. Am J Respir Crit Care Med. 2019;200(3):399–400.
   PubMed Web of Science ®Google Scholar
• Liu S, Yue Y, Pan P, et al. IRF-1 intervention in the classical ROS-Dependent release of NETs during LPS-Induced acute lung injury in mice. Inflammation. 2019;42(1):387–403.
   PubMed Web of Science ®Google Scholar
• Abraham E, Carmody A, Shenkar R, et al. Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2000;279(6):L1137–45.
   PubMed Web of Science ®Google Scholar
• Umeno D, Kimura Y, Kawai-Noma S. Transcription factors as evolvable biosensors. Anal Sci. 2021;37(5):699–705.
   PubMed Web of Science ®Google Scholar
• Xing J, Jia Z, Xu Y, et al. KLF9 (kruppel like factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells. Bioengineered. 2021;12(1):7563–7576.
   PubMed Web of Science ®Google Scholar
• Li Y, Sun Q, Jiang M, et al. KLF9 suppresses gastric cancer cell invasion and metastasis through transcriptional inhibition of MMP28. Faseb J. 2019;33(7):7915–7928.
   PubMed Web of Science ®Google Scholar
• Wang J, Li X, Liu Y, et al. CircHIPK3 promotes pyroptosis in acinar cells through regulation of the miR-193a-5p/GSDMD axis. Front Med (Lausanne). 2020;7:88.
   PubMed Web of Science ®Google Scholar
• Wang YY, Liu XL, Zhao R. Induction of pyroptosis and its implications in cancer management. Front Oncol. 2019;9:971.
   PubMed Web of Science ®Google Scholar