201
Views
1
CrossRef citations to date
0
Altmetric
Research Articles

Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)

, ORCID Icon, , , , , , , & show all
Pages 515-519 | Received 28 Mar 2022, Accepted 14 Aug 2022, Published online: 29 Sep 2022

References

  • Fernandes H, Brito I. Juvenile systemic lupus erythematosus: neuropsychiatric manifestations. Acta Reumatol Port. 2012;37(2):117–125.
  • Kamphuis S, Silverman ED. Prevalence and burden of pediatric-onset systemic lupus erythematosus. Nat Rev Rheumatol. 2010;6(9):538–546.
  • Tang SP, Lim SC, Arkachaisri T. Childhood-onset systemic lupus erythematosus: Southeast asian perspectives. JCM. 2021;10(4):559.
  • Charras A, Smith E, Hedrich CM. Systemic lupus erythematosus in children and young people. Curr Rheumatol Rep. 2021;23(3):20.
  • Cavalcanti A, Santos R, Mesquita Z, et al. Cytokine profile in childhood-onset systemic lupus erythematosus: a cross-sectional and longitudinal study. Braz J Med Biol Res. 2017;50(4):e5738.
  • Husakova M. MicroRNAs in the key events of systemic lupus erythematosus pathogenesis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016;160(3):327–342.
  • Ceribelli A, Yao B, Dominguez-Gutierrez PR, et al. MicroRNAs in systemic rheumatic diseases. Arthritis Res Ther. 2011;13(4):229.
  • Cao W, Qian G, Luo W, et al. miR-125b is downregulated in systemic lupus erythematosus patients and inhibits autophagy by targeting UVRAG. Biomed Pharmacother. 2018;99:791–797.
  • Luo X, Zhang L, Li M, et al. The role of miR-125b in T lymphocytes in the pathogenesis of systemic lupus erythematosus. Clin Exp Rheumatol. 2013;31:263–271.
  • Satake E, Pezzolesi MG, Md Dom ZI, et al. Circulating miRNA profiles associated with hyperglycemia in patients with type 1 diabetes. Diabetes. 2018;67(5):1013–1023.
  • Balzano F, Deiana M, Dei Giudici S, et al. MicroRNA expression analysis of centenarians and rheumatoid arthritis patients reveals a common expression pattern. Int J Med Sci. 2017;14(7):622–628.
  • Walsh MC, Lee J, Choi Y. Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system. Immunol Rev. 2015;266(1):72–92.
  • Bazzoni F, Rossato M, Fabbri M, et al. Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc Natl Acad Sci USA. 2009;106(13):5282–5287.
  • Ermakov EA, Kabirova EM, Sizikov AE, et al. IgGs-Abzymes from the sera of patients with systemic lupus erythematosus hydrolyzed miRNAs. J Inflamm Res. 2020;volume13:681–699.
  • El Gazzar M, McCall CE. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem. 2010;285(27):20940–20951.
  • Xu L, Bai S, Zhang L, et al. MicroRNA-9 influence lupus nephritis by targeting STK3 related MAPK signaling transduction pathway. 2017. 10:2784–2793.
  • Wang S, Wu L, Du L, et al. Reduction in miRNA-125b-5p levels is associated with obstructive renal injury. Biomed Rep. 2017;6(4):449–454.
  • Jia L, Levine AB, Lockshin MD. American college of rheumatology criteria for systemic lupus erythematosus exclude half of all systemic lupus erythematosus patients: concise communication. Arthritis Rheumatol. 2017;69(7):1502–1503.
  • Yee C-S, Farewell VT, Isenberg DA, et al. The use of systemic lupus erythematosus disease activity index-2000 to define active disease and minimal clinically meaningful change based on data from a large cohort of systemic lupus erythematosus patients. Rheumatology (Oxford). 2011;50(5):982–988.
  • Gladman DD, Ibañez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29(2):288–291.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using Real-Time quantitative PCR and the 2 − ΔΔCT method. Methods. 2001;25(4):402–408.
  • Quan W, An J, Li G, et al. Th cytokine profile in childhood-onset systemic lupus erythematosus. BMC Pediatr. 2021;21(1):187.
  • Zhu J, Huang X, Su G, et al. High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus. Clin Rheumatol. 2014;33(6):807–815.
  • Chung J-Y, Park HR, Lee S-J, et al. Elevated TRAF2/6 expression in parkinson’s disease is caused by the loss of parkin E3 ligase activity. Lab Invest. 2013;93(6):663–676.
  • Chiffoleau E, Kobayashi T, Walsh MC, et al. TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-Polarized inflammatory disease. J Immunol. 2003;171(11):5751–5759.
  • Ma X, Becker Buscaglia LE, Barker JR, et al. MicroRNAs in NF- B signaling. J Mol Cell Biol. 2011;3(3):159–166.
  • Murphy AJ, Guyre PM, Pioli PA. Estradiol suppresses NF-κB activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol. 2010;184(9):5029–5037.
  • Boldin MP, Baltimore D. MicroRNAs, new effectors and regulators of NF-κB. Immunol Rev. 2012;246(1):205–220.
  • Rasheed Z, Rasheed N, Abdulmonem WA, et al. MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes. Sci Rep. 2019;9(1):6882.
  • Qiu J, Zhu J, Zhang R, et al. miR-125b-5p targeting TRAF6 relieves skeletal muscle atrophy induced by fasting or denervation. Ann Transl Med. 2019;7(18):456–456.
  • Lalani AI, Zhu S, Gokhale S, et al. TRAF molecules in inflammation and inflammatory diseases. Curr Pharmacol Rep. 2018;4(1):64–90.
  • Wang J, Wu X, Jiang M, et al. Mechanism by which TRAF6 participates in the immune regulation of autoimmune diseases and cancer. In: Singh VK. BioMed research international. 2020. 2020:1–16.
  • Zhao H, Ma S-X, Shang Y-Q, et al. microRNAs in chronic kidney disease. Clin Chim Acta. 2019;491:59–65.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.