NR3C2 mediates oxidised low-density lipoprotein-induced human coronary endothelial cells dysfunction via modulation of NLRP3 inflammasome activation

References

• Malakar AK, Choudhury D, Halder B, et al. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):1–8.
   Web of Science ®Google Scholar
• Lala A, Desai AS. The role of coronary artery disease in heart failure. Heart Fail Clin. 2014;10(2):353–365.
   PubMed Web of Science ®Google Scholar
• Bruning RS, Sturek M. Benefits of exercise training on coronary blood flow in coronary artery disease patients. Prog Cardiovasc Dis. 2015;57(5):443–453.
   PubMed Web of Science ®Google Scholar
• Steg PG, Ducrocq G. Future of the prevention and treatment of coronary artery disease. Circ J. 2016;80(5):1067–1072.
   PubMed Web of Science ®Google Scholar
• Khera AV, Kathiresan S. Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet. 2017;18(6):331–344.
   PubMed Web of Science ®Google Scholar
• Cui Z, Xu J, Jiang W. NR3C2 gene polymorphism is associated with risk of gestational hypertension in Han Chinese women. Medicine. 2019;98(50):e18215.
   PubMed Web of Science ®Google Scholar
• Huang Y, Wang Y, Ouyang Y. Elevated microRNA-135b-5p relieves neuronal injury and inflammation in post-stroke cognitive impairment by targeting NR3C2. Int J Neurosci. 2022;132(1):58–66.
   PubMed Web of Science ®Google Scholar
• Wang C, Hu F. Long noncoding RNA SOX2OT silencing alleviates cerebral ischemia-reperfusion injury via miR-135a-5p-mediated NR3C2 inhibition. Brain Res Bull. 2021;173:193–202.
   PubMed Web of Science ®Google Scholar
• Cai J, Shangguan S, Li G, et al. Knockdown of lncRNA Gm11974 protect against cerebral ischemic reperfusion through miR-766-3p/NR3C2 axis. Artif Cells Nanomed Biotechnol. 2019;47(1):3847–3853.
   PubMed Web of Science ®Google Scholar
• Shao BZ, et al. NLRP3 inflammasome and its inhibitors: a review. Front Pharmacol. 2015;6:262.
   PubMed Web of Science ®Google Scholar
• Sandanger Ø, Ranheim T, Vinge LE, et al. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2013;99(1):164–174.
   PubMed Web of Science ®Google Scholar
• Li P, Zhong X, Li J, et al. MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis. Biochem Biophys Res Commun. 2018;503(4):2833–2840.
   PubMed Web of Science ®Google Scholar
• Sano S, Oshima K, Wang Y, et al. Tet2-Mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1beta/NLRP3 inflammasome. J Am Coll Cardiol. 2018;71(8):875–886.
   PubMed Web of Science ®Google Scholar
• Zhang W, Xu X, Kao R, et al. Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3 inflammasome activation. PLoS One. 2014;9(9):e107639.
   PubMed Web of Science ®Google Scholar
• Wang Y, Liu X, Shi H, et al. NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases. Clin Transl Med. 2020;10(1):91–106.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43(D1):D447–D452.
   PubMed Web of Science ®Google Scholar
• Nowrouzi-Sohrabi P, Seghatoleslam A, Kalani M, et al. Up-regulated lncRNA-PVT1 expression in peripheral blood mononuclear cells of patients with coronary artery disease is correlated with decreased interleukin-10 production. Mol Biol Rep. 2022;49(5):3453–3459.
   PubMed Web of Science ®Google Scholar
• Li P, Xing J, Zhang J, et al. Inhibition of long noncoding RNA HIF1A-AS2 confers protection against atherosclerosis via ATF2 downregulation. J Adv Res. 2020;26:123–135.
   PubMed Web of Science ®Google Scholar
• Diaz D, Prieto A, Reyes E, et al. Flow cytometry enumeration of apoptotic cancer cells by apoptotic rate. Methods Mol Biol. 2015;1219:11–20.
   PubMedGoogle Scholar
• Li Y, Yang W, Quinones-Hinojosa A, et al. Interference with protease-activated receptor 1 alleviates neuronal cell death induced by lipopolysaccharide-stimulated microglial cells through the PI3K/Akt pathway. Sci Rep. 2016;6(1):38247.
   PubMedGoogle Scholar
• Sato H, et al. A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice. Mol Vis. 2010;16:378–391.
   PubMed Web of Science ®Google Scholar
• Song C, Zhou C. HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/smad/METTL3 signaling axis. J Exp Clin Cancer Res. 2021;40(1):62.
   PubMed Web of Science ®Google Scholar
• Nelson JD. Fast chromatin immunoprecipitation assay. Nucleic Acids Res. 2006;34(1):e2–e2.
   PubMed Web of Science ®Google Scholar
• Yang Q, Guo X-P, Cheng Y-L, et al. MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway. Arthritis Res Ther. 2019;21(1):97.
   PubMedGoogle Scholar
• Pyxaras SA, Wijns W, Reiber JHC, et al. Invasive assessment of coronary artery disease. J Nucl Cardiol. 2018;25(3):860–871.
   PubMed Web of Science ®Google Scholar
• Yang C, Ma X, Guan G, et al. MicroRNA-766 promotes cancer progression by targeting NR3C2 in hepatocellular carcinoma. FASEB J. 2019;33(1):1456–1467.
   PubMed Web of Science ®Google Scholar
• Fan Y, Li Y, Zhu Y, et al. Mir-301b-3p regulates breast cancer cell proliferation, migration, and invasion by targeting nr3c2. J Oncol. 2021;2021:8810517.
   PubMed Web of Science ®Google Scholar
• Dumeny L, Vardeny O, Edelmann F, et al. NR3C2 genotype is associated with response to spironolactone in diastolic heart failure patients from the Aldo-DHF trial. Pharmacotherapy. 2021;41(12):978–987.
   PubMed Web of Science ®Google Scholar
• Mangan MSJ, Olhava EJ, Roush WR, et al. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 2018;17(8):588–606.
   PubMed Web of Science ®Google Scholar
• Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol. 2009;296(1):H1–12.
   PubMed Web of Science ®Google Scholar
• Hoseini Z, Sepahvand F, Rashidi B, et al. NLRP3 inflammasome: its regulation and involvement in atherosclerosis. J Cell Physiol. 2018;233(3):2116–2132.
   PubMed Web of Science ®Google Scholar