Effect of Skin Sensitizers on Inducible Nitric Oxide Synthase Expression and Nitric Oxide Production in Skin Dendritic Cells: Role of Different Immunosuppressive Drugs

REFERENCES

• Griffiths C.E., Dearman R.J., Cumberbatch M., Kimber I. Cytokines and Langerhans cell mobilisation in mouse and man. Cytokine 2005; 21: 67–70
   Google Scholar
• Randolph G.J., Angeli V., Swartz M.A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 2005; 5: 617–628
   PubMed Web of Science ®Google Scholar
• Saint-Mezard P., Rosieres A., Krasteva M., Berard F., Dubois B., et al. Allergic contact dermatitis. Eur. J. Dermatol. 2004; 14: 284–295
   PubMed Web of Science ®Google Scholar
• Aiba S., Manome H., Nakagawa S., Mollah Z.U., Mizuashi M., et al. p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J. Invest. Dermatol. 2003; 120: 390–399
   PubMed Web of Science ®Google Scholar
• Arrighi J.F., Rebsamen M., Rousset F., Kindler V., Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J. Immunol. 2001; 166: 3837–3845
   PubMed Web of Science ®Google Scholar
• De Smedt A.C., Van Den Heuvel R.L., Van Tendeloo V.F., Berneman Z.N., Schoeters G.E. Capacity of CD34+ progenitor-derived dendritic cells to distinguish between sensitizers and irritants. Toxicol. Lett. 2005; 28: 377–389
   Google Scholar
• Hulette B.C., Ryan C.A., Gildea L.A., Gerberick G.F. Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen. Toxicol. Appl. Pharmacol. 2005; 1: 159–166
   Google Scholar
• Manome H., Aiba S., Singh S., Yoshino Y., Tagami H. Dexamethasone and cyclosporin A affect the maturation of monocyte-derived dendritic cells differently. Int. Arch. Allergy Immunol. 2000; 122: 76–84
   PubMed Web of Science ®Google Scholar
• Staquet M., Sportouch M., Jacquet C., Schmitt D., Guesnet J., Peguet-Navarro J. Moderate skin sensitizers can induce phenotypic changes on in vitro generated dendritic cells. Toxicol. In Vitro 2004; 18: 493–500
   PubMed Web of Science ®Google Scholar
• Tuschl H., Kovac R. Langerhans cells and immature dendritic cells as model systems for screening of skin sensitizers. Toxicol. In Vitro 2001; 15: 327–331
   PubMed Web of Science ®Google Scholar
• Boisleve F., Kerdine-Romer S., Rougier-Larzat N., Pallardy M. Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. J. Invest. Dermatol. 2004; 123: 494–502
   PubMed Web of Science ®Google Scholar
• Toebak M.J., Pohlmann P.R., Sampat-Sardjoepersad S.C., von Blomberg B.M., Bruynzeel D.P., et al, Gibbs S. CXCL8 secretion by dendritic cells predicts contact allergens from irritants. Toxicol. In Vitro 2006; 20: 117–124
   PubMed Web of Science ®Google Scholar
• Verheyen G.R., Schoeters E., Nuijten J.M., Van Den Heuvel R.L., Nelissen I., et al. Cytokine transcript profiling in CD34+ -progenitor derived dendritic cells exposed to contact allergens and irritants. Toxicol. Lett. 2005; 15: 187–194
   Google Scholar
• Toebak M.J., Moed H., von Blomberg M.B., Bruynzeel D.P., Gibbs S., et al. Intrinsic characteristics of contact and respiratory allergens influence production of polarizing cytokines by dendritic cells. Contact Dermat 2006; 55: 238–245
   PubMed Web of Science ®Google Scholar
• Aiba S., Manome H., Tagami H. In vitro treatment of human transforming growth factor-beta1-treated monocyte-derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans cells in the initiation phase of allergic contact sensitivity reaction. Immunol. 2000; 101: 68–75
   PubMed Web of Science ®Google Scholar
• Boisleve F., Kerdine-Römer S., Pallardy M. Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha. Toxicol. 2005; 206: 233–244
   PubMed Web of Science ®Google Scholar
• Brand P., Plochmann S., Valk E., Zahn S., Saloga J., et al. Activation and translocation of p38 mitogen-activated protein kinase after stimulation of monocytes with contact sensitizers. J. Invest. Dermatol. 2002; 119: 99–106
   PubMedGoogle Scholar
• Bruchhausen S., Zahn S., Valk E., Knop J., Becker D. Thiol antioxidants block the activation of antigen-presenting cells by contact sensitizers. J. Invest. Dermatol. 2003; 121: 1039–1044
   PubMed Web of Science ®Google Scholar
• Matos T.J., Duarte C.B., Gonçalo M., Lopes M.C. DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells. J. Dermatol. Science 2005; 39: 113–123
   PubMed Web of Science ®Google Scholar
• Matos T.J., Duarte C.B., Gonçalo M., Lopes M.C. Role of oxidative stress in ERK and p38 MAPK activation induced by the chemical sensitizer DNFB in a fetal skin dendritic cell line. Immunol. Cell Biol. 2005; 83: 607–614
   PubMed Web of Science ®Google Scholar
• Mizuashi M., Ohtani T., Nakagawa S., Aiba S. Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells. J. Invest. Dermatol. 2005; 124: 579–586
   PubMed Web of Science ®Google Scholar
• Cruz M.T., Gonçalo M., Figueiredo A., Carvalho A.P., Duarte C.B., Lopes MC. Contact sensitizer nickel sulphate activates the transcription factors NF-kB and AP-1 and increases the expression of nitric oxide synthase in a skin dendritic cell line. Exp. Dermatol. 2004; 13: 18–26
   PubMed Web of Science ®Google Scholar
• Bruch-Gerharz D., Ruzicka T., Kolb-Bachofen V. Nitric oxide in human skin: current status and future prospects. J. Invest. Dematol. 1998; 110: 1–7
   PubMed Web of Science ®Google Scholar
• Cals-Grierson M.M., Ormerod A.D. Nitric oxide function in the skin. Nitric Oxide 2004; 10: 179–193
   PubMed Web of Science ®Google Scholar
• Nishioka Y., Wen H., Mitani K., Robbins P.D., Lotze M.T., et al. Differential effects of IL-12 on the generation of alloreactive CTL mediated by murine and human dendritic cells: a critical role for nitric oxide. J. Leukoc. Biol. 2003; 73: 621–629
   PubMedGoogle Scholar
• Ormerod A.D., Dwyer C.M., Reid A., Copeland P., Thompson W.D. Inducible nitric oxide synthase demonstrated in allergic and irritant contact dermatitis. Acta Derm. Venereol. 1997; 77: 436–440
   PubMed Web of Science ®Google Scholar
• Ross R., Gillitzer C., Kleinz R., Schwing J., Kleinert H., et al. Involvement of NO in contact hypersensitivity. Int. Immunol. 1998; 10: 61–69
   PubMed Web of Science ®Google Scholar
• Rowe A., Farrel A.M., Bunker C.B. Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses. Brit. J. Dermatol. 1997; 136: 18–23
   PubMed Web of Science ®Google Scholar
• Sahin S., Onder M., Sancak B., Bukan N., Gurer M.A. The role of nitric oxide in allergic contact dermatitis. Arch. Dermatol. Res. 2001; 293: 214–217
   PubMed Web of Science ®Google Scholar
• Wallengren J., Larsson B. Nitric oxide participates in prick test and irritant patch test reactions in human skin. Arch. Dermatol. Res. 2001; 293: 121–125
   PubMedGoogle Scholar
• Abe M., Thomson A.W. Influence of immunosuppressive drugs on dendritic cells. Transpl. Immunol. 2003; 11: 357–365
   PubMed Web of Science ®Google Scholar
• Girolomoni G., Lutz M.B., Pastore S., Abmann C.U., Cavani A., Ricciardi-Castagnoli P. Establishment of a cell line with features of early dendritic cell precursors from fetal mouse skin. Eur. J. Immunol. 1995; 25: 2163–2169
   PubMed Web of Science ®Google Scholar
• Cruz M.T., Duarte C.B., Gonçalo M., Carvalho A.P., Lopes M.C. Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells. Am. J. Physiol. 1999; 277: C1050–1057
   Web of Science ®Google Scholar
• Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 1982; 126: 131–138
   PubMed Web of Science ®Google Scholar
• Singh S., Aiba S., Manome H., Tagami H. The effects of dexamethasone, cyclosporine, and vitamin D(3) on the activation of dendritic cells stimulated by haptens. Arch. Dermatol. Res. 1999; 291: 548–554
   PubMed Web of Science ®Google Scholar
• Ross R., Reske-Kunz A.B. The role of NO in contact hypersensitivity. Int. Immunopharmacol. 2001; 1: 1469–1478
   PubMedGoogle Scholar
• Hyun E., Bolla M., Steinhoff M., Wallace J.L., Soldato P.D., Vergnolle N. Anti-inflammatory effects of nitric oxide-releasing hydrocortisone NCX 1022, in a murine model of contact dermatitis. Br. J. Pharmacol. 2004; 143: 618–625
   PubMed Web of Science ®Google Scholar
• Hoetzenecker W., Meingassner J.G., Ecker R., Stingl G., Stuetz A., Elbe-Burger A. Corticosteroids but not pimecrolimus affect viability, maturation and immune function of murine epidermal Langerhans cells. J. Invest. Dermatol. 2004; 122: 673–684
   PubMed Web of Science ®Google Scholar
• Kalthoff F.S., Chung J., Musser P., Stuetz A. Pimecrolimus does not affect the differentiation, maturation and function of human monocyte-derived dendritic cells, in contrast to corticosteroids. Clin. Exp. Immunol. 2003; 133: 350–359
   PubMed Web of Science ®Google Scholar
• Krummen M., Varga G., Steinert M., Stuetz A., Luger T.A., Grabbe S. Effect of pimecrolimus vs. corticosteroids on murine bone marrow-derived dendritic cell differentiation, maturation and function. Exp. Dermatol. 2006; 15: 43–50
   PubMed Web of Science ®Google Scholar
• Meingassner J., Kowalsky E., Schwendinger H., Elbe-Burger A., Stutz A. Pimecrolimus does not affect Langerhans cells in murine epidermis. Br. J. Dermatol. 2003; 149: 853–857
   PubMed Web of Science ®Google Scholar
• Woltman A.M., de Fijter J.W., Kamerling S.W., Paul L.C., Daha M.R., van Kooten C. The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. Eur. J. Immunol. 2000; 30: 1807–1812
   PubMed Web of Science ®Google Scholar
• Manome H., Aiba S., Tagami H. Simple chemicals can induce maturation and apoptosis of dendritic cells. Immunol. 1999; 98: 481–490
   PubMed Web of Science ®Google Scholar
• Duperrier K., Velten F.W., Bohlender J., Demory A., Metharom P., Goerdt S. Immunosuppressive agents mediate reduced allostimulatory properties of myeloid-derived dendritic cells despite induction of divergent molecular phenotypes. Mol. Immunol. 2005; 42: 1531–1540
   PubMedGoogle Scholar
• Matsue H., Yang C., Matsue K., Edelbaum D., Mummert M., Takashima A. Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during antigen presentation. J. Immunol. 2002; 169: 3555–3564
   PubMed Web of Science ®Google Scholar
• Stepkowski S.M. Molecular targets for existing and novel immunosuppressive drugs. Expert Rev. Mol. Med. 2000; 21: 1–23
   Google Scholar
• Kaibori M., Okumura T., Ito S., Oda M., Inoue T., Kamiyama Y. Inhibition of iNOS induction by FK506, but not by cyclosporine, in rat hepatocytes. Transplant. Proc. 1999; 31: 804–805
   PubMedGoogle Scholar
• Baumer W., Sulzle B., Weigt H., De Vries V.C., Hecht M., et al. Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis. Br. J. Dermatol. 2005; 153: 136–144
   PubMed Web of Science ®Google Scholar
• Yamamoto Y., Gaynor R.B. Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 2001; 107: 135–42
   PubMed Web of Science ®Google Scholar
• Kleinert H., Pautz A., Linker K., Schwarz P.M. Regulation of the expression of inducible nitric oxide synthase. Eur. J. Pharmacol. 2004; 500: 255–266
   PubMed Web of Science ®Google Scholar
• Li Y.H., Yan Z.Q., Brauner A., Tullus K. Activation of macrophage nuclear factor-kappa B and induction of inducible nitric oxide synthase by LPS. Respir. Res. 2002; 23
   Google Scholar
• Matsumura M., Kakishita H., Suzuki M., Banba N., Hattori Y. Dexamethasone suppresses iNOS gene expression by inhibiting NF-kappaB in vascular smooth muscle cells. Life Sci. 2001; 69: 1067–1077
   PubMed Web of Science ®Google Scholar
• Vital A.L., Gonçalo M., Cruz M.T., Figueiredo A., Duarte C.B., Lopes M.C. Dexamethasone prevents GM-CSF-induced NF-kB activation, iNOS expression and NO production in a skin dendritic cell line. Mediators Inflam. 2003; 12: 71–78
   PubMed Web of Science ®Google Scholar
• Cruz M.T., Duarte C.B., Goncalo M., Figueiredo A., Carvalho A.P., Lopes M.C. Granulocyte-macrophage colony-stimulating factor activates the transcription of nuclear factor kappa B and induces the expression of nitric oxide synthase in a skin dendritic cell line. Immunol. Cell Biol. 2001; 79: 590–596
   PubMedGoogle Scholar
• Cruz M.T., Duarte C.B., Gonçalo M., Figueiredo A., Carvalho A.P., Lopes M.C. LPS induction of IkB alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the JAK 2 inhibitor, Tyrphostin B42. Nitric Oxide 2001; 5: 53–61
   PubMedGoogle Scholar
• Goebeler M., Gillitzer R., Kilian K., Utzel K., Brocker E.B., et al. Multiple signalling pathways regulate NF-kB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. Blood 2001; 97: 46–55
   PubMedGoogle Scholar
• Goebeler M., Roth J., Brocker E.B., Sorg C., Schulze-Osthoff K. Activation of nuclear factor-kappa B and gene expression in human endothelila cells by the common haptens nickel and cobalt. J. Immunol. 1995; 155: 2459–2467
   PubMed Web of Science ®Google Scholar
• Barchowsky A., Soucy N.V., O'Hara K.A., Hwa J., Noreault T.L., Andrew A.S. A novel pathway for nickel-induced interleukin-8 expression. J. Biol. Chem. 2002; 277: 24225–24231
   PubMedGoogle Scholar
• Andrew A.S., Klei L.R., Barchowsky A. AP-1 dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. Am. J. Physiol. Lung Cell. Mol. Physiol. 2001; 28: L616–623
   Google Scholar