Hochu-ekki-to combined with interferon-gamma moderately enhances daily activity of chronic fatigue syndrome mice by increasing NK cell activity, but not neuroprotection

References

• Fukuda, K.; Straus, S.E.; Hickie, I.; Sharpe, M.C.; Dobbins, J.G.; Komaroff, A. The chronic fatigue syndrome. A comprehensive approach to its definition and study. Ann Intern Med. 1994, 121 (12):953–959.
   PubMed Web of Science ®Google Scholar
• Katafuchi, T.; Kondo, T.; Take, S.; Yoshimura, M. Brain cytokines and the 5-HT system during poly I:C-induced fatigue. Ann N Y Acad Sci. 2006, 1088:230–237.
   PubMedGoogle Scholar
• Rook, G.A.; Zumla, A. Gulf War syndrome: is it due to a systemic shift in cytokine balance towards a Th2 profile? Lancet. 1997, 349 (9068):1831–1833.
   PubMedGoogle Scholar
• de Lange, F.P.; Kalkman, J.S.; Bleijenberg, G.; Hagoort, P.; van der Meer, J.W.; Toni, I. Gray matter volume reduction in the chronic fatigue syndrome. Neuroimage. 2005, 26 (3):777–781.
   PubMedGoogle Scholar
• Brooks, J.C.; Roberts, N.; Whitehouse, G.; Majeed, T. Proton magnetic resonance spectroscopy and morphometry of the hippocampus in chronic fatigue syndrome. Br J Radiol. 2000, 73 (875):1206–1208.
   PubMedGoogle Scholar
• Wang, X.Q.; Takahashi, T.; Zhu, S.J.; Moriya, J.; Saegusa, S.; Yamakawa, J.; Kusaka, K.; Itoh, T.; Kanda, T. Effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, on daily activity in a murine model of chronic fatigue syndrome. Evid Based Complement Alternat Med. 2004, 1 (2):203–206.
   PubMedGoogle Scholar
• Moriya, J. Establishment of murine model for chronic fatigue syndrome and efficacy of kampo medicine on daily activity. J Kanazawa Med Univ. 2006, 31:1–6.
   Google Scholar
• Chen, R.; Moriya, J.; Yamakawa, J.I.; Takahashi, T.; Li, Q.; Morimoto, S.; Iwai, K.; Sumino, H.; Yamaguchi, N.; Kanda, T. Brain Atrophy in a murine model of chronic fatigue syndrome and beneficial effect of Hochu-ekki-to (TJ-41). Neurochem Res. Mar 4., 2008, [Epub ahead of print].
   Google Scholar
• Carlo-Stella, N.; Badulli, C.; De Silvestri, A.; Bazzichi, L.; Martinetti, M.; Lorusso, L.; Bombardieri, S.; Salvaneschi, L.; Cuccia, M. A first study of cytokine genomic polymorphisms in CFS: Positive association of TNF-857 and IFNgamma 874 rare alleles. Clin Exp Rheumatol. 2006, 24 (2):179–182.
   PubMedGoogle Scholar
• Lee, J.; Kim, S.J.; Son, T.G.; Chan, S.L.; Mattson, M.P. Interferon-gamma is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity. J Neurosci Res. 2006, 83 (8):1552–1557.
   PubMedGoogle Scholar
• Ottenweller, J.E.; Natelson, B.H.; Gause, W.C.; Carroll, K.K.; Beldowicz, D.; Zhou, X.D.; LaManca, J.J. Mouse running activity is lowered by Brucella abortus treatment: A potential model to study chronic fatigue. Physiol Behav. 1998, 63 (5):795–801.
   PubMedGoogle Scholar
• Kanda, T.; McManus, J.E.; Nagai, R.; Imai, S.; Suzuki, T.; Yang, D.; McManus, B.M.; Kobayashi, I. Modification of viral myocarditis in mice by interleukin-6. Circ Res. 1996, 78 (5):848–856.
   PubMedGoogle Scholar
• Becker, P.D.; McGregor, N.; Meirleir, K.D. Possible triggers and mode of onset of chronic fatigue syndrome. J Chronic Fatigue Syndr. 2002, 10:3–18.
   Google Scholar
• Prins, J.B.; van der Meer, J.W.; Bleijenberg, G. Chronic fatigue syndrome. Lancet. 2006, 367 (9507):346–355.
   PubMedGoogle Scholar
• Parker, N.R.; Barralet, J.H.; Bell, A.M. Q fever. Lancet. 2006, 367 (9511):679–688.
   PubMedGoogle Scholar
• Tarello, W. Chronic fatigue syndrome (CFS) associated with Staphylococcus spp. bacteremia, responsive to potassium arsenite 0.5 % in a veterinary surgeon and his coworking wife, handling with CFS animal cases. Comp Immunol Microbiol Infect Dis. 2001, 24 (4):233–246.
   PubMedGoogle Scholar
• Hickie, I.; Davenport, T.; Wakefield, D.; Vollmer-Conna, U.; Cameron, B.; Vernon, S.D.; Reeves, W.C.; Lloyd, A. (Dubbo Infection Outcomes Study Group.) Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ 2006, 333 (7568):575–580.
   PubMedGoogle Scholar
• Sacks, N.; Van Rensburg, A.J. Clinical aspects of chronic brucellosis. S Afr Med J. 1976, 50 (19):725–728.
   PubMedGoogle Scholar
• Natelson, B.H.; LaManca, J.J.; Denny, T.N.; Vladutiu, A.; Oleske, J.; Hill, N.; Bergen, M.T.; Korn, L.; Hay, J. Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis. Am J Med. 1998, 105 (3A):43S–49S.
   Google Scholar
• Chao, C.C.; Janoff, E.N.; Hu, S.X.; Thomas, K.; Gallagher, M.; Tsang, M.; Peterson, P.K. Altered cytokine release in peripheral blood mononuclear cell (PBMC) cultures from patients with the chronic fatigue syndrome (CFS). Cytokine. 1991, 3 (4):292–298.
   PubMedGoogle Scholar
• Tirelli, V.; Pinto, A.; Marotta, G.; Crovato, M.; Quaia, M.; De Paoli, P.; Galligioni, E.; Santini, G. Clinical and immunologic study of 205 patients with chronic fatigue syndrome: A case series from Italy. Arch Intern Med. 1993, 153 (1):116–117, 120.
   PubMedGoogle Scholar
• Strowig, T.; Brilot, F.; Münz, C. Noncytotoxic functions of NK cells: Direct pathogen restriction and assistance to adaptive immunity. J Immunol. 2008, 180 (12):7785–7791.
   PubMedGoogle Scholar
• Kato, Y.; Morikawa, A.; Sugiyama, T.; Koide, N.; Jiang, G.Z.; Lwin, T.; Yoshida, T.; Yokochi, T. Augmentation of lipopolysaccharide-induced thymocyte apoptosis by interferon-gamma. Cell Immunol. 1997, 177 (2):103–108.
   PubMedGoogle Scholar
• Cook, D.B.; O’Connor, P.J.; Lange, G. Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls. Neuroimage. 2007, 36 (1):108–122.
   PubMedGoogle Scholar
• Beck, T.; Lindholm, D.; Castrén, E.; Wree, A. Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J Cereb Blood Flow Metab. 1994, 14 (4):689–692.
   PubMedGoogle Scholar
• Martinowich, K.; Manji, H.; Lu, B. New insights into BDNF function in depression and anxiety. Nat Neurosci. 2007, 10 (9):1089–1093.
   PubMedGoogle Scholar
• Sasaki, T.; Kitagawa, K.; Yagita, Y.; Sugiura, S.; Omura-Matsuoka, E.; Tanaka, S.; Matsushita, K.; Okano, H.; Tsujimoto, Y.; Hori, M. 2006. Bcl2 enhances survival of newborn neurons in the normal and ischemic hippocampus. J Neurosci Res. 84 (6):1187–1196.
   Google Scholar
• Zhong, L.T.; Sarafian, T.; Kane, D.J.; Charles, A.C.; Mah, S.P.; Edwards, R.H.; Bredesen, D.E. Bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA. 1993, 90 (10):4533–4537.
   PubMedGoogle Scholar
• Vaynman, S.; Ying, Z.; Gomez-Pinilla, F. The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function. Neuroscience. 2007, 144 (3):825–833.
   PubMedGoogle Scholar
• Wang, X.J.; Ichikawa, H.; Konishi, T. Antioxidant potential of qizhu tang, a chinese herbal medicine, and the effect on cerebral oxidative damage after ischemia reperfusion in rats. Biol Pharm Bull. 2001, 24 (5):558–563.
   PubMedGoogle Scholar
• Shih, H.C.; Chang, K.H.; Chen, F.L.; Chen, C.M.; Chen, S.C.; Lin, Y.T.; Shibuya, A. Anti-aging effects of the traditional Chinese medicine bu-zhong-yi-qi-tang in mice. Am J Chin Med. 2000, 28 (1):77–86.
   PubMedGoogle Scholar
• Geiger, K.D.; Nash, T.C.; Sawyer, S.; Krahl, T.; Patstone, G.; Reed, J.C.; Krajewski, S.; Dalton, D.; Buchmeier, M.J.; Sarvetnick, N. Interferon-gamma protects against herpes simplex virus type 1-mediated neuronal death. Virology. 1997, 238 (2):189–197.
   PubMedGoogle Scholar