620
Views
37
CrossRef citations to date
0
Altmetric
Invited Review

Secretory immunoglobulin A: well beyond immune exclusion at mucosal surfaces

Pages 174-179 | Received 05 Aug 2008, Accepted 28 Aug 2008, Published online: 01 Jun 2008

References

  • Ogra, P.L.; Mestecky, J.; Lamm, M.E.; Strober, W.; Bienenstock, J.; McGhee, J.R. 1999, Mucosal Immunology, 2nd ed. San Diego, CA: Academic Press.
  • Johansen, F.E.; Braathen, R.; Brandtzaeg, P. Role of J chain in secretory immunoglobulin formation. Scand J Immunol. 2000, 52(3), 240–248.
  • Kaetzel, C.S. The polymeric immunoglobulin receptor: Bridging innate and adaptive immune responses at mucosal surfaces. Immunol Rev. 2005, 206, 83–99.
  • Mostov, K.E. Transepithelial transport of immunoglobulins. Annu Rev Immunol. 1994, 12, 63–84.
  • Nagler-Anderson, C. Man the barrier! Strategic defences in the intestinal mucosa. Nat Rev Immunol. 2001, 1(1), 59–67.
  • Robinson, J.K., Blanchard, T.G.; Levine, A.D.; Emancipator, S.N.; Lamm, M.E. A mucosal IgA-mediated excretory immune system in vivo. J Immunol. 2001, 166(6), 3688–3692.
  • Fujioka, H.; Emancipator, S.N.; Aikawa, M.; Huang, D.S.; Blatnik, F.; Karban, T.; DeFife, K.; Mazanec, M.B. Immunocytochemical colocalization of specific immunoglobulin A with sendai virus protein in infected polarized epithelium. J Exp Med. 1998, 188(7), 1223–1229.
  • Fernandez, M.I.; Pedron, T.; Tournebize, R.; Olivo-Marin, J.C.; Sansonetti, P.J.; Phalipon, A. Anti-inflammatory role for intracellular dimeric immunoglobulin A by neutralization of lipopolysaccharide in epithelial cells. Immunity. 2003, 18(6), 739–749.
  • Mahida, Y.R. Microbial-gut interactions in health and disease. Epithelial cell responses. Best Pract Res Clin Gastroenterol. 2004, 18(2), 241–253.
  • Sansonetti, P.J. War and peace at mucosal surfaces. Nat Rev Immunol. 2004, 4(12), 953–964.
  • Neutra, M.R. M cells in antigen sampling in mucosal tissues. Curr Top Microbiol Immunol. 1999, 236, 17–32.
  • Corthésy, B.; Kraehenbuhl, J.P. Antibody-mediated protection of mucosal surfaces. Curr Top Microbiol Immunol. 1999, 236, 93–111.
  • Mowat, A.M. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol. 2003, 3(4), 331–341.
  • Gallucci, S.; Matzinger, P. Danger signals: SOS to the immune system. Curr Opin Immunol. 2001, 13(1), 114–119.
  • Hamada, H.; Hiroi, T.; Nishiyama, Y.; Takahashi, H.; Masunaga, Y.; Hachimura, S.; Kaminogawa, S.; Takahashi-Iwanaga, H.; Iwanaga, T.; Kiyono, H.; Yamamoto, H.; Ishikawa, H. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J Immunol. 2002, 168(1), 57–64.
  • Jang, M.H.; Kweon, M.N.; Iwatani, K.; Yamamoto, M.; Terahara, K.; Sasakawa, C.; Suzuki, T.; Nochi, T.; Yokota, Y.; Rennert, P.D.; Hiroi, T.; Tamagawa, H.; Iijima, H.; Kunisawa, J.; Yuki, Y.; Kiyono, H. Intestinal villous M cells: An antigen entry site in the mucosal epithelium. Proc Natl Acad Sci USA. 2004, 101(16), 6110–6115.
  • Morelli, A.E. The immune regulatory effect of apoptotic cells and exosomes on dendritic cells: Its impact on transplantation. Am J Transplant. 2006, 6(2), 254–261.
  • Rescigno, M.; Urbano, M.; Valzasina, B.; Francolini, M.; Rotta, G.; Bonasio, R.; Granucci, F.; Kraehenbuhl, J.P.; Ricciardi-Castagnoli, P. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol. 2001, 2(4), 361–367.
  • Niess, J.H.; Brand, S.; Gu, X.; Landsman, L.; Jung, S.; McCormick, B.A.; Vyas, J.M.; Boes, M.; Ploegh, H.L.; Fox, J.G.; Littman, D.R.; Reinecker, H.C. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005, 307(5707), 254–258.
  • Neal, M.D.; Leaphart, C.; Levy, R.; Prince, J.; Billiar, T.R.; Watkins, S.; Li, J.; Cetin, S.; Ford, H.; Schreiber, A.; Hackam, D.J. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol. 2006, 176(5), 3070–3079.
  • Yoshida, M.; Claypool, S.M.; Wagner, J.S.; Mizoguchi, E.; Mizoguchi, A.; Roopenian, D.C.; Lencer, W.I.; Blumberg, R.S. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity. 2004, 20(6), 769–783.
  • Rey, J.; Garin, N.; Spertini, F.; Corthésy, B. Targeting of secretory IgA to Peyer’s patch dendritic and T cells after transport by intestinal M cells. J Immunol. 2004, 172(5), 3026–3033.
  • Kadaoui, K.A.; Corthésy, B. Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer’s patches with restriction to mucosal compartment. J Immunol. 2007, 179(11), 7751–7757.
  • Kelsall, B.L.; Leon, F. Involvement of intestinal dendritic cells in oral tolerance, immunity to pathogens, and inflammatory bowel disease. Immunol Rev. 2005, 206, 132–148.
  • Iwasaki, A. Mucosal dendritic cells. Annu Rev Immunol. 2007, 25, 381–418.
  • Cerutti, A.; Rescigno, M. The biology of intestinal immunoglobulin A responses. Immunity. 2008, 28(6), 740–750.
  • Worbs, T.; Bode, U.; Yan, S.; Hoffmann, M.W.; Hintzen, G.; Bernhardt, G.; Förster, R.; Pabst, O. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med. 2006, 203(3), 519–527.
  • Sun, C.M.; Hall, J.A.; Blank, R.B.; Bouladoux, N.; Oukka, M.; Mora, J.R.; Belkaid, Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 Treg cells via retinoic acid. J Exp Med. 2007, 204(8), 1775–1785.
  • Coombes, J.L.; Siddiqui, K.R.; Arancibia-Cárcamo, C.V.; Hall, J.; Sun, C.M.; Belkaid, Y.; Powrie, F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007, 204(8), 1757–1764.
  • Stagg, A.J.; Kamm, M.A.; Knight, S.C. Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin. Eur J Immunol. 2002, 32(5), 1445–1454.
  • Stenstad, H.; Ericsson, A.; Johansson-Lindbom, B.; Svensson, M.; Marsal, J.; Mack, M.; Picarella, D.; Soler, D.; Marquez, G.; Briskin, M.; Agace, W.W. Gut-associated lymphoid tissue-primed CD4+ T cells display CCR9-dependent and -independent homing to the small intestine. Blood. 2006, 107(9), 3447–3454.
  • Iwata, M.; Hirakiyama, A.; Eshima, Y.; Kagechika, H.; Kato, C.; Song, S.Y. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004, 21(4), 527–538.
  • Iwasaki, A.; Kelsall, B.L. Freshly isolated Peyer’s patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J Exp Med. 1999, 190(2), 229–239.
  • Sato A; Hashiguchi M; Toda E; Iwasaki A; Hachimura S; Kaminogawa S. CD11b+ Peyer’s patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells. J Immunol. 2003, 171(7), 3684–3690.
  • Mora, J.R.; Iwata, M.; Eksteen, B.; Song, S.Y.; Junt, T.; Senman, B.; Otipoby, K.L.; Yokota, A.; Takeuchi, H.; Ricciardi-Castagnoli, P.; Rajewsky, K.; Adams, D.H.; von Andrian, U.H. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006, 314(5802), 1157–1160.
  • Kelsall, B.L.; Rescigno, M. Mucosal dendritic cells in immunity and inflammation. Nat Immunol. 2004, 5(11), 1091–1095.
  • Salazar-Gonzalez, R.M.; Niess, J.H.; Zammit, D.J.; Ravindran, R.; Srinivasan, A.; Maxwell, J.R.; Stoklasek, T.; Yadav, R.; Williams, I.R.; Gu, X.; McCormick, B.A.; Pazos, M.A.; Vella, A.T.; Lefrancois, L.; Reinecker, H.C.; McSorley, S.J. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer’s patches. Immunity. 2006, 24, 623–632.
  • Chieppa, M.; Rescigno, M.; Huang, A.Y.; Germain, R.N. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med. 2006, 203(13), 2841–2852.
  • Pulendran, B.; Banchereau, J.; Maraskovsky, E.; Maliszewski, C. Modulating the immune response with dendritic cells and their growth factors. Trends Immunol. 2001, 22(1), 41–47.
  • Roy, M.J.; Varvayanis, M. Development of dome epithelium in gut-associated lymphoid tissues: Association of IgA with M cells. Cell Tissue Res. 1987, 248(3), 645–651.
  • Weltzin, R.; Lucia-Jandris, P.; Michetti, P.; Fields, B.N.; Kraehenbuhl, J.P.; Neutra, M.R. Binding and transepithelial transport of immunoglobulins by intestinal M cells: Demonstration using monoclonal IgA antibodies against enteric viral proteins. J Cell Biol. 1989, 108(5), 1673–1685.
  • Mantis, N.J.; Cheung, M.C.; Chintalacharuvu, K.R.; Rey, J.; Corthésy, B.; Neutra, M.R. Selective adherence of IgA to murine Peyer’s patch M cells: Evidence for a novel IgA receptor. J Immunol. 2002, 169(4), 1844–1851.
  • Zhou, F; Kraehenbuhl, J.P.; Neutra, M.R. Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes. Vaccine. 1995, 13(7), 637–644.
  • Corthésy, B.; Kaufmann, M.; Phalipon, A.; Peitsch, M.; Neutra, M.R.; Kraehenbuhl, J.P. A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral route. J Biol Chem. 1996, 271(52), 33670–33677.
  • Favre, L.I.; Spertini, F.; Corthésy, B. Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses. J Immunol. 2005,175(5), 2793–2800.
  • Mellman, I.; Steinman, R.M. Dendritic cells: Specialized and regulated antigen processing machines. Cell. 2001, 106(3), 255–258.
  • Mounier, J., Vasselon, T.; Hellio, R.; Lesourd, M.; Sansonetti, P.J. Shigella flexneri enters human colonic Caco-2 epithelial cells through the basolateral pole. Infect Immun. 1992, 60(1), 237–248.
  • Corthésy, B. Roundtrip ticket for secretory IgA: Role in mucosal homeostasis? J Immunol. 2007, 178(1), 27–32.
  • Bos, N.A.; Bun, J.C.; Popma, S.H.; Cebra, E.R.; Deenen, G.J.; van der Cammen, M.J.; Kroese, F.G.; Cebra, J.J. Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria. Infect Immun. 1996, 64(2), 616–623.
  • Cunningham-Rundles, C. Physiology of IgA and IgA deficiency. J Clin Immunol. 2001, 21(5), 303–309.
  • Brandtzaeg, P.; Johansen, F.E. Mucosal B cells: Phenotypic characteristics, transcriptional regulation, and homing properties. Immunol Rev. 2005, 206, 32–63.
  • Fagarasan, S.; Honjo, T. Regulation of IgA synthesis at mucosal surfaces. Curr Opin Immunol. 2004, 16(3), 277–283.
  • Bartemes, K.R.; Cooper, K.M.; Drain, K.L.; Kita, H. Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions. J Allergy Clin Immunol. 2005, 116(4), 827–835.
  • Pasquier, B.; Launay, P.; Kanamaru, Y.; Moura, I.C.; Pfirsch, S.; Ruffié, C.; Hénin, D.; Benhamou, M.; Pretolani, M.; Blank, U.; Monteiro, R.C. Identification of FcalphaRI as an inhibitory receptor that controls inflammation: Dual role of FcRgamma ITAM. Immunity. 2005, 22(1), 31–42.
  • He, B.; Xu, W.; Santini, P.A.; Polydorides, A.D.; Chiu, A.; Estrella, J.; Shan, M.; Chadburn, A.; Villanacci, V.; Plebani, A.; Knowles, D.M.; Rescigno, M.; Cerutti, A. Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity. 2007, 26(6), 812–826.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.