The inhibition of JNK and p38 MAPKs downregulates IL-10 and differentially affects c-Jun gene expression in human monocytes

References

• Opal, S.M.; DePalo, V.A. Anti-Inflammatory cytokines. CHEST. 2000, 117, 1162–1172.
   PubMed Web of Science ®Google Scholar
• Liu, Y.W.; Chen, C.C.; Tseng, H.P.; Chang, W.C. Lypopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-κB-induced CCAAT/enhancer-binding protein δ in mouse macrophages. Cell Signal. 2006, 18, 1492–1500.
   PubMed Web of Science ®Google Scholar
• Agematsu, K.; Nagumo, H.; Oguchi, Y.; Nakazava, T.; Fukushima, K.; Yasui, K.; Ito, S.; Kobata, T.; Morimoto, C.; Komiyama, A. Generation of plasma cells from peripheral blood memory B cells: Synergistic effect of interleukin-10 and CD27/CD70 interaction. Blood. 1998, 91, 173–180.
   PubMed Web of Science ®Google Scholar
• Cao, S.; Liu, J.; Chesi, M.; Bergsage, P.L.; Ho, I.C.; Donnelly, R.P.; Ma, X. Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. J Immunol. 2002, 169, 5715–5725.
   PubMed Web of Science ®Google Scholar
• Rao, K.M.K. MAP kinase activation in macrophages. J Leukoc Biol. 2001, 69, 3–10.
   PubMed Web of Science ®Google Scholar
• Obata, T.; Brown, G.E.; Yaffe, M.B. MAP kinase pathways activated by stress: The p38 MAPK pathway. Critical Care Medicine. 2000, 28, N67–N77.
   PubMed Web of Science ®Google Scholar
• Chang, L.; Karin, M. Mammalian MAP kinase signaling cascades. Nature. 2001, 410, 37–40.
   PubMed Web of Science ®Google Scholar
• Mansouri, A.; Ridgway, L.D.; Korapati, A.L.; Zhang, Q.; Tian, L.; Wang, Y.; Siddik, Z.H.; Mills, G.B.; Claret, F.X. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem. 2003, 278, 19245–19256.
   PubMedGoogle Scholar
• Ma, W.; Lim, W.; Gee, K.; Aucoin, S.; Nandan, D.; Kozlowski, M.; Diaz-Mitoma, F.; Kumar, A. The p38 mitogen activated kinase pathway regulates the human interleukin 10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages. J Biol Chem. 2001, 276, 13664–13674.
   PubMed Web of Science ®Google Scholar
• Chanteux, H.; Guisset, A.C.; Pilette, C.; Sibille, Y. LPS induces IL-10 production by alveolar macrophages via MAPKinases-and Sp1-dependent mechanisms. Respir Res. 2007, 8, 71.
   PubMed Web of Science ®Google Scholar
• Zhang, P.; Martin, M.; Michalek, S.M.; Katz, J. Role of mitogen-activated protein kinase and NF-κB in the regulation of proinflammatory and anti-inflammatory cytokines by Porphyromonas gingivalis hemagglutinin B. Infect Immunity. 2005, 73, 3990–3998.
   Web of Science ®Google Scholar
• Schwacha, M.G.; Chaudry, I.H.; Alexander, M. Regulation of macrophage IL-10 production postinjury via β2 integrin signaling and p38 MAP kinase pathway. Shock. 2003, 20, 529–535.
   PubMed Web of Science ®Google Scholar
• Sweet, M.J.; Hume, D.A. Endotoxin signal transduction in macrophages. J Leukoc Biol. 1996, 60, 8–26.
   PubMed Web of Science ®Google Scholar
• Murphy, T.L.; Cleveland, M.J.; Kulesza, P.; Magram, J.; Murphy, K.M. Regulation of IL-12p40 expression through an NF- κB half-site. Mol Cel Biol. 1995, 15, 5258–5267.
   PubMed Web of Science ®Google Scholar
• Plevy, S.E.; Gemberling, J.H.; Hsu, S.; Dorner, A.J.; Smale, S.T. Multiple control elements mediate activation of the murine and human interleukin-12p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol CelL Biol. 1997, 17, 4572–4588.
   PubMed Web of Science ®Google Scholar
• Tone, M.; Powel, M.J.; Tone, Y.; Thompson, S.A.; Waldmann, H. IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J Immunol. 2000, 165, 286–291.
   Web of Science ®Google Scholar
• Brightbill, H.D.; Plevy, S.E.; Modlin, R.L.; Smale, S.T. A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. J Immunol. 2000, 164, 1940–1951.
   PubMed Web of Science ®Google Scholar
• Saraiva, M.; Christensen, J.R.; Tsytsykova, A.V.; Goldfeld, A.E.; Ley, S.C.; Kioussis, D.; O’Garra, A. Identification of a macrophage-specific chromatin signature in the IL-10 locus. J Immunol. 2005, 175, 1041–1046.
   PubMed Web of Science ®Google Scholar
• Benkhart, E.M.; Siedlar, M.; Wedel, A.; Werner, T.; Ziegler-Heitbrock, H.W. Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression. J Immunol. 2000, 165, 1612–1617.
   PubMed Web of Science ®Google Scholar
• Cao, S.; Liu, J.; Song, L.; Ma, X. The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J Immunol. 2005, 174, 3484–3492.
   PubMed Web of Science ®Google Scholar
• Norkina, O.; Dolganiuc, A.; Shapiro, T.; Kodys, K.; Mandrekar, P.; Szabo, G. Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. J Leukoc Biol. 2007, 82, 752–762.
   PubMed Web of Science ®Google Scholar
• Morgan, M.E.; Van Bilsen, J.H.M.; Bakker, A.M.; Heemskerk, B.; Schilham, M.W.; Hartgers, F.C.; Elferink, B.G.; Van der Zanden, L.; De Vries, R.R.P.; Huizinga, T.W.J.; Ottenhoff, T.H.M.; Toes, R.E.M. Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells. Hum Immunol. 2005, 66, 13–20.
   PubMed Web of Science ®Google Scholar
• Fuji (Funeshima), N.; Tsuji, A.; Xaio-Kang, L.; Hiromitsu, K. High expression of Foxp3 in rat dendritic cells (DCs) generated a long-term culture of bone marrow cells (BMC). Molec Ther. 2006, 13, S389.
   Web of Science ®Google Scholar
• Zhelev, Z.; Stanilova, S.; Carpenter, B. Isolation, partial characterization and complement inhibiting activity of a new glycoprotein from Cuscuta europea. Biochem. Biophys Res Commun. 1994, 202, 186–94.
   PubMed Web of Science ®Google Scholar
• Bennet, B.L.; Sasaki, D.T.; Murray, B.W.; O’Leary, E.C.; Sakata, S.T.; Xu, W.; Leisten, J.C.; Motiwata, A.; Pierce, S.; Satoh, Y.; Bhagwat, S.S.; Manning, A.M.; Anderson, D.W. Sp600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. PNAS. 2001, 98, 13681–6.
   PubMed Web of Science ®Google Scholar
• Manthey, C.L.; Wang, S-W; Kinney, S.D.; Yao, Z. SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes. J Leucoc Biol. 1998, 64, 409–17.
   PubMed Web of Science ®Google Scholar
• Stanilova, S.A.; Dobreva, Z.G.; Slavov, E.S.; Miteva, L.D. C3 binding glycoprotein from Cuscuta europea induced different cytokine profiles from human PBMC compared to other plant and bacterial immunomodulators. Int Immunopharmacol. 2005, 5, 723–34.
   PubMed Web of Science ®Google Scholar
• Dobreva, Z.G.; Stanilova, S.A. The immunomodulatory activity of C3 binding glycoprotein (C3bgp) is mediated by the complement receptor type III and mitogen-activated protein kinase signal transduction pathways. Immunopharm Immunotoxicol. 2007, 29, 549–62.
   PubMed Web of Science ®Google Scholar
• Dobreva, Z.G.; Stanilova, S.A.; Miteva, L.D. Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: Involvement of p38 and JNK kinase pathways. Cytokine. 2008, 43, 76–82.
   Google Scholar
• Parry, S.L.; Sebbag, M.; Feldmann, M.; Brennan, F.M. Contact with T cells modulates monocyte IL-10 production: role of T cell membrane TNF-alpha. J Immunol. 1997, 158, 3673–3681.
   PubMed Web of Science ®Google Scholar
• Foey, A.D.; Parry, S.L.; Williams, L.M.; Feldmann, M.; Foxwell, B.M.J.; Brennan, F.M. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: Role of the p38 and p42/p44 mitogen-activated protein kinases. J Immunol. 1998, 160, 920–928.
   PubMed Web of Science ®Google Scholar
• Powell, M.J.; Thompson, S.A.J.; Tone, Y.; Waldmann, H.; Tone, M. Postranscriptional regulation of IL-10 gene expression through sequences in the 3’-untranslated region. J Immunol. 2000, 165, 292–296.
   PubMed Web of Science ®Google Scholar
• Schmitz, F.; Mages, J.; Heit, A.; Lang, R.; Wagner, H. Transcriptional activation induced in macrophages by Toll-like receptor (TLR) ligands: From expression profiling to a model of TLR signaling. Eur J Immunol. 2004, 34, 2863–2873.
   PubMed Web of Science ®Google Scholar
• Josephson, K.; Logsdon, N.J.; Walter, M.R. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 2001, 14, 35–46.
   Google Scholar
• Le, T.; Leung, L.; Carroll, W.L.; Schibler, K.R. Regulation of interleukin-10 gene expression: Possible mechanisms accounting for its upregulation and for maturational differences in its expression by blood mononuclear cells. Blood. 1997, 89, 4112–4119.
   PubMed Web of Science ®Google Scholar
• Wang, Z-Y.; Sato, H.; Kusam, S.; Sehra, S.; Toney, L.M.; Dent, A.L. Regulation of IL-10 gene expression in Th2 cells by Jun proteins. J Immunol. 2005, 174, 2098–2105.
   PubMed Web of Science ®Google Scholar
• Kayahara, M.; Wang, X.; Tournie, C. Selective c-jun gene expression by mitogen-activated protein kinase via 12-O-tetradecanoylphorbol-13-acetate-responsive element and myocyte enhancer factor binding sites. Mol Cell Biol. 2005, 25, 3784–3792.
   PubMed Web of Science ®Google Scholar