AMPK/Nrf2 signaling is involved in the anti-neuroinflammatory action of Petatewalide B from Petasites japonicus against lipopolysaccharides in microglia

References

• Hu X, Liou AK, Leak RK, et al. Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles. Prog Neurobiol 2014;119–120:60–84.
   PubMed Web of Science ®Google Scholar
• Fruhbeis C, Frohlich D, Kuo WP, Kramer-Albers EM. Extracellular vesicles as mediators of neuron-glia communication. Front Cell Neurosci 2013;7:182.
   PubMed Web of Science ®Google Scholar
• Kawabori M, Yenari MA. The role of the microglia in acute CNS injury. Metab Brain Dis 2015;30:381–392.
   PubMed Web of Science ®Google Scholar
• Kempuraj D, Thangavel R, Natteru PA, et al. Neuroinflammation induces neurodegeneration. J Neurol Neurosurg Spine 2016;1:1003.
   PubMedGoogle Scholar
• Alam Q, Alam MZ, Mushtaq G, et al. Inflammatory process in Alzheimer’s and Parkinson’s diseases: central role of cytokines. Curr Pharm Des 2016;22:541–548.
   PubMed Web of Science ®Google Scholar
• Vinoth Kumar R, Oh TW, Park YK. Anti-inflammatory effects of ginsenoside-Rh2 inhibits LPS-induced activation of microglia and overproduction of inflammatory mediators via modulation of TGF-β1/Smad pathway. Neurochem Res 2016;41:951–957.
   PubMed Web of Science ®Google Scholar
• Azevedo EP, Ledo JH, Barbosa G, et al. Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis. Cell Death Dis 2013;4:e789.
   PubMed Web of Science ®Google Scholar
• Collins LM, Toulouse A, Connor TJ, Nolan YM. Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease. Neuropharmacology 2012;62:2154–2168.
   PubMed Web of Science ®Google Scholar
• Tanaka S, Ishii A, Ohtaki H, et al. Activation of microglia induces symptoms of Parkinson's disease in wild-type, but not in IL-1 knockout mice. J Neuroinflammation 2013;10:907.
   Web of Science ®Google Scholar
• Su X, Chen Q, Chen W, et al. Mycoepoxydiene inhibits activation of BV2 microglia stimulated by lipopolysaccharide through suppressing NF-kappaB, ERK 1/2 and toll-like receptor pathways. Int Immunopharmacol 2014;19:88–93.
   PubMed Web of Science ®Google Scholar
• Suk K. Regulation of neuroinflammation by herbal medicine and its implications for neurodegenerative diseases. A focus on traditional medicines and flavonoids. Neurosignals 2005;14:23–33.
   PubMedGoogle Scholar
• Lee YY, Park JS, Lee EJ, et al. Anti-inflammatory mechanism of ginseng saponin metabolite Rh3 in lipopolysaccharide-stimulated microglia: critical role of 5′-adenosine monophosphate-activated protein kinase signaling pathway. J Agric Food Chem 2015;63:3472–3480.
   PubMed Web of Science ®Google Scholar
• Lin HY, Huang BR, Yeh WL, et al. Anti-neuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways. Neurobiol Aging 2014;35:191–202.
   PubMed Web of Science ®Google Scholar
• Lee J, Kim S. Up-regulation of heme oxygenase-1 expression by dehydrodiconiferyl alcohol (DHCA) through the AMPK-Nrf2 dependent pathway. Toxicol Appl Pharmacol 2014;281:87–100.
   PubMed Web of Science ®Google Scholar
• Park SY, Jin ML, Chae SY, et al. Novel compound from Polygonum multiflorum inhibits inflammatory response in LPS-stimulated microglia by up-regulating AMPK/Nrf2 pathways. Neurochem Int 2016;100:21–29.
   PubMed Web of Science ®Google Scholar
• Mo C, Wang L, Zhang J, et al. The crosstalk between Nrf2 and AMPK signal pathways is important for the antiinflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice. Antioxid Redox Signal 2014;20:574–588.
   PubMed Web of Science ®Google Scholar
• Lastres-Becker I, Ulusoy A, Innamorato NG, et al. Alpha-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease. Hum Mol Genet 2012;21:3173–3192.
   PubMed Web of Science ®Google Scholar
• Mazzuferi M, Kumar G, van Eyll J, et al. Nrf2 defense pathway: experimental evidence for its protective role in epilepsy. Ann Neurol 2013;74:560–568.
   PubMed Web of Science ®Google Scholar
• Lee JS, Yang EJ, Yun CY, et al. Suppressive effect of Petasites japonicus extract on ovalbumin-induced airway inflammation in an asthmatic mouse model. J Ethnopharmacol 2011;133:551–557.
   PubMed Web of Science ®Google Scholar
• Cui HS, Kim MR, Sok DE. Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid. J Agric Food Chem 2005;53:8526–8532.
   PubMed Web of Science ®Google Scholar
• Wang S, Jin DQ, Xie C, et al. Isolation, characterization and neuroprotective activities of sesquiterpenes from Petasites japonicus. Food Chem 2013;141:2075–2082.
   PubMed Web of Science ®Google Scholar
• Choi YW, Lee KP, Kim JM, et al. Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity. J Ethnopharmacol 2016;178:17–24.
   PubMed Web of Science ®Google Scholar
• Kang HG, Jeong SH, Cho JH. Antimutagenic and anticarcinogenic effect of methanol extracts of Petasites japonicus Maxim leaves. J Vet Sci 2010;11:51–58.
   PubMed Web of Science ®Google Scholar
• Min BS, Cui HS, Lee HK, et al. A new furofuran lignan with antioxidant and antiseizure activities from the leaves of Petasites japonicus. Arch Pharm Res 2005;28:1023–1026.
   PubMed Web of Science ®Google Scholar
• Lee YJ, Park SY, Kim SG, et al. Identification of a novel compound that inhibits iNOS and COX-2 expression in LPS-stimulated macrophages from Schisandra chinensis. Biochem Biophys Res Commun 2010;391:1687–1692.
   PubMed Web of Science ®Google Scholar
• Chen CC, Lin JT, Cheng YF, et al. Amelioration of LPS-induced inflammation response in microglia by AMPK activation. Biomed Res Int 2014;2014:692061.
   PubMed Web of Science ®Google Scholar
• Pradhan S, Andreasson K. Commentary: progressive inflammation as a contributing factor to early development of Parkinson’s disease. Exp Neurol 2013;241:148–155.
   PubMed Web of Science ®Google Scholar
• Theriault P, ElAli A, Rivest S. The dynamics of monocytes and microglia in Alzheimer's disease. Alzheimers Res Ther 2015;7:41.
   PubMed Web of Science ®Google Scholar
• Stamouli EC, Politis AM. Pro-inflammatory cytokines in Alzheimer’s disease. Psychiatriki 2016;27:264–275.
   PubMedGoogle Scholar
• Wang S, Jing H, Yang H, et al. Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson's disease. J Ethnopharmacol 2015;164:247–255.
   PubMed Web of Science ®Google Scholar
• Kim BW, Koppula S, Hong SS, et al. Regulation of microglia activity by glaucocalyxin-A: attenuation of lipopolysaccharide-stimulated neuroinflammation through NF-kappaB and p38 MAPK signaling pathways. PLoS One 2013;8:e55792.
   PubMed Web of Science ®Google Scholar
• Luo XL, Liu SY, Wang LJ, et al. A tetramethoxychalcone from Chloranthus henryi suppresses lipopolysaccharide-induced inflammatory responses in BV2 microglia. Eur J Pharmacol 2016;774:135–143.
   PubMed Web of Science ®Google Scholar
• Wang XR, Shi GX, Yang JW, et al. Acupuncture ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia through Nrf2-mediated antioxidant response. Free Radic Biol Med 2015;89:1077–1084.
   PubMed Web of Science ®Google Scholar