The epigenetic modification during the induction of Foxp3 with sodium butyrate

References

• Sakaguchi S ,Sakaguchi N, Asano N, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995;155:1151.
   PubMed Web of Science ®Google Scholar
• Taylor PA, Noelle RJ, Blazar BR. Cd4 + Cd25+ immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med. 2001;193:1311.
   PubMed Web of Science ®Google Scholar
• Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007;8:191.
   PubMed Web of Science ®Google Scholar
• Baecher-Allan C, Anderson DE. Regulatory cells and human cancer. Semin Cancer Biol. 2006;16:98–105.
   PubMed Web of Science ®Google Scholar
• Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol. 2003;3:199.
   PubMed Web of Science ®Google Scholar
• Ochs HD, Ziegler SF, Torgerson TR. FOXP3 acts as a rheostat of the immune response. Immunol Rev. 2005;203:156–164.
   PubMed Web of Science ®Google Scholar
• Sakaguchi S, Miyara M, Costantino CM, et al. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. 2010;10:490.
   PubMed Web of Science ®Google Scholar
• Sakaguchi S, Wing K, Yamaguchi T. Dynamics of peripheral tolerance and immune regulation mediated by Treg. Eur J Immunol. 2009;39:2331–2336.
   PubMed Web of Science ®Google Scholar
• Pasquet L, Douet JY, Sparwasser T, et al. Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells. Blood. 2013;121:4303–4310.
   PubMed Web of Science ®Google Scholar
• Hori S, Nomura T, Sakaguchi S. Pillars article: control of regulatory T cell development by the transcription factor Foxp3. Science. 2003; 299:1057–1061. J Immunol. 2017;981–985.
   PubMedGoogle Scholar
• Fontenot JD, Gavin MA, Rudensky AY. Pillars article: Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells. Nat. Immunol. 2003. 4: 330–336. J Immunol. 2017;198:986.
   PubMed Web of Science ®Google Scholar
• Lin F, Luo X, Tsun A, et al. Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation. Int Immunopharmacol. 2015;28:859.
   PubMed Web of Science ®Google Scholar
• Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68.
   PubMed Web of Science ®Google Scholar
• Hague A, Manning AM, Hanlon KA, et al. Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer. Int J Cancer. 1993;55:498.
   PubMed Web of Science ®Google Scholar
• Karagiannidis C, Akdis M, Holopainen P, et al. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol. 2004;114:1425–1433.
   PubMed Web of Science ®Google Scholar
• L, Yang HW, Sun X, Liu, et al. University, Progress of costimulatory molecules B7-CD_(28) in tumor immunity, China Practical Medicine;2014.
   Google Scholar
• Chen WJun, Jin W, Hardegen N. Conversion of peripheral CD4 + CD25- naive T cells to CD4 + CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003;198:1875–1886.
   PubMed Web of Science ®Google Scholar
• Bernstroem KE, Zhang H, Torres-Castillo M, et al. New dynabeads™treg CD3/CD28 and animal origin-free, serum-free media for regulatory T cell activation and expansion to be used in clinical applications. Cytotherapy. 2017;19:e6.
   Google Scholar
• Tai X, Cowan M, Feigenbaum L, et al. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol. 2005;6:152.
   PubMed Web of Science ®Google Scholar
• Lenschow DJ, Herold KC, Rhee L, et al. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity. 1996;5:285.
   PubMed Web of Science ®Google Scholar
• B S, Lenschow DJ, Rhee L, et al. B7/CD28 costimulation is essential for the homeostasis of the CD4 + CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12:431–440.
   PubMed Web of Science ®Google Scholar
• Martínez-Llordella M, Esensten JH, Bailey-Bucktrout SL, et al. CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. J Exp Med. 2013;210:1603.
   PubMed Web of Science ®Google Scholar
• Battaglia M, Stabilini A, Roncarolo MG. Rapamycin selectively expands CD4 + CD25 + FoxP3+ regulatory T cells. Blood. 2005;105:4743.
   PubMed Web of Science ®Google Scholar
• Benson MJ, Pino-Lagos K, Rosemblatt M, et al. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med. 2007;204:1765.
   PubMed Web of Science ®Google Scholar
• Kruisbeek AM, Shevach E, Thornton AM. Proliferative assays for T cell function, Curr Protocols Immunol Chapter 3 (2004) Unit 3.12.
   Google Scholar
• Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature. 2011;469:343–349.
   PubMed Web of Science ®Google Scholar
• Spivakov M, Fisher AG. Epigenetic signatures of stem-cell identity. Nat Rev Genet. 2007;8:263.
   PubMed Web of Science ®Google Scholar
• Mandal M, Powers SE, Maienschein-Cline M, et al. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nat Immunol. 2011;12:1212–1220.
   PubMed Web of Science ®Google Scholar
• Raaphorst FM, Otte AP, van Kemenade FJ, et al. Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation. J Immunol. 2001;166:5925–5934.
   PubMed Web of Science ®Google Scholar
• Su IH, Basavaraj A, Krutchinsky AN, et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol. 2003;4:124.
   PubMed Web of Science ®Google Scholar
• Su I-h, Dobenecker M-W, Dickinson E, et al. Polycomb group protein Ezh2 controls actin polymerization and cell signaling. Cell. 2005;121:425.
   PubMed Web of Science ®Google Scholar
• Dupage M, Chopra G, Quiros J, et al. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 2015;42:227.
   PubMed Web of Science ®Google Scholar
• Xiong Y, Khanna S, Grzenda AL, et al. Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. J Biol Chem. 2012;287:34372.
   PubMed Web of Science ®Google Scholar
• Arvey A, Van dVJ, Samstein RM, et al. Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells. Nat Immunol. 2014;15:580–587.
   PubMed Web of Science ®Google Scholar
• Tumes DJ, Onodera A, Suzuki A, et al. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type 1 and type 2 cells. Immunity. 2013;39:819–832.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Kinkel S, Maksimovic J, et al. The polycomb repressive complex 2 governs life and death of peripheral T cells. Blood. 2014;124:737.
   PubMed Web of Science ®Google Scholar
• Thorpe LM, Yuzugullu H, Zhao JJ. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer. 2015;15:7.
   PubMed Web of Science ®Google Scholar
• Spangle JM, Roberts TM, Zhao JJ. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. Biochim Biophys Acta. 2017;1868:123.
   PubMed Web of Science ®Google Scholar
• Gherardi S, Ripoche D, Mikaelian I, et al. Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification. Biochim Biophys Acta. 2017;1860:427.
   PubMedGoogle Scholar
• Gao SB, Feng ZJ, Xu B, et al. Suppression of lung adenocarcinoma through menin and polycomb gene-mediated repression of growth factor pleiotrophin. Oncogene. 2009;28:4095–4104.
   PubMed Web of Science ®Google Scholar
• Xu B, Zeng DQ, Wu Y, et al. Tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex. J Biol Chem. 2011;286:13937–13944.
   PubMed Web of Science ®Google Scholar
• Gao SB, Xu B, Ding LH, et al. The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma. J Hepatol. 2014;61:832.
   PubMed Web of Science ®Google Scholar
• Schones DE, Cui K, Cuddapah S. Genome-wide approaches to studying yeast chromatin modifications. Methods Mol Biol. 2011;759:61–71.
   Google Scholar
• Sharov AA, Ko MSH. Human ES cell profiling broadens the reach of bivalent domains. Cell Stem Cell. 2007;1:237–238.
   PubMed Web of Science ®Google Scholar
• Pan G, Tian S, Nie J, et al. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell. 2007;1:299.
   PubMed Web of Science ®Google Scholar
• Ku M, Koche RP, Rheinbay E, et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. Plos Genet. 2008;4:e1000242.
   PubMed Web of Science ®Google Scholar
• Liu T, Chen X, Li T, et al. Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway. Biochim Biophys Acta. 2017;1860(10):1094–1102.
   PubMedGoogle Scholar
• Spangle J, Dreijerink K, Groner A, et al. PI3K/AKT signaling regulates H3K4 methylation in breast cancer. Cell Rep. 2016;15:2692.
   PubMed Web of Science ®Google Scholar
• Khan S, Jena G. Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats. Food Chem Toxicol. 2014;73:127–139.
   PubMed Web of Science ®Google Scholar
• Mathew OP, Ranganna K, Yatsu FM. Butyrate, an HDAC inhibitor, stimulates interplay between different posttranslational modifications of histone H3 and differently alters G1-specific cell cycle proteins in vascular smooth muscle cells. Biomed Pharmacother. 2010;64:733–740.
   PubMed Web of Science ®Google Scholar
• Boffa L, Vidali CG, Mann RS, Allfrey VG. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J Biol Chem. 1978;253:3364–3366.
   PubMed Web of Science ®Google Scholar
• Lawless MW, Norris S, O’Byrne KJ, et al. Targeting histone deacetylases for the treatment of disease. J Cell Mol Med. 2009;13:826.
   PubMed Web of Science ®Google Scholar
• Layden BT, Angueira AR, Brodsky M, et al. Short chain fatty acids and their receptors: new metabolic targets. Transl Res. 2013;161:131–140.
   PubMed Web of Science ®Google Scholar
• Khan S, Jena GB. Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat. Chem Biol Interact. 2014;213:1–12.
   PubMed Web of Science ®Google Scholar
• Khan S, Jena GB. Effect of sodium valproate on the toxicity of cyclophosphamide in the testes of mice: influence of pre- and post-treatment schedule. Toxicol Int. 2013;20:68–76.
   PubMedGoogle Scholar
• Marchion DC, Bicaku E, Daud AI, et al. In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates. Mol Cancer Ther. 2005;4:1993.
   PubMed Web of Science ®Google Scholar
• King SW, Austin JW, Szalanski AL. Use of soldier pronotal width and mitochondrial DNA sequencing to distinguish the subterranean termites, Reticulitermes flavipes (Kollar) and R. virginicus (Banks) (Isoptera: Rhinotermitidae), on the Delmarva Peninsula: Delaware, Maryland, and Virginia, U.S.A. Entomol News. 2007;118:41–48.
   Web of Science ®Google Scholar
• Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr. 2003;133:2485S.
   PubMed Web of Science ®Google Scholar
• Nör C, Sassi FA, de Farias CB, et al. The histone deacetylase inhibitor sodium butyrate promotes cell death and differentiation and reduces neurosphere formation in human medulloblastoma cells. Mol Neurobiol. 2013;48:533–543.
   PubMed Web of Science ®Google Scholar
• Saldanha SN, Kala R, Tollefsbol TO. Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate. Exp Cell Res. 2014;324:40–53.
   PubMed Web of Science ®Google Scholar
• Zhang M, Qian Z, Dorfman RG, et al. Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats. Bmc Gastroenterol. 2016;16:84.
   PubMed Web of Science ®Google Scholar
• Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504:446–450.
   PubMed Web of Science ®Google Scholar
• Sharma B, Singh N. Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats. Psychopharmacology. 2011;215:677.
   PubMed Web of Science ®Google Scholar
• ChenSu X, Wan W, Yu T, Zhu J, Tang W, Liu F, Olsen G, Liang ND, Zheng SG. Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway. Biochem Pharmacol. 2017;
   Web of Science ®Google Scholar
• Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 2008;453:620.
   PubMed Web of Science ®Google Scholar
• Christensen GJ, Brüggemann H. Bacterial skin commensals and their role as host guardians. Benef Microbes. 2014;5(2):201–215.
   PubMed Web of Science ®Google Scholar
• Schwarz A, Bruhs A, Schwarz T. The short-chain fatty acid sodium butyrate functions as a regulator of the skin immune system. J Investig Dermatol. 2017;137:855.
   PubMed Web of Science ®Google Scholar
• Smith PM, Howitt MR, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013;341:569.
   PubMed Web of Science ®Google Scholar
• Egawa G, Honda T, Kabashima K. SCFAs control skin immune responses via increasing Tregs. J Investig Dermatol. 2017;137:800.
   PubMed Web of Science ®Google Scholar
• Abbas M, Habib M, Naveed M, et al. The relevance of gastric cancer biomarkers in prognosis and pre- and post-chemotherapy in clinical practice. Biomedi Pharmacother. 2017;95:1082–1090.
   PubMed Web of Science ®Google Scholar
• Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057.
   PubMed Web of Science ®Google Scholar
• Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells. Nat Immunol. 2003;4:330.
   PubMed Web of Science ®Google Scholar
• Turner BM, Turner BMHistone. Histone acetylation and an epigenetic code. BioEssays. 2000;22:836–845.
   PubMed Web of Science ®Google Scholar
• Lachner M, Jenuwein T. The many faces of histone lysine methylation. Curr Opin Cell Biol. 2002;14:286–298.
   PubMed Web of Science ®Google Scholar
• Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293:1074–1080.
   PubMed Web of Science ®Google Scholar
• Lee DY, Teyssier C, Strahl BD, et al. Role of protein methylation in regulation of transcription. Endocr Rev. 2005;26:147–170.
   PubMed Web of Science ®Google Scholar
• Paro R. Chromatin regulation. Formatting genetic text. Nature. 2000;406:579.
   PubMed Web of Science ®Google Scholar
• Mccabe MT, Ott HM, Ganji G, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012;492:108.
   PubMed Web of Science ®Google Scholar
• Chen YT, Zhu F, Lin WR, et al. The novel EZH2 inhibitor, GSK126, suppresses cell migration and angiogenesis via down-regulating VEGF-A. Cancer Chemother Pharmacol. 2016;77:757.
   PubMed Web of Science ®Google Scholar