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Original Articles

XAV939, a Wnt/β-catenin pathway modulator, has inhibitory effects on LPS-induced inflammatory response

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Pages 394-402 | Received 21 Apr 2018, Accepted 05 Oct 2018, Published online: 22 Nov 2018

References

  • Zimmerman ZF, Moon RT, Chien AJ. Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol. 2012;4:a008086.
  • Krishnamurthy N, Kurzrock R. Targeting the Wnt/beta-catenin pathway in cancer: update on effectors and inhibitors. Cancer Treat Rev. 2018;62:50–60.
  • Luu HH, Zhang R, Haydon RC, et al. Wnt/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets. 2004;4:653–671.
  • Cadigan KM, Liu YI. Wnt signaling: complexity at the surface. J Cell Sci. 2006;119:395–402.
  • Huang SM, Mishina YM, Liu S, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009;461:614–620.
  • Kirby CA, Cheung A, Fazal A, et al. Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:115–118.
  • Tian XH, Hou WJ, Fang Y, et al. XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway. J Exp Clin Cancer Res. 2013;32:100.
  • Tian X, Hou W, Bai S, et al. XAV939 inhibits the stemness and migration of neuroblastoma cancer stem cells via repression of tankyrase 1. Int J Oncol. 2014;45:121–128.
  • Jang J, Ha JH, Chung SI, et al. Beta-catenin regulates NF-kappaB activity and inflammatory cytokine expression in bronchial epithelial cells treated with lipopolysaccharide. Int J Mol Med. 2014;34:632–638.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–408.
  • Seo E, Jho EH. Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin. Biochem Biophys Res Commun. 2007;357:81–86.
  • Li J, Zhang D, Ward KM, et al. Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro. Toxicol in Vitro. 2012;26:603–612.
  • Ivanenkov YA, Balakin KV, Lavrovsky Y. Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics. Mini Rev Med Chem. 2011;11:55–78.
  • Guo W, Shen F, Xiao W, et al. Wnt inhibitor XAV939 suppresses the viability of small cell lung cancer NCI-H446 cells and induces apoptosis. Oncol Lett. 2017;14:6585–6591.
  • Wu X, Luo F, Li J, et al. Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. Int J Oncol. 2016;48:1333–1340.
  • Chen J, Li J, Miao Z, et al. XAV939, a small molecular inhibitor, provides neuroprotective effects on oligodentrocytes. J Neurosci Res. 2014;92:1252–1258.
  • Chen L, Zhuang J, Singh S, et al. XAV939 inhibits intima formation by decreasing vascular smooth muscle cell proliferation and migration through blocking Wnt signaling. J Cardiovasc Pharmacol. 2016;68:414–424.
  • Matsusaka T, Fujikawa K, Nishio Y, et al. Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A. 1993;90:10193–10197.
  • Koopmans T, Eilers R, Menzen M, et al. Beta-catenin directs nuclear factor-kappaB p65 output via CREB-binding protein/p300 in human airway smooth muscle. Front Immunol. 2017;8:1086.
  • Bandino A, Compagnone A, Bravoco V, et al. Beta-catenin triggers nuclear factor kappaB-dependent up-regulation of hepatocyte inducible nitric oxide synthase. Int J Biochem Cell Biol. 2008;40:1861–1871.
  • Lin JC, Chang RL, Chen YF, et al. β-Catenin overexpression causes an increase in inflammatory cytokines and NF-κB activation in cardiomyocytes. Cell Mol Biol. 2016;63:17–22.
  • Montefort S, Herbert CA, Robinson C, et al. The bronchial epithelium as a target for inflammatory attack in asthma. Clin Exp Allergy. 1992;22:511–520.
  • Rietschel ET, Kirikae T, Schade FU, et al. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 1994;8:217–225.
  • Michel O. Role of lipopolysaccharide (LPS) in asthma and other pulmonary conditions. J Endotoxin Res. 2003;9:293–300.
  • Striz I, Mio T, Adachi Y, et al. The CD14 molecule participates in regulation of IL-8 and IL-6 release by bronchial epithelial cells. Immunol Lett. 1998;62:177–181.

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