303
Views
27
CrossRef citations to date
0
Altmetric
Original Articles

Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-β signaling pathways in carbon tetrachloride (CCl4)-induced liver fibrosis in rats

, ORCID Icon, , &
Pages 163-171 | Received 21 Oct 2018, Accepted 06 Jan 2019, Published online: 01 Feb 2019

References

  • Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005;115:209–218.
  • Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease. Development. 2014;141:1614–1626.
  • Yu F-X, Guan K-L. The Hippo pathway: regulators and regulations. Genes Dev. 2013;27:355–371.
  • Grannas K, Arngården L, Lönn P, et al. Crosstalk between Hippo and TGFβ: subcellular localization of YAP/TAZ/Smad complexes. J Mol Biol. 2015;427:3407–3415.
  • Piersma B, Bank RA, Boersema M. Signaling in fibrosis: TGF-β, WNT, and YAP/TAZ converge. Front Med (Lausanne). 2015;2:59.
  • Zhang Q, Xu M, Cai X, et al. Myofibroblastic transformation of rat hepatic stellate cells: the role of Notch signaling and epithelial-mesenchymal transition regulation. Eur Rev Med Pharmacol Sci. 2015;19:4130–4138.
  • Hansen CG, Moroishi T, Guan K-L. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol. 2015;25:499–513.
  • Mannaerts I, Leite SB, Verhulst S, et al. The Hippo pathway effector YAP controls mouse hepatic stellate cell activation. J Hepatol. 2015;63:679–688.
  • Jin H, Lian N, Zhang F, et al. Inhibition of YAP signaling contributes to senescence of hepatic stellate cells induced by tetramethylpyrazine. Eur J Pharm Sci. 2017;96:323–333.
  • Mohammadalipour A, Karimi J, Khodadadi I, et al. Dasatinib prevent hepatic fibrosis induced by carbon tetrachloride (CCl4) via anti-inflammatory and antioxidant mechanism. Immunopharmacol Immunotoxicol. 2017;39:19–27.
  • Bahabadi M, Mohammadalipour A, Karimi J, et al. Hepatoprotective effect of parthenolide in rat model of nonalcoholic fatty liver disease. Immunopharmacol Immunotoxicol. 2017;39:233–242.
  • Guan C, Qiao S, Lv Q, et al. Orally administered berberine ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting activation of PPAR-γ and subsequent expression of HGF in colons. Toxicol Appl Pharmacol. 2018;343:1–15.
  • Can Baser K. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. CPD. 2008;14:3106–3119.
  • Bakır M, Geyikoglu F, Colak S, et al. The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response. Cytotechnology. 2016;68:1131–1146.
  • Hussein J, El-Banna M, Mahmoud KF, et al. The therapeutic effect of nano-encapsulated and nano-emulsion forms of carvacrol on experimental liver fibrosis. Biomed Pharmacother. 2017;90:880–887.
  • Gordon M, El-Kalla M, Zhao Y, et al. The tumor suppressor gene, RASSF1A, is essential for protection against inflammation-induced injury. PLoS One. 2013;8:e75483.
  • Arunasree K. Anti-proliferative effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231. Phytomedicine. 2010;17:581–588.
  • Dai W, Sun C, Huang S, et al. Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma. OncoTargets Ther. 2016;9:2297.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254.
  • Ishak K, Baptista A, Bianchi L, et al. Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22:696–699.
  • Reddy GK, Enwemeka CS. A simplified method for the analysis of hydroxyproline in biological tissues. Clin Biochem. 1996;29:225–229.
  • Jiang Z, Chen C, Wang J, et al. Purple potato (Solanum tuberosum L.) anthocyanins attenuate alcohol-induced hepatic injury by enhancing antioxidant defense. J Nat Med. 2016;70:45–53.
  • Ezhumalai M, Radhiga T, Pugalendi KV. Antihyperglycemic effect of carvacrol in combination with rosiglitazone in high-fat diet-induced type 2 diabetic C57BL/6J mice. Mol Cell Biochem. 2014;385:23–31.
  • Li R, Xu L, Liang T, et al. Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. Food Chem Toxicol. 2013;52:69–75.
  • Rajan B, Ravikumar R, Premkumar T, et al. Carvacrol attenuates N-nitrosodiethylamine induced liver injury in experimental Wistar rats. Food Sci Human Wellness. 2015;4:66–74.
  • Parisi OI, Puoci F, Restuccia D, et al. Polyphenols and their formulations: different strategies to overcome the drawbacks associated with their poor stability and bioavailability. Polyphenols in human health and disease. San Diego, CA, USA: Elsevier Inc.; 2014. p. 29–45.
  • Gressner AM, Weiskirchen R, Breitkopf K, et al. Roles of TGF-beta in hepatic fibrosis. Front Biosci. 2002;7:d793–d807.
  • Kianmehr M, Rezaei A, Boskabady MH. Effect of carvacrol on various cytokines genes expression in splenocytes of asthmatic mice. Iran J Basic Med Sci. 2016;19:402.
  • Ji Y, Dou Y-n, Zhao Q-w, et al. Paeoniflorin suppresses TGF-β mediated epithelial-mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway. Acta Pharmacol Sin. 2016;37:794.
  • Lytle KA, Depner CM, Wong CP, et al. Docosahexaenoic acid attenuates western diet induced hepatic fibrosis in Ldlr-/-mice by targeting the TGFβ-Smad3 pathway. J Lipid Res. 2015;jlr-M061275.
  • Zhang K, Chang Y, Shi Z, et al. ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation. Sci Rep. 2016;6:30029.
  • Wang X, Zheng Z, Caviglia JM, et al. Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis. Cell Metab. 2016;24:848–862.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.