Anti-inflammatory effect of synthesized indole-based chalcone (2E)-3-(4-bromophenyl)-1-(1H-indol-3-yl) prop-2-en-1-one: an in vitro and in vivo studies

References

• Lind L. Circulating markers of inflammation and atherosclerosis. Atherosclerosis. 2003;169(2):203–214.
   PubMed Web of Science ®Google Scholar
• Bertolini A, Ottani A, Sandrini M. Dual acting anti-inflammatory drugs: a reappraisal. Pharmacol Res. 2001;44(6):437–450.
   PubMed Web of Science ®Google Scholar
• Kanno S, Shouji A, Tomizawa A, et al. Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages. Life Sci. 2006;78(7):673–681.
   PubMed Web of Science ®Google Scholar
• Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282(5396):2085–2088.
   PubMed Web of Science ®Google Scholar
• Takeda K, Akira S. Microbial recognition by Toll-like receptors. J Dermatol Sci. 2004;34(2):73–82.
   PubMed Web of Science ®Google Scholar
• Shuto T, Kato K, Mori Y, et al. Membrane-anchored CD14 is required for LPS-induced TLR4 endocytosis in TLR4/MD-2/CD14 overexpressing CHO cells. Biochem Biophys Res Commun. 2005;338(3):1402–1409.
   PubMed Web of Science ®Google Scholar
• MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol. 1997;15(1):323–350.
   PubMedGoogle Scholar
• DeFranco AL, Hambleton J, McMahon M, et al. Examination of the role of MAP kinase in the response of macrophages to lipopolysaccharide. Prog Clin Biol Res. 1995;392:407–420.
   PubMedGoogle Scholar
• Anwar MA, Basith S, Choi S. Negative regulatory approaches to the attenuation of Toll-like receptor signalling. Exp Mol Med. 2013;45:11.
   PubMed Web of Science ®Google Scholar
• Datla P, Kalluri MD, Basha K, et al. 10-Dihydro-2,5-dime-thoxyphenanthrene-1,7-diol, from Eulophia ochreata, inhibits inflammatory signalling mediated by Toll-like receptors. Br J Pharmacol. 2010;160(5):1158–1170.
   PubMed Web of Science ®Google Scholar
• Li X, Xu W. TLR4-mediated activation of macrophages by the polysaccharide fraction form Polyporus umbellatus (pers.) Fries. J Ethnopharmacol. 2011;135(1):1–6.
   PubMed Web of Science ®Google Scholar
• Bandgar BP, Gawande SS, Bodade RG, et al. Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents. Bioorg Med Chem. 2010;18(3):1364–1370.
   PubMed Web of Science ®Google Scholar
• Gómez-Rivera A, Aguilar-Mariscal H, Romero-Ceronio N, et al. Synthesis and anti-inflammatory activity of three nitro chalcones. Bioorg Med Chem Lett. 2013;23(20):5519–5522.
   PubMed Web of Science ®Google Scholar
• Kil JS, Son Y, Cheong YK, et al. Okanin. A chalcone found in the genus Bidens, and 3-penten-2-one inhibit inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with lipopolysaccharide. J Clin Biochem Nutr. 2011;50(1):53–58.
   PubMed Web of Science ®Google Scholar
• Ramesh B, Sumana T. Synthesis and anti-inflammatory activity of pyrazolines. J Chem. 2010;7:514–516.
   Web of Science ®Google Scholar
• Bharate SB, Mahajan TR, Gole YR, et al. Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors. Bioorg Med Chem. 2008;16(15):7167–7176.
   PubMed Web of Science ®Google Scholar
• Lorenzo P, Alvarez R, Ortiz MA, et al. Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids. J Med Chem. 2008;51(17):5431–5440.
   PubMed Web of Science ®Google Scholar
• Rao YK, Fang SH, Tzeng YM. Synthesis and biological evaluation of 3′,4′,5′-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation. Bioorg Med Chem. 2009;17(23):7909–7914.
   PubMed Web of Science ®Google Scholar
• Srinivasan B, Johnson TE, Lad R, et al. Structure–activity relationship studies of chalcone leading to 3-hydroxy-4,3′,4′,5′-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities. J Med Chem. 2009;52(22):7228–7235.
   PubMed Web of Science ®Google Scholar
• Sasidharan R, Manju SL, Ucar G, et al. Identification of indole-based chalcones: discovery of a potent, selective, and reversible class of MAO-B inhibitors. Arch Pharm Chem Life Sci. 2016;349(8):627–637.
   PubMed Web of Science ®Google Scholar
• Pauwels R, Balzarini J, Baba M, et al. Rapid and automated tetrazoliumbased colorimetric assay for the detection of anti-HIV compounds. J Virol Methods. 1988;20(4):309–321.
   PubMed Web of Science ®Google Scholar
• Shimizu T, Kondo K, Hayaishi O. Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction. Arch Biochem Biophys. 1981;206(2):271–276.
   PubMed Web of Science ®Google Scholar
• Leloup C, Magnan C, Benani A, et al. Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing. Diabetes. 2006;55(7):2084–2090.
   PubMed Web of Science ®Google Scholar
• Winter CA, Risley EA, Nuss GW. Carrageenan-induced oedema in the hind paw of rat as an assay for anti-inflammatory activity. Proc Soc Exp Biol Ther. 1962;111(3):544–547.
   PubMed Web of Science ®Google Scholar
• Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21(1):335–376.
   PubMed Web of Science ®Google Scholar
• Lee JK, Kim SY, Kim YS, et al. Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol. 2009;77(8):1391–1400.
   PubMed Web of Science ®Google Scholar
• Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell. 2002;109(2):S81–S96.
   PubMed Web of Science ®Google Scholar
• Collot-Teixeira S, Martin J, McDermott-Roe C, et al. CD36 and macrophages in atherosclerosis. Cardiovasc Res. 2007;75(3):468–477.
   PubMed Web of Science ®Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1–2):55–63.
   PubMed Web of Science ®Google Scholar
• Baldwin AS. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649–683.
   PubMed Web of Science ®Google Scholar
• Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-Kappa B activity. Annu Rev Immunol. 2000;18(1):621–663.
   PubMed Web of Science ®Google Scholar
• Laskin DL, Pendino KJ. Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol. 1995;35(1):655–677.
   PubMedGoogle Scholar
• Taira J, Nanbu H, Ueda K. Nitric oxide-scavenging compounds in Agrimonia pilosa Ledeb on LPS-induced RAW264.7 macrophages. Food Chem. 2009;115(4):1221–1227.
   Web of Science ®Google Scholar