264
Views
9
CrossRef citations to date
0
Altmetric
Original Articles

Prophylactic effect of Biochanin A in lipopolysaccharide-stimulated BV2 microglial cells

, , &
Pages 330-339 | Received 19 Sep 2019, Accepted 10 May 2020, Published online: 01 Jun 2020

References

  • Perry VH, Teeling J. Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration. Semin Immunopathol. 2013;35(5):601–612.
  • Schwartz M, Kipnis J, Rivest S, et al. How do immune cells support and shape the brain in health, disease, and aging? J Neurosci. 2013;33(45):17587–17596.
  • Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem. 2007;14(11):1189–1197.
  • Smith JA, Das A, Ray SK, et al. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull. 2012;87(1):10–20.
  • Hirsch EC, Hunot S. Neuroinflammation in Parkinson’s disease: a target for neuroprotection? Lancet Neurol. 2009;8(4):382–397.
  • Singhal G, Jaehne EJ, Corrigan F, et al. Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci. 2014;8:1–13.
  • Min KJ, Jou I, Joe E. Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species. Biochem Biophys Res Commun. 2003;312(4):969–974.
  • Min KJ, Pyo HK, Yang MS, et al. Gangliosides activate microglia via protein kinase C and NADPH oxidase. Glia. 2004;48(3):197–206.
  • Simpkins JW, Rajakumar G, Zhang YQ, et al. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J Neurosurg. 1997;87(5):724–730.
  • Sirotkin AV, Harrath AH. Phytoestrogens and their effects. Eur J Pharmacol. 2014;741:230–236.
  • Křížová L, Dadáková K, Kašparovská J, et al. Isoflavones. Molecules. 2019;24(6):1076.
  • Zhou X, Yuan L, Zhao X, et al. Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB. Nutrition. 2014;30(1):90–95.
  • El-Bakoush A, Olajide OA. Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia. Int Immunopharmacol. 2018;61:325–337.
  • Wu WY, Wu YY, Huang H, et al. Biochanin A attenuates LPS-induced pro-inflammatory responses and inhibits the activation of the MAPK pathway in BV2 microglial cells. Int J Mol Med. 2015;35(2):391–398.
  • Wang L, Li L, Han Q, et al. Identification and biological evaluation of natural product Biochanin A. Bioorg Chem. 2020;97:103674.
  • Mazur WM, Duke JA, Wähälä K, et al. Isoflavonoids and lignans in legumes: nutritional and health aspects in humans. J Nutr Biochem. 1998;9(4):193–200.
  • Qiu L, Lin B, Lin Z, et al. Biochanin A ameliorates the cytokine secretion profile of lipopolysaccharide-stimulated macrophages by a PPARγ-dependent pathway. Mol Med Rep. 2012;5(1):217–222.
  • Guo M, Lu H, Qin J, et al. Biochanin A provides neuroprotection against cerebral ischemia/reperfusion injury by Nrf2-mediated inhibition of oxidative stress and inflammation signaling pathway in rats. Med Sci Monit. 2019;25:8975–8983.
  • Zhang S, Morris ME. Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport. J Pharmacol Exp Ther. 2003;304(3):1258–1267.
  • Sadri H, Goodarzi MT, Salemi Z, et al. Antioxidant effects of Biochanin a in streptozotocin induced diabetic rats. Braz Arch Biol Technol. 2017;60:1–10.
  • Li Y, Yu H, Han F, et al. Biochanin A induces S phase arrest and apoptosis in lung cancer cells. Biomed Res Int. 2018;2018:3545376–3545312.
  • Ren G, Shi Z, Teng C, et al. Antiproliferative activity of combined Biochanin A and Ginsenoside Rh2 on MDA-MB-231 and MCF-7 human breast cancer cells. Molecules. 2018;23(11):2908.
  • Zhao Y, Wang L, Zhai X, et al. The effect of biochanin A on cell growth, apoptosis, and migration in osteosarcoma cells. Pharmazie. 2018;73(6):335–341.
  • Silva RFM, Pogačnik L. Polyphenols from food and natural products: neuroprotection and safety. Antioxidants (Basel). 2020;9(1):61.
  • Mairuae N, Cheepsunthorn P, Louicharoen Cheepsunthorn C, et al. Okra (Abelmoschus esculentus Linn.) inhibits lipopolysaccharide-induced inflammatory mediators in BV2 microglial cells. Trop J Pharm Res. 2017;16(6):1285–1292.
  • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1–2):55–63.
  • Park BK, Kim YH, Kim YR, et al. Antineuroinflammatory and neuroprotective effects of Gyejibokryeong–Hwan in lipopolysaccharide-stimulated BV2 microglia. Evid Based Complement Alternat Med. 2019;2019:7585896.
  • González-Guerrero C, Ocaña-Salceda C, Berzal S, et al. Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells. Toxicol Appl Pharmacol. 2013;272(3):825–841.
  • Cipollone F, Rocca B, Patrono C. Cyclooxygenase-2 expression and inhibition in atherothrombosis. Arterioscler Thromb Vasc Biol. 2004;24(2):246–255.
  • Osseni RA, Debbasch C, Christen MO, et al. Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger. Toxicol In Vitro. 1999;13(4–5):683–688.
  • Chung HJ, Koh W, Kim WK, et al. The anti-inflammatory effects of Shinbaro3 is mediated by downregulation of the TLR4 signalling pathway in LPS-stimulated RAW 264.7 macrophages. Mediators Inflamm. 2018;2018:4514329.
  • Ko WC, Lin LH, Shen HY, et al. Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness. Evid Based Complement Alternat Med. 2011;2011:635058–635013.
  • Ghasemi M, Fatemi A. Pathologic role of glial nitric oxide in adult and pediatric neuroinflammatory diseases. Neurosci Biobehav Rev. 2014;45:168–182.
  • Lee JY, Jun DY, Yoon YH, et al. Anti-inflammatory effect of flavonoids kaempferol and Biochanin A-enriched extract of Barnyard Millet (Echinochloa crus-galli var. frumentacea) grains in LPS-stimulated RAW264.7 cells. J Life Sci. 2014;24(11):1157–1167.
  • Zarghi A, Arfaei S, Ghodsi R. Design and synthesis of new 2, 4, 5-triarylimidazole derivatives as selective cyclooxygenase (COX-2) inhibitors. Med Chem Res. 2012;21(8):1803–1810.
  • Sil S, Ghosh T. Role of COX-2 mediated neuroinflammation on the neurodegeneration and cognitive impairments in colchicine induced rat model of Alzheimer's Disease. J Neuroimmunol. 2016;291:115–124.
  • Müller N, Ulmschneider M, Scheppach C, et al. COX-2 inhibition as a treatment approach in schizophrenia: immunological considerations and clinical effects of celecoxib add-on therapy. Eur Arch Psychiatry Clin Neurosci. 2004;254(1):14–22.
  • Subedi L, Ji E, Shin D, et al. Equol, a dietary daidzein gut metabolite attenuates microglial activation and potentiates neuroprotection in vitro. Nutrients. 2017;9(3):207–216.
  • Lim TG, Kim JE, Jung SK, et al. MLK3 is a direct target of biochanin A, which plays a role in solar UV-induced COX-2 expression in human keratinocytes. Biochem Pharmacol. 2013;86(7):896–903.
  • Zhao X, Tang X, Guo N, et al. Biochanin A enhances the defense against Salmonella enterica infection through AMPK/ULK1/mTOR-mediated autophagy and extracellular traps and reversing SPI-1-dependent macrophage (MΦ) M2 polarization. Front Cell Infect Microbiol. 2018;8:1–14.
  • Chung MJ, Sohng JK, Choi DJ, et al. Inhibitory effect of phloretin and biochanin A on IgE-mediated allergic responses in rat basophilic leukemia RBL-2H3 cells. Life Sci. 2013;93(9–11):401–408.
  • Mankan AK, Lawless MW, Gray SG, et al. NF-kappaB regulation: the nuclear response. J Cell Mol Med. 2009;13(4):631–643.
  • Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev. 2001;81(2):807–869.
  • Dang Y, Xu Y, Wu W, et al. Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB and ERK signaling pathways in BV2 cells. PLoS One. 2014;9(8):e102522-10.
  • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805–820.
  • Ziegler G, Harhausen D, Schepers C, et al. TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem Biophys Res Commun. 2007;359(3):574–579.
  • Hua F, Ma J, Ha T, et al. Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion. J Neuroimmunol. 2007;190(1–2):101–111.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.