The isoflavonoid calycosin inhibits inflammation and enhances beta cell function in gestational diabetes mellitus by suppressing RNF38 expression

References

• Wang C, Yang HX. Diagnosis, prevention and management of gestational diabetes mellitus. Chronic Dis Transl Med. 2016;2(4):199–203.
   PubMedGoogle Scholar
• Rani PR, Begum J. Screening and diagnosis of gestational diabetes mellitus, Where do we stand. J Clin Diagn Res. 2016;10(4):QE01–QE04.
   PubMed Web of Science ®Google Scholar
• Moyce BL, Dolinsky VW. Maternal beta-cell adaptations in pregnancy and placental signalling: implications for gestational diabetes. Int J Mol Sci. 2018;19(11):3467.
   Web of Science ®Google Scholar
• Zhang H, Zhang J, Pope CF, et al. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen. Diabetes. 2010;59(1):143–152.
   PubMed Web of Science ®Google Scholar
• Alfadhli EM. Gestational diabetes mellitus. Saudi Med J. 2015;36(4):399–406.
   PubMed Web of Science ®Google Scholar
• Vickers A, Zollman C, Lee R. Herbal medicine. West J Med. 2001;175(2):125–128.
   PubMedGoogle Scholar
• Li L, Zheng S, Brinckmann JA, et al. Chemical and genetic diversity of Astragalus mongholicus grown in different eco-climatic regions. PLoS One. 2017;12(9):e0184791
   PubMed Web of Science ®Google Scholar
• Ng MC, Lau TY, Fan K, et al. Prediction of Radix astragali immunomodulatory effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship. Biomed Res Int. 2017;2017:3923865.
   PubMed Web of Science ®Google Scholar
• Hu G, Siu SO, Li S, et al. Metabolism of calycosin, an isoflavone from Astragali Radix, in Zebrafish larvae. Xenobiotica. 2012;42(3):294–303.
   PubMed Web of Science ®Google Scholar
• Gao J, Liu ZJ, Chen T, et al. Pharmaceutical properties of calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali. Pharm Biol. 2014;52(9):1217–1222.
   PubMed Web of Science ®Google Scholar
• Gong AGW, Duan R, Wang HY, et al. Evaluation of the pharmaceutical properties and value of Astragali Radix. Medicines. 2018;5(2):46.
   Google Scholar
• Zhang D, Zhuang Y, Pan J, et al. Investigation of effects and mechanisms of total flavonoids of Astragalus and calycosin on human erythroleukemia cells. Oxid Med Cell Longev. 2012;2012:209843.
   PubMed Web of Science ®Google Scholar
• Tian J, Wang Y, Zhang X, et al. Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling. J Exp Clin Cancer Res. 2017;36(1):153
   PubMedGoogle Scholar
• Wu G, Niu M, Qin J, et al. Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells. Gene. 2019;709:48–55.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Liu QH, Liu CL, et al. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Tumour Biol. 2015;36(7):5333–5339.
   PubMedGoogle Scholar
• Zhou L, Wu Y, Guo Y, et al. Calycosin enhances some chemotherapeutic drugs inhibition of Akt signaling pathway in gastric cells. Cancer Invest. 2017;35(5):289–300.
   PubMed Web of Science ®Google Scholar
• Zhai J, Tao L, Zhang S, et al. Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway. Phytother Res. 2020;34(3):649–659.
   PubMed Web of Science ®Google Scholar
• Guo C, Tong L, Xi M, et al. Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats. J Ethnopharmacol. 2012;144(3):768–774.
   PubMed Web of Science ®Google Scholar
• Dong L, Yin L, Zhang Y, et al. Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells. Molecular Immunology. 2017;83:46–51.
   PubMed Web of Science ®Google Scholar
• Pantham P, Aye IL, Powell TL. Inflammation in maternal obesity and gestational diabetes mellitus. Placenta. 2015;36(7):709–715.
   PubMed Web of Science ®Google Scholar
• Rubsam A, Parikh S, Fort PE. Role of inflammation in diabetic retinopathy. Int . Mol Sci. 2018;19(4):942.
   PubMed Web of Science ®Google Scholar
• Burhans MS, Hagman DK, Kuzma JN, et al. Contribution of adipose tissue inflammation to the development of Type 2 diabetes mellitus. Compr Physiol. 2018;9(1):1–58.
   PubMed Web of Science ®Google Scholar
• Chen L, Deng H, Cui H, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9(6):7204–7218.
   PubMedGoogle Scholar
• Levy DE, Lee CK. What does Stat3 do? J Clin Invest. 2002;109(9):1143–1148.
   PubMed Web of Science ®Google Scholar
• Mashili F, Chibalin AV, Krook A, et al. Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes. Diabetes. 2013;62(2):457–465.
   PubMed Web of Science ®Google Scholar
• Lu TC, Wang ZH, Feng X, et al. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int. 2009;76(1):63–71.
   PubMed Web of Science ®Google Scholar
• Jones HN, Jansson T, Powell TL. Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells. Diabetes. 2010;59(5):1161–1170.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wu H, Yi B, et al. RING finger protein 38 induces gastric cancer cell growth by decreasing the stability of the protein tyrosine phosphatase SHP-1. FEBS Lett. 2018;592(18):3092–3100.
   PubMed Web of Science ®Google Scholar
• Xiong D, Zhu SQ, Wu YB, et al. Ring finger protein 38 promote non-small cell lung cancer progression by endowing cell EMT phenotype. J Cancer. 2018;9(5):841–850.
   PubMed Web of Science ®Google Scholar
• Saez I, Vilchez D. The mechanistic links between proteasome activity, aging and age-related Diseases. Curr Genomics. 2014;15(1):38–51.
   PubMed Web of Science ®Google Scholar
• Nacheva EP, Brazma D, Virgili A, et al. Deletions of immunoglobulin heavy chain and T cell receptor gene regions are uniquely associated with lymphoid blast transformation of chronic myeloid leukemia. BMC Genomics. 2010;11(1):41.
   PubMedGoogle Scholar
• Peng R, Zhang PF, Yang X, et al. Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma . J Exp Clin Cancer Res. 2019;38(1):113
   PubMedGoogle Scholar
• Sheren JE, Kassenbrock CK. RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53. Biochem Biophys Res Commun. 2013;440(4):473–478.
   PubMed Web of Science ®Google Scholar
• Dempke WCM, Uciechowski P, Fenchel K, et al. Targeting SHP-1, 2 and SHIP pathways: a novel strategy for cancer treatment? Oncology. 2018;95(5):257–269.
   PubMed Web of Science ®Google Scholar