Amphiregulin alleviated concanavalin A-induced acute liver injury via IL-22

References

• Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369(26):2525–2534.
   PubMed Web of Science ®Google Scholar
• Fyfe B, Zaldana F, Liu C. The pathology of acute liver failure. Clin Liver Dis. 2018;22(2):257–268.
   PubMed Web of Science ®Google Scholar
• Heymann F, Tacke F. Immunology in the liver-from homeostasis to disease. Nat Rev Gastroenterol Hepatol. 2016;13(2):88–110.
   PubMed Web of Science ®Google Scholar
• Bonkovsky HL, Barnhart HX, Foureau DM, et al. Cytokine profiles in acute liver injury-results from the US drug-induced liver injury network (DILIN) and the acute liver failure study group. PLoS One. 2018;13(10):e0206389.
   PubMed Web of Science ®Google Scholar
• Bernal W, Hyyrylainen A, Gera A, et al. Lessons from look-back in acute liver failure? A single centre experience of 3300 patients. J Hepatol. 2013;59(1):74–80.
   PubMed Web of Science ®Google Scholar
• Olivo R, Guarrera JV, Pyrsopoulos NT. Liver transplantation for acute liver failure. Clin Liver Dis. 2018;22(2):409–417.
   PubMed Web of Science ®Google Scholar
• Berasain C, Avila MA. Amphiregulin. Semin Cell Dev Biol. 2014;28:31–41.
   PubMed Web of Science ®Google Scholar
• Zaiss DMW, Gause WC, Osborne LC, et al. Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair. Immunity. 2015;42(2):216–226.
   PubMed Web of Science ®Google Scholar
• Berasain C, Garcia-Trevijano ER, Castillo J, et al. Novel role for amphiregulin in protection from liver injury. J Biol Chem. 2005;280(19):19012–19020.
   PubMed Web of Science ®Google Scholar
• Rayego-Mateos S, Rodrigues-Diez R, Morgado-Pascual JL, et al. Role of epidermal growth factor receptor (EGFR) and its ligands in kidney inflammation and damage. Mediators Inflamm. 2018;2018:8739473.
   PubMed Web of Science ®Google Scholar
• Poole JA, Nordgren TM, Heires AJ, et al. Amphiregulin modulates murine lung recovery and fibroblast function following exposure to agriculture organic dust. Am J Physiol Lung Cell Mol Physiol. 2019;318:L180–L191.
   PubMed Web of Science ®Google Scholar
• Santamaria E, Rodriguez-Ortigosa CM, Uriarte I, et al. The epidermal growth factor receptor ligand amphiregulin protects from cholestatic liver injury and regulates bile acids synthesis. Hepatology. 2019;69(4):1632–1647.
   PubMed Web of Science ®Google Scholar
• Garcia-Irigoyen O, Carotti S, Latasa MU, et al. Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair. Liver Int. 2014;34(7):e257–e270.
   PubMed Web of Science ®Google Scholar
• Perugorria MJ, Latasa MU, Nicou A, et al. The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis. Hepatology. 2008;48(4):1251–1261.
   PubMed Web of Science ®Google Scholar
• Pardo-Saganta A, Latasa MU, Castillo J, et al. The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression. J Hepatol. 2009;51(6):1010–1020.
   PubMed Web of Science ®Google Scholar
• Heymann F, Hamesch K, Weiskirchen R, et al. The concanavalin A model of acute hepatitis in mice. Lab Anim. 2015;49(1):12–20.
   PubMed Web of Science ®Google Scholar
• Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest. 1992;90(1):196–203.
   PubMed Web of Science ®Google Scholar
• Gantner F, Leist M, Lohse AW, et al. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology. 1995;21(1):190–198.
   PubMed Web of Science ®Google Scholar
• He GW, Gunther C, Kremer AE, et al. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut. 2017;66(4):716–723.
   PubMed Web of Science ®Google Scholar
• Wen Z, Lei Z, Yao L, et al. Circulating histones are major mediators of systemic inflammation and cellular injury in patients with acute liver failure. Cell Death Dis. 2016;7(9):e2391.
   PubMedGoogle Scholar
• Hurbin A, Coll JL, Dubrez-Daloz L, et al. Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. J Biol Chem. 2005;280(20):19757–19767.
   PubMed Web of Science ®Google Scholar
• Busser B, Sancey L, Josserand V, et al. Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. Mol Ther. 2010;18(3):536–543.
   PubMed Web of Science ®Google Scholar
• Platen C, Dreschers S, Wappler J, et al. Amphiregulin regulates phagocytosis-induced cell death in monocytes via EGFR and the Bcl-2 protein family. Mediators Inflamm. 2019;2019:1603131.
   PubMed Web of Science ®Google Scholar
• Chinnaiyan AM, Chaudhary D, O’Rourke K, et al. Role of CED-4 in the activation of CED-3. Nature. 1997;388(6644):728–729.
   PubMed Web of Science ®Google Scholar
• Cheng EH, Kirsch DG, Clem RJ, et al. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science. 1997;278(5345):1966–1968.
   PubMed Web of Science ®Google Scholar
• Pan G, O’Rourke K, Dixit VM. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J Biol Chem. 1998;273(10):5841–5845.
   PubMed Web of Science ®Google Scholar
• Xu R, Huang H, Zhang Z, et al. The role of neutrophils in the development of liver diseases. Cell Mol Immunol. 2014;11(3):224–231.
   PubMed Web of Science ®Google Scholar
• Qi Z, Wang X, Wei H, et al. Infiltrating neutrophils aggravate metabolic liver failure in fah-deficient mice. Liver Int. 2015;35(3):774–785.
   PubMed Web of Science ®Google Scholar
• Wu C, Zhu Y, Yu M. Serum metabonomics analysis of liver failure treated by nonbioartificial liver support systems. Can J Gastroenterol Hepatol. 2018;2018:1–10.
   Web of Science ®Google Scholar
• Strzepa A, Pritchard KA, Dittel BN. Myeloperoxidase: a new player in autoimmunity. Cell Immunol. 2017;317:1–8.
   PubMed Web of Science ®Google Scholar
• Chung RT, Stravitz RT, Fontana RJ, et al. Pathogenesis of liver injury in acute liver failure. Gastroenterology. 2012;143(3):e1–e7.
   PubMedGoogle Scholar
• Dudakov JA, Hanash AM, van den Brink MR. Interleukin-22: immunobiology and pathology. Annu Rev Immunol. 2015;33:747–785.
   PubMed Web of Science ®Google Scholar
• Pan H, Hong F, Radaeva S, et al. Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell Mol Immunol. 2004;1(1):43–49.
   PubMed Web of Science ®Google Scholar
• Sabat R, Ouyang W, Wolk K. Therapeutic opportunities of the IL-22-IL-22R1 system. Nat Rev Drug Discov. 2014;13(1):21–38.
   PubMed Web of Science ®Google Scholar
• Kong X, Feng D, Wang H, et al. Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology. 2012;56(3):1150–1159.
   PubMed Web of Science ®Google Scholar
• Ki SH, Park O, Zheng M, et al. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology. 2010;52(4):1291–1300.
   PubMed Web of Science ®Google Scholar
• Chestovich PJ, Uchida Y, Chang W, et al. Interleukin-22: implications for liver ischemia-reperfusion injury. Transplantation. 2012;93(5):485–492.
   PubMed Web of Science ®Google Scholar
• Yang L, Zhang Y, Wang L, et al. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. J Hepatol. 2010;53(2):339–347.
   PubMed Web of Science ®Google Scholar
• Radaeva S, Sun R, Pan HN, et al. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology. 2004;39(5):1332–1342.
   PubMed Web of Science ®Google Scholar