The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-κB and Akt/VEGF signaling in CCl₄-induced pancreas damage in rats

References

• Bulut ÖH. The importance of drain fluid amylase levels in assessment of pancreatic fistulas in patients underwent pancreatic resection Medical Specialty Thesis. Erzurum, Turkey: Atatürk University Health Sciences Institute; 2013.
   Google Scholar
• Ahmad B, Khan MR, Shah NA. Amelioration of carbon tetrachloride-induced pulmonary toxicity with Oxalis corniculata. Toxicol Ind Health. 2015;31(12):1243–1251.
   PubMed Web of Science ®Google Scholar
• Aslan A, Can MI. Milk thistle impedes the development of carbontetrachloride-induced liver damage in rats through suppression of Bcl-2 and regulating caspase pathway. Life Sci. 2014;117(1):13–18.
   PubMed Web of Science ®Google Scholar
• Lavrentiadou SN, Tsantarliotou MP, Zervos IA, et al. CCl4 induces tissue-type plasminogen activator in rat brain; protective effects of oregano, rosemary or vitamin E. Food Chem Toxicol. 2013;61:196–202.
   PubMed Web of Science ®Google Scholar
• Taslidere E, Taslidere M, Elbe H, et al. Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats. Exp Lung Res. 2014;40(2):59–65.
   PubMed Web of Science ®Google Scholar
• Tekeli İO, Ateşşahin A, Sakin F, et al. Protective efects of conventional and colon targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats. Inflammopharmacol. 2019;27(2):313–322.
   Web of Science ®Google Scholar
• Aslan A, Gok O, Beyaz S, et al. The preventive effect of ellagic acid on brain damage in rats via regulating of Nrf-2, NF-kB and apoptotic pathway. J Food Biochem. 2020c;44(6):e13217. DOİ: 10.1111/jfbc.13217.
   Web of Science ®Google Scholar
• Aksit H, Aksit D, Bildik A, et al. Effects of N-acetyl cysteine on glutathione metabolism and lipid peroxidation in the experimental hepatic intoxication. Ankara Üniv Vet Fak Derg. 2015;62:1–5.
   Web of Science ®Google Scholar
• Aslan A, Boydak D, Can MI, et al. Black cumin may be a potential drug for development of carbontetrachloride-induced lung damage in rats. Prog Nutr. 2016;18:56–62.
   Web of Science ®Google Scholar
• Aslan A, Can MI, Kuloglu T, et al. Milk thistle may induce apoptosis in development of carbontetrachloride-induced liver DNA damage in rats. Prog in Nutr. 2016;18:146–151.
   Web of Science ®Google Scholar
• Masamune A, Satoh M, Kikuta K, et al. Ellagic acid blocks activation of pancreatic stellate cells. Biochem Pharmacol. 2005;70(6):869–878.
   PubMed Web of Science ®Google Scholar
• Aslan A, Beyaz S, Gok O, et al. The effect of ellagic acid on caspase-3/Bcl-2/Nrf-2/NF-kB/TNF-α /COX-2 gene expression product apoptosis pathway: a new approach for muscle damage therapy. Mol Biol Rep. 2020b;47(4):2573–2582.
   PubMed Web of Science ®Google Scholar
• Fatima N, Hafizur RM, Hameed A, et al. Ellagic acid in emblica officinalis exerts anti-diabetic activity through the action on β-Cells of pancreas. Eur J Nutr. 2017;56(2):591–601.
   PubMed Web of Science ®Google Scholar
• Ding X, Jian T, Wu Y, et al. Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated Hepg2 cells via Mir-223/Keap1-Nrf2 pathway. Biomed Pharmacother. 2019;110:85–94.
   PubMed Web of Science ®Google Scholar
• Yilmaz EE, Bozdag Z, Ibiloglu I, et al. Therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis. Acta Cir Bras. 2016;31:396–401.
   PubMed Web of Science ®Google Scholar
• Aslan A, Boydak D, Can MI, et al. Nigella sativa improves the carbon tetrachloride-induced lung damage in rats through repression of ERK/Akt pathway. Bangladesh J Pharmacol. 2015;10(3):654–659.
   Web of Science ®Google Scholar
• Aslan A, Gok O, Erman O, et al. Ellagic acid impedes carbontetrachloride-induced liver damage in rats through suppression of Nf-kB, Bcl-2 and regulating Nrf-2 and caspase pathway. Biomed Pharmacother. 2018;105:662–669.
   PubMed Web of Science ®Google Scholar
• Grossi MR, Berni A, Pepe G, et al. Evaluation of the effects of ellagic acid (EA) on 7,12-dimethylbenz(α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo. Toxicol Lett. 2014;224(2):240–245.
   PubMed Web of Science ®Google Scholar
• Kaya I. Effect of ellagic acid on plasma paraoxonase, sialic acid and oxidative stress parameters in mice with chronic fluorosis PhD Thesis. Kars, Turkey: Kafkas University Health Sciences Institute; 2012.
   Google Scholar
• Gu L, Deng WS, Liu Y, et al. Ellagic acid protects lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice. Int Immunopharmacol. 2014;22(2):341–345.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–358.
   PubMed Web of Science ®Google Scholar
• Altınbasak M. Investigation of the hepatoprotective and antioxidant role of lyophilized extract of hawthorn (Crataegus orientalis) fruit in carbon tetrachloride (CCl4) induced oxidative stress and liver damage Master Thesis. Van, Turkey: Yüzüncü Yıl University Institute of Science; 2019.
   Google Scholar
• Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227(5259):680–685.
   PubMed Web of Science ®Google Scholar
• Gafurogulları S. Can caspase 3 activity determine stroke duration? Bursa, Turkey: Emergency Medicine Department, University of Medical Sciences Bursa High Specialization Health Practice and Research Center; 2018.
   Google Scholar
• Seker D. Prognostic importance of CD163, CD68, C-met, Bcl-2 and NF-κB expressions in classical hodgkin lymphoma patients Medical Specialty Thesis. Aydın, Turkey: Adnan Menderes University Health Sciences Institute; 2015.
   Google Scholar
• Bashir N, Manoharan V, Miltonprabu S. Grape seed proanthocyanidins protects against cadmium induced oxidative pancreatitis in rats by attenuating oxidative stress, inflammation and apoptosis via Nrf-2/HO-1 signaling. J Nutr Biochem. 2016;32:128–141.
   PubMed Web of Science ®Google Scholar
• Du D, Yao L, Zhang R, et al. Protective effects of flavonoids from Coreopsis tinctoria nutt. on experimental acute pancreatitis via Nrf-2/ARE-mediated antioxidant pathways. J Ethnopharmacol. 2018;224:261–272.
   PubMed Web of Science ®Google Scholar
• Gunay B. Role of TNF-alpha gene polymorphisms as a biomarker in response to treatment of psoriasis with anti-TNF agents Medical Specialty Thesis. Bursa, Turkey: Uludağ University Faculty of Medicine; 2017.
   Google Scholar
• Gokdeniz D. Expression of VEGF-A, FGF-2, VEGFR-2, VD105 (endoglin) in endometrioma cyst tissue and eutopic endometrium tissue in patient with endometrioma, determine serum and peritoneal fluid levels of VEGF-A, iron and ferritin Medical Specialty Thesis. İzmir, Turkey: Dokuz Eylul University Institute of Health Sciences; 2016.
   Google Scholar
• Sahin C, Nal G, Aricioglu F. The involvement of Akt and GSK-3: two pathways, two pathology. MUSBED. 2014;4:1–57.
   Google Scholar
• Lopez L, Valadez M, Sanchez G. Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vıvo and in vıtro. Neuroscience. 2016;322:208–220.
   PubMed Web of Science ®Google Scholar
• Tang K, Xia FC, Wagner PD, et al. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle. Respir Physiol Neurobiol. 2010;170(1):16–22.
   PubMed Web of Science ®Google Scholar
• Ding Y, Wang L, Song J, et al. Protective effects of ellagic acid against tetrachloride-induced cirrhosis in mice through the inhibition of reactive oxygen species formation and angiogenesis. Exp Ther Med. 2017;14(4):3375–3380.
   PubMed Web of Science ®Google Scholar
• Aslan A. Cell culture developing and the imaging of total protein product changing with SDS-PAGE in Saccharomyces cerevisiae. Prog Nutr. 2018;20:128–132.
   Web of Science ®Google Scholar
• Gungormez Y. Examination of antioxidant system mechanisms and enzyme levels (CAT, GSH, MDA) of muay Thai sports Master Thesis. Ağrı, Turkey: Ağrı İbrahim Çeçen University Institute of Social Sciences; 2019.
   Google Scholar
• Liu B, Miao J, Peng M, et al. Effect of 3: 7 ratio of Astragalus total saponins and curcumin on the diabetic nephropathy rats model. Saudi J Biol Sci. 2019;26(1):188–194.
   PubMed Web of Science ®Google Scholar
• Zhang S, Xu H, Yu X, et al. Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes. Exp Ther Med. 2017;14(1):383–390.
   PubMed Web of Science ®Google Scholar
• Guller P. The investigation of the effects of gentamicin, amokcicilin and cefazolin sodium antibıotics on the enzyme activity, protein and gene expression levels of glutathione reductase in mouse liver and kidney PhD Thesis. Erzurum, Turkey: Atatürk University Graduate School of Natural and Applied Sciences; 2015.
   Google Scholar
• Sharma S, Kulkarni SK, Chopra K. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2006;33(10):940–945.
   PubMed Web of Science ®Google Scholar
• Suzuki N, Masamune A, Kikuta K, et al. Ellagic acid inhibits pancreatic fibrosis in male Wistar Bonn/Kobori rats. Dig Dis Sci. 2009;54(4):802–810.
   PubMed Web of Science ®Google Scholar
• Ahad A, Ganai AA, Mujeeb M, et al. Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy. Chem Biol Interact. 2014;219:64–75.
   PubMed Web of Science ®Google Scholar
• Xu L, Li W, Chen Z, et al. Inhibitory effect of epigallocatechin-3-O-gallate on α-glucosidase and its hypoglycemic effect via targeting PI3K/AKT signaling pathway in L6 skeletal muscle cells. Int J Biol Macromol. 2019;125:605–661.
   PubMed Web of Science ®Google Scholar
• Ceci C, Lacal PM, Tentori L, et al. Experimental evidence of the antitumor, antimetastatic and antiangiogenic activity of ellagic acid. Nutrients. 2018;10(11):1756–1723.
   PubMed Web of Science ®Google Scholar
• Aslan A, Hussein YT, Gok O, et al. Ellagic acid ameliorates lung damage in rats via modulating antioxidant activities, inhibitory effects on inflammatory mediators and apoptosis-inducing activities. Environ Sci Pollut Res Int. 2020a;27(7):7526–7537.
   PubMed Web of Science ®Google Scholar
• Aslan A. The effects of different essential fruit juice and their combination on Saccharomyces cerevisiae cell growth. Prog Nutr. 2015;17:36–40.
   Web of Science ®Google Scholar