Combination of tetrandrine and 3-n-butylphthalide protects against cerebral ischemia-reperfusion injury via ATF2/TLR4 pathway

References

• Tsai CF, Yip PK, Chen CC, et al. Cerebral infarction in acute anemia. J Neurol. 2010;257(12):2044–2051.
   PubMed Web of Science ®Google Scholar
• Shao M, Shen Y, Sun H, et al. Protectiveness of artesunate given prior ischemic cerebral infarction is mediated by increased autophagy. Front Neurol. 2018;9:634.
   PubMed Web of Science ®Google Scholar
• Meng C, Zhang J, Zhang L, et al. Effects of NLRP6 in cerebral ischemia/reperfusion (I/R) injury in rats. J Mol Neurosci. 2019;69(3):411–418.
   PubMed Web of Science ®Google Scholar
• Zhou L, Zhang J, Wang C, et al. Tanshinone inhibits neuronal cell apoptosis and inflammatory response in cerebral infarction rat model. Int J Immunopathol Pharmacol. 2017;30(2):123–129.
   PubMed Web of Science ®Google Scholar
• Watson G, Ronai ZA, Lau E. ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease. Pharmacol Res. 2017;119:347–357.
   PubMed Web of Science ®Google Scholar
• Srivastava M, Saqib U, Naim A, et al. The TLR4-NOS1-AP1 signaling axis regulates macrophage polarization. Inflamm Res. 2017;66(4):323–334.
   PubMed Web of Science ®Google Scholar
• Yang H, Wang H, Ju Z, et al. MD-2 is required for disulfide HMGB1-dependent TLR4 signaling. J Exp Med. 2015;212(1):5–14.
   PubMed Web of Science ®Google Scholar
• van Delft MA, Huitema LF, Tas SW. The contribution of NF-κB signalling to immune regulation and tolerance . Eur J Clin Invest. 2015;45(5):529–539.
   PubMed Web of Science ®Google Scholar
• Hu J, Liu B, Zhao Q, et al. Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats. Neuroscience. 2016;324:11–19.
   PubMed Web of Science ®Google Scholar
• Guo D, Ma J, Yan L, et al. Down-Regulation of lncrna MALAT1 attenuates neuronal cell death through suppressing Beclin1-dependent autophagy by regulating mir-30a in cerebral ischemic stroke. Cell Physiol Biochem. 2017;43(1):182–194.
   PubMedGoogle Scholar
• Zhou J, Zhang YH, Song HZ, et al. 5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury. Oncotarget. 2016;7(26):39444–39457.
   PubMedGoogle Scholar
• Zhao Q, Zhang C, Wang X, et al. (S)-ZJM-289, a nitric oxide-releasing derivative of 3-n-butylphthalide, protects against ischemic neuronal injury by attenuating mitochondrial dysfunction and associated cell death. Neurochem Int. 2012;60(2):134–144.
   PubMed Web of Science ®Google Scholar
• Liao W, Zhong Y, Cheng W, et al. 3-N-butylphthalide inhibits neuronal apoptosis in rats with cerebral infarction via targeting P38/MAPK. Eur Rev Med Pharmacol Sci. 2019;23:144–152.
   PubMedGoogle Scholar
• Ho LJ, Chang DM, Chang ML, et al. Mechanism of immunosuppression of the antirheumatic herb TWHf in human T cells. J Rheumatol. 1999;26:14–24.
   PubMed Web of Science ®Google Scholar
• Chen Y, Chen JC, Tseng SH. Effects of tetrandrine plus radiation on neuroblastoma cells. Anticancer Res. 2009;29:3163–3171.
   PubMed Web of Science ®Google Scholar
• Chen Y, Chen JC, Tseng SH. Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats. Int J Cancer. 2009;124(10):2260–2269.
   PubMed Web of Science ®Google Scholar
• Chen Y, Tseng SH. The potential of tetrandrine against gliomas. Anticancer Agents Med Chem. 2010;10(7):534–542.
   PubMed Web of Science ®Google Scholar
• Ruan L, Huang HS, Jin WX, et al. Tetrandrine attenuated cerebral ischemia/reperfusion injury and induced differential proteomic changes in a MCAO mice model using 2-D DIGE. Neurochem Res. 2013;38(9):1871–1879.
   PubMed Web of Science ®Google Scholar
• Hao MQ, Xie LJ, Leng W, et al. Trim47 is a critical regulator of cerebral ischemia-reperfusion injury through regulating apoptosis and inflammation. Biochem Biophys Res Commun. 2019;515(4):651–657.
   PubMed Web of Science ®Google Scholar
• Janyou A, Wicha P, Jittiwat J, et al. Dihydrocapsaicin attenuates blood brain barrier and cerebral damage in focal cerebral ischemia/reperfusion via oxidative stress and inflammatory. Sci Rep. 2017;7(1):10556.
   PubMedGoogle Scholar
• Liu Z, Xu Z, Shen W, et al. Effect of pharmacologic preconditioning with tetrandrine on subsequent ischemia/reperfusion injury in rat liver. World J Surg. 2004;28(6):620–624.
   PubMed Web of Science ®Google Scholar
• Zhang TJ, Guo RX, Li X, et al. Tetrandrine cardioprotection in ischemia-reperfusion (I/R) injury via JAK3/STAT3/hexokinase II. Eur J Pharmacol. 2017;813:153–160.
   PubMed Web of Science ®Google Scholar
• Wang J, Guo M, Ma R, et al. Tetrandrine alleviates cerebral ischemia/reperfusion injury by suppressing NLRP3 inflammasome activation via sirt-1. PeerJ. 2020;8:e9042.
   PubMed Web of Science ®Google Scholar
• Song XL, Liu S, Jiang Y, et al. Targeting vincristine plus tetrandrine liposomes modified with DSPE-PEG2000-transferrin in treatment of brain glioma. Eur J Pharm Sci. 2017;96:129–140.
   PubMed Web of Science ®Google Scholar
• Zz C, Feng YP. Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion. Zhongguo Yao Li Xue Bao. 1999;18:505–508.
   Web of Science ®Google Scholar
• Gx D, Feng YP. Effects of NBP on ATPase and anti-oxidant enzymes activities and lipid peroxidation in transient focal cerebral ischemic rats. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002;24:93–97.
   PubMedGoogle Scholar
• Schaller B, Graf R. Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab. 2004;24(4):351–371.
   PubMed Web of Science ®Google Scholar
• Liao SJ, Lin JW, Pei Z, et al. Enhanced angiogenesis with dl-3n-butylphthalide treatment after focal cerebral ischemia in RHRSP. Brain Res. 2009;1289:69–78.
   PubMed Web of Science ®Google Scholar
• Liu CL, Liao SJ, Zeng JS, et al. dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP. J Neurol Sci. 2007;260(1-2):106–113.
   PubMed Web of Science ®Google Scholar
• Li M, Zhang D, Ge X, et al. TRAF6-p38/JNK-ATF2 axis promotes microglial inflammatory activation. Exp Cell Res. 2019;376(2):133–148.
   PubMed Web of Science ®Google Scholar
• Kumar V, Weng YC, Wu YC, et al. PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration. BMC Neurosci. 2018;19(1):76.
   PubMedGoogle Scholar
• Hsieh HL, Lin CC, Shih RH, et al. NADPH oxidase-mediated redox signal contributes to lipoteichoic acid-induced MMP-9 upregulation in brain astrocytes. J Neuroinflammation. 2012;9:110.
   PubMed Web of Science ®Google Scholar
• Song B, Xie B, Wang C, et al. Caspase-3 is a target gene of c-Jun:ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons. Neurosci Lett. 2011;505(2):76–81.
   PubMed Web of Science ®Google Scholar
• Lee IT, Shih RH, Lin CC, et al. Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells. Cell Commun Signal. 2012;10(1):33.
   PubMedGoogle Scholar
• Chen X, Yao Z, Peng X, et al. Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF-κB signaling pathway. Mol Med Rep. 2020;22(6):5135–5144.
   PubMed Web of Science ®Google Scholar
• Liu Q, Zhang Y. PRDX1 enhances cerebral ischemia-reperfusion injury through activation of TLR4-regulated inflammation and apoptosis. Biochem Biophys Res Commun. 2019;519(3):453–461.
   PubMed Web of Science ®Google Scholar
• Dai M, Wu L, Yu K, et al. D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway. Biomed Pharmacother. 2020;132:110870.
   PubMed Web of Science ®Google Scholar
• Otsuki S, Saito T, Taylor S, et al. Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition. JCI Insight. 2021;6(15):146416.
   PubMed Web of Science ®Google Scholar