Isorhamnetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting mTOR signaling pathway

References

• Rubenfeld GD, Caldwell E, Peabody E, et al. Incidence and outcomes of acute lung injury. N Engl J Med. 2005;353(16):1685–1693.
   PubMed Web of Science ®Google Scholar
• Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med. 2011;17(3-4):293–307.
   PubMed Web of Science ®Google Scholar
• Castillo RL, Carrasco Loza R, Romero-Dapueto C. Pathophysiological approaches of acute respiratory distress syndrome: novel bases for study of lung injury. Open Respir Med J. 2015;9:83–91.
   PubMedGoogle Scholar
• Zhao Y, Jiang Y, Chen L, et al. Inhibition of the endoplasmic reticulum (ER) stress-associated IRE-1/XBP-1 pathway alleviates acute lung injury via modulation of macrophage activation. J Thorac Dis. 2020;12(3):284–295.
   PubMed Web of Science ®Google Scholar
• Chen S-P, Su C-H, Huang-Liu R, et al. Protective effect of nerolidol on lipopolysaccharide-induced acute lung injury through the inhibition of NF-κB activation by the reduction of p38 MAPK and JNK phosphorylation. J Funct Foods. 2020;69:103943.
   Web of Science ®Google Scholar
• Nadeem A, Al-Harbi NO, Ahmad SF, et al. Blockade of interleukin-2-inducible T-cell kinase signaling attenuates acute lung injury in mice through adjustment of pulmonary Th17/Treg immune responses and reduction of oxidative stress. Int Immunopharmacol. 2020;83:106369.
   PubMed Web of Science ®Google Scholar
• Bakheet SA, Alrwashied BS, Ansari MA, et al. CXC chemokine receptor 3 antagonist AMG487 shows potent anti-arthritic effects on collagen-induced arthritis by modifying B cell inflammatory profile. Immunol Lett. 2020;225:74–81.
   PubMed Web of Science ®Google Scholar
• Nadeem A, Ahmad SF, Al-Harbi NO, et al. Inhibition of spleen tyrosine kinase signaling protects against acute lung injury through blockade of NADPH oxidase and IL-17A in neutrophils and γδ T cells respectively in mice. Int Immunopharmacol. 2019;68:39–47.
   PubMed Web of Science ®Google Scholar
• Yue H, Mao Y-Y, Lai T-W, et al. Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury. Autophagy. 2016;9(2):31–32.
   Google Scholar
• Perkins ND. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat Rev Mol Cell Biol. 2007;8(1):49–62.
   PubMed Web of Science ®Google Scholar
• Gao L, Yao R, Liu Y, et al. Isorhamnetin protects against cardiac hypertrophy through blocking PI3K-AKT pathway. Mol Cell Biochem. 2017; 429(1–2):167–177.
   PubMed Web of Science ®Google Scholar
• Yang B, Li XP, Ni YF, et al. Protective effect of isorhamnetin on lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2016; 39(1):129–137.
   PubMed Web of Science ®Google Scholar
• Mari Hamalainen RN, Vuorela P, Heinonen M, et al. Activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflammation. 2007;2007(5):1–10.
   Google Scholar
• Yang JH, Shin BY, Han JY, et al. Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes. Toxicol Appl Pharmacol. 2014;274(2):293–301.
   PubMed Web of Science ®Google Scholar
• Yang JH, Kim SC, Shin BY, et al. O-Methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-kappaB activation. Food Chem Toxicol. 2013;59:362–372.
   PubMed Web of Science ®Google Scholar
• Li Y, Chi G, Shen B, et al. Isorhamnetin ameliorates LPS-induced inflammatory response through downregulation of NF-kappaB signaling. Inflammation. 2016;39(4):1291–1301.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147(4):728–741.
   PubMed Web of Science ®Google Scholar
• Xue L, Zhang WJ, Fan QX, et al. Licochalcone a inhibits PI3K/Akt/mTOR signaling pathway activation and promotes autophagy in breast cancer cells. Oncol Lett. 2018;15(2):1869–1873.
   PubMed Web of Science ®Google Scholar
• Lorne E, Zhao X, Zmijewski JW, et al. Participation of mammalian target of rapamycin complex 1 in toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol. 2009;41(2):237–245.
   PubMed Web of Science ®Google Scholar
• Nadeem A, Siddiqui N, Al-Harbi NO, et al. Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model. Int Immunopharmacol. 2017;47:218–226.
   PubMed Web of Science ®Google Scholar
• Bakheet SA, Alrwashied BS, Ansari MA, et al. CXCR3 antagonist AMG487 inhibits glucocorticoid-induced tumor necrosis factor-receptor-related protein and inflammatory mediators in CD45 expressing cells in collagen-induced arthritis mouse model. Int Immunopharmacol. 2020;84:106494.
   PubMed Web of Science ®Google Scholar
• Fielhaber JA, Carroll SF, Dydensborg AB, et al. Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis. J Immunol. 2012;188(9):4535–4542.
   PubMed Web of Science ®Google Scholar
• Yen YT, Yang HR, Lo HC, et al. Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury. Surgery. 2013;153(5):689–698.
   PubMed Web of Science ®Google Scholar
• Lo S, Yuan SS, Hsu C, et al. Lc3 over-expression improves survival and attenuates lung injury through increasing autophagosomal clearance in septic mice. Ann Surg. 2013;257(2):352–363.
   PubMed Web of Science ®Google Scholar
• Tanaka A, Jin Y, Lee SJ, et al. Hyperoxia-induced LC3B interacts with the fas apoptotic pathway in epithelial cell death. Am J Respir Cell Mol Biol. 2012;46(4):507–514.
   PubMed Web of Science ®Google Scholar
• Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101–1108.
   PubMed Web of Science ®Google Scholar
• Smith KM, Mroze JD, Simonton SC, et al. Prolonged partial liquid ventilation using conventional and high-frequency ventilatory techniques: gas exchange and lung pathology in an animal model of respiratory distress syndrome. Crit Care Med. 1997;25(11):1888–1897.
   PubMed Web of Science ®Google Scholar