Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway

References

• Maudens P, Jordan O, Allémann E. Recent advances in intra-articular drug delivery systems for osteoarthritis therapy. Drug Discov Today. 2018;23(10):1761–1775.
   PubMed Web of Science ®Google Scholar
• Mandl LA. Osteoarthritis year in review 2018: clinical. Osteoarthritis Cartilage. 2019;27(3):359–364.
   PubMed Web of Science ®Google Scholar
• Charlier E, Deroyer C, Ciregia F, et al. Chondrocyte dedifferentiation and osteoarthritis (OA). Biochem Pharmacol. 2019;165:49–65.
   PubMed Web of Science ®Google Scholar
• Musumeci G, Aiello FC, Szychlinska MA, et al. Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression. Int J Mol Sci. 2015;16(3):6093–6112.
   PubMed Web of Science ®Google Scholar
• Mobasheri A, Batt M. An update on the pathophysiology of osteoarthritis. Ann Phys Rehabil Med. 2016;59(5–6):333–339.
   PubMed Web of Science ®Google Scholar
• Hermann W, Lambova S, Muller-Ladner U. Current treatment options for osteoarthritis. Curr Rheumatol Rev. 2018;14(2):108–116.
   PubMed Web of Science ®Google Scholar
• Khan HI, Aitken D, Chou L, et al. A family history of knee joint replacement increases the progression of knee radiographic osteoarthritis and medial tibial cartilage volume loss over 10 years. Osteoarthritis Cartilage. 2015;23(2):203–209.
   PubMed Web of Science ®Google Scholar
• Liu J, Yang L, Dong Y, et al. Echinacoside, an inestimable natural product in treatment of neurological and other disorders. Molecules. 2018;23(5):1213.
   PubMed Web of Science ®Google Scholar
• Lei L, Yang F, Zhang T, et al. Preparative isolation and purification of acteoside and 2'-acetyl acteoside from cistanches salsa (C.A. Mey.) G. Beck by high-speed counter-current chromatography. J Chromatogr A. 2001;912(1):181–185.
   PubMed Web of Science ®Google Scholar
• Zhang Z-N, Hui Z, Chen C, et al. Neuroprotective effects and related mechanisms of echinacoside in MPTP-induced PD mice. Neuropsychiatr Dis Treat. 2021; 17:1779–1792.
   PubMed Web of Science ®Google Scholar
• Zhang D, Lu C, Yu Z, et al. Echinacoside alleviates UVB irradiation-mediated skin damage via inhibition of oxidative stress, DNA damage, and apoptosis. Oxid Med Cell Longev. 2017;2017:6851464.
   PubMed Web of Science ®Google Scholar
• Yang X, Li F, Yang Y, et al. Efficacy and safety of echinacoside in a rat osteopenia model. Evid Based Complement Alternat Med. 2013;2013:926928.
   PubMed Web of Science ®Google Scholar
• Li S, Jiang H, Gu X. Echinacoside suppresses dexamethasone-induced growth inhibition and apoptosis in osteoblastic MC3T3-E1 cells. Exp Ther Med. 2018;16(2):643–648.
   PubMed Web of Science ®Google Scholar
• Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev. 2006;38(4):769–789.
   PubMed Web of Science ®Google Scholar
• Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev. 2013;27(20):2179–2191.
   PubMed Web of Science ®Google Scholar
• Corona D, Ekser B, Gioco R, et al. Heme-oxygenase and kidney transplantation: a potential for target therapy? Biomolecules. 2020;10(6):840.
   PubMed Web of Science ®Google Scholar
• Wang Y, Yang C, Elsheikh NAH, et al. HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress. Aging. 2019;11(15):5535–5547.
   PubMedGoogle Scholar
• Chen Z, Zhong H, Wei J, et al. Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis. Arthritis Res Ther. 2019;21(1):300.
   PubMed Web of Science ®Google Scholar
• Wu Y, Lin Z, Yan Z, et al. Sinomenine contributes to the inhibition of the inflammatory response and the improvement of osteoarthritis in mouse-cartilage cells by acting on the Nrf2/HO-1 and NF-κB signaling pathways. Int Immunopharmacol. 2019;75:105715.
   PubMed Web of Science ®Google Scholar
• Fei J, Liang B, Jiang C, et al. Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model. Biomed Pharmacother. 2019;109:1586–1592.
   PubMed Web of Science ®Google Scholar
• Singh A, Venkannagari S, Oh KH, et al. Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-Deficient NSCLC tumors. ACS Chem Biol. 2016;11(11):3214–3225.
   PubMed Web of Science ®Google Scholar
• Qiu Y-B, Wan B-B, Liu G, et al. Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis. Respir Res. 2020;21(1):232.
   PubMed Web of Science ®Google Scholar
• Szychlinska M, Trovato F, Di Rosa M, et al. Co-expression and co-localization of cartilage glycoproteins CHI3L1 and lubricin in osteoarthritic cartilage: morphological, immunohistochemical and gene expression profiles. IJMS. 2016;17(3):359.
   Google Scholar
• Zhuang C, Ni S, Yang Z-C, et al. Oxidative stress induces chondrocyte apoptosis through caspase-dependent and caspase-independent mitochondrial pathways and the antioxidant mechanism of angelica sinensis polysaccharide. Oxid Med Cell Longev. 2020;2020:3240820.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Que K-T, Zhang Z, et al. Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway. Cancer Med. 2018;7(8):4012–4022.
   PubMed Web of Science ®Google Scholar
• Pritzker KPH, Gay S, Jimenez SA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. 2006;14(1):13–29.
   PubMed Web of Science ®Google Scholar
• Huang Y, Huang L, Li L, et al. MicroRNA-25-3p therapy for intervertebral disc degeneration by targeting the IL-1β/ZIP8/MTF1 signaling pathway with a novel thermo-responsive vector. Ann Transl Med. 2020;8(22):1500.
   PubMed Web of Science ®Google Scholar
• Ansari MY, Ahmad N, Haqqi TM. Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacother. 2020;129:110452.
   PubMed Web of Science ®Google Scholar
• Sun J, Wei X, Lu Y, et al. Glutaredoxin 1 (GRX1) inhibits oxidative stress and apoptosis of chondrocytes by regulating CREB/HO-1 in osteoarthritis. Mol Immunol. 2017;90:211–218.
   PubMed Web of Science ®Google Scholar
• Wu D, Jin S, Lin Z, et al. Sauchinone inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocytes to attenuate osteoarthritis via Nrf2/HO-1 and NF-κB pathways. Int Immunopharmacol. 2018;62:181–190.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Sun Y, Wang G, et al. Dendrobium officinale polysaccharides protect against MNNG-Induced PLGC in rats via activating the NRF2 and antioxidant enzymes HO-1 and NQO-1. Oxid Med Cell Longev. 2019;2019:9310245.
   PubMed Web of Science ®Google Scholar
• Li L, Wan G, Han B, et al. Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway. Biomed Pharmacother. 2018;104:622–628.
   PubMed Web of Science ®Google Scholar
• Lu CW, Hsieh HL, Lin TY, et al. Echinacoside, an active constituent of cistanche herba, exerts a neuroprotective effect in a kainic acid rat model by inhibiting inflammatory processes and activating the akt/GSK3β pathway. Biol Pharm Bull. 2018;41(11):1685–1693.
   PubMed Web of Science ®Google Scholar
• Zhou L, Yao M, Tian Z, et al. Echinacoside attenuates inflammatory response in a rat model of cervical spondylotic myelopathy via inhibition of excessive mitochondrial fission. Free Radic Biol Med. 2020;152:697–714.
   PubMed Web of Science ®Google Scholar
• Wang Y-H, Xuan Z-H, Tian S, et al. Echinacoside protects against 6-hydroxydopamine-induced mitochondrial dysfunction and inflammatory responses in PC12 cells via reducing ROS production. Evid Based Complement Alternat Med. 2015;2015:189239.
   PubMed Web of Science ®Google Scholar
• Hashimoto M, Nakasa T, Hikata T, et al. Molecular network of cartilage homeostasis and osteoarthritis. Med Res Rev. 2008;28(3):464–481.
   PubMed Web of Science ®Google Scholar
• Wang C, Gao Y, Zhang Z, et al. Ursolic acid protects chondrocytes, exhibits anti-inflammatory properties via regulation of the NF-κB/NLRP3 inflammasome pathway and ameliorates osteoarthritis. Biomed Pharmacother. 2020;130:110568.
   PubMed Web of Science ®Google Scholar
• Ding S-l, Pang Z-y, Chen X-M, et al. Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes. J Inflamm. 2020;17(1):13.
   Google Scholar
• Gao Y, Liu S, Huang J, et al. The ECM-cell interaction of cartilage extracellular matrix on chondrocytes. Biomed Res Int. 2014;2014:648459.
   PubMed Web of Science ®Google Scholar
• Okada A, Okada Y. Progress of research in osteoarthritis. Metalloproteinases in osteoarthritis. Clin Calcium. 2009;19(11):1593–1601.
   PubMedGoogle Scholar
• Zeng T, Gan J, Liu Y, et al. ADAMTS-5 decreases in aortas and plasma from aortic dissection patients and alleviates angiotensin II-induced smooth muscle-cell apoptosis. Front Cardiovasc Med. 2020;7:136.
   PubMed Web of Science ®Google Scholar
• Lan W, Xu M, Zhang X, et al. Biomimetic polyvinyl alcohol/type II collagen hydrogels for cartilage tissue engineering. J Biomater Sci Polym Ed. 2020;31(9):1179–1198.
   PubMed Web of Science ®Google Scholar
• Huang K, Wu LD. Aggrecanase and aggrecan degradation in osteoarthritis: a review. J Int Med Res. 2008;36(6):1149–1160.
   PubMed Web of Science ®Google Scholar
• Yang B, Kang X, Xing Y, et al. Effect of microRNA-145 on IL-1β-induced cartilage degradation in human chondrocytes. FEBS Lett. 2014;588(14):2344–2352.
   PubMed Web of Science ®Google Scholar
• Lepetsos P, Papavassiliou AG. ROS/oxidative stress signaling in osteoarthritis. Biochim Biophys Acta. 2016;1862(4):576–591.
   PubMed Web of Science ®Google Scholar
• Shin HJ, Park H, Shin N, et al. p47phox siRNA-loaded PLGA nanoparticles suppress ROS/oxidative stress-induced chondrocyte damage in osteoarthritis. Polymers (Basel). 2020;12(2):443.
   PubMed Web of Science ®Google Scholar
• Park C, Jeong JW, Lee DS, et al. Sargassum serratifolium extract attenuates interleukin-1β-Induced oxidative stress and inflammatory response in chondrocytes by suppressing the activation of NF-κB, p38 MAPK, and PI3K/akt. Int J Mol Sci. 2018;19(8):2308.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang T, Hamilton JL, et al. Wnt/β-catenin signaling in osteoarthritis and in other forms of arthritis. Curr Rheumatol Rep. 2017;19(9):53.
   PubMed Web of Science ®Google Scholar
• Ding Y, Wang L, Zhao Q, et al. MicroRNA‑93 inhibits chondrocyte apoptosis and inflammation in osteoarthritis by targeting the TLR4/NF‑κB signaling pathway. Int J Mol Med. 2019;43(2):779–790.
   PubMed Web of Science ®Google Scholar
• He Z, Li H, Han X, et al. Irisin inhibits osteocyte apoptosis by activating the erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice. Bone. 2020;141:115573.
   PubMed Web of Science ®Google Scholar
• Cai D, Feng W, Liu J, et al. 7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis. Exp Ther Med. 2019;18(3):1677–1684.
   PubMed Web of Science ®Google Scholar
• Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47:89–116.
   PubMed Web of Science ®Google Scholar
• Loboda A, Damulewicz M, Pyza E, et al. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci. 2016;73(17):3221–3247.
   PubMed Web of Science ®Google Scholar
• Pan X, Chen T, Zhang Z, et al. Activation of Nrf2/HO-1 signal with myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis. Int Immunopharmacol. 2019;75:105742.
   PubMed Web of Science ®Google Scholar
• Cai D, Wang J, Chen S, et al. Coniferaldehyde prevents articular cartilage destruction in a murine model via Nrf2/HO‑1 pathway. Mol Med Rep. 2021;23(3):224.
   PubMed Web of Science ®Google Scholar
• Zhou S, Shi J, Wen H, et al. A chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes. Food Funct. 2020;11(9):7935–7945.
   PubMed Web of Science ®Google Scholar
• Zheng H, Su Y, Sun Y, et al. Echinacoside alleviates hypobaric hypoxia-induced memory impairment in C57 mice. Phytother Res. 2019;33(4):1150–1160.
   PubMed Web of Science ®Google Scholar
• Lin Z, Teng C, Ni L, et al. Echinacoside upregulates Sirt1 to suppress endoplasmic reticulum stress and inhibit extracellular matrix degradation in vitro and ameliorates osteoarthritis in vivo. Oxid Med Cell Longev. 2021;2021:3137066.
   PubMed Web of Science ®Google Scholar
• Zhu W, Tang H, Cao L, et al. Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway. Chem Biol Drug Des. 2022;100(1):108–120.
   PubMed Web of Science ®Google Scholar
• Zhu W, Tang H, Li J, et al. Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Bioengineered. 2022;13(4):9233–9247.
   PubMed Web of Science ®Google Scholar