Triptolide attenuates LPS-induced activation of RAW 264.7 macrophages by inducing M1-to-M2 repolarization via the mTOR/STAT3 signaling

References

• Flynn S, Eisenstein S. Inflammatory bowel disease presentation and diagnosis. Surg Clin North Am. 2019;99(6):1051–1062.
   PubMed Web of Science ®Google Scholar
• Hodson R. Inflammatory bowel disease. Nature. 2016;540(7634):S97.
   PubMed Web of Science ®Google Scholar
• Wright EK, Ding NS, Niewiadomski O. Management of inflammatory bowel disease. Med J Aust. 2018;209(7):318–323.
   PubMed Web of Science ®Google Scholar
• Mass E, Lachmann N. From macrophage biology to macrophage-based cellular immunotherapies. Gene Ther. 2021;28(9):473–476.
   PubMed Web of Science ®Google Scholar
• Orecchioni M, Ghosheh Y, Pramod AB, et al. Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. alternatively activated macrophages. Front Immunol. 2019;10:1084.
   PubMed Web of Science ®Google Scholar
• Ye Y, Wang Y, Yang Y, et al. Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-kappaB pathway. Inflamm Res. 2020;69(4):375–383.
   PubMed Web of Science ®Google Scholar
• Song CY, Xu YG, Lu YQ. Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects. J Zhejiang Univ Sci B. 2020;21(4):280–290.
   PubMed Web of Science ®Google Scholar
• Zhang C, Sun PP, Guo HT, et al. Safety Profiles of Tripterygium wilfordii Hook F: a systematic review and meta-analysis. Front Pharmacol. 2016;7:402.
   PubMed Web of Science ®Google Scholar
• Zhou YY, Xia X, Peng WK, et al. The effectiveness and safety of Tripterygium wilfordii hook. F extracts in rheumatoid arthritis: a systematic review and meta-analysis. Front. Pharmacol. 2018;9:356.
   PubMed Web of Science ®Google Scholar
• Tong L, Zhao Q, Datan E, et al. Triptolide: reflections on two decades of research and prospects for the future. Nat Prod Rep. 2021;38(4):843–860.
   PubMed Web of Science ®Google Scholar
• Chen Q, Lei YQ, Liu JF, et al. Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest. Aging (Albany NY). 2021;13(2):3031–3044.
   PubMedGoogle Scholar
• Song C, Wang Y, Cui L, et al. Triptolide attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of NF-kappaB pathway. BMC Complement Altern Med. 2019;19(1):198.
   PubMed Web of Science ®Google Scholar
• Yao P, Li Y, Yang Y, et al. Triptolide improves cognitive dysfunction in rats with vascular dementia by activating the SIRT1/PGC-1alpha signaling pathway. Neurochem Res. 2019;44(8):1977–1985.
   PubMed Web of Science ®Google Scholar
• Zhao X, Tang X, Yan Q, et al. Triptolide ameliorates lupus via the induction of miR-125a-5p mediating treg upregulation. Int Immunopharmacol. 2019;71:14–21.
   PubMed Web of Science ®Google Scholar
• Tsuge K, Inazumi T, Shimamoto A, et al. Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases. Int Immunol. 2019;31(9):597–606.
   PubMed Web of Science ®Google Scholar
• Wang Y, Smith W, Hao D, et al. M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds. Int Immunopharmacol. 2019;70:459–466.
   PubMed Web of Science ®Google Scholar
• Shapouri-Moghaddam A, Mohammadian S, Vazini H, et al. Macrophage plasticity, polarization, and function in health and disease. J Cell Physiol. 2018;233(9):6425–6440.
   PubMed Web of Science ®Google Scholar
• Mills CD. Anatomy of a discovery: m1 and m2 macrophages. Front Immunol. 2015;6:212.
   PubMed Web of Science ®Google Scholar
• Atri C, Guerfali FZ, Laouini D. Role of human macrophage polarization in inflammation during infectious diseases. IJMS. 2018;19(6):1801.
   Google Scholar
• Ruytinx P, Proost P, Van Damme J, et al. Chemokine-Induced macrophage polarization in inflammatory conditions. Front Immunol. 2018;9:1930.
   PubMed Web of Science ®Google Scholar
• Yunna C, Mengru H, Lei W, et al. Macrophage M1/M2 polarization. Eur J Pharmacol. 2020;877:173090.
   PubMed Web of Science ®Google Scholar
• Funes SC, Rios M, Escobar-Vera J, et al. Implications of macrophage polarization in autoimmunity. Immunology. 2018;154(2):186–195.
   PubMed Web of Science ®Google Scholar
• Liu G, Guo Z, Zhang Q, et al. AHNAK2 promotes migration, invasion, and Epithelial-Mesenchymal transition in lung adenocarcinoma cells via the TGF-β/Smad3 pathway. Onco Targets Ther. 2020;13:12893–12903.
   PubMedGoogle Scholar
• Jiang X, Cao G, Gao G, et al. Triptolide decreases tumor-associated macrophages infiltration and M2 polarization to remodel Colon cancer immune microenvironment via inhibiting tumor-derived CXCL12. J Cell Physiol. 2021;236(1):193–204.
   PubMed Web of Science ®Google Scholar
• Lai K, Gong Y, Zhao W, et al. Triptolide attenuates laser-induced choroidal neovascularization via M2 macrophage in a mouse model. Biomed Pharmacother. 2020;129:110312.
   PubMed Web of Science ®Google Scholar
• Fu J, Zang Y, Zhou Y, et al. A novel triptolide derivative ZT01 exerts anti-inflammatory effects by targeting TAK1 to prevent macrophage polarization into pro-inflammatory phenotype. Biomed Pharmacother. 2020;126:110084.
   PubMed Web of Science ®Google Scholar
• Chen Y, Pan R, Zhang J, et al. Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF-kappaB signaling in pressure overload-induced rats. J Ethnopharmacol. 2021;272:113920.
   PubMed Web of Science ®Google Scholar
• Deng L, Zhou JF, Sellers RS, et al. A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis. Am J Pathol. 2010;176(2):952–967.
   PubMed Web of Science ®Google Scholar
• Lee SY, Lee SH, Yang EJ, et al. Metformin ameliorates inflammatory bowel disease by suppression of the STAT3 signaling pathway and regulation of the between Th17/treg balance. PLoS One. 2015;10(9):e0135858.
   PubMed Web of Science ®Google Scholar
• Li L, Wan G, Han B, et al. Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway. Biomed Pharmacother. 2018;104:622–628.
   PubMed Web of Science ®Google Scholar
• Zhu J, Luo L, Tian L YS, et al. Aryl hydrocarbon receptor promotes IL-10 expression in inflammatory macrophages through Src-STAT3 signaling pathway. Front Immunol. 2018;9:2033.
   PubMed Web of Science ®Google Scholar
• Luo S, Gan L, Liu S, et al. The synergistic reduning and cefmetazole sodium treatment of severe pneumonia is mediated by the AhR-Src-STAT3 pathway. J Thorac Dis. 2022;14(2):474–493.
   PubMed Web of Science ®Google Scholar
• Li S, Hua X, Zheng M, et al. PLXNA2 knockdown promotes M2 microglia polarization through mTOR/STAT3 signaling to improve functional recovery in rats after cerebral ischemia/reperfusion injury. Exp Neurol. 2021;346:113854.
   PubMed Web of Science ®Google Scholar