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Original Articles

Compound glycyrrhiza oral solution alleviates oxidative stress and inflammation by regulating SRC/MAPK pathway in chronic obstructive pulmonary disease

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Pages 1032-1043 | Received 24 Feb 2022, Accepted 09 Jul 2022, Published online: 11 Aug 2022

References

  • Duffy SP, Criner GJ. Chronic obstructive pulmonary disease: evaluation and management. Med Clin North Am. 2019;103(3):453–461.
  • Stolz D. Chronic obstructive pulmonary disease risk: does genetics hold the answer? Lancet Respir Med. 2020;8(7):653–654.
  • Varmaghani M, Dehghani M, Heidari E, et al. Global prevalence of chronic obstructive pulmonary disease: systematic review and Meta-analysis. East Mediterr Health J. 2019;25(1):47–57.
  • Gentry S, Gentry B. Chronic obstructive pulmonary disease: diagnosis and management. Am Fam Physician. 2017;95(7):433–441.
  • Marti JD, McWilliams D, Gimeno-Santos E. Physical therapy and rehabilitation in chronic obstructive pulmonary disease patients admitted to the intensive care unit. Semin Respir Crit Care Med. 2020;41(6):886–898.
  • Labaki WW, Rosenberg SR. Chronic obstructive pulmonary disease. Ann Intern Med. 2020;173(3):ITC17–ITC32.
  • Wiegman CH, Li F, Ryffel B, et al. Oxidative stress in Ozone-Induced chronic lung inflammation and emphysema: a facet of chronic obstructive pulmonary disease. Front Immunol. 2020;11:1957.
  • Yang R, Wang LQ, Yuan BC, et al. The pharmacological activities of licorice. Planta Med. 2015;81(18):1654–1669.
  • Upadhyay S, Mantha AK, Dhiman M. Glycyrrhiza glabra (licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 cardiomyocytes. J Ethnopharmacol. 2020;258:112690.
  • Kim SH, Hong JH, Yang WK, et al. Herbal combinational medication of glycyrrhiza glabra, agastache rugosa containing glycyrrhizic acid, tilianin inhibits neutrophilic lung inflammation by affecting CXCL2, interleukin-17/STAT3 signal pathways in a murine model of COPD. Nutrients. 2020;12(4):926.
  • Kao TC, Wu CH, Yen GC. Glycyrrhizic acid and 18beta-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation. Phytomedicine. 2013;20(3-4):295–302.
  • De Kock L, Freson K. The (patho)biology of SRC kinase in platelets and megakaryocytes. Medicina. 2020;56(12):633.
  • Su Q, Yu XJ, Yang Q, et al. Inhibition of maternal c-Src ameliorates the male offspring hypertension by suppressing inflammation and neurotransmitters in the paraventricular nucleus. Cardiovasc Toxicol. 2021;21(10):820–834.
  • Lakshmi SP, Reddy AT, Reddy RC. Emerging pharmaceutical therapies for COPD. Int J Chron Obstruct Pulmon Dis. 2017;12:2141–2156.
  • Xu X, Huang H, Yin X, et al. Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model. Biosci Rep. 2020;40:BSR20193667.
  • Karahan S, Erol K, Yuksel RC, et al. Antiphospholipid antibodies in COVID-19-associated pneumonia patients in intensive care unit. Mod Rheumatol. 2021;32(1):163–168.
  • Zhang M, Zhang Y, Roth M, et al. Sirtuin 3 inhibits airway epithelial mitochondrial oxidative stress in cigarette Smoke-Induced COPD. Oxid Med Cell Longev. 2020;2020:7582980.
  • Hussain T, Al-Attas OS, Alamery S, et al. The plant flavonoid, fisetin alleviates cigarette smoke-induced oxidative stress, and inflammation in wistar rat lungs. J Food Biochem. 2019;43(8):e12962.
  • Lareau SC, Fahy B, Meek P, et al. Chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med. 2019;199(1):P1–P2.
  • Riley CM, Sciurba FC. Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review. JAMA. 2019;321(8):786–797.
  • Vogelmeier CF, Roman-Rodriguez M, Singh D, et al. Goals of COPD treatment: focus on symptoms and exacerbations. Respir Med. 2020;166:105938.
  • Brightling C, Greening N. Airway inflammation in COPD: progress to precision medicine. Eur Respir J. 2019;54(2):1900651.
  • Polverino F, Sam A, Guerra S. COPD: to be or not to be, that is the question. Am J Med. 2019;132(11):1271–1278.
  • Jing L, Su S, Zhang D, et al. Srolo bzhtang, a traditional tibetan medicine formula, inhibits cigarette smoke induced airway inflammation and muc5ac hypersecretion via suppressing IL-13/STAT6 signaling pathway in rats. J Ethnopharmacol. 2019;235:424–434.
  • Liu Z, Wang P, Lu S, et al. Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury. Cell Calcium. 2020;88:102198.
  • Samareh Fekri M, Poursalehi HR, Sharififar F, et al. The effects of methanolic extract of glycyrrhiza glabra on the prevention and treatment of bleomycin-induced pulmonary fibrosis in rat: experimental study. Drug Chem Toxicol. 2021;44(4):365–371.
  • Guan Y, Li FF, Hong L, et al. Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. Fundam Clin Pharmacol. 2012;26(4):473–483.
  • Liu ST, Pham H, Pandol SJ, et al. Src as the link between inflammation and cancer. Front Physiol. 2013;4:416.
  • Ren Q, Guo F, Tao S, et al. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting src-mediated NF-kappaB p65 and MAPK signaling pathways in septic AKI mice. Biomed Pharmacother. 2020;122:109772.
  • Yang Q, Yu XJ, Su Q, et al. Blockade of c-Src within the paraventricular nucleus attenuates inflammatory cytokines and oxidative stress in the mechanism of the TLR4 signal pathway in Salt-Induced hypertension. Neurosci Bull. 2020;36(4):385–395.
  • Qi S, Feng Z, Li Q, et al. Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H2O2-induced apoptosis in PC12 cells. Drug Des Devel Ther. 2018;12:3973–3984.
  • Charron CE, Russell P, Ito K, et al. RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-alpha and -gamma selectivity, suppresses COPD inflammation. Eur Respir J. 2017;50(4):1700188.
  • Hsu YL, Wu LY, Hou MF, et al. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/rho signaling pathway. Mol Nutr Food Res. 2011;55(2):318–327.
  • Uto T, Ohta T, Yamashita A, et al. Liquiritin and liquiritigenin induce melanogenesis via enhancement of p38 and PKA signaling pathways. Medicines. 2019;6(2):68.
  • Grimes JM, Grimes KV. p38 MAPK inhibition: a promising therapeutic approach for COVID-19. J Mol Cell Cardiol. 2020;144:63–65.

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