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Research Articles

Scutellarin alleviates lipopolysaccharide-provoked septic nephrotoxicity via attenuation of inflammatory and oxidative events and mitochondrial dysfunction

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Pages 295-303 | Received 13 May 2022, Accepted 22 Oct 2022, Published online: 04 Nov 2022

References

  • Li Z, Liu Z, Luo M, et al. The pathological role of damaged organelles in renal tubular epithelial cells in the progression of acute kidney injury. Cell Death Discov. 2022;8(1):239.
  • Gomez H, Ince C, De Backer D, et al. A unified theory of sepsis-induced acute kidney injury: inflammation, microcirculatory dysfunction, bioenergetics and the tubular cell adaptation to injury. Shock. 2014;41(1):3–11.
  • Kalantari K, Rosner MH. Recent advances in the pharmacological management of sepsis-associated acute kidney injury. Expert Rev Clin Pharmacol. 2021;14(11):1401–1411.
  • Yang Y, Song M, Liu Y, et al. Renoprotective approaches and strategies in acute kidney injury. Pharmacol Ther. 2016;163:58–73.
  • Fry DE. Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues. Am Surg. 2012;78(1):1–8.
  • Doi K, Leelahavanichkul A, Yuen PST, et al. Star RA animal models of sepsis and sepsis-induced kidney injury. J Clin Invest. 2009;119(10):2868–2878.
  • Rujia ZGQST experimental study of effect of combining breviscapine with ischemic/preconditioning on the expression of myocardial protein tumor necrosis factor-α, nuclear factor-kappa B during myocardial ischemia/reperfusion in rabbits. J Clin Cardiol. 2010;8:024.
  • Zhou H, Chen X, Chen L, et al. Anti-fibrosis effect of scutellarin via inhibition of endothelial–mesenchymal transition on Isoprenaline-Induced myocardial fibrosis in rats. Molecules. 2014;19(10):15611–15623.
  • Wang Z, Yu J, Wu J, et al. Scutellarin protects cardiomyocyte ischemia–reperfusion injury by reducing apoptosis and oxidative stress. Life Sci. 2016;157:200–207.
  • Liu H, Yang X, Tang R, et al. Effect of scutellarin on nitric oxide production in early stages of neuron damage induced by hydrogen peroxide. Pharmacol Res. 2005;51(3):205–210.
  • Liu Y, Wang J, Zhang X, et al. Scutellarin exerts hypoglycemic and renal protective effects in db/db mice via the Nrf2/HO-1 signaling pathway. Oxid Med Cell Longev. 2019;2019:1354345.
  • Sun CY, Nie J, Zheng ZL, et al. Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: impact on inflammation, apoptosis, and autophagy. Biomed Pharmacother. 2019;112:108647.
  • Li G, Guan C, Xu L, et al. Scutellarin ameliorates renal injury via increasing CCN1 expression and suppressing NLRP3 inflammasome activation in hyperuricemic mice. Front Pharmacol. 2020;11:584942.
  • Bagshaw SM, Lapinsky S, Dial S, Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group, et al. Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med. 2009;35(5):871–881.
  • Chen Y, Du Y, Li Y, et al. Panaxadiol saponin and dexamethasone improve renal function in Lipopolysaccharide-Induced mouse model of acute kidney injury. PLoS One. 2015;10(7):e0134653.
  • Khajevand-Khazaei MR, Mohseni-Moghaddam P, Hosseini M, et al. A quercetin glycoside, alleviates acute endotoxemic kidney injury in C57BL/6 mice via suppression of inflammation and up-regulation of antioxidants and SIRT1. Eur J Pharmacol. 2018;833:307–313.
  • Sedaghat R, Roghani M, Khalili M. Neuroprotective effect of thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model. Iran J Pharm Res. 2014;13(1):227–234.
  • Samie A, Sedaghat R, Baluchnejadmojarad T, et al. A citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis. Life Sci. 2018;210:132–139.
  • Claiborne A. Catalase activity. In: Greenwald RA, editors. CRC handbook of methods for oxygen radical research. Boca Raton, FL: CRC. 1985. pp. 283–284.
  • Ding J, Yu HL, Ma WW, et al. Soy isoflavone attenuates brain mitochondrial oxidative stress induced by beta-amyloid peptides 1–42 injection in lateral cerebral ventricle. J Neurosci Res. 2013;91(4):562–567.
  • Pulli B, Ali M, Forghani R, et al. Measuring myeloperoxidase activity in biological samples. PLoS One. 2013;8(7):e67976.
  • Tilyek A, Chai C, Hou X, et al. The protective effects of ribes diacanthum pall on cisplatin-induced nephrotoxicity in mice. J Ethnopharmacol. 2016;178:297–306.
  • Zhang H, Zhang W, Jiao F, et al. The nephroprotective effect of MS-275 on lipopolysaccharide (LPS)-induced acute kidney injury by inhibiting reactive oxygen species (ROS)-oxidative stress and endoplasmic reticulum stress. Med Sci Monit. 2018;24:2620–2630.
  • Khajevand-Khazaei MR, Azimi S, Sedighnejad L, et al. S-allyl cysteine protects against lipopolysaccharide-induced acute kidney injury in the C57BL/6 mouse strain: Involvement of oxidative stress and inflammation. Int Immunopharmacol. 2019;69:19–26.
  • Li S, Lei Y, Lei J, et al. All‑trans retinoic acid promotes macrophage phagocytosis and decreases inflammation via inhibiting CD14/TLR4 in acute lung injury. Mol Med Rep. 2021;24(6):868.
  • Lee DH, Park MH, Hwang CJ, et al. CCR5 deficiency increased susceptibility to lipopolysaccharide-induced acute renal injury. Arch Toxicol. 2016;90(5):1151–1162.
  • Singh AP, Junemann A, Muthuraman A, et al. Animal models of acute renal failure. Pharmacol Rep. 2012;64(1):31–44.
  • Liang NN, Zhao Y, Guo YY, et al. Mitochondria-derived reactive oxygen species are involved in renal cell ferroptosis during lipopolysaccharide-induced acute kidney injury. Int Immunopharmacol. 2022;107:108687.
  • Huang J, Wei S, Peng Z, et al. Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice. J Pharm Pharmacol. 2022;74(2):259–267.
  • Zhu K, Wang X, Weng Y, et al. Sulfated galactofucan from sargassum thunbergii attenuates atherosclerosis by suppressing inflammation via the TLR4/MyD88/NF-κB signaling pathway. Cardiovasc Drugs Ther. 2022. DOI:10.1007/s10557-022-07383-3
  • Kalakeche R, Hato T, Rhodes G, et al. Endotoxin uptake by S1 proximal tubular segment causes oxidative stress in the downstream S2 segment. J Am Soc Nephrol. 2011;22(8):1505–1516.
  • Zhang L, Sun S, Li W, et al. Effect of scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation. Mol Med Rep. 2017;16(4):5555–5560.
  • Dai J, Li C, Zhao L, et al. Scutellarin protects the kidney from ischemia/reperfusion injury by targeting Nrf2. Nephrology (Carlton). 2022;27(8):690–700.
  • Yang H, Li W, Wang L, et al. The protective effects of sika deer antler protein on cisplatin-induced nephrotoxicity. Cell Physiol Biochem. 2017;43(1):395–404.
  • Sun H, Yang H, Ruan H, et al. The protective effect of sika deer antler protein on gentamicin-induced nephrotoxicity in vitro and in vivo. Cell Physiol Biochem. 2018;50(3):841–850.
  • Yang H, Li W, Wang L, et al. The proteins from sika deer antler as potential modulators on cisplatin-induced cytotoxicity in human embryonic kidney 293 cells. Nat Prod Res. 2018;32(16):1982–1986.
  • Chen Y, Jin S, Teng X, et al. Hydrogen sulfide attenuates LPS-Induced acute kidney injury by inhibiting inflammation and oxidative stress. Oxid Med Cell Longev. 2018;2018:6717212.
  • Salari S, Ghorbanpour A, Marefati N, et al. Therapeutic effect of lycopene in lipopolysaccharide nephrotoxicity through alleviation of mitochondrial dysfunction, inflammation, and oxidative stress. Mol Biol Rep. 2022;49(9):8429–8438.
  • Yang Q, Wang Y, Chen H, et al. Protective activities of scutellarin against alcohol-induced acute kidney injury. Chem Biodivers. 2022:e202200254.
  • Chen Q, Gu Y, Tan C, et al. Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer. Front Nutr. 2022;9:963662.
  • Suliman HB, Piantadosi CA. Mitochondrial quality control as a therapeutic target. Pharmacol Rev. 2016;68(1):20–48.
  • Yang M, He Y, Deng S, et al. Mitochondrial quality control: a pathophysiological mechanism and therapeutic target for stroke. Front Mol Neurosci. 2021;14:786099.
  • Li J, Zhang Z, Wang L, et al. Maresin 1 attenuates lipopolysaccharide-induced acute kidney injury via inhibiting NOX4/ROS/NF-κB pathway. Front Pharmacol. 2021;12:782660.
  • Dizaji R, Sharafi A, Pourahmad J, et al. The effects of Hemiscorpius lepturus induced-acute kidney injury on PGC-1α gene expression: from induction to suppression in mice. Toxicon. 2020;174:57–63.
  • Nagata S, Kato A, Isobe S, et al. Regular exercise and branched-chain amino acids prevent ischemic acute kidney injury-related muscle wasting in mice. Physiol Rep. 2020;8(16):e14557.
  • Zhou L, Han Y, Yang Q, et al. Scutellarin attenuates doxorubicin-induced oxidative stress, DNA damage, mitochondrial dysfunction, apoptosis and autophagy in H9c2 cells, cardiac fibroblasts and HUVECs. Toxicol in Vitro. 2022;82:105366.
  • Fan D, Wang D, Zhu L. Protective role of scutellarin on LPS induced – acute lung injury and regulation of apoptosis, oxidative stress and reduction of mitochondrial dysfunction. Saudi J Biol Sci. 2022;29(1):371–378.
  • Xi J, Rong Y, Zhao Z, et al. Scutellarin ameliorates high glucose-induced vascular endothelial cells injury by activating PINK1/parkin-mediated mitophagy. J Ethnopharmacol. 2021;271:113855.
  • Li X, Wang L, Li Y, et al. Acute and subacute toxicological evaluation of scutellarin in rodents. Regul Toxicol Pharmacol. 2011;60(1):106–111.

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