199
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Extracellular vesicle-derived LINC00511 promotes glycolysis and mitochondrial oxidative phosphorylation of pancreatic cancer through macrophage polarization by microRNA-193a-3p-dependent regulation of plasminogen activator urokinase

, , , , , & show all
Pages 355-369 | Received 25 Aug 2022, Accepted 31 Oct 2022, Published online: 08 Dec 2022

References

  • Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
  • Goess R, Friess H. A look at the progress of treating pancreatic cancer over the past 20 years. Expert Rev Anticancer Ther. 2018;18(3):295–304.
  • McGuigan A, Kelly P, Turkington RC, et al. Pancreatic cancer: a review of clinical diagnosis, epidemiology, treatment and outcomes. World J Gastroenterol. 2018;24(43):4846–4861.
  • Stevic I, Buescher G, Ricklefs FL. Monitoring therapy efficiency in cancer through extracellular vesicles. Cells. 2020;9(1):130.
  • Ruhen O, Meehan K. Tumor-Derived extracellular vesicles as a novel source of protein biomarkers for cancer diagnosis and monitoring. Proteomics. 2019;19(1-2):e1800155.
  • Marzan AL, Stewart SE. Elucidating the role of extracellular vesicles in pancreatic cancer. Cancers (Basel). 2021;13(22):5669.
  • Takahashi K, Taniue K, Ono Y, et al. Long Non-Coding RNAs in Epithelial-Mesenchymal transition of pancreatic cancer. Front Mol Biosci. 2021;8:717890.
  • Robless EE, Howard JA, Casari I, et al. Exosomal long non-coding RNAs in the diagnosis and oncogenesis of pancreatic cancer. Cancer Lett. 2021;501:55–65.
  • Ma P, Pan Y, Li W, et al. Extracellular vesicles-mediated noncoding RNAs transfer in cancer. J Hematol Oncol. 2017;10(1):57.
  • Kołat D, Hammouz R, Bednarek AK, et al. Exosomes as carriers transporting long noncoding RNAs: molecular characteristics and their function in cancer (review). Mol Med Rep. 2019;20(2):851–862.
  • Xiang J, Guan Y, Bhandari A, et al. LINC00511 influences cellular proliferation through cyclin-dependent kinases in papillary thyroid carcinoma. J Cancer. 2020;11(2):450–459.
  • Sun S, Xia C, Xu Y. HIF-1alpha induced lncRNA LINC00511 accelerates the colorectal cancer proliferation through positive feedback loop. Biomed Pharmacother. 2020;125:110014.
  • Baig MS, Roy A, Rajpoot S, et al. Tumor-derived exosomes in the regulation of macrophage polarization. Inflamm Res. 2020;69(5):435–451.
  • Attri KS, Mehla K, Singh PK. Evaluation of macrophage polarization in pancreatic cancer microenvironment under hypoxia. Methods Mol Biol. 2018;1742:265–276.
  • Jiang Z, Liu Z, Li M, et al. Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment. EBioMedicine. 2019;42:431–442.
  • Gill KS, Fernandes P, O'Donovan TR, et al. Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response. Biochim Biophys Acta. 2016;1866(1):87–105.
  • Chen F, Chen J, Yang L, et al. Extracellular vesicle-packaged HIF-1alpha-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nat Cell Biol. 2019;21(4):498–510.
  • Schultz CW, McCarthy GA, Nerwal T, et al. The FDA-Approved anthelmintic pyrvinium pamoate inhibits pancreatic cancer cells in Nutrient-Depleted conditions by targeting the mitochondria. Mol Cancer Ther. 2021;20(11):2166–2176.
  • Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478):eaau6977.
  • Buchakjian MR, Kornbluth S. The engine driving the ship: metabolic steering of cell proliferation and death. Nat Rev Mol Cell Biol. 2010;11(10):715–727.
  • Xu D, Wang Y, Zhou K, et al. Identification of an extracellular vesicle-related gene signature in the prediction of pancreatic cancer clinical prognosis. Biosci Rep. 2020;40(12):BSR20201087.
  • Jia E, Ren N, Shi X, et al. Extracellular vesicle biomarkers for pancreatic cancer diagnosis: a systematic review and meta-analysis. BMC Cancer. 2022;22(1):573.
  • Huang X, Zhi X, Gao Y, et al. LncRNAs in pancreatic cancer. Oncotarget. 2016;7(35):57379–57390.
  • Ji D, Hou L, Xie C, et al. Deoxyelephantopin suppresses pancreatic cancer progression in vitro and in vivo by targeting linc00511/miR-370-5p/p21 promoter axis. J Oncol. 2022;2022:3855462.
  • Li J, Li Y, Meng F, et al. Knockdown of long non-coding RNA linc00511 suppresses proliferation and promotes apoptosis of bladder cancer cells via suppressing wnt/beta-catenin signaling pathway. Biosci Rep. 2018;38(4):BSR20171701.
  • Kim KM, Abdelmohsen K, Mustapic M, et al. RNA in extracellular vesicles. Wiley Interdiscip Rev RNA. 2017;8(4).
  • Gregory CD, Paterson M. An apoptosis-driven ‘onco-regenerative niche’: roles of tumour-associated macrophages and extracellular vesicles. Philos Trans R Soc Lond B Biol Sci. 2018;373(1737):20170003.
  • Tian X, Wu Y, Yang Y, et al. Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating wnt/beta-catenin signaling. Mol Oncol. 2020;14(2):462–483.
  • Wang X, Luo G, Zhang K, et al. Hypoxic Tumor-Derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kgamma to promote pancreatic cancer metastasis. Cancer Res. 2018;78(16):4586–4598.
  • Chen ZM, Yu Q, Chen G, et al. MiR-193a-3p inhibits pancreatic ductal adenocarcinoma cell proliferation by targeting CCND1. Cancer Manag Res. 2019;11:4825–4837.
  • Bournet B, Pointreau A, Souque A, et al. Gene expression signature of advanced pancreatic ductal adenocarcinoma using low density array on endoscopic ultrasound-guided fine needle aspiration samples. Pancreatology. 2012;12(1):27–34.
  • Lin M, Zhang Z, Gao M, et al. MicroRNA-193a-3p suppresses the colorectal cancer cell proliferation and progression through downregulating the PLAU expression. Cancer Manag Res. 2019;11:5353–5363.
  • Zhang H, Zhao B, Wang X, et al. LINC00511 knockdown enhances paclitaxel cytotoxicity in breast cancer via regulating miR-29c/CDK6 axis. Life Sci. 2019;228:135–144.
  • Lu G, Li Y, Ma Y, et al. Long noncoding RNA LINC00511 contributes to breast cancer tumourigenesis and stemness by inducing the miR-185-3p/E2F1/nanog axis. J Exp Clin Cancer Res. 2018;37(1):289.
  • Hosein AN, Beg MS. Pancreatic cancer metabolism: molecular mechanisms and clinical applications. Curr Oncol Rep. 2018;20(7):56.
  • Guillaumond F, Iovanna JL, Vasseur S. Pancreatic tumor cell metabolism: focus on glycolysis and its connected metabolic pathways. Arch Biochem Biophys. 2014;545:69–73.
  • Dasgupta A, Shukla SK, Gunda V, et al. Evaluating the metabolic alterations in pancreatic cancer. Methods Mol Biol. 2019;1882:221–228.
  • Yang J, Ren B, Yang G, et al. The enhancement of glycolysis regulates pancreatic cancer metastasis. Cell Mol Life Sci. 2020;77(2):305–321.
  • M de-Brito N, Duncan-Moretti J, C da-Costa H, et al. Aerobic glycolysis is a metabolic requirement to maintain the M2-like polarization of tumor-associated macrophages. Biochim Biophys Acta Mol Cell Res. 2020;1867(2):118604.
  • Zhao H, Yang L, Baddour J, et al. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife. 2016;5:e10250.
  • Fonseca P, Vardaki I, Occhionero A, et al. Metabolic and signaling functions of cancer Cell-Derived extracellular vesicles. Int Rev Cell Mol Biol. 2016;326:175–199.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.