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Research Articles

Morita-Baylis-Hillman adduct 2-(3-hydroxy-2-oxoindolin-3-yl)acrylonitrile (ISACN) modulates the inflammatory process during LPS-induced acute lung injury

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Pages 485-496 | Received 06 Feb 2022, Accepted 31 Jan 2023, Published online: 09 Feb 2023

References

  • Medzhitov R. Inflammation 2010: new adventures of an old flame. Cell [Internet]. 2010;140(6):771–776.
  • Fullerton JN, Gilroy DW. Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov. 2016;15(8):551–567.
  • Kameritsch P, Renkawitz J. Principles of leukocyte migration strategies. Trends Cell Biol. 2020;30(10):818–832.
  • Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008;454(7203):428–435.
  • Matthay MA, Zemans RL, Zimmerman GA, et al. Acute respiratory distress syndrome. Nat Rev Dis Prim. 2018;5:18.
  • Goodman RB, Pugin J, Lee JS, et al. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 2003;14(6):523–535.
  • Butt Y, Kurdowska A, Allen TC. Acute lung injury: a clinical and molecular review. Arch Pathol Lab Med. 2016;140(4):345–350.
  • de França JS, de Sales-Neto JM, Carvalho DCM, et al. Morita-Baylis-Hillman adduct 2-(3-Hydroxy-2-oxoindolin-3-yl)acrylonitrile (ISACN) modulates inflammatory process in vitro and in vivo. Inflammation. 2021;44(3):899–907.
  • Lima CG, Faheina-Martins GV, Bomfim CCB, et al. Synthesis, cytotoxic activity on leukemia cell lines and quantitative Structure-Activity relationships (QSAR) studies of Morita-Baylis-Hillman adducts. Med Chem. 2016;12(7):602–612.
  • Mokra D, Mikolka P, Kosutova P, et al. Corticosteroids in acute lung injury: the dilemma continues. IJMS. 2019;20(19):4765.
  • do Nascimento Xavier BM, Ferreira LAMP, Ferreira LKDP, et al. MHTP, a synthetic tetratetrahydroisoquinoline alkaloid, attenuates lipopolysaccharide-induced acute lung injury via p38MAPK/p65NF-κB signaling pathway-TLR4 dependent. Inflamm Res. 2019;68(12):1061–1070.
  • Wei F, Wen S, Wu H, et al. Partial liquid ventilation–induced mild hypothermia improves the lung function and alleviates the inflammatory response during acute respiratory distress syndrome in canines. Biomed Pharmacother. 2019;118:109344.
  • Moraes TJ, Zurawska JH, Downey GP. Neutrophil granule contents in the pathogenesis of lung injury. Curr Opin Hematol. 2006;13(1):21–27.
  • Kandasamy R, Park SJ, Boyapalle S, et al. Isatin down-regulates expression of atrial natriuretic peptide receptor a and inhibits airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2010;10(2):218–225.
  • Park WY, Goodman RB, Steinberg KP, et al. Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2001;164(10 Pt 1):1896–1903.
  • Faheina-Martins GV, Leite JA, Dantas BB, et al. Morita-Baylis-Hillman adducts display anti-Inflammatory effects by modulating inflammatory mediator expression in RAW264.7 cells. Mediators Inflamm [Internet]. 2017;2017:1–9.
  • Ware LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006;27(4):337–349.
  • Matute-Bello G, Frevert CW, Martin TR. Animal models of acute lung injury. Am J Physiol. 2008; 295(3):L379–399.
  • Lee C-H, Choi EY. Macrophages and inflammation. J Rheum Dis. 2018;25(1):11.
  • Biswas SK, Chittezhath M, Shalova IN, et al. Macrophage polarization and plasticity in health and disease. Immunol Res. 2012;53(1-3):11–24.
  • He W, Kapate N, Shields CW, et al. Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases. Adv Drug Deliv Rev. 2020;165-166:15–40.
  • Lacerda LM. Avaliação Da Atividade Anti-Inflamatória E Antitumoral De Novos Adutos Da Reação De Morita- Baylis-Hillman2017.
  • Matheus ME, Violante F de A, Garden SJ, et al. Isatins inhibit cyclooxygenase-2 and inducible nitric oxide synthase in a mouse macrophage cell line. Eur J Pharmacol. 2007;556(1-3):200–206.
  • Rossol M, Heine H, Meusch U, et al. LPS-induced cytokine production in human monocytes and macrophages. Crit Rev Immunol. 2011;31(5):379–446.
  • Lu YC, Yeh WC, Ohashi PS. LPS/TLR4 signal transduction pathway. Cytokine. 2008;42(2):145–151.
  • Ospelt C, Gay S. TLRs and chronic inflammation. Int J Biochem Cell Biol. 2010;42(4):495–505.
  • Kiechl S, Lorenz E, Reindl M, et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med. 2002;347(3):185–192.
  • Edfeldt K, Bennet AM, Eriksson P, et al. Association of hypo-responsive toll-like receptor 4 variants with risk of myocardial infarction. Eur Heart J. 2004;25(16):1447–1453.
  • Fukata M, Shang L, Santaolalla R, et al. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm Bowel Dis. 2011;17(7):1464–1473.
  • Gao W, Xiong Y, Li Q, et al. Inhibition of toll-like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics. Front Physiol. 2017;8:508.
  • Marzio R, Jirillo E, Ransijn A, et al. Expression and function of the early activation antigen CD69 in murine macrophages. J Leukoc Biol. 1997;62(3):349–355.
  • Cibrián D, Sánchez-Madrid F. CD69: from activation marker to metabolic gatekeeper. Eur J Immunol. 2017;47(6):946–953.
  • Murata K, Inami M, Hasegawa A, et al. CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int Immunol. 2003;15(8):987–992.
  • Yamauchi K, Kasuya Y, Kuroda F, et al. Attenuation of lung inflammation and fibrosis in CD69-deficient mice after intratracheal bleomycin. Respir Res. 2011;12(1):131–110.
  • Ishizaki S, Kasuya Y, Kuroda F, et al. Role of CD69 in acute lung injury. Life Sci. 2012;90(17-18):657–665.
  • Wang HY, Dai Y, Wang JL, et al. Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma. J Zhejiang Univ Sci B. 2015;16(7):622–631.
  • Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 1995;270(28):16483–16486.
  • Castellanos MC, Muñoz C, Montoya MC, et al. Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1. J Immunol. 1997;159(11):5463–5473.
  • Pearson G, Robinson F, Gibson TB, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001;22(2):153–183.
  • Gao W, Zhang L, Wang X, et al. The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice. Biochem Cell Biol. 2018;96(5):636–645.
  • Zeeshan S, Naveed M, Khan A, et al. N-Pyrazoloyl and N-thiopheneacetyl hydrazone of isatin exhibited potent anti-inflammatory and anti-nociceptive properties through suppression of NF-κB, MAPK and oxidative stress signaling in animal models of inflammation. Inflamm Res. 2019;68(7):613–632.

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