22
Views
6
CrossRef citations to date
0
Altmetric
Research Article

Anti-TNF Antibody Treatment Has No Positive Effect on Survival in a Model of Pneumococcal Sepsis in Pigs

, , , , , , & show all
Pages 291-297 | Published online: 09 Jul 2009

  • Bone RC. The pathogenesis of sepsis. Ann Intern Med. 1991;115:457-69.
  • Chalfin DB, Fein AM. The economic impact and costeffectiveness of monoclonal antibody therapy for sepsis. Clin Infect Dis. 1993;17(suppl 2):S520-S524.
  • Farthmann EH, Schöffel U. Pathophysiologie der Sepsis. Chir Gastroenterol. 1994;10:8-13.
  • Staubach KH. Neue therapeutische Aspekte in der Sepsis. Chir Gastroenterol. 10:58-63.
  • Cannon JG, Tompkins RG, Gelfand JA, Michie HR, Stanford GG, van der Meer JW, Endres S, Lonnemann G, Corsetti J, Chernow B, et al. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis. 1990;161:79-84.
  • Hinshaw LB, Emerson TE Jr, Chang AC, Duerr M, Peer G, Fournel M. Study of septic shock in the non-human primate: relationship of pathophysiological response to therapy with anti-TNF antibody. Circ Shock. 1994;44:221229.
  • lnoue Y, Bode BP, Souba WW. Antibody to tumor necrosis factor attenuates endotoxin-stimulated amino acid transport in rat liver. Surgery. 1994;116:356-365; discussion 365-366.
  • Thiemermann C, Wu CC, Szabo C, Perretti M, Vane JR. Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. Br J Pharmacol. 1993;110:177-182.
  • Chmel H. Overview of the management of sepsis. Clin InfectDis. 1993;17:S525-S526.
  • Friedland IR. Comparison of the response to antimicrobial therapy of penicillin-resistant and penicillin-susceptible pneumococcal disease [see comments]. Pediatr Infect Dis J. 1995;14:885-890.
  • Chesney PJ, Wilimas JA, Presbury G, Abbasi S, Leggiadro W, Davis Y, Day SW, Schutze GE, Wang WC. Penicillin-and cephalosporin-resistant strains of Streptococcus pneumoniae causing sepsis and meningitis in children with sickle cell disease [see comments]. J Pediatr. 1995;127:526532.
  • Cundell DR, Gerard NP, Gerard C, Idanpaan-Heikkila I, Tuomanen El. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature. 1995;377:435-438.
  • Devaux AM, Barre V, Blanc T, Nouvellon M, Ensel P. [Neonatal septicemia due to Pneumococcus resistant to beta-lactam antibiotics]. Arch Fr Pediatr. 1993;50:131133.
  • Moreno F, Crisp C, Jorgensen JH, Patterson JE. The clinical and molecular epidemiology of bacteremias at a university hospital caused by pneumococci not susceptible to penicillin. J Infect Dis. 1995;172:427-432.
  • Vukelic D, Bozinovic D, Knezovic I, Sterk-Kuzmanovic N, Novak M. A case of fatal sepsis in a child due to highly resistant Streptococcus pneumoniae. Lijec Vjesn. 1995;117(suppl 2):90-91
  • Izbicki JR, Raedler C, Ruckdeschel G, Lutticken R, Wilker DK, Siebeck M, Dornschneider G, Sklarek J, Schweiberer L, Ziegler-Heitbrock HW. Establishment of a pneumococcal septicemia model in the miniature swine. Zentralbl Veterinarmed [A]. 1992;39:152-159.
  • Ziegler-Heitbrock HW, Passlick B, Kafferlein E, Coulie PG, Izbicki JR. Protection against lethal pneumococcal septicemia in pigs is associated with decreased levels of interleukin-6 in blood. Infect Immun. 1992;60:16221624.
  • Fleiss JL. Statistical Methods for Rates and Proportions. New York: John Wiley and Sons, 1981;81.
  • Burd RS, Battafarano RJ, Cody CS, Farber MS, Ratz CA, Dunn DL. Anti-endotoxin monoclonal antibodies inhibit secretion of tumor necrosis factor-alpha by two distinct mechanisms. Ann Surg. 1993;218:250-259; discussion 259-261.
  • Gerdes-Fenge HF, Lohde H, Ziegler D, Hund M, Wagner J, Fangmann W, Loehr A. Erregerspektrum der Sepsis. ChemotherJ. 1994;3:131-143.
  • Pennington JE. Therapy with antibody to tumor necrosis factor in sepsis. Clin Infect Dis. 1993;17(suppl 2):S515S519.
  • Izbicki JR, Raedler C, Anke A, Brunner P, Siebeck M, Leinisch E, Luttiken R, Ruckdeschel G, Wilker DK, Schweiberer L, et al. Beneficial effect of liposomeencapsulated muramyl tripeptide in experimental septicemia in a porcine model. Infect Immun. 1991;59:126-130.
  • Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science. 1985;229:869871.
  • Jesmok G, Lindsey C, Duerr M, Fournel M, Emerson T Jr. Efficacy of monoclonal antibody against human recombinant tumor necrosis factor in E. coli-challenged swine. Am J Pathol. 1992;141:1197-1207.
  • Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature. 1987;330:662-664.
  • Hinshaw LB, Emerson TE Jr, Taylor FB Jr, Chang AC, Duerr M, Peer GT, Flournoy DJ, White GL, Kosanke SD, Murray CK, et al. Lethal Staphylococcus aureus-induced shock in primates: prevention of death with anti-TNF antibody. J Trauma. 1992;33:568-573.
  • Stevens DL, Bryant AE, Hackett SP, Chang A, Peer G, Kosanke S, Emerson T, Hinshaw L. Group A streptococcal bacteremia: The role of tumor necrosis factor in shock and organ failure. J Infect Dis. 1996;173:619-626.
  • Wayte J, Suva AT, Krausz T, Cohen J. Observations on the role of tumor necrosis factor-alpha in a murine model of shock due to Streptococcus pyogenes. Crit Care Med. 1993;21:1207-1212.
  • Walsh CJ, Leeper-Woodford SK, Carey PD, Cook DJ, Bechard DE, Fowler AA, Sugerman HJ. CD18 adhesion receptors, tumor necrosis factor, and neutropenia during septic lung injury. J Surg Res. 1991;50:323-329.
  • Horgan MJ, Palace GP, Everitt JE, Malik AB. TNF-alpha release in endotoxemia contributes to neutrophil-dependent pulmonary edema. Am J Physiol. 1993;264:H1161-H1165.
  • Hadjiminas DJ, McMasters KM, Peyton JC, Cook MD, Cheadle WG. Passive immunization against tumor necrosis factor and interleukin-1 fails to reduce lung neutrophil sequestration in chronic sepsis. Shock. 1994;2:376380.
  • Cirelli RA, Carey LA, Fisher JK, Rosolia DL, Elsasser TH, Caperna TJ, Gee MH, Albertine KH. Endotoxin infusion in anesthetized sheep is associated with intrapulmonary sequestration of leukocytes that immunohistochemically express tumor necrosis factor-alpha. J Leukocyte Biol. 1995;57:820-826.
  • Sorkine P, Setton A, Halpern P, Miller A, Rudick V, Marmor S, Klausner JM, Goldman G. Soluble tumor necrosis factor receptors reduce bowel ischemia-induced lung permeability and neutrophil sequestration. Crit Care Med. 1995;23:1377-1381.
  • Neumann B, Zantl N, Veihelmann A, Emmanuilidis K, Pfeffer K, Heidecke CD, Holzmann B. Mechanisms of acute inflammatory lung injury induced by abdominal sepsis, lnt lmmunol. 1999;11:217-227.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.