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ORIGINAL RESEARCH

Cyclosporin A Has a Protective Effect with Induced Upregulation of Hsp70 and nNOS on Severe Spinal Cord Ischemic Injury in Rabbits

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Pages 113-120 | Published online: 09 Jul 2009

REFERENCES

  • Mauney M C, Blackbourne L H, Langenburg S E, Buchanan S A, Kron I L, Tribble C G. Prevention of spinal cord injury after repair of the thoracic or thoracoabdominal aorta. Ann Thorac Surg 1995; 59: 245–252
  • Coselli J S, Conflin L D, LeMaire S A. Thoracoabdominal aortic aneurysm repair: Review and update of current strategies. Ann Thorac Surg 2002; 74: S1881–S1884
  • Kuniyoshi Y, Koja K, Miyagi K, Shimoji M, Uezu T, Arakaki K, Yamashiro S, Mabuni K, Senaha S, Nakasone Y. Prevention of postoperative paraplegia during thoracoabdominal aortic surgery. Ann Thorac Surg 2003; 76: 1477–1484
  • Shiga Y, Onodera H, Matsuo Y, Kogure K. Cyclosporin a protects against ischemia—reperfusion injury in the brain. Brain Res 1992; 595: 145–148
  • Sato M, Horinouchi T, Sakurai M, Murakami N, Sato S, Kato M. Cyclosporin A reduces delayed motor neuron death after spinal cord ischemia in rabbits. Ann Thorac Surg 2003; 75: 1294–1299
  • Lee C H, Choi K Y, Kim Y J, Kim W G. Neuroprotective effect of KR-31378, a novel potassium channel activator, on spinal cord ischemic injury in rabbits. J Invest Surg 2005; 18: 297–304
  • Johnson S H, Kraimer J M, Graeber G M. Effects of flunarizine on neurological recovery and spinal cord blood flow in experimental spinal cord ischemia in 20 rabbits. Stroke 1993; 24: 1547–1553
  • Cassada D C, Tribble C G, Long S M, Long S M, Kaza A K, Linden J, Rieger J M, Rosin D, Kron I L, Kern J A. Adenosine A2A agonist reduces paralysis after spinal cord ischemia: Correlation with A2A receptor expression on motor neurons. Ann Thorac Surg 2002; 74: 728–733
  • Chen H W, Chien C T, Yu S L, Lee Y T, Chen W J. Cyclosporin A regulates oxidative stress-induced apoptosis in cardiomyocytes: Mechanism via ROS generation, iNOS and Hsp70. Br J Pharmacol 2002; 137: 771–781
  • Tarlov I M. Spinal Cord Compression: Mechanisms of Paralysis and Treatment. Charles C. Thomas, Springfield, IL 1957; 147
  • Wakamatsu Y, Shiiya N, Kunihara T, Watanabe S, Yasuda K. The adenosine triphosphate-sensitive potassium channel opener nicornadil protects the ischemic rabbit spinal cord. J Thorac Cardiovasc Surg 2001; 122: 728–733
  • Caparrelli D J, Cattaneo S M, 2nd, Bethea B T, Shake J G, Eberhart C, Blue M E, Marban E, Johnston M V, Baumgartner W A, Gott V L. Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia. Ann Thorac Surg 2002; 74: 838–845
  • Borutaite V, Jekabsone A, Morkuniene R, Brown G C. Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. J Mol Cell Cardiol. 2003; 35: 357–366
  • Charriaut-Marlangue C, Ben-Ari Y. Acautionary note on the use of the TUNEL stain to determine apoptosis. NeuroReport 1995; 7: 61–64
  • Glick B S. Can HSP70 proteins act as force-generating motors?. Cell 1995; 80: 11–14
  • Martin J L, Mestril R, Hilal-Dandan R, Brunton L L, Dillmann W H. Small heat shock proteins and protection against ischemic injury in cardiac myocyte. Circulation 1997; 96: 4343–4348
  • Xu Q, Hu Y, Kleindienst R, Wick G. Nitric oxcide induces heat shock proteins 70 expression in vascular smooth muscle cells via activation of heat shock factor I. J ClinInvest. 1997; 100: 1089–1097
  • Rajdev S, Hara K, Kokubo Y, Mestril R, Dillmann W, Weinstein P R, Sharp R. Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol 2000; 47: 782–779
  • Sharp A R, Lu A, Tang Y, Milhorn D E. Multiple molecular penumbras after focal cerebral ischemia. J Cereb Blood Flow Metab 2000; 20: 1011–1032
  • Yan X B, Meng F J, Zhang G Y. Brain ischemia induces serine phosphorylation of neuronal nitric oxcide synthase by Ca(2+)/calmodulin-dependent protein kinase II in rat hippocampus. Acta Pharmacol Sin 2004; 25: 617–622

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