Altered Expression of Zonula Occludens-2 Precedes Increased Blood–Brain Barrier Permeability in a Murine Model of Fulminant Hepatic Failure

REFERENCES

• Vaquero J, Blei A T. Etiology and management of fulminant hepatic failure. Curr Gastroenterol Rep 2003; 5: 39–47
   Google Scholar
• Larsen F S, Wendon J. Brain edema in liver failure: basic physiologic principles and management. Liver Transpl 2002; 8: 983–989
   PubMed Web of Science ®Google Scholar
• Ede R J, Williams R W. Hepatic encephalopathy and cerebral edema. Semin Liver Dis 1986; 6: 107–118
   PubMed Web of Science ®Google Scholar
• Harhaj N S, Antonetti D A. Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol 2004; 36: 1206–1237
   PubMed Web of Science ®Google Scholar
• Asahi M, Wang X, Mori T, et al. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci 2001; 21: 7724–7732
   PubMed Web of Science ®Google Scholar
• Kago T, Takagi N, Date I, et al. Cerebral ischemia enhances tyrosine phosphorylation of occludin in brain capillaries. Biochem Biophys Res Commun 2006; 339: 1197–1203
   PubMed Web of Science ®Google Scholar
• Wolburg H, Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol 2002; 38: 323–337
   PubMed Web of Science ®Google Scholar
• Wolburg H, Wolburg-Buchholz K, Kraus J, et al. Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol (Berl) 2003; 105: 586–592
   PubMed Web of Science ®Google Scholar
• Nitta T, Hata M, Gotoh S, et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 2003; 161: 653–660
   PubMed Web of Science ®Google Scholar
• Desjardins P, Belanger M, Butterworth R F. Alterations in expression of genes coding for key astrocytic proteins in acute liver failure. J Neurosci Res 2001; 66: 967–971
   Google Scholar
• Belanger M, Desjardins P, Chatauret N, et al. Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure. Glia 2006; 53: 557–562
   PubMed Web of Science ®Google Scholar
• Nguyen J H, Yamamoto S, Steers J, et al. Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice. J Hepatol 2006; 44: 1105–1114
   PubMed Web of Science ®Google Scholar
• Matkowskyj K A, Marrero J A, Carroll R E, et al. Azoxymethane-induced fulminant hepatic failure in C57BL/6J mice: characterization of a new animal model. Am J Physiol 1999; 277: G455–G462
   Google Scholar
• Belanger M, Cote J, Butterworth R F. Neurobiological characterization of an azoxymethane mouse model of acute liver failure. Neurochem Int 2006; 48: 434–440
   PubMed Web of Science ®Google Scholar
• Krizbai I A, Lenzser G, Szatmari E, et al. Blood-brain barrier changes during compensated and decompensated hemorrhagic shock. Shock 2005; 24: 428–433
   Google Scholar
• Grammas P. A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease. Neurobiol Aging 2000; 21: 199–205
   PubMed Web of Science ®Google Scholar
• Musch M W, Walsh-Reitz M M, Chang E B. Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption. Am J Physiol Gastrointest Liver Physiol 2006; 290: G222–G231
   PubMed Web of Science ®Google Scholar
• Pflugfelder S C, Farley W, Luo L, et al. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol 2005; 166: 61–71
   PubMed Web of Science ®Google Scholar
• Hawkins B T, Abbruscato T J, Egleton R D, et al. Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution. Brain Res 2004; 1027: 48–58
   PubMed Web of Science ®Google Scholar
• Traber P, DalCanto M, Ganger D, et al. Effect of body temperature on brain edema and encephalopathy in the rat after hepatic devascularization. Gastroenterology 1989; 96: 885–891
   Google Scholar
• Dixit V, Chang T M. Brain edema and the blood brain barrier in galactosamine-induced fulminant hepatic failure rats. An animal model for evaluation of liver support systems. ASAIO Trans 1990; 36: 21–27
   PubMedGoogle Scholar
• Livingstone A S, Potvin M, Goresky C A, et al. Changes in the blood-brain barrier in hepatic coma after hepatectomy in the rat. Gastroenterology 1977; 73: 697–704
   PubMedGoogle Scholar
• Sawara K, Desjardins P, Jian W, et al. Temperature-sensitive alterations in expression of vascular endothelial genes in brains of rats with acute liver failure. Hepatology 2006; 44(Suppl 1)479A
   Google Scholar
• Itoh M, Furuse M, Morita K, et al. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 1999; 147: 1351–1363
   PubMed Web of Science ®Google Scholar
• Wittchen E S, Haskins J, Stevenson B R. Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J Biol Chem 1999; 274: 35179–35185
   PubMed Web of Science ®Google Scholar
• Umeda K, Ikenouchi J, Katahira-Tayama S, et al. ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation. Cell 2006; 126: 741–754
   PubMed Web of Science ®Google Scholar
• Mark K S, Davis T P. Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation. Am J Physiol Heart Circ Physiol 2002; 282: H1485–H1494
   PubMedGoogle Scholar
• Fischer S, Wiesnet M, Renz D, et al. H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway. Eur J Cell Biol 2005; 84: 687–697
   Google Scholar
• Stamatovic S M, Shakui P, Keep R F, et al. Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. J Cereb Blood Flow Metab 2005; 25: 593–606
   PubMedGoogle Scholar
• Hom S, Fleegal M A, Egleton R D, et al. Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats. Am J Physiol Regul Integr Comp Physiol 2007; 292: R1881–892
   Google Scholar
• Hawkins B T, Lundeen T F, Norwood K M, et al. Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases. Diabetologia 2007; 50: 202–211
   PubMed Web of Science ®Google Scholar
• Lohmann C, Krischke M, Wegener J, et al. Tyrosine phosphatase inhibition induces loss of blood-brain barrier integrity by matrix metalloproteinase-dependent and -independent pathways. Brain Res 2004; 995: 184–196
   PubMedGoogle Scholar
• Braunton J L, Wong V, Wang W, et al. Reduction of tyrosine kinase activity and protein tyrosine dephosphorylation by anoxic stimulation in vitro. Neuroscience 1998; 82: 161–70
   Google Scholar
• Staddon J, Ratcliffe M, Morgan L, et al. Protein phosphorylation and the regulation of cell-cell junctions in brain endothelial cells. Heart Vessels 1997; 106–109, (suppl 12)
   Google Scholar
• Kale G, Naren A P, Sheth P, et al. Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3. Biochem Biophys Res Commun 2003; 302: 324–329
   PubMed Web of Science ®Google Scholar
• Avila-Flores A, Rendon-Huerta E, Moreno J, et al. Tight-junction protein zonula occludens 2 is a target of phosphorylation by protein kinase C. Biochem J 2001; 360: 295–304
   Google Scholar