REFERENCES
- Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F. The burden of liver disease in Europe: A review of available epidemiological data. J Hepatol. 2013;58:593–608.
- Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008;371:838–51.
- Rosmorduc O, Wendum D, Corpechot C, Galy B, Sebbagh N, Raleigh J et al. Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am J Pathol. 1999;155:1065–73.
- Corpechot C, Barbu V, Wendum D, Kinnhan N, Rey C, Poupon R et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology. 2002;35:1010–21.
- Moon JO, Welch TP, Gonzalez FJ, Copple BL. Reduced liver fibrosis in hypoxia-inducible factor-1 alpha-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2009;296:582–92.
- Copple BL. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010;30:669–82.
- Bozova S, Elpek GO. Hypoxia-inducible factor-1 alpha expression in experimental cirrhosis: correlation with vascular endothelial growth factor expression and angiogenesis. APMIS. 2007;115:795–801.
- Rosmorduc O, Housset C. Hypoxia: a link between fibrogenesis, angiogenesis, and carcinogenesis in liver disease. Semin Liver Dis. 2010;30:258–70.
- Cavadas MA, Nguyen LK, Cheong A. Hypoxia-inducible factor (HIF) network: insights from mathematical models. Cell Commun Signal. 2013;11:42
- van Uden P, Kenneth NS, Rocha S. Regulation of hypoxia-inducible factor-1 alpha by NF-kappa B. Biochem J. 2008;412:477–84.
- Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V et al. NF-kappa B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1 alpha. Nature. 2008;453:807–11.
- Margadant C, Sonnenberg A. Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep. 2010;11:97–105.
- Laemmli UK. Cleavage of structural proteins during assembly of head of bacteriophage-T4. Nature. 1970;227:680–5.
- Gerling B, Becker M, Waldschmidt J, Rehmann M, Schuppan D. Elevated serum aminoterminal procollagen type-III-peptide parallels collagen accumulation in rats with secondary biliary fibrosis. J Hepatol. 1996;25:79–84.
- Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Unemori EN, Lark MW et al. Cytokine-stimulated human vascular smooth-muscle cells synthesize a complement of enzymes required for extracellular-matrix digestion. Circ Res. 1994;75:181–9.
- Uitto J, Kouba D. Cytokine modulation of extracellular matrix gene expression: relevance to fibrotic skin diseases. J Dermatol Sci. 2010;24(suppl.1):60–9.
- Verrecchia F, Mauviel A. TGF-beta and TNF-alpha: antagonistic cytokines controlling type I collagen gene expression. Cell Signal. 2004;16:873–80.
- Robinson SM, Mann DA. Role of nuclear factor kappa B in liver health and disease. Clin Sci (Lond). 2010;118:691–705.
- Luedde T, Schwabe RF. NF-kappa B in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2011;8:108–18.
- Seki E, De Minicis S, Oesterreicher CH, Kluwe J, Osawa Y, Brenner DA et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13:1324–32.
- Liu B, Zhang X, Zhang FC, Zong JB, Zhang W, Zhao Y. Aberrant TGF-beta 1 signaling contributes to the development of primary biliary cirrhosis in murine model. World J Gastroenterol. 2013;19:5828–36.
- Honda E, Yoshida K, Munakata H. Transforming growth factor-beta upregulates the expression of integrin and related proteins in MRC-5 human myofibroblasts. Tohoku J Exp Med. 2010;220:319–27.
- Delire B, Starkel P, Leclercq I. Animal models for fibrotic liver diseases: what we have, what we need, and what is under development. J Clin Transl Hepatol.2015;3:53–66.
- Shyu KG, Hsu FL, Wang MJ, Wang BW, Lin S. Hypoxia-inducible factor 1 alpha regulates lung adenocarcinoma cell invasion. Exp Cell Res. 2007;313:1181–91.