Can Human Recombinant Epidermal Growth Factor Improve Ischemia and Induce Healing of Anastomosis in an Experimental Study in a Rabbit Model?

REFERENCES

• Kirkpatrick AW, Baxter KA, Simons RK, et al. Intra-abdominal complications after surgical repair of small bowel injuries: an international review. J Trauma. 2003;55:399–406.
   PubMedGoogle Scholar
• Boccola MA, Buettner PG, Rozen WM, et al. Risk factors and outcomes for anastomotic leakage in colorectal surgery: a single institution analysis of 1576 patients. World J Surg. 2011;35:186–195.
   PubMed Web of Science ®Google Scholar
• Trencheva K, Morrissey KP, Wells M, et al. Identifying important predictors for anastomotic leak after colon and rectal resection: prospective study on 616 patients. Ann Surg. 2013;257:108–113.
   PubMed Web of Science ®Google Scholar
• Thompson SK, Cahng EY, Jobe BA. Clinical review: healing in gastrointestinal anastomoses, part I. Microsurgery. 2006;26:131–136.
   PubMed Web of Science ®Google Scholar
• Nasirkhan MU, Abir F, Longo W, et al. Anastomotic disruption after bowel resection. World J Gastroenterol. 2006;12:2497–2504.
   PubMed Web of Science ®Google Scholar
• Ishii M, Tanaka E, Imaizumi T, et al. Local VEGF administration enhances healing of colonic anastomoses in a rabbit model. Eur Surg Res. 2009;42:249.
   PubMed Web of Science ®Google Scholar
• Grose R, Werner S. Wound-healing studies in transgenic and knockout mice. Mol Biotechnol. 2004;28:147.
   PubMed Web of Science ®Google Scholar
• Van Cruijsen H, Giaccone G, Hoekman K. Epidermal growth factor receptor and angiogenesis: opportunities for combined anticancer strategies. Int J Cancer. 2005;117:883–888.
   PubMed Web of Science ®Google Scholar
• Brown GL, Nanney BL, Griffen J, et al. Enhancement of wound healing by topical treatment with epidermal growth factor. N Engl J Med. 1989;321:76–79.
   PubMed Web of Science ®Google Scholar
• Brown GL, Curtsinger L, Jurkiewicz MJ, et al. Stimulation of healing of chronic wounds by epidermal growth factor. Plast Reconstr Surg1991;88:189–194.
   PubMed Web of Science ®Google Scholar
• Falanga V, Eaglstein WH, Bucalo B, et al. Topical use of human recombinant epidermal growth factor (h-EGF) in venous ulcers. J Dermatol Surg Oncol. 1992;18:604–606.
   PubMedGoogle Scholar
• Elder JB, Gillespie IE, Ganguli P, et al. Effect of urogastrone in the Zollinger-Ellison syndrome. Lancet. 1975;306:424–425.
   Google Scholar
• Drumm B, Cutz E, Tomkins KB, et al. Urogastrone/epidermal growth factor in treatment of congenital microvillous atrophy. Lancet. 1988;331:111–112.
   Google Scholar
• Sullivan PB, Brueton MJ, Tabara ZB, et al. Epidermal growth factor in necrotizing enteritis. Lancet. 1991;338:53–54.
   PubMed Web of Science ®Google Scholar
• Mohan VK. Recombinant human epidermal growth factor (REGEN-D 150): effect on healing of diabetic foot ulcers. Diabetes Res Clin Pract. 2007;78:405–411.
   PubMed Web of Science ®Google Scholar
• Tabrizi MN, Chams-Davatchi C, Esmaeeli N, et al. Accelerating effects of epidermal growth factor on skin lesions of pemphigus vulgaris: a double-blind, randomized, controlled trial. J Eur Acad Dermatol Venereol. 2007;21:79–84.
   PubMed Web of Science ®Google Scholar
• Fernández-Montequín JI, Betancourt BY, Leyva-Gonzalez G, et al. Intralesional administration of epidermal growth factor-based formulation (Heberprot-P) in chronic diabetic foot ulcer: treatment up to complete wound closure. Int Wound J. 2009;6:67–72.
   PubMed Web of Science ®Google Scholar
• Sakallioglu AE, Yagmurlu A, Dindar H, et al. Sustained local application of low-dose epidermal growth factor on steroid-inhibited colonic wound healing. J Pediatr Surg. 2004;39:591.
   PubMed Web of Science ®Google Scholar
• Radulescu A, Zhang HY, Chen CL, et al. Heparin-binding EGF-like growth factor promotes intestinal anastomotic healing. J Surg Res. 2011;171:540–550.
   PubMed Web of Science ®Google Scholar
• Chiu CJ, McArdle AH, Brown RA, et al. Intestinal mucosal lesion in low-flow states. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 1970;101:478–483.
   PubMedGoogle Scholar
• Garcia JC, Arias C, Garcia C, et al. Modiicacion de los mediadores inflamatorios en isquemia-reperfusion intestinal en un modelo de diabetes tipo II. Cir Esp. 2002;71:276–286.
   Google Scholar
• Membrives PP, Ruiz-Luque V, Escudero-Severin C, et al. Effect of pentoxifylline on the healing of ischemic colorectal anastomoses. Dis Colon Rectum. 2006;50:369–375.
   Web of Science ®Google Scholar
• Henry G, Garner WL. Inflammatory mediators in wound healing. Surg Clin North Am. 2003;83:483–507.
   PubMed Web of Science ®Google Scholar
• Smiell JM, Wieman TJ, Steed DL, et al. Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor BB) in patients with non healing, lower extremity diabetic ulcers: a combined analysis of four randomised trials. Wound Repair Regen. 1999;7:335.
   PubMed Web of Science ®Google Scholar
• Knighton DR, Ciresi KF, Fiegel VD, et al. Classification and treatment of chronic nonhealing wounds. Ann Surg. 1986;204:322–330.
   PubMed Web of Science ®Google Scholar
• Rijcken E, Sachs L, Fuchs T, et al. Growth factors and gastrointestinal anastomotic healing. J Surg Res. 2014;187:202–210.
   PubMed Web of Science ®Google Scholar
• Pastore S, Mascia F, Mariani V, et al. The epidermal growth factor receptor system in skin repair and inflammation. J Invest Dermatol. 2008;128:1365–1374.
   PubMed Web of Science ®Google Scholar
• Dinc S, Alagol H, Gulcelik MA, et al. Locally applied granulocyte-macrophage colony-stimulating factor improves the impaired bowel anastomoses in rats with long term corticosteroid treatment. World J Surg. 2002;26:1208–1213.
   PubMed Web of Science ®Google Scholar
• Prats PA, Duconge J, Valenzuela C, et al. Disposition and receptor-site binding of (125)I-EGF after topical administration to skin wounds. Biopharm Drug Dispos. 2002;23:67–76.
   PubMed Web of Science ®Google Scholar
• Brown GL, Curtsinger LJ, White M et al. Acceleration of tensile strength of incisions treated with EGF and TGF-beta. Ann Surg. 1988;208:788–794.
   PubMed Web of Science ®Google Scholar
• Kingsnorth AN, Vowles R, Nash JR. Epidermal growth factor increases tensile strength in intestinal wounds in pigs. Br J Surg. 1990;77:409.
   PubMed Web of Science ®Google Scholar
• Yang J, Zhao JB, Zeng YJ, et al. Biomechanical properties of ileum after systemic treatment with epithelial growth factor. World J Gastroenterol. 2003;9:2278–2283.
   PubMed Web of Science ®Google Scholar
• Yang J, Zhao J, Zeng Y. Morphological properties of zero-stress state in rat large intestine during systemic EGF treatment. Dig Dis Sci. 2003;3:442–448.
   Web of Science ®Google Scholar
• Kissmeyer-Nielsen P, Vinter-Jensen L, Smerup M. Effects of long term epidermal growth factor treatment on the normal rat colon. Gut. 1996;38:582–586.
   PubMed Web of Science ®Google Scholar
• Hollenberg MD, Cuatrecasas P. Insulin and epidermal growth factor. Human fibroblast receptors related to deoxy ribonucleic acid synthesis and amino acid uptake. J Biol Chem. 1975;250:3845–3853.
   PubMed Web of Science ®Google Scholar
• Laato M, Niinikoski J, Lundberg C, Arfors K-E. Effect of epidermal growth factor (EGF) on experimental granulation tissue. J Surg Res. 1986;41:252–255.
   PubMed Web of Science ®Google Scholar
• Laato M, Niinikoski J, Gerdin B, et al. Stimulation of wound healing by epidermal growth factor: a dose dependent effect. Ann Surg. 1986;203:379–381.
   PubMed Web of Science ®Google Scholar
• Braskén P, Renvall S, Sandberg M. Expression of epidermal growth factor and epidermal growth factor receptor genes in healing colonic anastomoses in rats. Eur J Surg. 1991;157:607–611.
   PubMedGoogle Scholar
• Pillai SB, Hinman CE, Luquette MH, et al. Heparin-binding epidermal growth factor-like growth factor protects rat intestine from ischemia/reperfusion injury. J Surg Res. 1999;87:225–231.
   PubMed Web of Science ®Google Scholar
• Engler JA, Gupta A, Li L, et al. Inhibition of DNA synthesis in Caco-2 cells by oxidative stress: amelioration by epidermal growth factor. Dig Dis Sci. 1999;44:1902–1909.
   PubMed Web of Science ®Google Scholar