157
Views
7
CrossRef citations to date
0
Altmetric
Original Research

Alarmins and Clinical Outcomes After Major Abdominal Surgery—A Prospective Study

, MD, , MD, PhD, , MD, CSc, , MD, & , MD, PhD
Pages 152-161 | Received 06 Jun 2016, Accepted 25 Aug 2016, Published online: 30 Sep 2016

REFERENCES

  • Barie PS, Hydo LJ. Epidemiology of multiple organ dysfunction syndrome in critical surgical illness. Surg Infect (Larchmt) 2000;1:173–185.
  • Jakobson T, Karjagin J, Vipp L, et al. Postoperative complications and mortality after major gastrointestinal surgery. Medicina (Kaunas) 2014;50:111–117.
  • Khuri SF, Henderson WG, DePalma RG, et al. Determinants of long-term survival after major surgery and the adverse effect of postoperative complications. Ann Surg. 2005;242:326–341.
  • Dobson GP. Addressing the global burden of trauma in major surgery. Front Surg. 2015;2:43.
  • Jhanji S, Thomas B, Ely A, et al. Mortality and utilization of critical care resources amongst high-risk surgical patients in a large NHS trust. Anaesthesia. 2008;63:695–700.
  • Pearse RM, Harrison DA, James P, et al. Identification and characterisation of the high-risk surgical population in the United Kingdom. Crit Care 2006;10:R81.
  • Chu D, Bakaeen FG, Wang XL, et al. Does the duration of surgery affect outcomes in patients undergoing coronary artery bypass grafting? Am J Surg. 2008;196:652–656. doi: 10.1016/j.amjsurg.2008.07.003.
  • Kim JY, Khavanin N, Rambachan A, et al. Surgical duration and risk of venous thromboembolism. JAMA Surg. 2015;150:110–117. doi: 10.1001/jamasurg.2014.1841.
  • Spence RK, Carson JA, Poses R, et al. Elective surgery without transfusion: influence of preoperative hemoglobin level and blood loss on mortality. Am J Surg. 1990;159:320–324.
  • Wu WC, Trivedi A, Friedmann PD, et al. Association between hospital intraoperative blood transfusion practices for surgical blood loss and hospital surgical mortality rates. Ann Surg. 2012;255:708–714. doi: 10.1097/SLA.0b013e31824a55b9.
  • Van Haren RM, Thorson CM, Valle EJ, et al. Vasopressor use during emergency trauma surgery. Am Surg. 2014;80:472–478.
  • Swanson EW, Cheng HT, Susarla SM, et al. Intraoperative use of vasopressors is safe in head and neck free tissue transfer. J ReconstrMicrosurg. 2016;32:87–93. doi: 10.1055/s-0035-1563381.
  • Bamboat ZM, Bordeianou L. Perioperative fluid management. Clin Colon Rectal Surg. 2009;22:28–33. doi: 10.1055/s-0029-1202883.
  • Pugin J. How tissue injury alarms the immune system and causes inflammatory response syndrome. Ann Intensive Care 2012;2:27.
  • Arslan F, Keogh B, McGuirk P, et al. TLR2 and TLR4 in ischemia reperfusion injury. Mediators Inflamm. 2010;2010:704202.
  • Marik PE, Flemmer M. The immune response to surgery and trauma: implications for treatment. J Trauma Acute Care Surg. 2012;73:801–808.
  • Kimura F, Shimizu H, Yoshidome H, et al. Immunosuppression following surgical and traumatic injury. Surg Today 2010;40:793–808.
  • Gentle LF, Cuenca AG, Efron PA, et al. Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care. J Trauma Acute Care Surg. 2012;72:1491–1501.
  • Reinhardt R, Pohlmann S, Kleinertz H, et al. Invasive surgery impairs the regulatory function of human CD56 bright natural killer cells in response to Staphylococcus aureus. Suppression of interferon-γ synthesis. PLoS One 2015;10:e0130155.
  • Becher RD, Hoth JJ, Miller PR, et al. Systemic inflammation worsens outcomes in emergency surgical patients. J Trauma Acute Care Surg. 2012;72:1140–1149.
  • NeSmith EG, Weinrich SP, Andrews JO, et al. Systemic inflammatory response syndrome score and race as predictors of length of stay in the intensive care unit. Am J Crit Care 2009;18:339–346.
  • Baue AE, Durham R, Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 1998;10:79–89.
  • Terrando N, Brzezinski M, Degos V, et al. Perioperative cognitive decline in the aging population. Mayo Clin Proc. 2011;86:885–893.
  • Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644–1655.
  • Levy MM, Fink MP, Marshall JC, et al. International Sepsis Definitions Conference. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. 2003;29:530–538.
  • Bertsch T, Triebel J, Bollheimer C, et al. C-reactive protein and the acute phase reaction in geriatric patients. Z Gerontol Geriatr. 2015;48:595–600. doi: 10.1007/s00391-015-0938-4.
  • Gewurz H, Mold C, Siegel J, et al. C-reactive protein and the acute phase response. Adv Intern Med. 1982;27:345–372.
  • Okeny PK, Ongom P, Kituuka O. Serum interleukin-6 level as an early marker of injury severity in trauma patients in an urban low-income setting: a cross-sectional study. BMC Emerg Med. 2015;15:22.
  • Gebhard F, Pfetsch H, Steinbach G, et al. Is interleukin 6 an early marker of injury severity following major trauma in humans? Arch Surg. 2000;135:291–295.
  • Norberg Å, Rooyackers O, Segersvärd R, et al. Albumin kinetics in patients undergoing major abdominal surgery. PLoS One 2015;10:e0136371.
  • Oppenheim JJ, Yang D. Alarmins: chemotactic activators of immune responses. Curr Opin Immunol. 2005;17:359–365.
  • Foell D, Wittkowski H, Vogl T, et al. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol. 2007;81:28–37.
  • Denk S, Perl M, Huber-Lang M. Damage- and pathogen-associated molecular patterns and alarmins: keys to sepsis? Eur Surg Res. 2012;48:171–179.
  • Seong SY, Matzinger P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol. 2004;4:469–478.
  • Lotze MT, Deisseroth A, Rubartelli A. FOCiS on damage associated molecular pattern molecules. Clin Immunol. 2007;124:1–4.
  • Kaczmarek A, Vendenabeele P, Krysko DV. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity. 2013;38:209–223.
  • Coffelt SB, Scandurro AB. Tumors sound the alarmin(s). Cancer Res. 2008;68:6482–6485. doi: 10.1158/0008-5472.
  • Salama I, Malone PS, Mihaimeed F, et al. A review of the S100 proteins in cancer. Eur J Surg Oncol. 2008;34:357–364.
  • Sims GP, Rowe DC, Rietdijk ST, et al. HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol. 2010;28:367–388.
  • Davies SJ, Francis J, Dilley J, et al. Measuring outcome after major abdominal surgery during hospitalization: reliability and validity of the postoperative morbidity survey. Perioper Med (Lond) 2013;2:1.
  • http://www.csim.cz/dokumenty/#categories:path=do-porucene-postupy.
  • http://www.sccm.org/Research/Guidelines/Pages/Guidelines.aspx.
  • R Core Team. R: a language and environment for statistical computing. In: R Foundation for Statistical Computing, Vienna, Austria; 2015. URL: https://www.R-project.org/.
  • Heizmann CW, Fritz G, Schafer BW. S100 proteins: structure, functions and pathology. Front. Biosci. 2002;7:1356–1368.
  • Foell D, Frosch M, Sorg C, et al. Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation. Clin Chim Acta. 2004;344:37–51.
  • Foell D, Roth J. Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum. 2004;50:3762–3771.
  • Pietzch J, Hoppmann S. Human S100A12: a novel key player in inflammation? Amino Acids. 2009;36:381–389.
  • Meijer B, Gearry RB, Day AS. The role of S100A12 as a systemic marker of inflammation. Int J Inflam. 2012;2012:907078.
  • Ogawa EN, Ishizaka A, Tasaka S, et al. Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury. Am J Respir Crit Care Med. 2006;174:400–407.
  • Wang H, Yang H, Tracey KJ. Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med. 2004;255:320–331.
  • Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol. 2005;5:331–342.
  • Yanai Ban T, Taniguchi T. High-mobility group box family of proteins: ligand and sensor for innate immunity. Trends Immunol. 2012;33:633–640.
  • Tsan MF. Heat shock protein and high mobility group box 1 protein lack cytokine function. J Leukoc Biol. 2011;89:847–853.
  • Stros M. HMGB proteins interactions with DNA and chromatin. Biochim Biophys Acta. 2010;1799:101–113.
  • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002;418:191–195.
  • Gardella S, Andrei C, Ferrera D, et al. The nuclear HMGB1 is secreted by monocytes via non-classical vesicle mediated secretory pathway. EMBO Rep. 2002;3:995–1001.
  • Hartl FU, Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 2002;295:1852–1858.
  • Caderwood SK, Mambula SS, Gray PJ Jr. Exracellular heat shock proteins in cell signaling and immunity. Ann N Y Acad Sci. 2007;1113:28–39.
  • Andersson U, Tracey KJ. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol. 2011;29:139–162. doi: 10.1146/annurev-immunol-030409-101323.
  • Tsung A, Sahai R, Tanaka H, et al. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 2005;201:1135–1143.
  • Kruger B, Krick S, Dhillon N, et al. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc. Natl. Acad. Sci. USA 2009;106:3390–3395.
  • Ombrellino M, Wang H, Ajemian MS, et al. Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet. 1999;354:1446–1447.
  • Lantos J, Foldi V, Roth E, et al. Burn trauma induces early HMGB1 release in patients: its correlation with cytokines. Shock 2010;33:562–567.
  • Manganelli V, Signore M, Pacini I, et al. Increased HMGB1 expression and release by mononuclear cells following surgical/anesthesia trauma. Crit. Care 2010;14:R197.
  • Abraham E. Unraveling the role of high mobility group box protein 1 in severe trauma. Crit Care 2009;13(6):1004. doi: 10.1186/cc8141.
  • Suda K, Kitagawa Y, Ozawa S, et al. Serum concentrations of high-mobility group box chromosomal protein 1 before and after exposure to the surgical stress of thoracic esophagectomy: a predictor of clinical course after surgery? Dis Esophagus. 2006;19:5–9.
  • Peltz ED, Moore EE, Eckels PC, et al. HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock 2009;32:17–22.
  • Charoensup J, Sermswan RW, Paeyao A, et al. High HMGB1 level is associated with poor outcome of septicemicmelioidosis. Int J Infect Dis. 2014;28:111–116. doi: 10.1016/j.ijid.2014.07.025.
  • Pilzweger C, Holdenrieder S. Circulating HMGB1 and RAGE as clinical biomarkers in malignant and autoimmune diseases. Diagnostics 2015;5:219–253. doi:10.3390/diagnostics5020219.
  • Zhu XD, Chen JS, Zhou F, et al. Relationship between plasma high mobility group box-1 protein levels and clinical outcomes of aneurysmal subarachnoid hemorrhage. J Neuroinflammation. 2012;9:194. doi: 10.1186/1742-2094-9-194.
  • Tong HS, Tang YQ, Chen Y, et al. Early elevated HMGB1 level predicting the outcome in exertional heatstroke. J Trauma. 2011;71:808–814. doi: 10.1097/TA.0b013e318220b957.
  • Karlsson S, Pettilä V, Tenhunen J, et al. HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis. Intens Care Med. 2008;34:1046–1053. doi: 10.1007/s00134-008-1032-9.
  • Chen H, Xu C, Jin Q, et al. S100 protein family in human cancer. Am J Cancer Res. 2014;4:89–115.
  • Shrikrishna G. Freeze HH endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia. 2009;11:615–628.
  • Nedjadi T, Kitteringham N, Campbell F, et al. S100A6 binds to annexin 2 in pancreatic cancer cells and promotes pancreatic cancer cell motility. Br J Cancer 2009;101:1145–1154. doi: 10.1038/sj.bjc.6605289.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.