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Journal of Investigative Surgery Volume 30, 2017 - Issue 3
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Original Research

Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model

Ioannis ChristakisDepartment of Investigative Medicine, Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK
, MD, PhD,
Rebecca ScottDepartment of Investigative Medicine, Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK
, BM, BCh, MRCP,
James MinnionDepartment of Investigative Medicine, Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK
, PhD,
Joyceline CuencoDepartment of Investigative Medicine, Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK
, PhD,
Tricia TanDepartment of Investigative Medicine, Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK
, MD, PhD,
Fausto PalazzoDepartment of Thyroid and Endocrine Surgery, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK
, MD, FRCS &
Stephen BloomDepartment of Investigative Medicine, Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UKCorrespondence[email protected]
, MD, FRS, FMEDSCI show all
Pages 162-169 | Received 15 Jun 2016, Accepted 30 Aug 2016, Published online: 30 Sep 2016

REFERENCES

  • Bhatta-Dhar N, Reuther AM, Zippe C. No difference in six-year biochemical failure rates with or without pelvic lymph node dissection during radical prostatectomy in low-risk patients with localized prostate cancer. Urology 2004;63(3):528–531.
  • Che Y, Cleland JG, Ali MM. Periodic abstinence in developing countries: An assessment of failure rates and consequences. Contraception 2004;69(1):15–21.
  • Hughes M, Inglese J, Kurtz A. Early drug discovery and development guidelines: for academic researchers, collaborators, and start-up companies.In: Assay Guidance Manual, Sittampalam GS, et al., eds. Bethesda, MD: Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004: 2–20.
  • Mosby, MT. Pharmacokinetics. In: Mosby's Dictionary of Medicine, Nursing, & Health Professions. Philadelphia, PA: Elsevier Health Sciences; 2006: 208, 9th edition, 2013.
  • Ruiz-Garcia A, Bermejo M, Moss A, et al. Pharmacokinetics in drug discovery. J Pharm Sci. 2008;97(2):654–690.
  • Benet LZ. Drug Metabolism and Drug Toxicity, Horning JMaM, ed. New York, NY: Raven Press; 1984.
  • Pfeifer HJ, Greenblatt DJ. An introduction to clinical pharmacokinetics. Compr Ther. 1979;5(3):33–37.
  • Derendorf H, Meibohm B. Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: Concepts and perspectives. Pharm Res. 1999;16(2):176–185.
  • Bellissant E, Sebille V, Paintaud G. Methodological issues in pharmacokinetic–pharmacodynamic modelling. Clin Pharmacokinet. 1998;35(2):151–166.
  • Kervran A, Dubrasquet M, Blache P, et al. Metabolic clearance rates of oxyntomodulin and glucagon in the rat: Contribution of the kidney. Regul Pept. 1990;31(1):41–52.
  • Oshima I, Hirota M, Ohboshi C, et al. Comparison of half-disappearance times, distribution volumes and metabolic clearance rates of exogenous glucagon-like peptide 1 and glucagon in rats. Regul Pept. 1988;21(1–2):85–93.
  • Young A, Parkes D, Jodka C, et al. Pharmacokinetic actions of exendin-4 in the rat: comparison with glucagon-like peptide-1. Drug Develop Res. 2001;53:260–267.
  • Cao Y, Gao W, Jusko WJ. Pharmacokinetic/pharmacodynamic modeling of GLP-1 in healthy rats. Pharm Res. 2012;29(4):1078–1086.
  • Gao W, Jusko WJ. Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans. Drug Metab Dispos. 2012;40(5):990–997.
  • Gao W, Jusko WJ. Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats. J Pharmacol Exp Ther. 2011;336(3):881–890.
  • Hay M, Thomas DW, Craighead JL, et al. Clinical development success rates for investigational drugs. Nat Biotechnol. 2014;32(1):40–51.
  • Jones BJ, Bloom SR. The new era of drug therapy for obesity: the evidence and the expectations. Drugs 2015;75(9):935–945.
  • Cooke D, Bloom S. The obesity pipeline: current strategies in the development of anti-obesity drugs. Nat Rev Drug Discov. 2006;5(11):919–931.
  • Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov. 2004;3(8):711–715.
  • Solomon I. Tubing information 2013, Plymouth Meeting, PA USA.
  • Kreymann B, Williams G, Ghatei MA, et al. Glucagon-like peptide-1 7-36: A physiological incretin in man. Lancet 1987;2(8571):1300–1304.
  • Adrian TE, Bloom SR, Bryant MG, et al. Proceedings: Radioimmunoassay of a new gut hormone-human pancreatic polypeptide. Gut 1976;17(5):393–394.
  • Christakis I, Georgiou P, Minnion J, et al. Learning curve of vessel cannulation in rats using cumulative sum analysis. J Surg Res. 2015;193(1):69–76.
  • Emmanouel DS, Jaspan JB, Rubenstein AH, et al. Glucagon metabolism in the rat. J Clin Invest. 1978;62(1):6–13.
  • Gwadry-Sridhar FH, Flintoft V, Lee DS, et al. A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med. 2004;164(21):2315–2320.
  • Colatsky TJ, Higgins AJ, Bullard BR. Editorial overview. Biomarker-enabled drug discovery: Bridging the gap between disease and target knowledge. Curr Opin Investig Drugs 2004;5(3):269–270.
  • Carlson B. Biomarkers gain prominence in drug discovery and development. Biotechnol Healthcare 2004;1(3):8–11.

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