Advanced search
Publication Cover
Journal of Investigative Surgery Volume 31, 2018 - Issue 5
Submit an article Journal homepage
184
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

Autotaxin Expression in Hepatocellular Carcinoma

Ilker MemetPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;Democritus University of Thrace, Faculty of Medicine, Second Department of Surgery and Laboratory of Experimental Surgery, Dragana, Alexandroupolis, GreeceCorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-5950-8621
, MD ORCID Icon,
Evanthia TsalkidouPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;Democritus University of Thrace, Faculty of Medicine, Second Department of Surgery and Laboratory of Experimental Surgery, Dragana, Alexandroupolis, Greece
, MD, PhD,
Alexandra K TsarouchaPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;Democritus University of Thrace, Faculty of Medicine, Second Department of Surgery and Laboratory of Experimental Surgery, Dragana, Alexandroupolis, Greece
, MD, PhD,
Maria LambropoulouDemocritus University of Thrace, Faculty of Medicine, Laboratory of Histology-Embryology, Dragana, Alexandroupolis, Greece
, MD, PhD,
Ekaterini ChatzakiDemocritus University of Thrace, Faculty of Medicine, Laboratory of Pharmacology, Dragana, Alexandroupolis, Greece
, PhD,
Gregory TrypsianisDemocritus University of Thrace, Faculty of Medicine, Laboratory of Medical Statistics, Dragana, Alexandroupolis, Greece
, PhD,
Dimitrios SchizasNational and Kapodistrian University of Athens, Laikon Hospital, First Department of Surgery, Athens, Greece
, MD, PhD,
Michael PitiakoudisPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;Democritus University of Thrace, Faculty of Medicine, Second Department of Surgery and Laboratory of Experimental Surgery, Dragana, Alexandroupolis, Greece
, MD, PhD &
Constantinos SimopoulosPostgraduate Program in Hepatobiliary/Pancreatic Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece;Democritus University of Thrace, Faculty of Medicine, Second Department of Surgery and Laboratory of Experimental Surgery, Dragana, Alexandroupolis, Greece
, MD, PhD show all
Pages 359-365 | Received 01 Mar 2017, Accepted 12 May 2017, Published online: 09 Jun 2017

REFERENCES

  • Greten TF, Korangy F, Manns MP, Malek NP. Molecular therapy for the treatment of hepatocellular carcinoma. Br J Cancer. 2009;100:19–23.
  • Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol. 2009;27:1485–1491.
  • Wu JM, Xu Y, Skill NJ, et al. Autotaxin expression and its connection with the TNFalpha-NF-kappaB axis in human hepatocellular carcinoma. Mol Cancer. 2010;9:71.
  • Llovet JM, Bru´ C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19:329–338.
  • Newell P, Villanueva A, Llovet JM. Molecular targeted therapies in hepatocellular carcinoma: from pre-clinical models to clinical trials. J Hepatol. 2008;49:1–5.
  • Kondo M, Ishizawa T, Enooku K, Tokuhara Y, Ohkawa R, et al. Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma. Clin Chim Acta. 2014;433:128–134.
  • Tokumura A, Majima E, Kariya Y, et al. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem. 2002;277:39436–39442.
  • Umezu-Goto M, Kishi Y, Taira A, et al. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol. 2002;158:227–233.
  • Baumforth KR, Flavell JR, Reynolds GM, et al. Induction of autotaxin by the Epstein– Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Blood. 2005;106:2138–2146 [Epub 2005 Jun 2132].
  • Kishi Y, Okudaira S, Tanaka M, et al. Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem. 2006;281:17492–17500.
  • Yang Y, Mou L, Liu N, Tsao MS. Autotaxin expression in non-small-cell lung cancer. Am J Respir Cell Mol Biol. 1999;21:216–222.
  • Stassar MJ, Devitt G, Brosius M, et al. Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization. Br J Cancer. 2001;85:1372–1382.
  • Debies MT, Welch DR. Genetic basis of human breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2001;6:441–451.
  • Kehlen A, Englert N, Seifert A, et al. Expression, regulation and function of autotaxin in thyroid carcinomas. Int J Cancer. 2004;109:833–838.
  • Stracke ML, Clair T, Liotta LA. Autotaxin, tumor motility-stimulating exophosphodiesterase. Adv Enzym Regul. 1997;37:135–144.
  • Zhang G, Zhao Z, Xu S, Ni L, Wang X. Expression of autotaxin mRNA in human hepatocellular carcinoma. Chin Med J. 1999;112:330–332.
  • Cooper AB, Wu J, Lu D, Maluccio MA. Is autotaxin (ENPP2) the link between hepatitis C and hepatocellular cancer? J Gastrointest Surg. 2007;11:1628–1634 [discussion 1634–1625].
  • Mazzocca A, Dituri F, Lupo L, Quaranta M, Antonaci S, Giannelli G. Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts. Hepatology 54:920–930.
  • Wu JM, Xu Y, Skill NJ, et al. Autotaxin expression and its connection with the TNFalpha- NF-kappaB axis in human hepatocellular carcinoma. Mol Cancer. 2010;9:71.
  • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999;340:745–750.
  • Forner A., Reig M., Bruix J. Alpha-fetoprotein for hepatocellular carcinoma diagnosis: The demise of a brilliant star. Gastroenterology. 2009;137:26–29.
  • Chen JG, Parkin DM, Chen QG, et al. Screening for liver cancer: results of a randomised controlled trial in Qidong, China. J Med Screen. 2003;10:204–209.
  • Lok AS, Lai CL. alpha-Fetoprotein monitoring in Chinese patients with chronic hepatitis B virus infection: role in the early detection of hepatocellular carcinoma. Hepatology 1989;9:110–115.
  • Di Bisceglie AM, Sterling RK, Chung RT, et al. Serum alphafetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial. J Hepatol. 2005;43:434–441.
  • Adachi Y, Tsuchihashi J, Shiraishi N, et al. AFP-producing gastric carcinoma: multivariate analysis of prognostic factors in 270 patients. Oncology 2003;65:95–101.
  • Ishikawa K, Sasaki A, Haraguchi N, et al. A case of an alphafetoprotein -producing intrahepatic cholangiocarcinoma suggests probable cancer stem cell origin. Oncologist 2007;12:320–324.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.