Insulin Metabolism and Assessment of Hepatic Insulin Extraction During Liver Regeneration. A Study in a Rat Model

REFERENCES

• Forbes SJ, Newsome PN. Liver regeneration – mechanisms and models to clinical application. Nat Rev Gastroenterol Hepatol. 2016;13(8):473–85. doi:10.1038/nrgastro.2016.97.
   PubMed Web of Science ®Google Scholar
• Yi PS, Zhang M, Xu MQ. Role of microRNA in liver regeneration. Hepatobiliary Pancreat Dis Int. 2016;15(2):141–6. doi:10.1016/S1499-3872(15)60036-4.
   PubMed Web of Science ®Google Scholar
• Harrison PM, Hughes RD, Forbes A, Portmann B, Alexander GJ, Williams R. Failure of insulin and glucagon infusion to stimulate liver regeneration in fulminant hepatic failure. J Hepatol. 1990;10(3):332–6. doi:10.1016/0168-8278(90)90141-D. PMID:2195108.
   PubMed Web of Science ®Google Scholar
• Caruana JA, Jr., Goldman JK, Camara DS, Gage AA. Insulin, glucagon and glucose in the regeneration response of the liver. Surg Gynecol Obstet. 1981;153(5):626–30.
   PubMedGoogle Scholar
• Xu MQ, Yan LN, Li B, et al. Augmented hepatic regeneration of living donor liver graft by intraportal insulin administration. Zhonghua wai ke za zhi [Chin. J. Surg.] 2009;47(11):821–4. PMID:19994469.
   PubMedGoogle Scholar
• Xu MQ, Yan LN, Li B, et al. Initial clinical effect of intraportal insulin administration on liver graft regeneration in adult patients underwent living donor right lobe liver transplantation. Transplant Proc. 2009;41(5):1698–702. doi:10.1016/j.transproceed.2008.10.094. PMID:19545710.
   PubMed Web of Science ®Google Scholar
• Burguera B, Werner H, Sklar M, et al. Liver regeneration is associated with increased expression of the insulin-like growth factor-II/mannose-6-phosphate receptor. J Mol Endocrinol. 1990;4(10):1539–45. doi:10.1210/mend-4-10-1539. PMID:2178219.
   PubMedGoogle Scholar
• Dobozy O, Csaba G, Inczefi-Gonda A, Buki B, Nemeth J, Karabelyos C. Impact of a single insulin treatment (imprinting) applied during liver regeneration on hepatic insulin receptor development, blood glucose level and liver function parameters in adult rats. Acta Physiol Hung. 1992;79(3):331–8. PMID:1340089.
   PubMedGoogle Scholar
• Bessems M, t Hart NA, Tolba R, et al. The isolated perfused rat liver: standardization of a time-honoured model. Lab Anim. 2006;40(3):236–46. doi:10.1258/002367706777611460. PMID:16803641.
   PubMedGoogle Scholar
• Pagano C, Rizzato M, Lombardi AM, et al. Effect of lactate on hepatic insulin clearance in perfused rat liver. Am J Physiol. 1996;270(3 Pt 2):R682–7. PMID:8780237.
   PubMedGoogle Scholar
• Vassiliou I, Lolis E, Nastos C, et al. The combined effect of erythropoietin and granulocyte macrophage colony stimulating factor on liver regeneration after major hepatectomy in rats. World J Surg Oncol. 2010;8:57. doi:10.1186/1477-7819-8-57. PMID:20604971.
   PubMed Web of Science ®Google Scholar
• Dietrich DR, Candrian R, Marsman DS, Popp JA, Kaufmann WK, Swenberg JA. Retrospective assessment of liver cell proliferation via PCNA: a comparison with tritiated thymidine. Cancer Lett. 1994;79(1):45–51. doi:10.1016/0304-3835(94)90061-2. PMID:7910515.
   PubMed Web of Science ®Google Scholar
• Dietrich DR. Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation. Crit Rev Toxicol. 1993;23(1):77–109. doi:10.3109/10408449309104075. PMID:8097093.
   PubMed Web of Science ®Google Scholar
• LaBrecque D. Liver regeneration: a picture emerges from the puzzle. Am J Gastroenterol. 1994;89(8 Suppl):S86–96. PMID:8048418.
   PubMed Web of Science ®Google Scholar
• Caruana J Jr, Gage A. Increased uptake of insulin and glucagon by the liver as a signal for regeneration. Surg Gynecol Obstet. 1980;150(3):390–4.
   PubMedGoogle Scholar
• Kogut K, Wiley Nifong L, Witt M, Krusch D, editors. Hepatic glucose production after liver resection. Chicago: Surgical Forum, American College of Surgeons; 1995.
   Google Scholar
• Cohen DM, Jaspan JB, Polonsky KS, Lever EG, Moossa AR. Pancreatic hormone profiles and metabolism posthepatectomy in the dog. Evidence for a hepatotrophic role of insulin, glucagon, and pancreatic polypeptide. Gastroenterology. 1984;87(3):679–87. PMID:6146553.
   PubMed Web of Science ®Google Scholar
• Cornell RP. Hyperinsulinemia and hyperglucagonemia in fasted rats during liver regeneration. Am J Physiol. 1981;240(2):E112–8. PMID:7008625.
   PubMedGoogle Scholar
• Varsos P, Nastos C, Papoutsidakis N, et al. Desferrioxamine attenuates pancreatic injury after major hepatectomy under vascular control of the liver: experimental study in pigs. HPB Surg. 2012; 2012. doi:10.1155/2012/714672. PMID:22791933.
   PubMedGoogle Scholar
• Kogut KA, Nifong LW, Witt MJ, Krusch DA. Hepatic insulin extraction after major hepatectomy. Surgery. 1998;123(4):415–20. doi:10.1016/S0039-6060(98)70162-X. PMID:9551067.
   PubMed Web of Science ®Google Scholar
• Brömme H, Blech W. Insulin extraction by the isolated perfused rat liver using infusion conditions of a biphasic insulin concentration profile. Biomedica Biochimica Acta. 1983;43(3):371–80.
   Google Scholar
• Gorska M, Gorski J. Failure to demonstrate the effect of glucose on insulin removal by perfused rat liver. Endocrinologia experimentalis. 1990;24(3):369–73. PMID:2226282.
   PubMedGoogle Scholar
• Mondon CE, Dolkas CB, Olefsky JM, Reaven GM. Insulin sensitivity of isolated perfused rat liver. Diabetes. 1975;24(2):225–9. doi:10.2337/diab.24.2.225. PMID:1123110.
   PubMed Web of Science ®Google Scholar
• Berzins R, Tam YK, Molnar GD, et al. Pharmacokinetic approach to the estimation of hepatic removal of insulin. Pancreas. 1986;1(6):544–9. doi:10.1097/00006676-198611000-00013. PMID:3550790.
   PubMedGoogle Scholar
• Honey RN, Price S. The determinants of insulin extraction in the isolated perfused rat liver. Horm Metab Res. 1979;11(2):111–7. doi:10.1055/s-0028-1092691. PMID:437674.
   PubMed Web of Science ®Google Scholar
• Chap Z, Ishida T, Chou J, et al. Effect of metabolic clearance rate and hepatic extraction of insulin on hepatic and peripheral contributions to hypoglycemia. J Clin Invest. 1985;76(6):2222–34. doi:10.1172/JCI112231. PMID:3908485.
   PubMed Web of Science ®Google Scholar
• El-Gibaly AM, Scheuer C, Menger MD, Vollmar B. Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis. Hepatology. 2004;39(6):1553–62. doi:10.1002/hep.20243. PMID:15185296.
   PubMed Web of Science ®Google Scholar
• Macho L, Fickova M, Zorad S, Knopp J. Changes of insulin and glucagon binding to receptors in hepatocytes during liver regeneration. Physiol Res. 1994;43(5):281–7. PMID:7711005.
   PubMed Web of Science ®Google Scholar
• Sato H, Terasaki T, Mizuguchi H, Okumura K, Tsuji A. Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver. Diabetologia. 1991;34(9):613–21. doi:10.1007/BF00400989.PMID:1955094.
   PubMed Web of Science ®Google Scholar
• Leffert HL, Koch KS, Moran T, Rubalcava B. Hormonal control of rat liver regeneration. Gastroenterology. 1979;76(6):1470–82. PMID:220134.
   PubMed Web of Science ®Google Scholar
• Kahn D, van Hoorn-Hickman R, Terblanche J, Child P. Transhepatic changes in insulin and glucagon following partial hepatectomy in the pig. Surg Gynecol Obstet. 1984;158(5):475–81.
   PubMedGoogle Scholar
• Martinez-Hernandez A, Amenta PS. The extracellular matrix in hepatic regeneration. FASEB J. 1995;9(14):1401–10. doi:10.1096/fasebj.9.14.7589981. PMID:7589981.
   PubMed Web of Science ®Google Scholar
• Scott CD, Baxter RC. Regulation of soluble insulin-like growth factor-II/mannose 6-phosphate receptor in hepatocytes from intact and regenerating rat liver. Endocrinology. 1996;137(9):3864–70. doi:10.1210/endo.137.9.8756558. PMID:8756558.
   PubMed Web of Science ®Google Scholar