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Original Research

Evaluation of the Effect of Topical Hypericum perforatum Oil on Excisional Palatal Wound Healing in Rabbits

ORCID Icon, , , , &
Pages 49-58 | Received 25 Feb 2018, Accepted 07 May 2018, Published online: 01 Jun 2018

REFERENCES

  • Kondo T. Timing of skin wounds. Leg Med. 2007;9(2):109–114. doi:10.1016/j.legalmed.2006.11.009. PMID:17275383.
  • Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen. 2014;22(5):569–578. doi:10.1111/wrr.12205. PMID:24942811.
  • Morelli T, Neiva R, Nevins ML, McGuire MK, Scheyer ET, Oh TJ, et al. Angiogenic biomarkers and healing of living cellular constructs. J Dent Res. 2011;90(4):456–462. doi:10.1177/0022034510389334. PMID:21248359.
  • Powell CA, Mealey BL, Deas DE, McDonnell HT, Moritz AJ. Post-surgical infections: prevalence associated with various periodontal surgical procedures. J Periodontol. 2005;76(3):329–333. doi:10.1902/jop.2005.76.3.329. PMID:15857064.
  • Tanideh N, Namazi F, Andisheh Tadbir A, Ebrahimi H, Koohi-Hosseinabadi O. Comparative assessment of the therapeutic effects of the topical and systemic forms of Hypericum perforatum extract on induced oral mucositis in golden hamsters. Int J Oral Maxillofac Surg. 2014;43(10):1286–92. doi:10.1016/j.ijom.2014.05.013. PMID:24948410.
  • Orhan IE, Kartal M, Gulpinar AR, et al. Inhibitory effect of St. Johns Wort oil macerates on TNFalpha-induced NF-kappaB activation and their fatty acid composition. J Ethnopharmacol. 2014;155(2):1086–1092. doi:10.1016/j.jep.2014.06.030. PMID:24993886.
  • Suntar IP, Akkol EK, Yilmazer D, Baykal T, Kirmizibekmez H, Alper M, et al. Investigations on the in vivo wound healing potential of hypericum perforatum L. J Ethnopharmacol. 2010;127(2):468–477. doi:10.1016/j.jep.2009.10.011. PMID:19833187.
  • Lavagna SM, Secci D, Chimenti P, Bonsignore L, Ottaviani A, Bizzarri B. Efficacy of hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. Farmaco. 2001;56(5–7):451–453. doi:10.1016/S0014-827X(01)01060-6. PMID:11482776.
  • Prisacaru AI, Andritoiu CV, Andriescu C, et al. Evaluation of the wound-healing effect of a novel Hypericum perforatum ointment in skin injury. Rom J Morphol Embryol. 2013;54(4):1053–9. PMID:24399001.
  • Mainetti S, Carnevali F. An experience with paediatric burn wounds treated with a plant-derived wound therapeutic. J Wound Care. 2013;22(12):681–682, 4–5, 8–9. doi:10.12968/jowc.2013.22.12.681. PMID:24335892.
  • Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM. Azithromycin and the risk of cardiovascular death. N Engl J Med. 2012;366(20):1881–1890. doi:10.1056/NEJMoa1003833. PMID:22591294.
  • Walker CB. Selected antimicrobial agents: mechanisms of action, side effects and drug interactions. Periodontol 2000. 1996;10:12–28. doi:10.1111/j.1600-0757.1996.tb00066.x. PMID:9567935.
  • Gurgan CA, Zaim E, Bakirsoy I, Soykan E. Short-term side effects of 0.2% alcohol-free chlorhexidine mouthrinse used as an adjunct to non-surgical periodontal treatment: a double-blind clinical study. J Periodontol. 2006;77(3):370–384. doi:10.1902/jop.2006.050141. PMID:16512751.
  • Bayer S, Kazancioglu HO, Acar AH, Demirtas N, Kandas NO. Comparison of laser and ozone treatments on oral mucositis in an experimental model. Lasers Med Sci. 2017;32(3):673–677. doi:10.1007/s10103-017-2166-1. PMID:28190112.
  • Keceli HG, Aylikci BU, Koseoglu S, Dolgun A. Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery. J Clin Periodontol. 2015;42(6):582–589. doi:10.1111/jcpe.12404. PMID:25892528.
  • Saglam M, Koseoglu S, Hatipoglu M, Esen HH, Koksal E. Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats. J Appl Oral Sci. 2015;23(1):33–41. doi:10.1590/1678-775720140288. PMID:25760266.
  • Ganzera M, Zhao J, Khan IA. Hypericum perforatum–chemical profiling and quantitative results of St. John's Wort products by an improved high-performance liquid chromatography method. Journal of pharmaceutical sciences. 2002;91(3):623–6230. doi:10.1002/jps.10057. PMID:11920747.
  • Orhan IE, Kartal M, Gulpinar AR, et al. Assessment of antimicrobial and antiprotozoal activity of the olive oil macerate samples of hypericum perforatum and their LC-DAD-MS analyses. Food Chem. 2013;138(2–3):870–875. doi:10.1016/j.foodchem.2012.11.053. PMID:23411190.
  • Wang X, Mi J, Dong Y, Yang J. Optimization of extraction process of hypericin from St. John's Wort by central composite design-response surface methodology. J Chem Pharm Res. 2014;6(7):1667–1675.
  • Avato P, Guglielmi G. Determination of major constituents in St. John's Wort under different extraction conditions. Pharmaceutical Biology. 2004;42(1):83–89. doi:10.1080/13880200490505663.
  • Li K, Diao Y, Zhang H, et al. Tannin extracts from immature fruits of terminalia chebula fructus retz. Promote cutaneous wound healing in rats. BMC Complement Altern Med. 2011;11:86. doi:10.1186/1472-6882-11-86. PMID:21982053.
  • Isacchi B, Bergonzi MC, Carnevali F, van der Esch SA, Vincieri FF, Bilia AR. Analysis and stability of the constituents of St. John's wort oils prepared with different methods. J Pharm Biomed Anal. 2007;45(5):756–761. doi:10.1016/j.jpba.2007.08.025. PMID:17920801.
  • Maisenbacher P, Kovar KA. Analysis and stability of hyperici oleum. Planta Med. 1992;58(4):351–354. doi:10.1055/s-2006-961483. PMID:1438595.
  • Rinastiti M, Harijadi, Santoso AL, Sosroseno W. Histological evaluation of rabbit gingival wound healing transplanted with human amniotic membrane. Int J Oral Maxillofac Surg. 2006;35(3):247–251. doi:10.1016/j.ijom.2005.09.012. PMID:16386878.
  • Romanos GE, Gladkova ND, Feldchtein FI, et al. Oral mucosa response to laser patterned microcoagulation (LPM) treatment. An animal study. Lasers Med Sci. 2013;28(1):25–31. doi:10.1007/s10103-011-1024-9.
  • Yasar M, Kaya A, Karaman H, et al. Potential curative role of hypericum perforatum in an experimental rat model of tympanic membrane perforation. J Int Adv Otol. 2016;12(3):252–256. doi:10.5152/iao.2016.1612. PMID:27487359.
  • Egilmez OK, Kokten N, Ekici AI, Kalcioglu MT, Yesilada E, Tekin M. The effect of Hypericum perforatum L. (St. John's Wort) on prevention of myringosclerosis after myringotomy in a rat model. Int J Pediatr Otorhinolaryngol. 2015;79(7):1128–1134. doi:10.1016/j.ijporl.2015.05.009. PMID:26022750.
  • Suntar I, Akkol EK, Keles H, Oktem A, Baser KH, Yesilada E. A novel wound healing ointment: a formulation of hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge. J Ethnopharmacol. 2011;134(1):89–96. doi:10.1016/j.jep.2010.11.061. PMID:21130859.
  • Farsak M, Ozdagli G, Ozmus D, et al. Effects of hypericum perforatum on an experimentally induced diabetic wound in a rat model. Wounds. 2017;29(2):E10–E17. PMID:28272017.
  • Altiparmak M, Eskitascioglu T. Comparison of systemic and topical hypericum perforatum on diabetic surgical wounds. J Invest Surg. 2018;31(1):29–37.
  • Arsic I, Zugic A, Tadic V, et al. Estimation of dermatological application of creams with St. John's Wort oil extracts. Molecules. 2011;17(1):275–294. doi:10.3390/molecules17010275. PMID:22205093.
  • Ramya, Kumar S. Expression of VEGF in periodontal tissues of type ii diabetes mellitus patients with chronic periodontitis -an immunohistochemical study. J Clin Diagn Res. 2014;8(8):ZC01–3. PMID:25302255.
  • Kiyan HT, Demirci B, Baser KH, Demirci F. The in vivo evaluation of anti-angiogenic effects of hypericum essential oils using the chorioallantoic membrane assay. Pharm Biol. 2014;52(1):44–50. doi:10.3109/13880209.2013.810647. PMID:24044783.
  • Billard C, Merhi F, Bauvois B. Mechanistic insights into the antileukemic activity of hyperforin. Curr Cancer Drug Targets. 2013;13(1):1–10. doi:10.2174/156800913804486601. PMID:22924417.
  • Lorusso G, Vannini N, Sogno I, et al. Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent. Eur J Cancer. 2009;45(8):1474–1784. doi:10.1016/j.ejca.2009.01.014. PMID:19223175.
  • Dell'Aica I, Niero R, Piazza F, et al. Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis. J Pharmacol Exp Ther. 2007;321(2):492–500. doi:10.1124/jpet.106.116459. PMID:17289834.
  • Schempp CM, Kiss J, Kirkin V, et al. Hyperforin acts as an angiogenesis inhibitor. Planta Med. 2005;71(11):999–1004. doi:10.1055/s-2005-871303. PMID:16320199.
  • Przybylski M. A review of the current research on the role of bFGF and VEGF in angiogenesis. J Wound Care. 2009;18(12):516–519. doi:10.12968/jowc.2009.18.12.45609. PMID:20081577.
  • Zaher M, Tang R, Bombarda I, Merhi F, Bauvois B, Billard C. Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa. Int J Oncol. 2012;40(1):269–276. PMID:21947285.
  • Merhi F, Tang R, Piedfer M, et al. Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells. PLoS One. 2011;6(10):e25963. doi:10.1371/journal.pone.0025963. PMID:21998731.
  • Hostanska K, Reichling J, Bommer S, Weber M, Saller R. Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines. European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2003;56(1):121–132. doi:10.1016/S0939-6411(03)00046-8.
  • Chiang IT, Chen WT, Tseng CW, et al. Hyperforin inhibits cell growth by inducing intrinsic and extrinsic apoptotic pathways in hepatocellular carcinoma cells. Anticancer Res. 2017;37(1):161–167. doi:10.21873/anticanres.11301. PMID:28011486.
  • Sun F, Liu JY, He F, et al. In-vitro antitumor activity evaluation of hyperforin derivatives. J Asian Nat Prod Res. 2011;13(8):688–699. doi:10.1080/10286020.2011.584532. PMID:21751836.
  • Schempp CM, Kirkin V, Simon-Haarhaus B, et al. Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis. Oncogene. 2002;21(8):1242–1250. doi:10.1038/sj.onc.1205190. PMID:11850844.
  • Novelli M, Menegazzi M, Beffy P, et al. St. John's wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic beta cells. The international journal of biochemistry & cell biology. 2016;81(Pt A):92–104. doi:10.1016/j.biocel.2016.10.017.
  • Hohmann MS, Cardoso RD, Fattori V, et al. Hypericum perforatum reduces paracetamol-induced hepatotoxicity and lethality in mice by modulating inflammation and oxidative stress. Phytother Res. 2015;29(7):1097–1101. doi:10.1002/ptr.5350. PMID:25851311.
  • Singh A, Naidu PS, Gupta S, Kulkarni SK. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. J Med Food. 2002;5(4):211–20. doi:10.1089/109662002763003366. PMID:12639396.
  • Bayramoglu G, Bayramoglu A, Engur S, Senturk H, Ozturk N, Colak S. The hepatoprotective effects of Hypericum perforatum L. on hepatic ischemia/reperfusion injury in rats. Cytotechnology. 2014;66(3):443–448. doi:10.1007/s10616-013-9595-x. PMID:23794084.
  • Sanchez-Reus MI, Gomez del Rio MA, Iglesias I, Elorza M, Slowing K, Benedi J. Standardized hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats. Neuropharmacology. 2007;52(2):606–616. doi:10.1016/j.neuropharm.2006.09.003. PMID:17070561.
  • Bozin B, Kladar N, Grujic N, et al. Impact of origin and biological source on chemical composition, anticholinesterase and antioxidant properties of some St. John's wort species (Hypericum spp., Hypericaceae) from the Central Balkans. Molecules. 2013;18(10):11733–11750. doi:10.3390/molecules181011733. PMID:24071982.
  • Paterniti I, Briguglio E, Mazzon E, et al. Effects of Hypericum Perforatum, in a rodent model of periodontitis. BMC Complement Altern Med. 2010;10:73. doi:10.1186/1472-6882-10-73. PMID:21092263.

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