132
Views
3
CrossRef citations to date
0
Altmetric
Original Research

Toll-Like Receptors -2, -3, -4 and -7 Expression Patterns in the Liver of a CLP-Induced Sepsis Mouse Model

, , , ORCID Icon, , , , , , & show all
Pages 109-117 | Received 21 Jan 2018, Accepted 11 May 2018, Published online: 30 May 2018

REFERENCES

  • Gad SC. Acute and chronic systemic chromium toxicity. Sci Total Environ. 1989;86:149–157. doi:10.1016/0048-9697(89)90201-5. PMID:2690338.
  • Vincent JL, Opal SM, Marshall JC, Tracey KJ. Sepsis definitions: time for change. Lancet. 2013;381:774–775. doi:10.1016/S0140-6736(12)61815-7. PMID:23472921.
  • Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. Am J Respir Crit Care Med. 2016;193:259–272. doi:10.1164/rccm.201504-0781OC. PMID:26414292.
  • Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. Bmj (Clin Res Ed.). 2016;353:i1585. PMID:27217054.
  • Toscano MG, Ganea D, Gamero AM. Cecal ligation puncture procedure. J of visualized experiments : JoVE. 2011; 7:e2860. doi:10.3791/2860. PMID:21587163.
  • Zanotti-Cavazzoni SL, Goldfarb RD. Animal models of sepsis. Crit Care Clin. 2009;25:703–719, vii-viii. doi:10.1016/j.ccc.2009.08.005.
  • Srivastava B, Gimson A. Hepatic changes in systemic infection. Best practice & research. Clin Gastroenterol. 2013;27:485–495. PMID:24090937.
  • Yan J, Li S, Li S. The role of the liver in sepsis. Int Rev Immunol. 2014;33:498–510. doi:10.3109/08830185.2014.889129. PMID:24611785.
  • Bauer M, Press AT, Trauner M. The liver in sepsis: patterns of response and injury. Curr Opin in Critical Care. 2013;19:123–127. doi:10.1097/MCC.0b013e32835eba6d. PMID:23448974.
  • Nesseler N, Launey Y, Aninat C, Morel F, Malledant Y, Seguin P. Clinical review: The liver in sepsis. Crit Care. 2012;16:235. doi:10.1186/cc11381. PMID:23134597.
  • Kim SJ, Park JS, Lee DW, Lee SM. Trichostatin A Protects Liver against Septic Injury through Inhibiting Toll-Like Receptor Signaling. Biomolecules & Ther. 2016;24:387–394. doi:10.4062/biomolther.2015.176.
  • Cook DN, Pisetsky DS, Schwartz DA. Toll-like receptors in the pathogenesis of human disease. Nat Immunol. 2004;5:975–979. doi:10.1038/ni1116. PMID:15454920.
  • Siednienko J, Miggin SM. Expression analysis of the Toll-like receptors in human peripheral blood mononuclear cells. Methods Mol Biol. 2009;517:3–14. doi:10.1007/978-1-59745-541-1_1. PMID:19378036.
  • Bakopoulos A, Kapelouzou A, Tsilimigras DI, et al. Expression of Toll-like receptors (TLRs) in the lungs of an experimental sepsis mouse model. Plos One. 2017;12:e0188050. doi:10.1371/journal.pone.0188050. PMID:29136027.
  • Williams DL, Ha T, Li C, et al. Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit Care Med. 2003;31:1808–1818. doi:10.1097/01.CCM.0000069343.27691.F3. PMID:12794424.
  • Liu S, Salyapongse AN, Geller DA, Vodovotz Y, Billiar TR. Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide. Shock (Augusta, Ga.). 2000;14:361–365. doi:10.1097/00024382-200014030-00021. PMID:11028557.
  • Hochhauser E, Avlas O, Fallach R, et al. Bone marrow and nonbone marrow Toll like receptor 4 regulate acute hepatic injury induced by endotoxemia. Plos One. 2013;8:e73041. doi:10.1371/journal.pone.0073041. PMID:23977376.
  • Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nature Protoc. 2009;4:31–36. doi:10.1038/nprot.2008.214. PMID:19131954.
  • Doerflinger M, Glab J, Puthalakath H. Experimental In Vivo Sepsis Models to Monitor Immune Cell Apoptosis and Survival in Laboratory Mice. Methods Mol Biol. 2016;1419:69–81. doi:10.1007/978-1-4939-3581-9_6. PMID:27108432.
  • Li H, Wang S, Zhan B, et al. Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice. Parasit Vectors. 2017;10:222. doi:10.1186/s13071-017-2162-0. PMID:28482922.
  • Liu X, Wang N, Wei G, et al. Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery. Int Immunopharmacol. 2016;32:66–75. doi:10.1016/j.intimp.2015.12.041. PMID:26802602.
  • Schick MA, Isbary JT, Stueber T, et al. Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents. BMC Gastroenterol. 2012;12:179. doi:10.1186/1471-230X-12-179. PMID:23245375.
  • Spapen H. Liver perfusion in sepsis, septic shock, and multiorgan failure. Anat Rec. 2008;291:714–720. doi:10.1002/ar.20646.
  • Dhainaut JF, Marin N, Mignon A, Vinsonneau C. Hepatic response to sepsis: interaction between coagulation and inflammatory processes. Crit Care Med. 2001;29:S42–47. doi:10.1097/00003246-200107001-00016. PMID:11445733.
  • Cao C, Chai Y, Shou S, Wang J, Huang Y, Ma T. Toll-like receptor 4 deficiency increases resistance in sepsis-induced immune dysfunction. Int Immunopharmacol. 2018;54:169–176. doi:10.1016/j.intimp.2017.11.006. PMID:29149705.
  • Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nature Rev Immunol. 2009;9:313–323. doi:10.1038/nri2515. PMID:19343057.
  • Koskinas J, Gomatos IP, Tiniakos DG, et al. Liver histology in ICU patients dying from sepsis: a clinico-pathological study. World J Gastroenterol. 2008;14:1389–1393. doi:10.3748/wjg.14.1389. PMID:18322953.
  • van Malenstein H, Wauters J, Mesotten D, et al. Molecular analysis of sepsis-induced changes in the liver: microarray study in a porcine model of acute fecal peritonitis with fluid resuscitation. Shock (Augusta, Ga.). 2010;34:427–436. doi:10.1097/SHK.0b013e3181dc41aa. PMID:20610940.
  • van Lieshout MH, van der Poll T, van't Veer C. TLR4 inhibition impairs bacterial clearance in a therapeutic setting in murine abdominal sepsis. Inflamm Res : Off J Eur Histamine Res Soc … [et al.]. 2014;63:927–933. doi:10.1007/s00011-014-0766-9.
  • Hu D, Yang X, Xiang Y, et al. Inhibition of Toll-like receptor 9 attenuates sepsis-induced mortality through suppressing excessive inflammatory response. Cell Immunol. 2015;295:92–98. doi:10.1016/j.cellimm.2015.03.009. PMID:25880099.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.