Liver Regeneration After Major Liver Resection for Hepatocellular Carcinoma in the Elderly

References

• Cannon RM, Martin RC, Callender GG, et al. Safety and efficacy of hepatectomy for colorectal metastases in the elderly. J Surg Oncol. 2011;104(7):804–808.
   PubMed Web of Science ®Google Scholar
• Cho SW, Steel J, Tsung A, et al. Safety of liver resection in the elderly: how important is age? Ann Surg Oncol. 2011;18(4):1088–1095.
   PubMed Web of Science ®Google Scholar
• Katsuta E, Tanaka S, Mogushi K, et al. Age-related clinicopathologic and molecular features of patients receiving curative hepatectomy for hepatocellular carcinoma. Am J Surg. 2014;208(3):450–456.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Zhang X, Zhang Z, et al. Hepatectomy in elderly patients: does age matter? World J Surg. 2013;37(12):2899–2910.
   PubMed Web of Science ®Google Scholar
• Hanazaki K, Kajikawa S, Shimozawa N, et al. Hepatic resection for hepatocellular carcinoma in the elderly. J Am Coll Surg. 2001;192(1):38–46.
   PubMed Web of Science ®Google Scholar
• Jaeck D, Bachellier P, Oussoultzoglou E, et al. Surgical resection of hepatocellular carcinoma. Post-operative outcome and long-term results in Europe: an overview. Liver Transpl. 2004;10(2 Suppl 1):S58–S63.
   PubMedGoogle Scholar
• Fukushima K, Fukumoto T, Kuramitsu K, et al. Assessment of ISGLS definition of posthepatectomy liver failure and its effect on outcome in patients with hepatocellular carcinoma. J Gastrointest Surg. 2014;18(4):729–736.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Kojima T, Murata M, et al. p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes. J Hepatol. 2005;42(5):707–718.
   PubMed Web of Science ®Google Scholar
• Wang X, Krupczak-Hollis K, Tan Y, et al. Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression. J Biol Chem. 2002;277(46):44310–44316.
   PubMed Web of Science ®Google Scholar
• Fry M, Silber J, Loeb LA, et al. Delayed and reduced cell replication and diminishing levels of DNA polymerase-alpha in regenerating liver of aging mice. J Cell Physiol. 1984;118(3):225–232.
   PubMed Web of Science ®Google Scholar
• Shirabe K, Takeishi K, Morita K, et al. Human early liver regeneration after hepatectomy in patients with hepatocellular carcinoma: special reference to age. Scand J Surg. 2013;102:101–105.
   PubMed Web of Science ®Google Scholar
• Schiergens TS, Stielow C, Schreiber S, et al. Liver resection in the elderly: significance of comorbidities and blood loss. J Gastrointest Surg. 2014;18(6):1161–1170.
   PubMed Web of Science ®Google Scholar
• Nakajima Y, Nagao M, Ko S, et al. Clinical predictors of recurrence site after hepatectomy for metastatic colorectal cancer. Hepatogastroenterology. 2001;48(42):1680–1684.
   PubMedGoogle Scholar
• Nakajima Y, Ko S, Kanamura T, et al. Repeat liver resection for hepatocellular carcinoma. J Am Coll Surg. 2001;192(3):339–344.
   PubMed Web of Science ®Google Scholar
• Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–213.
   PubMed Web of Science ®Google Scholar
• Rahbari NN, Garden OJ, Padbury R, et al. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011;149(5):713–724.
   PubMed Web of Science ®Google Scholar
• Ishizawa T, Hasegawa K, Kokudo N, et al. Risk factors and management of ascites after liver resection to treat hepatocellular carcinoma. Arch Surg. 2009;144(1):46–51.
   PubMedGoogle Scholar
• Koch M, Garden OJ, Padbury R, et al. Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery. Surgery. 2011;149(5):680–688.
   PubMed Web of Science ®Google Scholar
• Lin TY, Lee CS, Chen CC, et al. Regeneration of human liver after hepatic lobectomy studied by repeated liver scanning and repeated needle biopsy. Ann Surg. 1979;190(1):48–53.
   PubMed Web of Science ®Google Scholar
• Pomfret EA, Pomposelli JJ, Gordon FD, et al. Liver regeneration and surgical outcome in donors of right-lobe liver grafts. Transplantation. 2003;76(1):5–10.
   PubMed Web of Science ®Google Scholar
• Haga J, Shimazu M, Wakabayashi G, et al. Liver regeneration in donors and adult recipients after living donor liver transplantation. Liver. Liver Transpl. 2008;14(12):1718–1724.
   PubMed Web of Science ®Google Scholar
• Kamat A, Ghosh PM, Glover RL, et al. Reduced expression of epidermal growth factor receptors in rat liver during aging. J Gerontol A Biol Sci Med Sci. 2008;63(7):683–692.
   PubMed Web of Science ®Google Scholar
• Palmer HJ, Tuzon CT, Paulson KE. Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases. J Biol Chem. 1999;274(16):11424–11430.
   PubMed Web of Science ®Google Scholar
• Shirabe K, Motomura T, Takeishi K, et al. Human early liver regeneration after hepatectomy in patients with hepatocellular carcinoma: special reference to age. Scand J Surg. 2013;102:101–105.
   PubMed Web of Science ®Google Scholar
• Zhu C, Ikemoto T, Utsunomiya T, et al. Senescence-related genes possibly responsible for poor liver regeneration after hepatectomy in elderly patients. J Gastroenterol Hepatol. 2014;29(5):1102–1108.
   PubMed Web of Science ®Google Scholar
• Shimada M, Matsumata T, Maeda T, et al. Hepatic regeneration following right lobectomy: estimation of regenerative capacity. Surg Today. 1994;24(1):44–48.
   PubMed Web of Science ®Google Scholar
• Yamamoto K, Takenaka K, Matsumata T, et al. Right hepatic lobectomy in elderly patients with hepatocellular carcinoma. Hepatogastroenterology. 1997;44(14):514–518.
   PubMedGoogle Scholar
• Balzan S, Belghiti J, Farges O, et al. The “50-50 criteria” on postoperative day 5: an accurate predictor of liver failure and death after hepatectomy. Ann Surg. 2005;242(6):824–828; discussion 828–829.
   PubMed Web of Science ®Google Scholar
• Yamanaka N, Okamoto E, Kawamura E, et al. Dynamics of normal and injured human liver regeneration after hepatectomy as assessed on the basis of computed tomography and liver function. Hepatology. 1993;18(1):79–85.
   PubMed Web of Science ®Google Scholar
• Nagasue N, Yukaya H, Ogawa Y, et al. Human liver regeneration after major hepatic resection. A study of normal liver and livers with chronic hepatitis and cirrhosis. Ann Surg. 1987;206(1):30–39.
   PubMed Web of Science ®Google Scholar