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Journal of Investigative Surgery Volume 33, 2020 - Issue 7
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Original Research

The Effect of Shu Xue Tong Treatment on Random Skin Flap Survival via the VEGF-Notch/Dll4 Signaling Pathway

Chaoyang QiDepartment of Hand Surgery, The Second Affiliated Hospital Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China; ;Department of Trauma surgery, Zhejiang Tiantai People’s Hospital, Tiantai, ChinaView further author information
,
Yuting LinDepartment of Hand Surgery, The Second Affiliated Hospital Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China; Correspondence[email protected]
View further author information
&
Dingsheng LinDepartment of Hand Surgery, The Second Affiliated Hospital Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China; View further author information
Pages 615-620 | Published online: 15 Jan 2019

References

  • Xu L, Lin D, Cao B, Ping D. Effects of traditional Chinese medicine, dilong injection, on random skin flap survival in rats. J Invest Surg. 2018;31(1):38–43.
  • Yang M, Sheng L, Li H, Weng R, Li QF. Improvement of the skin flap survival with the bone marrow-derived mononuclear cells transplantation in a rat model. Microsurgery 2010;30(4):275–281.
  • Holzbach T, Neshkova I, Vlaskou D, et al. Searching for the right timing of surgical delay: angiogenesis, vascular endothelial growth factor and perfusion changes in a skin-flap model. J Plast Reconstr Aesthet Surg. 2009;62(11):1534–1542.
  • Yin GQ, Sun ZY. Investigation on the microcirculation effect of local application of natural hirudin on porcine random skin flap venous congestion. Cell Biochem Biophys. 2012;62(1):141–146.
  • Aparicio LM, Villaamil VM, Gallego GA, et al. Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study. Cancer Genomics Proteomics. 2011;8(2):93–101.
  • Lobov IB, Renard RA, Papadopoulos N, et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci USA. 2007;104(9):3219–3224.
  • Abbas OL, Borman H, Terzi YK, et al. Inhibition of the notch pathway promotes flap survival by inducing functional neoangiogenesis. Ann Plast Surg. 2015;75(4):455–462.
  • Tang Q, Jin H, Tong M, et al. Inhibition of Dll4/Notch1 pathway promotes angiogenesis of Masquelet's induced membrane in rats. Exp Mol Med. 2018;50(4):41.
  • Jin X, Shen G, Gao F, et al. Traditional Chinese drug ShuXueTong facilitates angiogenesis during wound healing following traumatic brain injury. J Ethnopharmacol. 2008;117(3):473–477.
  • Cai L, Huang W, Lin D. Effects of traditional Chinese medicine Shuxuetong injection on random skin flap survival in rats. ScientificWorldJournal. 2014;2014(1):1.
  • Mcfarlane RM, Deyoung G, Henry RA. The design of a pedicle flap in the rat to study necrosis and its prevention. Plast Reconstr Surg. 1965;35(2):177–182.
  • Xu PF, Fang MJ, Jin YZ, Wang LS, Lin DS. Effect of oxytocin on the survival of random skin flaps. Oncotarget. 2017;8(54):92955–92965.
  • Xiao-Xiao T, Sen-Min W, Ding-Sheng L. Effects of vinpocetine on random skin flap survival in rats. J Reconstr Microsurg. 2013;29(6):393–398.
  • Chen T, Tu Q, Cheng L, Li Z, Lin D. Effects of curculigoside A on random skin flap survival in rats. Eur J Pharmacol. 2018;834:281–287.
  • Lin Y, Lin B, Lin D, Huang G, Cao B. Effect of thymosin β4 on the survival of random skin flaps in rats. J Reconstr Microsurg. 2015;31(6):464–470.
  • Ren H, Lin D, Mou Z, Dong P. The adverse effect of selective cyclooxygenase-2 inhibitor on random skin flap survival in rats. PLoS One. 2013;8(12):e82802.
  • Zhang F, Brooks D, Chen W, Mustain W, Chen MB, Lineaweaver WC. Improvement of venous flap survival by application of vascular endothelial growth factor in a rat model. Ann Plast Surg. 2006;56(6):670–673.
  • Vourtsis SA, Papalois AE, Agrogiannis GD, Spyriounis PK, Patsouris E, Ionac M. Improvement of a long random skin flap survival by application of vascular endothelial growth factor in various ways of local administration in a rat model. Indian J Plast Surg. 2012;45(1):102–108.
  • Cai L, Cao B, Lin D. Effects of traditional Chinese medicine Huangqi Injection (Radix astragali) on random skin flap survival in rats. J Reconstr Microsurg. 2015;31(08):565–570.
  • Lin Y, Lin B, Lin D. Effects of morroniside on the viability of random skin flaps in rats. J Invest Surg. 2018 [Jun 5];[1–7]. [Epub ahead of print]. doi: 10.1080/08941939.2018.1479007
  • Kailiang Z, Yihui Z, Dingsheng L, Xianyao T. Effects of muscone on random skin flap survival in rats. J Reconst Microsurg. 2016;32(03):200–207.
  • Ehebauer M, Hayward P, Martinez-Arias A. Notch signaling pathway. Sci STKE. 2006;2006(364):cm7.
  • Liu R, Trindade A, Sun Z, et al. Inhibition of notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues. Biochem Biophys Res Commun. 2012;418(1):173–179.
  • Al Haj Zen A, Oikawa A, Bazan-Peregrino M, Meloni M, Emanueli C, Madeddu P. Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Circ Res. 2010;107(2):283–293.
  • Trindade A, Djokovic D, Gigante J, et al. Low-dosage inhibition of dll4 signaling promotes wound healing by inducing functional neo-angiogenesis. PLoS One. 2012;7(1):e29863.

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