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Original Research

Rapamycin Inhibits Nf-ΚB Activation by Autophagy to Reduce Catabolism in Human Chondrocytes

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REFERENCES

  • Giunta S, Castorina A, Marzagalli R, et al. Ameliorative effects of PACAP against cartilage degeneration. Morphological, immunohistochemical and biochemical evidence from in vivo and in vitro models of rat osteoarthritis. Int J Mol Sci. 2015;16(3):5922–5944.
  • Szychlinska MA, Trovato FM, Di Rosa M, et al. Co-expression and co-localization of cartilage glycoproteins CHI3L1 and lubricin in osteoarthritic cartilage: morphological, immunohistochemical and gene expression profiles. Int J Mol Sci. 2016;17(3):359.
  • Shane Anderson A, Loeser RF. Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol. 2010;24(1):15–26.
  • Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697–1707.
  • Musumeci G, Aiello FC, Szychlinska MA, Di Rosa M, Castrogiovanni P, Mobasheri A. Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression. Int J Mol Sci. 2015;16(3):6093–6112.
  • Musumeci G, Castrogiovanni P, Trovato FM, Weinberg AM, Alwasiyah MK, Alqahtani MH. Biomarkers of chondrocyte apoptosis and autophagy in osteoarthritis. IJMS. 2015;16(9):20560–20575.
  • Musumeci G, Mobasheri A, Trovato FM, et al. Biosynthesis of collagen I, II, RUNX2 and lubricin at different time points of chondrogenic differentiation in a 3D in vitro model of human mesenchymal stem cells derived from adipose tissue. Acta Histochem. 2014;116(8):1407–1417.
  • Chen D, Shen J, Zhao W, et al. Osteoarthritis: toward a comprehensive understanding of pathological mechanism . Bone Res. 2017;5:16044. (
  • Di Rosa M, Szychlinska MA, Tibullo D, Malaguarnera L, Musumeci G. Expression of CHI3L1 and CHIT1 in osteoarthritic rat cartilage model. a morphological study. Eur J Histochem. 2014;58(3):2423.
  • Ru LB, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015;11(1):35.
  • Tetlow LC, Adlam DJ, Woolley DE. Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis & Rheumatism. 2010;44(3):585–594.
  • Loeser RF. Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide. Arthritis Rheum. 2010;54(5):1357–1360.
  • Olivotto E, Otero M, Marcu KB, Goldring MB. Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation. RMD Open. 2015;1(1):e000061.
  • Cheleschi S, Palma AD, Pecorelli A, et al. Hydrostatic pressure regulates microrna expression levels in osteoarthritic chondrocyte cultures via the wnt/β-catenin pathway. IJMS. 2017;18(1):133.
  • Martínez-Borra J, López-Larrea C. Autophagy and self-defense. Advances in Experimental Medicine & Biology 2012;738:169–184.
  • Li YS, Zhang FJ, Zeng C, et al. Autophagy in osteoarthritis. Joint Bone Spine. 2016;83(2):143–148.
  • Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT. The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthr Cartil. 2001;9(2):85–91.
  • Musumeci G, Trovato FM, Pichler K, Weinberg AM, Loreto C, Castrogiovanni P. Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin expression. J Nutr Biochem. 2013;24(12):2064–2075.
  • Musumeci G, Castrogiovanni P, Trovato FM, et al. Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression. Scand J Med Sci Sports. 2015;25(2):e222–e230.
  • Wojdasiewicz P, Poniatowski ŁA, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm. 2014;2014(2):561459.
  • Wu X, Kondragunta V, Kornman KS, et al. Il-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort. Osteoarthr Cartil. 2013;21(7):930–938.
  • Santangelo KS, Nuovo GJ, Bertone AL. In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis. Osteoarthr Cartil. 2012;20(12):1610–1618.
  • Romanblas JA, Contrerasblasco MA, Largo R, Alvarezsoria MA, Castañeda S, Herrerobeaumont G. Differential effects of the antioxidant n-acetylcysteine on the production of catabolic mediators in il-1beta-stimulated human osteoarthritic synoviocytes and chondrocytes. Eur J Pharmacol. 2009;623(1):125–131.
  • Sandell LJ, Xing X, Franz C, Davies S, Chang LW, Patra D. Exuberant expression of chemokine genes by adult human articular chondrocytes in response to il-1beta. Osteoarthr Cartil. 2008;16(12):1560–1571.
  • Wang C, Zeng L, Zhang T, Liu J, Wang W. Tenuigenin prevents il-1β-induced inflammation in human osteoarthritis chondrocytes by suppressing pi3k/akt/nf-κb signaling pathway. Inflammation. 2016;39(2):1–6.
  • Schaefer JF, Millham ML, Crombrugghe BD, Buckbinder L. Fgf signaling antagonizes cytokine-mediated repression of sox9 in sw1353 chondrosarcoma cells. Osteoarthr Cartil. 2003;11(4):233–241.
  • YungChang L, Jayakumar T, Duann YF, et al. Chondroprotective role of sesamol by inhibiting mmps expression via retaining nf-κb signaling in activated sw1353 cells. J Agric Food Chem. 2011;59(9):4969–4978.
  • Tetsunaga T, Nishida K, Furumatsu T, et al. Regulation of mechanical stress-induced mmp-13 and adamts-5 expression by runx-2 transcriptional factor in sw1353 chondrocyte-like cells. Osteoarthr Cartil. 2011;19(2):222–232.
  • Cheng NT, Meng H, Ma LF, et al. Role of autophagy in the progression of osteoarthritis: the autophagy inhibitor, 3-methyladenine, aggravates the severity of experimental osteoarthritis. Int J Mol Med. 2017;39(5):1224–1232.
  • Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (dmm) model of osteoarthritis in the 129/svev mouse. Osteoarthr Cartil. 2007;15(9):1061–1069.
  • Caramés B, Hasegawa A, Taniguchi N, Miyaki S, Blanco FJ, Lotz M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis. Ann Rheum Dis. 2012;71(4):575.
  • Gu Z, Wei T, Ji J, et al. Rapamycin reverses the senescent phenotype and improves immuno-regulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway. Aging. 2017;8(5):1102–1114.
  • Verma P, Dalal K. ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis. J Cell Biochem. 2011;112(12):3507–3514.
  • Lefebvre V, Peeters-Joris C, Vaes G. Modulation by interleukin 1 and tumor necrosis factor α of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes. Biochim Biophys Acta. 1990;1052(3):366–378.
  • Calne RY, Collier DS, Lim S, et al. Rapamycin for immunosuppression in organ allografting. Lancet. 1989;2(8656):227.
  • Jiang LB, Meng DH, Lee SM, et al. Dihydroartemisinin inhibits catabolism in rat chondrocytes by activating autophagy via inhibition of the NF-κb pathway. Sci Rep. 2016;6:38979.
  • Dubey S, Yoon H, Cohen MS, Nagarkatti P, Nagarkatti M, Karan D. Withaferin a associated differential regulation of inflammatory cytokines. Front Immunol. 2018;9:195.
  • Rigoglou S, Papavassiliou AG. The NF- kappa b signalling pathway in osteoarthritis. Int J Biochem Cell Biol. 2013;45(11):2580–2584.
  • Guo B, Yang N, Borysiewicz E, et al. Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an nfкb-dependent pathway. Osteoarthr Cartil. 2015;23(11):1981–1988.
  • Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier J-P, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42.
  • Gao H, Lin L, Haq IU, Zeng SM. Inhibition of NF-κb promotes autophagy via JNK signaling pathway in porcine granulosa cells. Biochem Biophys Res Commun. 2016;473(1):311–316.
  • Wang P, Mao Z, Pan Q, et al. Histone deacetylase-4 and histone deacetylase-8 regulate interleukin-1β-induced cartilage catabolic degradation through MAPK/JNK and ERK pathways. Int J Mol Med. 2018;41(4):2117–2127.
  • Corr M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol. 2008;4(10):550–556.

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