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Commentary

Apoptosis and Autophagy in the Pathogenesis of Osteoarthritis

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References

  • Musumeci G, Carnazza ML, Leonardi R, Loreto C. Expression of β-defensin-4 in “in vivo and ex vivo model" of human osteoarthritic knee meniscus”. Knee Surg Sports Traumatol Arthrosc. 2012;20(2):216–222.
  • Musumeci G, Loreto C, Carnazza ML, Martinez G. Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2011;19(2):307–313.
  • Zamli Z, Sharif M. Chondrocyte apoptosis: A cause or consequence of osteoarthritis? Int J Rheum Dis. 2011;14(2):159–166.
  • Musumeci G, Loreto C, Carnazza ML, Strehin I, Elisseeff J. OA cartilage derived chondrocytes encapsulated in poly(ethylene glycol) diacrylate (PEGDA) for the evaluation of cartilage restoration and apoptosis in an in vitro model. Histol Histopathol. 2011; 26:1265–1278.
  • Wu GJ, Chen TG, Chang HC, et al. Nitric oxide from both exogenous and endogenous sources activates mitochondria-dependent events and induces insults to human chondrocytes. J Cell Biochem. 2007;101(6):1520–1531.
  • Kim SJ, Hwang SG, Shin DY, Kang SS, Chun JS. P38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J Biol Chem. 2002;277(36):33501–33508.
  • Almonte-Becerril M, Navarro-Garcia F, Gonzalez-Robles A, et al. Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model. Apoptosis 2010;15(5):631–638.
  • Musumeci G, Castrogiovanni P, Trovato FM, et al. Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis. Int J Mol Sci. 2015;16(9):20560–20575.
  • Liu Y, Li X, Jin A. Rapamycin inhibits NF-κB activation by autophagy to reduce catabolism in human chondrocytes. J Invest Surg. 2019;33(9):861–873.
  • Takayama K, Kawakami Y, Kobayashi M, et al. Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis. Arthritis Res Ther 2014;16:482.

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