Evaluation of Cholestyramine 15% Ointment in Relieving Pruritus and Burning After Ileostomy: A Rrandomized, Double-Blind Placebo-Controlled Clinical Trial

References

• Cima RR, Pemberton JH. Medical and surgical management of chronic ulcerative colitis. Arch Surg. 2005;140(3):300–310.
   PubMedGoogle Scholar
• Andersson P, Söderholm JD. Surgery in ulcerative colitis: indication and timing. Dig Dis. 2009;27(3):335–340. doi:10.1159/000228570.
   PubMed Web of Science ®Google Scholar
• Bernstein CN, Ng SC, Lakatos PL. A review of mortality and surgery in ulcerative colitis: milestones of the seriousness of the disease. Inflamm Bowel Dis. 2013;19(9):2001–2010. doi:10.1097/MIB.0b013e318281f3bb.
   PubMed Web of Science ®Google Scholar
• Halfvarson J, Järnerot G. Treatment of choice for acute severe steroid-refractory ulcerative colitis is remicade. Inflamm Bowel Dis. 2009;15(1):143–145. doi:10.1002/ibd.20782.
   PubMed Web of Science ®Google Scholar
• Hurst RD, Finco C, Rubin M, Michelassi F. Prospective analysis of perioperative morbidity in one hundred consecutive colectomies for ulcerative colitis. Surgery. 1995;118(4):748–755. doi:10.1016/S0039-6060(05)80045-5.
   PubMed Web of Science ®Google Scholar
• Windsor A, Michetti P, Bemelman W, Ghosh S. The positioning of colectomy in the treatment of ulcerative colitis in the era of biologic therapy. Inflamm Bowel Dis. 2013;19(12):2695–2703. doi:10.1097/MIB.0b013e318292fae6.
   PubMed Web of Science ®Google Scholar
• Kock NG. Intra-abdominal reservoir in patients with permanent ileostomy: preliminary observations on a procedure resulting in fecal continence in five ileostomy patients. Arch Surg. 1969;99(2):223–231. doi:10.1001/archsurg.1969.01340140095014.
   PubMedGoogle Scholar
• Holubar SD, Larson DW, Dozois EJ, Pattana-Arun J, Pemberton JH, Cima RR. Minimally invasive subtotal colectomy and ileal pouch-anal anastomosis for fulminant ulcerative colitis: a reasonable approach? Dis Colon Rectum. 2009;52(2):187–192.
   PubMed Web of Science ®Google Scholar
• Edwards D, Leppington‐Clarke A, Sexton R, Heald R, Moran B. Stoma-related complications are more frequent after transverse colostomy than loop ileostomy: a prospective randomized clinical trial . Br J Surg. 2001;88(3):360–363.
   PubMed Web of Science ®Google Scholar
• Park JJ, Del Pino A, Orsay CP, et al. Stoma complications: the Cook County Hospital experience. Dis Colon Rectum. 1999;42(12):1575–1580.
   PubMed Web of Science ®Google Scholar
• Leong A, Londono‐Schimmer E, Phillips R. Life-table analysis of stomal complications following ileostomy . Br J Surg. 1994;81(5):727–729.
   PubMed Web of Science ®Google Scholar
• Feinberg SM, McLeod RS, Cohen Z. Complications of loop ileostomy. Am J Surg. 1987;153(1):102–107.
   PubMed Web of Science ®Google Scholar
• Palmer RH, Glickman PB, Kappas A. Pyrogenic and inflammatory properties of certain bile acids in man. J Clin Invest. 1962;41(8):1573–1577.
   PubMed Web of Science ®Google Scholar
• Gracey M, Papadimitriou J, Burke V, Thomas J, Bower G. Effects on small-intestinal function and structure induced by feeding a deconjugated bile salt. Gut. 1973;14(7):519–528. doi:10.1136/gut.14.7.519.
   PubMed Web of Science ®Google Scholar
• Teem MV, Phillips SF. Perfusion of the hamster jejunum with conjugated and unconjugated bile acids: inhibition of water absorption and effects on morphology. Gastroenterology. 1972;62(2):261–267.
   PubMed Web of Science ®Google Scholar
• Bertolotti M, Abate N, Loria P. Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7 alpha-hydroxylation rates in vivo. Hepatology. 1991;14(5):830–837.
   PubMed Web of Science ®Google Scholar
• Miyata M, Yamakawa H, Hayashi K, Kuribayashi H, Yamazoe Y, Yoshinari K. Ileal apical sodium-dependent bile acid transporter protein levels are down-regulated through ubiquitin-dependent protein degradation induced by bile acids. Eur J Pharmacol. 2013;714(1-3):507–514. doi:10.1016/j.ejphar.2013.06.036.
   PubMed Web of Science ®Google Scholar
• Vlahcevic ZR, Heuman DM, Hylemon PB. Regulation of bile acid synthesis. Hepatology. 1991;13(3):590–600.
   PubMed Web of Science ®Google Scholar
• Ala S, Eshghi F, Enayatifard R, Fazel P, Rezaei B, Hadianamrei R. Efficacy of cholestyramine ointment in reduction of postoperative pain and pain during defecation after open hemorrhoidectomy: results of a prospective, single-center, randomized, double-blind, placebo-controlled trial. World J Surg. 2013;37(3):657–662. doi:10.1007/s00268-012-1895-3.
   PubMed Web of Science ®Google Scholar
• Boiko S. Treatment of diaper dermatitis. Dermatol Clin. 1999;17(1):235–240.
   PubMed Web of Science ®Google Scholar
• Møller P, Lohmann M, Brynitz S. Cholestyramine ointment in the treatment of perianal skin irritation following ileoanal anastomosis. Dis Colon Rectum. 1987;30(2):106–107. doi:10.1007/BF02554944.
   PubMed Web of Science ®Google Scholar
• Rodriguez J, Huang T, Ferry G, Klish W, Harberg F, Nichols B. Treatment of skin irritation around enterostomies with cholestyramine ointment. J Pediatr. 1976;88(4):659–661. doi:10.1016/S0022-3476(76)80031-5.
   PubMed Web of Science ®Google Scholar
• Bell SN, Varigos GA. Treatment of skin irritations around biliary fistulas with cholestyramine. Br J Surg. 1980;67(11):785
   PubMed Web of Science ®Google Scholar
• White CM, Gailey RA, Lippe S. Cholestyramine ointment to treat buttocks rash and anal excoriation in an infant. Ann Pharmacother. 1996;30(9):954–956.
   PubMed Web of Science ®Google Scholar
• White CM, Kalus JS, Caron MF, Suski K. Cholestyramine ointment used on an infant for severe buttocks rash resistant to standard therapeutic modalities. J Pharm Technol. 2003;19(1):11–13. doi:10.1177/875512250301900104.
   Google Scholar
• Revision USPCCo, editor The United States Pharmacopeia1984: United States Pharmacopeial Convention, Incorporated.
   Google Scholar
• Reamy BV, Bunt CW, Fletcher S. A diagnostic approach to pruritus. Am Fam Physician. 2011;84(2):195–202.
   PubMed Web of Science ®Google Scholar
• Charlesworth EN, Beltrani VS. Pruritic dermatoses: overview of etiology and therapy. Am J Med. 2002;113(9):25–33. doi:10.1016/S0002-9343(02)01434-1.
   Google Scholar
• Pearl RK, Prasad ML, Orsay CP, Abcarian H, Tan AB, Melzl MT. Early local complications from intestinal stomas. Arch Surg. 1985;120(10):1145–1147.
   PubMedGoogle Scholar
• Thomson H, Hill D. Solitary rectal ulcer: Always a self-induced condition? Br J Surg. 1980;67(11):784–785.
   PubMed Web of Science ®Google Scholar
• Merrick M. Bile acid malabsorption. Clinical presentations and diagnosis. Dig Dis. 1988;6(3):159–169.
   PubMed Web of Science ®Google Scholar
• Scheinfeld N. Diaper dermatitis. Am J Clin Dermatol. 2005;6(5):273–281. doi:10.2165/00128071-200506050-00001.
   PubMed Web of Science ®Google Scholar
• Sa G, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219–229. doi:10.1177/0022034509359125.
   PubMed Web of Science ®Google Scholar