The Healing Effects of Thymoquinone and Dexpanthenol in Sciatic Nerve Compression Injury in Rats

References

• Ramli K, Gasim AI, Ahmad AA, et al. Efficacy of human cell-seeded muscle-stuffed vein conduit in rat sciatic nerve repair. Tissue Eng Part A. 2019. doi:10.1089/ten.TEA.2018.0279.
   PubMed Web of Science ®Google Scholar
• Ozturk O, Tezcan AH, Adali Y, et al. Effect of ozone and methylprednisolone treatment following crush type sciatic nerve injury. Acta Cir Bras. 2016;31:730–735. doi:10.1590/s0102-865020160110000005.
   PubMed Web of Science ®Google Scholar
• Tokmak M, Sehitoglu MH, Yuksel Y, et al. The axon protective effects of syringic acid on ischemia/reperfusion injury in a rat sciatic nerve model. Turk Neurosurg. 2017;27:124–132.
   PubMed Web of Science ®Google Scholar
• Guy R, Grynspan F, Ben-Zur T, et al. Human muscle progenitor cells overexpressing neurotrophic factors improve neuronal regeneration in a sciatic nerve injury mouse model. Front Neurosci. 2019;13:151.
   PubMed Web of Science ®Google Scholar
• Lan SM, Yang CC, Lee CL, et al. The effect of molecular weight and concentration of hyaluronan on the recovery of the rat sciatic nerve sustaining acute traumatic injury. Biomed Mater. 2017;12:045024. doi:10.1088/1748-605X/aa6f1a.
   PubMed Web of Science ®Google Scholar
• Ni XJ, Wang XD, Zhao YH, et al. The effect of low-intensity ultrasound on brain-derived neurotropic factor expression in a rat sciatic nerve crushed injury model. Ultrasound Med Biol. 2017;43:461–468. doi:10.1016/j.ultrasmedbio.2016.09.017.
   PubMed Web of Science ®Google Scholar
• Wang G, Wu W, Yang H, et al. Intact polyaniline coating as a conductive guidance is beneficial to repairing sciatic nerve injury. J Biomed Mater Res B Appl Biomater. 2019. doi:10.1002/jbm.b.34372.
   Web of Science ®Google Scholar
• Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, et al. Thymoquinone and its therapeutic potentials. Pharmacol Res. 2015;95–96:138–158. doi:10.1016/j.phrs.2015.03.011.
   PubMed Web of Science ®Google Scholar
• Kassab RB, El-Hennamy RE. The role of thymoquinone as a potent antioxidant in ameliorating the neurotoxic effect of sodium arsenate in female rat. Egypt J Basic Appl Sci. 2017;4:160–167. doi:10.1016/j.ejbas.2017.07.002.
   Google Scholar
• Pehlivanlı F, Aydin O, Karaca G, et al. Healing of ischemic colon anastomosis in rats could be provided by administering dexpanthenol or coenzyme Q10. J Clin Med. 2018;7(7):161. doi:10.3390/jcm7070161.
   Web of Science ®Google Scholar
• Cui Y, Li J, Zhu Y, et al. The neuroprotective effects of aspirin following crush injury to rat sciatic nerve. Int J Clin Exp Med. 2015;8:18185–18190.
   PubMed Web of Science ®Google Scholar
• Kizilay Z, Aktas S, Kahraman Cetin N, et al. Effect of systemic application of bone marrow-derived mesenchymal stem cells on healing of peripheral nerve injury in an experimental sciatic nerve injury model. Turk Neurosurg. 2018;28:654–662.
   Web of Science ®Google Scholar
• Sung MA, Jung HJ, Lee JW, et al. Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves. Neural Regen Res. 2012;7:2018–2027.
   PubMed Web of Science ®Google Scholar
• Abukhader MM. The effect of route of administration in thymoquinone toxicity in male and female rats. Indian J Pharm Sci. 2012;74:195–200. doi:10.4103/0250-474X.106060.
   PubMed Web of Science ®Google Scholar
• Emel E, Ergün SS, Kotan D, et al. Effects of insulin-like growth factor-I and platelet-rich plasma on sciatic nerve crush injury in a rat model. JNS. 2011;114:522–528. doi:10.3171/2010.9.JNS091928.
   PubMed Web of Science ®Google Scholar
• Bridge PM, Ball DJ, Mackinnon SE, et al. Nerve crush injuries – a model for axonotmesis. Exp Neurol. 1994;127:284–290. doi:10.1006/exnr.1994.1104.[PMC] [8033968]
   PubMed Web of Science ®Google Scholar
• Bauder AR, Ferguson TA. Reproducible mouse sciatic nerve crush and subsequent assessment of regeneration by whole mount muscle analysis. J Vis Exp. 2012. doi:10.3791/3606.
   PubMed Web of Science ®Google Scholar
• Cavalcante Miranda de Assis D, Martins Lima Ê, Teixeira Goes B, et al. The parameters of transcutaneous electrical nerve stimulation are critical to its regenerative effects when applied just after a sciatic crush lesion in mice. Biomed Res Int. 2014;2014:1. doi:10.1155/2014/572949.
   Web of Science ®Google Scholar
• Raginov IS, Egorov VI, Valiullin LR, et al. Morphological and functional evaluation of the effect of novel pyrimidine derivatives on regeneration of the sciatic nerve in rats. Neurosci Lett. 2019;706:110–113. doi:10.1016/j.neulet.2019.05.008.
   PubMed Web of Science ®Google Scholar
• Zhao YH, Zhang SJ, Yang ZH, et al. Relationship of distraction rate with inferior alveolar nerve degeneration-regeneration shift. Neural Regen Res. 2018;13:360–365. doi:10.4103/1673-5374.226426.
   PubMed Web of Science ®Google Scholar
• Raimondo S, Fornaro M, Di Scipio F, et al. Chapter 5: Methods and protocols in peripheral nerve regeneration experimental research: Part II – morphological techniques. Int Rev Neurobiol. 2009;87:81–103.
   PubMed Web of Science ®Google Scholar
• Vleggeert-Lankamp CL. The role of evaluation methods in the assessment of peripheral nerve regeneration through synthetic conduits: a systematic review. Laboratory investigation. JNS. 2007;107:1168–1189. doi:10.3171/JNS-07/12/1168.
   Google Scholar
• de Medinaceli L, Freed WJ, Wyatt RJ. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol. 1982;77:634–643. doi:10.1016/0014-4886(82)90234-5.
   PubMed Web of Science ®Google Scholar
• Khan MA, Younus H. Thymoquinone shows the diverse therapeutic actions by modulating multiple cell signaling pathways: single drug for multiple targets. CPB. 2019;19:934–945. doi:10.2174/1389201019666181113122009.
   Google Scholar
• Velagapudi R, Kumar A, Bhatia HS, et al. Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling. Int Immunopharmacol. 2017;48:17–29. doi:10.1016/j.intimp.2017.04.018.
   PubMed Web of Science ®Google Scholar
• Erkut A, Cure MC, Kalkan Y, et al. Protective effects of thymoquinone and alpha-tocopherol on the sciatic nerve and femoral muscle due to lower limb ischemia-reperfusion injury. Eur Rev Med Pharmacol Sci. 2016;20:1192–1202.
   PubMed Web of Science ®Google Scholar
• Schneider-Stock R, Fakhoury IH, Zaki AM, et al. Thymoquinone: fifty years of success in the battle against cancer models. Drug Discov Today. 2014;19:18–30. doi:10.1016/j.drudis.2013.08.021.
   PubMed Web of Science ®Google Scholar
• Karadag A, Ozdemir R, Kurt A, et al. Protective effects of dexpanthenol in an experimental model of necrotizing enterocolitis. J Pediatr Surg. 2015;50:1119–1124. doi:10.1016/j.jpedsurg.2014.10.053.
   PubMed Web of Science ®Google Scholar
• Li-Mei W, Jie T, Shan-He W, et al. Anti-inflammatory and anti-oxidative effects of dexpanthenol on lipopolysaccharide induced acute lung injury in mice. Inflammation. 2016;39:1757–1763. doi:10.1007/s10753-016-0410-7.
   PubMed Web of Science ®Google Scholar
• Slyshenkov VS, Dymkowska D, Wojtczak L. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004;569:169–172. doi:10.1016/j.febslet.2004.05.044.
   PubMed Web of Science ®Google Scholar