Combination Therapy of Allopurinol and Dantrolene and Its Role In The Prevention of Experimental Ischemia Reperfusion Injury Of The Small Intestine

References

• Castaneda MP, Swiatecka-Urban A, Mitsnefes MM, et al. Activation of mitochondrial apoptotic pathways in human renal allografts after ischemia reperfusion injury. Transplant. 2003;76(1):50–54. doi:10.1097/01.TP.0000069835.95442.9F.
   PubMed Web of Science ®Google Scholar
• Devarajan P. Update on mechanisms of ischemic acute kidney injury. JASN. 2006;17(6):1503–1520. doi:10.1681/ASN.2006010017.
   Web of Science ®Google Scholar
• Lalkovicová M, Danielisová V. Neuroprotection and antioxidants. Neural Regen Res. 2016;11:865–874. doi:10.4103/1673-5374.184447.
   PubMed Web of Science ®Google Scholar
• Belda-Antolí M, Padrón-Sanz C, Cejalvo-Lapeña D, et al. Antioxidant potential of Himanthalia elongata for protection against ischemia-reperfusion injury in the small bowel. Surgery. 2017;162(3):577–585. doi:10.1016/j.surg.2017.04.017.
   PubMed Web of Science ®Google Scholar
• Maslov LN, Naryzhnaya NV, Podoksenov YK, et al. Signaling mechanism of cardioprotective effect of reactive oxygen species. Ros Fiziol ZH Im I M Sechenva. 2015;101(4):377–385.
   PubMedGoogle Scholar
• Bhattacharyya A, Chattopadhyay R, Mitra S, et al. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014;94(2):329–354. doi:10.1152/physrev.00040.2012.
   PubMed Web of Science ®Google Scholar
• Akinrinmade FJ, Akinrinde AS, Soyemi OO, et al. Antioxidant potential of the methanol extract of Parquetina nigrescens mediates protection against intestinal ischemia-reperfusion injury in rats. J Diet Suppl. 2016;13(4):420–432. doi:10.3109/19390211.2015.1103828.
   PubMedGoogle Scholar
• Khadaroo RG, Churchill TA, Tso V, et al. Metabolomic profiling to characterize acute intestinal ischemia/reperfusion injury. PLoS ONE. 2017;12(6):e0179326. doi:10.1371/journal.pone.0179326.
   PubMed Web of Science ®Google Scholar
• Holzerová E, Prokisch H. Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production? Int J Biochem Cell Biol. 2015;63:16–20. doi:10.1016/j.biocel.2015.01.021.
   PubMed Web of Science ®Google Scholar
• Bianciardi P, Scorza R, Ghilardi G, et al. Xanthine oxido-reductase activity in ischemic human and rat intestine. Free Radic Res. 2004;38(9):919–925. doi:10.1080/10715760412331273430.
   PubMed Web of Science ®Google Scholar
• Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol. 2002;282(2):C227–41. doi:10.1152/ajpcell.00112.2001.
   PubMed Web of Science ®Google Scholar
• Sasaki M, Joh T. Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents. J Clin Biochem Nutr. 2007;40(1):1–12. doi:10.3164/jcbn.40.1.
   PubMed Web of Science ®Google Scholar
• Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox Biol. 2015;6:524–551. doi:10.1016/j.redox.2015.08.020.
   PubMed Web of Science ®Google Scholar
• Murrel GAC, Rapeport WG. Clinical pharmacokinetics of allopurinol. Clin Pharmacokinet. 1986;11:343–353. doi:10.2165/00003088-198611050-00001.
   PubMed Web of Science ®Google Scholar
• Prieto-Moure B, Caraben-Redaño A, Aliena-Valero A, et al. Allopurinol in renal ischemia. J Invest Surg. 2014;27(5):304–316. doi:10.3109/08941939.2014.911395.
   PubMed Web of Science ®Google Scholar
• Messiha BA, Abo-Youssef AM. Protective effects of fish oil, allopurinol, and verapamil on hepatic ischemia-reperfusion injury in rats. J Nat Sci Biol Med. 2015;6(2):351–355. doi:10.4103/0976-9668.160003.
   PubMedGoogle Scholar
• Prieto-Moure B, Lloris-Carsí JM, Belda-Antolí M, et al. Allopurinol protective effect of renal ischemia by downregulating TNF-α, IL-1β and IL-6 response. J Invest Surg. 2016;3:1–9.
   Google Scholar
• Grootjans J, Lenaerts K, Buurman WA, et al. Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion. WJG. 2016;22(9):2760–2770. doi:10.3748/wjg.v22.i9.2760.
   PubMed Web of Science ®Google Scholar
• Sapalidis K, Papavramidis TS, Gialamas E, et al. The role of allopurinol's timing in the ischemia reperfusion injury of small intestine. J Emerg Trauma Shock. 2013;6:203–208. doi:10.4103/0974-2700.115346.
   PubMedGoogle Scholar
• López-Neblina F, Toledo-Pereyra LH, Toledo AH, et al. Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10. J Surg Res. 2007;140(1):121–128. doi:10.1016/j.jss.2006.12.003.
   PubMed Web of Science ®Google Scholar
• Seidlmayer LK, Juettner VV, Kettlewell S, et al. Distinct mPTP activation mechanisms in ischaemia-reperfusion: contributions of Ca2+, ROS, pH, and inorganic polyphosphate. Cardiovasc Res. 2015;106(2):237–248. doi:10.1093/cvr/cvv097.
   PubMed Web of Science ®Google Scholar
• Mohammed NE, Messiha BA, Abo-Saif AA. Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats. Saudi Pharm J. 2016;24(6):635–644. doi:10.1016/j.jsps.2015.04.004.
   PubMed Web of Science ®Google Scholar
• Ozkan OV, Yuzbasioglu MF, Ciralik H, et al. Resveratrol, a natural antioxidant, attenuates intestinal ischemia/reperfusion injury in rats. Tohoku J Exp Med. 2009;218(3):251–258. doi:10.1620/tjem.218.251.
   PubMed Web of Science ®Google Scholar
• Chiu C, McArdle AH, Brown R, et al. Intestinal mucosal lesion in low flow states: a morphological, hemodynamic, and metabolic reappraisal. Arch Surg. 1970;101(4):478–483. doi:10.1001/archsurg.1970.01340280030009.
   PubMedGoogle Scholar
• Park PO, Haglund U, Bulkley GB, et al. The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion. Surgery. 1990;107(5):574–580.
   PubMed Web of Science ®Google Scholar
• Zanoni FL, Benabou S, Greco KV, et al. Mesenteric microcirculatory dysfunctions and translocation of indigenous bacteria in a rat model of strangulated small bowel obstruction. Clinics. 2009;64(9):911–919. doi:10.1590/S1807-59322009000900013.
   PubMed Web of Science ®Google Scholar
• Paterno F, Longo WE. The etiology and pathogenesis of vascular disorders of the intestine. Radiol Clin North Am. 2008;46(5):877–885. doi:10.1016/j.rcl.2008.06.005.
   PubMed Web of Science ®Google Scholar
• Sayan-Ozacmack H, Ozacmak VH, Turan I, et al. Pretreatment with remifentanil protects against the reduced-intestinal contractility related to the ischemia and reperfusion injury in rat. Braz J Anesthesiol. 2015;65:483–490. doi:10.1016/j.bjane.2013.09.007.
   PubMedGoogle Scholar
• Rubattu S, Pagliaro B, Pierelli G, et al. Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress. IJMS. 2014;16(1):823–839. doi:10.3390/ijms16010823.
   Google Scholar
• Kalia N, Wood RF, Pockley AG, et al. Mucosal villus microcirculatory disturbances associated with rat intestinal ischaemia-reperfusion injury are not prevented by tacrolimus. Digestion. 2003;67(3):154–160. doi:10.1159/000071295.
   PubMed Web of Science ®Google Scholar
• Riveros E, Pérez I, Becerra K, et al. El pretratamiento con alopurinol disminuye la translocación bacteriana y atenúa los cambios morfológicos de la mucosa intestinal en un modelo de isquemia - reperfusión intestinal en ratas. Rev Colomb Cir. 2012;27:227–234.
   Google Scholar
• Giménez-Crouseilles J, Puig-Parellada P. Puig-Parellada, P. Pharmacologically induced ischemia-reperfusion syndrome in the rat small intestine. J Surg Res. 2011;168(1):34–41. doi:10.1016/j.jss.2010.02.022.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Pan C, Wang HZ, et al. Protective effects of osthole on intestinal ischemia-reperfusion injury in mice. Exp Clin Transplant. 2014;12(3):246–252.
   PubMed Web of Science ®Google Scholar
• Prieto-Moure B, Lloris-Carsí JM, Barrios-Pitarque C, et al. Pharmacology of ischemia-reperfusion. Translational research considerations. J Invest Surg. 2016;29(4):234–249. doi:10.3109/08941939.2015.1119219.
   PubMed Web of Science ®Google Scholar
• Li Y, Cao TT, Guo S, et al. Discovery of novel allopurinol derivatives with anticancer activity and attenuated xanthine oxidase inhibition. Molecules. 2016;21(6):771. doi:10.3390/molecules21060771.
   PubMed Web of Science ®Google Scholar
• Büyükokuroğlu ME, Taysi S, Polat F, et al. Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats. Pharmacol Res. 2002;45(5):421–425. doi:10.1006/phrs.2002.0951.
   PubMed Web of Science ®Google Scholar
• Chauhan SS, Ojha S, Mahmood A. Modulation of lipid peroxidation and antioxidant defense systems in rat intestine by subchronic fluoride and ethanol administration. Alcohol. 2011;45(7):663–672. doi:10.1016/j.alcohol.2010.10.008.
   PubMed Web of Science ®Google Scholar
• Liu XH, Yang YW, Dai HT, et al. Protective role of adiponectin in a rat model of intestinal ischemia reperfusion injury. WJG. 2015;21(47):13250–13258. doi:10.3748/wjg.v21.i47.13250.
   PubMed Web of Science ®Google Scholar
• De la Lastra CA, Villegas I. Resveratrol as an antioxidant and pro-oxidant agent: Mechanisms and clinical implications. Biochem Soc Trans. 2007;35:1156–1160. doi:10.1042/BST0351156.
   PubMed Web of Science ®Google Scholar
• El-Habit OHM, Saada HN, Azab KS, et al. The modifying effect of β-carotene on gamma radiation-induced elevation of oxidative reactions and genotoxicity in male rats. Mutat Res-Fund Mol M. 2000;466(2):179–186. doi:10.1016/S1383-5718(00)00010-3.
   PubMed Web of Science ®Google Scholar
• Wang ZZ, Zhao WJ, Zhang XS, et al. Protection of Veratrum nigrum L. var. ussuriense Nakai alkaloids against ischemia-reperfusion injury of the rat liver. WJG. 2007;13(4):564–571. doi:10.3748/wjg.v13.i4.564.
   PubMed Web of Science ®Google Scholar
• De-Faria FM, Almeida AC, Luiz-Ferreira A, et al. Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat. Sci World J. 2012;2012:1. doi:10.1100/2012/327071.
   Google Scholar
• Tas U, Ayan M, Sogut E, et al. Protective effects of thymoquine and melatonin on intestinal ischemia-reperfusion injury. Saudi J Gastroenterol. 2015;21(5):284–289. doi:10.4103/1319-3767.166203.
   PubMed Web of Science ®Google Scholar
• Sugawara T, Fujimura M, Noshita N, et al. Neuronal death/survival signaling pathways in cerebral ischemia. Neurotherapeutics. 2004;1(1):17–25. doi:10.1602/neurorx.1.1.17.
   Google Scholar
• Zhang X, Zhou X, Zhang Q, et al. The preventive effects of dexmedetomidine against intestinal ischemia-reperfusion injury in Wistar rats. Iran J Basic Med Sci. 2015;18(6):604–609.
   PubMed Web of Science ®Google Scholar
• Abdeen SM, Mathew T, Dashti HM, et al. Protective effects of green tea on intestinal ischemia-reperfusion injury. Nutrition. 2011;27(5):598–603. doi:10.1016/j.nut.2010.05.014.
   PubMed Web of Science ®Google Scholar
• Azari O, Kheirandish R, Rohani H, et al. Effect of pretreatment with extract of Origanum vulgare leaves on experimental intestinal ischemia-reperfusión injury in rats. Zahedan J Res Med Sci. 2016;18(4):e6436.
   Google Scholar
• Ceulemans LJ, Verbeke L, Decuypere JP, et al. Farnesoid X receptor activation attenuates intestinal ischemia reperfusion injury in rats. PLos One. 2017;12(1):e0169331. doi:10.1371/journal.pone.0169331.
   PubMed Web of Science ®Google Scholar