177
Views
4
CrossRef citations to date
0
Altmetric
Original Research

A Nomogram for Predicting Lymph Nodal Metastases in Patients with Appendiceal Cancers: An Analysis of SEER Database

, MD, , MD, , PhD, , MD, , PhD, , MD, , MD, , MD, , MD, , PhD & , MDORCID Icon show all

References

  • McCusker ME, Cote TR, Clegg LX, et al. Primary malignant neoplasms of the appendix: a population-based study from the surveillance, epidemiology and end-results program, 1973-1998. Cancer-Am Cancer Soc. 2002;94(12):3307–3312. doi:10.1002/cncr.10589.
  • Marmor S, Portschy PR, Tuttle TM, et al. The rise in appendiceal cancer incidence: 2000-2009. J Gastrointest Surg. 2015;19(4):743–750. doi:10.1007/s11605-014-2726-7.
  • Connor SJ, Hanna GB, Frizelle FA. Appendiceal tumors: retrospective clinicopathologic analysis of appendiceal tumors from 7,970 appendectomies. Dis Colon Rectum. 1998;41(1):75–80. doi:10.1007/BF02236899.
  • Moertel CG, Weiland LH, Nagorney DM, et al. Carcinoid tumor of the appendix: treatment and prognosis. N Engl J Med. 1987;317(27):1699–1701. doi:10.1056/NEJM198712313172704.
  • Roggo A, Wood WC, Ottinger LW. Carcinoid tumors of the appendix. Ann Surg. 1993;217(4):385–390. doi:10.1097/00000658-199304000-00010.
  • Fornaro R, Frascio M, Sticchi C, et al. Appendectomy or right hemicolectomy in the treatment of appendiceal carcinoid tumors?. Tumori. 2007;93(6):587–590. doi:10.1177/030089160709300612.
  • Bamboat ZM, Berger DL. Is right hemicolectomy for 2.0-cm appendiceal carcinoids justified?. Arch Surg. 2006;141(4):349–352. discussion 352
  • Brighi N, La Rosa S, Rossi G, et al. Morphological factors related to nodal metastases in neuroendocrine tumors of the appendix: a multicentric retrospective study. Ann Surg. 2018. doi:10.1097/SLA.0000000000002939.
  • Foster JM, Gupta PK, Carreau JH, et al. Right hemicolectomy is not routinely indicated in pseudomyxoma peritonei. Am Surg. 2012;78(2):171–177.
  • Pawa N, Clift AK, Osmani H, et al. Surgical management of patients with neuroendocrine neoplasms of the appendix: appendectomy or more. Neuroendocrinology. 2018;106(3):242–251. doi:10.1159/000478742.
  • Rault-Petit B, Do CC, Guyetant S, et al. Current management and predictive factors of lymph node metastasis of appendix neuroendocrine tumors: a national study from the french group of endocrine tumors (GTE). Ann Surg. 2019;270(1):165–171. doi:10.1097/SLA.0000000000002736.
  • Whitfield CG, Amin SN, Garner JP. Surgical management of primary appendiceal malignancy. Colorectal Dis. 2012;14(12):1507–1511. doi:10.1111/j.1463-1318.2012.03052.x.
  • Pape UF, all other Vienna Consensus Conference participants, Niederle B, Costa F, et al. ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas). Neuroendocrinology. 2016;103(2):144–152. doi:10.1159/000443165.
  • Boudreaux JP, Klimstra DS, Hassan MM, et al. The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum. Pancreas. 2010;39(6):753–766. doi:10.1097/MPA.0b013e3181ebb2a5.
  • Groth SS, Virnig BA, Al-Refaie WB, et al. Appendiceal carcinoid tumors: Predictors of lymph node metastasis and the impact of right hemicolectomy on survival. J Surg Oncol. 2011;103(1):39–45. doi:10.1002/jso.21764.
  • Ciarrocchi A, Pietroletti R, Carlei F, et al. Clinical significance of metastatic lymph nodes in the gut of patients with pure and mixed primary appendiceal carcinoids. Dis Colon Rectum. 2016;59(6):508–512. doi:10.1097/DCR.0000000000000574.
  • Daskalakis K, Alexandraki K, Kassi E, et al. The risk of lymph node metastases and their impact on survival in patients with appendiceal neuroendocrine neoplasms: a systematic review and meta-analysis of adult and paediatric patients. Endocrine. 2019.
  •  Li Y, Zhao L, Gungor C et al. The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database. Therap Adv Gastroenterol. 2019;12:1756284819862154
  • Nussbaum DP, Speicher PJ, Gulack BC, et al. Management of 1- to 2-cm carcinoid tumors of the appendix: using the national cancer data base to address controversies in general surgery. J Am Coll Surg. 2015;220(5):894–903. doi:10.1016/j.jamcollsurg.2015.01.005.
  • Elias H, Galata C, Warschkow R, et al. Survival after resection of appendiceal carcinoma by hemicolectomy and less radical than hemicolectomy: a population-based propensity score matched analysis. Colorectal Dis. 2017;19(10):895–906. doi:10.1111/codi.13746.
  • Ito H, Osteen RT, Bleday R, et al. Appendiceal adenocarcinoma: long-term outcomes after surgical therapy. Dis Colon Rectum. 2004;47(4):474–480. doi:10.1007/s10350-003-0077-7.
  • Day RW, Chang YH, Stucky CC, et al. A Predictive model for nodal metastases in patients with appendiceal cancers. Ann Surg. 2019. doi:10.1097/SLA.0000000000003501.
  • Mosquera C, Fitzgerald TL, Vora H, et al. Novel nomogram combining depth of invasion and size can accurately predict the risk for regional nodal metastases for appendiceal neuroendocrine tumors (A-NET). J Surg Oncol. 2017;116(6):651–657. doi:10.1002/jso.24714.
  • Alexandraki KI, Griniatsos J, Bramis KI, et al. Clinical value of right hemicolectomy for appendiceal carcinoids using pathologic criteria. J Endocrinol Invest. 2011;34(4):255–259. doi:10.1007/BF03347081.
  • Hu J, Cui Y, Liu P, et al. Predictors of inguinal lymph node metastasis in penile cancer patients: a meta-analysis of retrospective studies. CMAR.. 2019;11:6425–6441. doi:10.2147/CMAR.S206579.
  • Mehrvarz SA, Advani S, Halperin DM, et al. Regional lymph node involvement and outcomes in appendiceal neuroendocrine tumors: a SEER database analysis. Oncotarget. 2017;8(59):99541–99551.
  • Liu E, Telem DA, Hwang J, et al. The clinical utility of Ki-67 in assessing tumor biology and aggressiveness in patients with appendiceal carcinoids. J Surg Oncol. 2010;102(4):338–341. doi:10.1002/jso.21634.
  • Partelli S, Gaujoux S, Boninsegna L, et al. Pattern and clinical predictors of lymph node involvement in nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs). Jama Surg. 2013;148(10):932–939. doi:10.1001/jamasurg.2013.3376.
  • Galanopoulos M, McFadyen R, Drami I, et al. Challenging the current risk factors of appendiceal neuroendocrine neoplasms: can they accurately predict local lymph nodal invasion? Results from a large case series. Neuroendocrinology. 2019;109(2):179–186. doi:10.1159/000499381.
  • Kleiman DA, Finnerty B, Beninato T, et al. Features associated with metastases among well-differentiated neuroendocrine (carcinoid) tumors of the appendix: the significance of small vessel invasion in addition to size. Dis Colon Rectum. 2015;58(12):1137–1143. doi:10.1097/DCR.0000000000000492.
  • Pei Q, Zhu H, Tan F, et al. Intravascular emboli is an independent risk factor for the prognosis of stage III colorectal cancer patients after radical surgery. Oncotarget. 2016;7(35):57268–57276. doi:10.18632/oncotarget.11266.
  • Pei H, Zhu H, Zeng S, et al. Proteome analysis and tissue microarray for profiling protein markers associated with lymph node metastasis in colorectal cancer. J Proteome Res. 2007;6(7):2495–2501. doi:10.1021/pr060644r.
  • Li C, Pei Q, Zhu H, et al. Survival nomograms for stage III colorectal cancer. Medicine (Baltimore). 2018;97(49):e13239. doi:10.1097/MD.0000000000013239.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.