Quantification of Dermal Microcirculatory Changes after Topical Administration of Capsaicin: A Randomized Placebo-Controlled Study in 46 Subjects

References

• Kerrigan CL. Skin flap failure. Plast Reconstr Surg. 1983;72(6):766–774. doi:10.1097/00006534-198312000-00003.
   PubMed Web of Science ®Google Scholar
• Atalay C, Koçkaya EA, Çetin B, Kismet K, Akay MT. Efficacy of topical nitroglycerin and transcutaneous electrical nerve stimulation on survival of random-pattern skin flaps in rats. Scand J Plast Reconstr Surg Hand Surg. 2003;37(1):10–13. doi:10.1080/alp.37.1.10.13.
   PubMed Web of Science ®Google Scholar
• Jurell G, Jonsson CE. Increased survival of experimental skin flaps in rats following treatment with antiadrenergic drugs. Scand J Plast Reconstr Surg. 1976;10(3):169–172. doi:10.3109/02844317609012964.
   PubMed Web of Science ®Google Scholar
• Smith DK, Dolan RW. Effects of vasoactive topical agents on the survival of dorsal skin flaps in rats. Otolaryngol Head Neck Surg. 1999;121(3):220–223. doi:10.1016/S0194-5998(99)70175-0.
   PubMed Web of Science ®Google Scholar
• Denzinger M, Held M, Amr A, et al. The influence of topically administered heparin on peripheral microcirculation of the skin: a double-blind, randomized, controlled preliminary study on 50 healthy subjects. J Reconstr Microsurg. 2021;37(8):694–703. doi:10.1055/s-0041-1726028.
   PubMedGoogle Scholar
• Fichter AM, Ritschl LM, Robitzky LK, et al. Impact of different antithrombotics on the microcirculation and viability of perforator-based ischaemic skin flaps in a small animal model. Sci Rep. 2016;6(1):35833. doi:10.1038/srep35833.
   PubMedGoogle Scholar
• Davis RE, Wachholz JH, Jassir D, Perlyn CA, Agrama MH. Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats. Arch Facial Plast Surg. 1999;1(1):27–32. doi:10.1001/archfaci.1.1.27.
   PubMedGoogle Scholar
• Miyawaki T, Jackson IT, Bier UC, Andrus L, Williams F, Bradford M. The effect of capsaicin ointment on skin for the survival of a cutaneous flap. Eur J Plast Surg. 2001;24(1):28–30. doi:10.1007/s002380000221.
   Web of Science ®Google Scholar
• Holzer P. Neurogenic vasodilatation and plasma leakage in the skin. Gen Pharmacol. 1998;30(1):5–11. doi:10.1016/S0306-3623(97)00078-5.
   PubMedGoogle Scholar
• Fattori V, Hohmann M, Rossaneis A, Pinho-Ribeiro F, Verri W. Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses. Molecules. 2016;21(7):844. doi:10.3390/molecules21070844.
   PubMed Web of Science ®Google Scholar
• Aranda FJ, Villalaín J, Gómez-Fernández JC. Capsaicin affects the structure and phase organization of phospholipid membranes. Biochimt Biophys Acta (BBA) - Biomembr. 1995;1234(2):225–234. doi:10.1016/0005-2736(94)00293-X.
   PubMed Web of Science ®Google Scholar
• Srinivasan K. Biological activities of red pepper (Capsicum annuum) and its pungent principle capsaicin: a review. Crit Rev Food Sci Nutr. 2016;56(9):1488–1500. doi:10.1080/10408398.2013.772090.
   PubMed Web of Science ®Google Scholar
• Kempaiah R, Srinivasan K. Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J Nutr Biochem. 2006;17(7):471–478. doi:10.1016/j.jnutbio.2005.09.005.
   PubMed Web of Science ®Google Scholar
• Kolbenschlag J, Sogorski A, Kapalschinski N, et al. Remote ischemic conditioning improves blood flow and oxygen saturation in pedicled and free surgical flaps. Plast Reconstr Surg. 2016;138(5):1089–1097. doi:10.1097/PRS.0000000000002664.
   PubMed Web of Science ®Google Scholar
• Fullerton A, Stücker M, Wilhelm KP, European Society of Contact Dermatitis Standardization Group, et al. Guidelines for visualization of cutaneous blood flow by laser Doppler perfusion imaging. Contact Dermat. 2002;46(3):129–140. doi:10.1034/j.1600-0536.2002.460301.x.
   PubMed Web of Science ®Google Scholar
• Rothenberger J, Amr A, Schaller HE, Rahmanian-Schwarz A. Evaluation of a non-invasive monitoring method for free flap breast reconstruction using laser doppler flowmetrie and tissue spectrophotometry. Microsurgery. 2013;33(5):350–357. doi:10.1002/micr.22096.
   PubMed Web of Science ®Google Scholar
• Munce TA, Kenney WL. Age-specific skin blood flow responses to acute capsaicin. J Gerontol Ser A: Biol Sci Med Sci. 2003;58(4):B304–B310. doi:10.1093/gerona/58.4.B304.
   PubMed Web of Science ®Google Scholar
• Godoy GRd, Liebano RE, Corrêa JB, Hochman B, Ferreira LM. Capsaicin on the viability of random-pattern skin flaps in rats. Acta Cir Bras. 2010;25(5):440–443. doi:10.1590/S0102-86502010000500010.
   PubMed Web of Science ®Google Scholar
• Iinuma T, Sawada Y. Topical application of capsaicin and flap survival. Brit J Plast Surg. 1996;49(5):319–320. doi:10.1016/S0007-1226(96)90163-0.
   PubMedGoogle Scholar
• Wang YY, Hong CT, Chiu WT, Fang JY. In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. Int J Pharm. 2001;224(1-2):89–104. doi:10.1016/S0378-5173(01)00755-4.
   PubMedGoogle Scholar
• Magnusson BM, Koskinen LO. Effects of topical application of capsaicin to human skin: a comparison of effects evaluated by visual assessment, sensation registration, skin blood flow and cutaneous impedance measurements. Acta Derm Venereol. 1996;76(2):129–132. doi:10.2340/0001555576129132.
   PubMed Web of Science ®Google Scholar
• Akerman S, Kaube H, Goadsby PJ. Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation. Brit J Pharmacol. 2003;140(4):718–724. doi:10.1038/sj.bjp.0705486.
   PubMed Web of Science ®Google Scholar
• Newbold P, Brain SD. An investigation into the mechanism of capsaicin-induced oedema in rabbit skin. Brit J Pharmacol. 1995;114(3):570–577. doi:10.1111/j.1476-5381.1995.tb17177.x.
   PubMed Web of Science ®Google Scholar
• Manzini S, Perretti F, Benedetti L, Pradelles P, Maggi CA, Geppetti P. A comparison of bradykinin- and capsaicin-induced myocardial and coronary effects in isolated perfused heart of guinea-pig: involvement of substance P and calcitonin gene-related peptide release. Br J Pharmacol. 1989;97(2):303–312. doi:10.1111/j.1476-5381.1989.tb11955.x.
   PubMed Web of Science ®Google Scholar
• Trbovich M, Yang H. Capsaicin 8% patch for central and peripheral neuropathic pain of persons with incomplete spinal cord injury. Am J Phys Med Rehabil. 2015;94(8):e66–e72. doi:10.1097/PHM.0000000000000301.
   PubMed Web of Science ®Google Scholar
• Stergaard L, Terkelsen AJ, Finnerup NB, et al. Capillary dysfunction and impaired tissue oxygenation in complex regional pain syndrome: a hypothesis. Pain. 2014;155(10):1922–1926. doi:10.1016/j.pain.2014.06.005.
   PubMed Web of Science ®Google Scholar
• Adams MJ, Ahuja KDK, Geraghty DP. Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation. Thromb Res. 2009;124(6):721–723. doi:10.1016/j.thromres.2009.05.001.
   PubMed Web of Science ®Google Scholar
• Mittelstadt SW, Nelson RA, Daanen JF, et al. Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1. Blood Coagul Fibrinol. 2012;23(1):94–97. doi:10.1097/MBC.0b013e32834ddf18.
   PubMed Web of Science ®Google Scholar