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Original Research

The Effect of Antioxidant Astaxanthin on Intestinal Ischemia Reperfusion Damage in Rats

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Article: 2182930 | Received 28 Sep 2022, Accepted 15 Feb 2023, Published online: 05 Mar 2023

References

  • Zimmerman BJ, Granger DN. Reperfusion injury. Surg Clin North Am. 1992;72(1):1–9. doi:10.1016/s0039-6109(16)45628-8.
  • Guerin M, Huntley ME, Olaizola M. Haematococcus astaxanthin: Applications for human health and nutrition. Trends Biotechnol. 2003;21(5):210–216. doi:10.1016/S0167-7799(03)00078-7.
  • Tinkler JH, Böhm F, Schalch W, Truscott TG. Dietary carotenoids protect human cells from damage. J Photochem Photobiol B. 1994;26(3):283–285. doi:10.1016/1011-1344(94)07049-0.
  • Collard CD, Gelman S. Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology. 2001;94(6):1133–1138. doi:10.1097/00000542-200106000-00030.
  • Demiryilmaz I, Turan MI, Kisaoglu A, Gulapoglu M, Yilmaz I, et al. Protective effect of nimesulide against hepatic ischemia/reperfusion injury in rats: Effects on oxidant/antioxidants, DNA mutation and COX-1/COX-2 levels. Pharmacol Rep. 2014;66(4):647–652. doi:10.1016/j.pharep.2014.02.015.
  • Gonzalez LM, Moeser AJ, Blikslager AT. Animal models of ischemia-reperfusion-induced intestinal injury: Progress and promise for translational research. Am J Physiol Gastrointest Liver Physiol. 2015;308(2):G63–G75. doi:10.1152/ajpgi.00112.2013.
  • Riaz AA, Wan MX, Schäfer T, Dawson P, Menger MD, et al. Allopurinol and superoxide dismutase protect against leucocyte-endothelium interactions in a novel model of colonic ischaemia-reperfusion. Br J Surg. 2002;89(12):1572–1580. doi:10.1046/j.1365-2168.2002.02279.x.
  • Ambati RR, Phang SM, Ravi S, Aswathanarayana RG. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications-a review. Marine Drugs. 2014;12(1):128–152. doi:10.3390/md12010128.
  • Nagao A. Absorption and metabolism of dietary carotenoids. Biofactors. 2011;37(2):83–87. doi:10.1002/biof.151.
  • Lee DH, Lee YJ, Kwon KH. Neuroprotective effects of astaxanthin in oxygen-glucose deprivation in sh-sy5y cells and global cerebral ischemia in rat. J Clin Biochem Nutr. 2010;47(2):121–129. doi:10.3164/jcbn.10-29.
  • Nakajima Y, Inokuchi Y, Shimazawa M, Otsubo K, Ishibashi T, et al. Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo. J Pharm Pharmacol. 2008;60(10):1365–1374. doi:10.1211/jpp/60.10.0013.
  • Yang Y, Kim B, Lee JY. Astaxanthin structure, metabolism, and health benefits. J Human Nutr Food Sci. 2013;1(1003):1–1003.
  • Kuroki T, Ikeda S, Okada T, Maoka T, Kitamura A, et al. Astaxanthin ameliorates heat stress-induced impairment of blastocyst development in vitro: Astaxanthin colocalization with and action on mitochondria. J Assist Reprod Genet. 2013;30(5):623–631. doi:10.1007/s10815-013-9987-z.
  • Çolak E. Testiste oluşturulan iskemi/reperfüzyon hasarı üzerine Astaksantin’in koruyucu etkisi. ESOGÜ, Sağlık Bilimleri Enstitüsü (in Turkish) [Master’s Thesis], 2014.
  • Zheng D, Li Y, He L, Tang Y, Li X, et al. The protective effect of astaxanthin on fetal alcohol spectrum disorder in mice. Neuropharmacology. 2014;84:13–18. doi:10.1016/j.neuropharm.2014.04.013.
  • Ranga Rao A, Raghunath Reddy RL, Baskaran V, Sarada R, Ravishankar GA. Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model. J Agric Food Chem. 2010;58(15):8553–8559. doi:10.1021/jf101187k..
  • Coral-Hinostroza GN, Ytrestøyl T, Ruyter B, Bjerkeng B. Plasma appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3’R/S isomers of astaxanthin fatty acyl diesters. Comp Biochem Physiol C Toxicol Pharmacol. 2004;139(1-3):99–110. doi:10.1016/j.cca.2004.09.011.
  • Chang JX, Chen S, Ma LP, Jiang LY, Chen JW, et al. Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock. World J Gastroenterol. 2005;11(35):5485–5491. doi:10.3748/wjg.v11.i35.5485.
  • Petrat F, Swoboda S, de Groot H, Schmitz KJ. Quantification of ischemia-reperfusion injury to the small intestine using a macroscopic score. J Invest Surg. 2010;23(4):208–217. doi:10.3109/08941931003623622.
  • Tanyeli A, Ekinci Akdemir FN, Eraslan E, Özbek Sebin S, Gulcin İ. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Tıp Dergisi. 2020;9(1):166–173. (in Turkish).
  • Grootjans J, Lenaerts K, Buurman WA, Dejong CH, Derikx JP. Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion. World J Gastroenterol. 2016;22(9):2760–2770. doi:10.3748/wjg.v22.i9.2760.
  • Mallick IH, Yang W, Winslet MC, Seifalian AM. Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci. 2004;49(9):1359–1377. doi:10.1023/b:ddas.0000042232.98927.91.
  • Mester A, Magyar Z, Sogor V, Tanczos B, Stark Y, et al. Intestinal ischemia-reperfusion leads to early systemic micro-rheological and multiorgan microcirculatory alterations in the rat. Clin Hemorheol Microcirc. 2018;68(1):35–44. doi:10.3233/CH-170278.
  • Carden DL, Granger DN. Pathophysiology of ischaemia-reperfusion injury. J Pathol. 2000;190(3):255–266. doi:10.1002/(SICI)1096-9896(200002)190:3 < 255::AID-PATH526 > 3.0.CO;2-623. Granger DN, Korthuis RJ. Physiologic mechanisms of postischemic tissue injury. Annual Review of Physiology 1995; 57:311-332. doi:10.1146/annurev.ph.57.030195.001523.
  • Gülçin I. Antioxidant properties of resveratrol: A structure–activity insight. Innovative Food Sci Emerg Technol. 2010;11(1):210–218. doi:10.1016/j.ifset.2009.07.002.
  • Barut I, Tarhan OR, Kapucuoglu N, Sutcu R, Akdeniz Y. Lamotrigine reduces intestinal I/R injury in the rat. Shock. 2007;28(2):202–206. doi:10.1097/SHK.0b013e3180311dee.
  • Yildiz Y, Kose H, Cecen S, Ergin K, Demir EM, et al. Protective effects of leflunomide on intestinal ischemia-reperfusion injury: leflunomide against intestinal ischemia-reperfusion. Dig Dis Sci. 2010;55(2):245–252. doi:10.1007/s10620-009-0737-0.
  • Aygun H, Olguner C, Koca U, Ergur BU, Sisman AR, et al. The effect of post-reperfusion levosimendan in an experimental intestinal ischemia–reperfusion model. J Anesth Analg Crit Care. 2022;2(1):45. doi:10.1186/s44158-022-00074-3.
  • Belda-Antolí M, Padrón-Sanz C, Cejalvo-Lapeña D, Prieto-Moure B, Lloris-Cejalvo JM, et al. Antioxidant potential of Himanthalia elongata for protection against ischemia-reperfusion injury in the small bowel. Surgery. 2017;162(3):577–585. doi:10.1016/j.surg.2017.04.017.
  • Liu L, Zhuang R, Xiao L, Chung HK, Luo J, et al. HuR enhances early restitution of the intestinal epithelium by increasing Cdc42 translation. Mol Cell Biol. 2017;37(7):e00574-16. doi:10.1128/MCB.00574-16.
  • Özkaya MO. Effects of Levosimendan on Rats Intestinal Ischemia Reperfusion Injury. Dokuz Eylül Üniversitesi Tıp Fakültesi (in Turkish) [Doctoral dissertation], 2010.
  • Zhang W, Zhu W, Zhang J, Li N, Li J. Protective effects of glucagon-like peptide 2 on intestinal ischemia-reperfusion rats. Microsurgery. 2008;28(4):285–290. doi:10.1002/micr.20491.
  • Liao XP, She YX, Shi CR, Li M. Changes in body fluid markers in intestinal ischemia. J Pediatr Surg. 1995;30(10):1412–1415. doi:10.1016/0022-3468(95)90394-1.
  • Zhonghui Z, Xiaowei Z, Fang F. Ganoderma lucidum polysaccharides supplementation attenuates exercise-induced oxidative stress in skeletal muscle of mice. Saudi J Biol Sci. 2014;21(2):119–123. doi:10.1016/j.sjbs.2013.04.004.
  • Hasturk A, Atalay B, Calisaneller T, Ozdemir O, Oruckaptan H, et al. Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia/reperfusion injury and correlation with tissue damage. Turkish Neurosurg. 2009;19(4):353–359.
  • Kandemir M, Yaşar NF, Özkurt M, Özyurt R, Bektur Aykanat NE, et al. The role of anakinra in the modulation of intestinal cell apoptosis and inflammatory response during ischemia/reperfusion. Turk J Med Sci. 2021;51(4):2177–2184. doi:10.3906/sag-2008-258.
  • Zheng X, Mao Y, Cai J, Li Y, Liu W, et al. Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res. 2009;43(5):478–484. doi:10.1080/10715760902870603.
  • Shen H, Kuo CC, Chou J, Delvolve A, Jackson SN, et al. Astaxanthin reduces ischemic brain injury in adult rats. Faseb J. 2009;23(6):1958–1968. doi:10.1096/fj.08-123281.
  • Dimakakos PB, Kotsis T, Kondi-Pafiti A, Katsenis K, Doufas A, et al. Oxygen free radicals in abdominal aortic surgery. An experimental study. J Cardiovasc Surg. 2002;43(1):77–82.
  • Sakurai M, Nagata T, Abe K, Horinouchi T, Itoyama Y, et al. Survival and death-promoting events after transient spinal cord ischemia in rabbits: induction of Akt and caspase3 in motor neurons. J Thorac Cardiovasc Surg. 2003;125(2):370–377. doi:10.1067/mtc.2003.112.
  • Nezu Y, Nezu Y, Shigihara K, Harada Y, Yogo T, et al. Effects of small intestinal ischemia and reperfusion on expression of tumor necrosis factor-alpha and interleukin-6 messenger RNAs in the jejunum, liver, and lungs of dogs. Am J Vet Res. 2008;69(4):512–518. doi:10.2460/ajvr.69.4.512.
  • Karaağaç H, Zeybek N, Peker Y, Yağcı G, Şengül A, et al. Diagnostic value of plasma cytokine levels in acute mesenteric ischemia: an experimental study. GüLhane Tip Dergisi. 2007;49(4):216.
  • Li J, Wang F, Xia Y, Dai W, Chen K, et al. Astaxanthin pretreatment attenuates hepatic ischemia reperfusion-induced apoptosis and autophagy via the ROS/MAPK pathway in mice. Mar Drugs. 2015;13(6):3368–3387. doi:10.3390/md13063368.
  • Kiess W, Gallaher B. Hormonal control of programmed cell death/apoptosis. Eur J Endocrinol. 1998;138(5):482–491. doi:10.1530/eje.0.1380482.
  • Topaloğlu Ü, Güran M, Odabaşı M, Karadağ N. The Effects of Prostaglandın E2 on Ischemia-Reperfusion Damage, Resulting From Mesenter Arterial Ischemia in Small Intestines. Ulusal travma ve acil cerrahi dergisi. 1997;3(4):258–264. (in Turkish).
  • Stallion A, Kou TD, Latifi SQ, Miller KA, Dahms BB, et al. Ischemia/reperfusion: A clinically relevant model of intestinal injury yielding systemic inflammation. J Pediatr Surg. 2005;40(3):470–477. doi:10.1016/j.jpedsurg.2004.11.045.
  • Hierholzer C, Kalff JC, Audolfsson G, Billiar TR, Tweardy DJ, et al. Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury. Transplantation. 1999;68(9):1244–1254. doi:10.1097/00007890-199911150-00006.
  • Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119(3):493–501. doi:10.1083/jcb.119.3.493.
  • Kressel M, Groscurth P. Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA. Cell Tissue Res. 1994;278(3):549–556. doi:10.1007/BF00331373.
  • Halliwell B. Antioxidants and human disease: a general introduction. Nutr Rev. 1997;55(1 Pt 2):S44–S52. doi:10.1111/j.1753-4887.1997.tb06100.x.
  • Li S, Takahara T, Fujino M, Fukuhara Y, Sugiyama T, et al. Astaxanthin prevents ischemia-reperfusion injury of the steatotic liver in mice. PLoS One. 2017;12(11):e0187810. doi:10.1371/journal.pone.0187810.
  • Cakir E, Cakir U, Tayman C, Turkmenoglu TT, Gonel A, et al. Favorable effects of astaxanthin on brain damage due to ischemia- reperfusion injury. Comb Chem High Throughput Screen. 2020;23(3):214–224. doi:10.2174/1386207323666200219121600.
  • Qiu X, Fu K, Zhao X, Zhang Y, Yuan Y, et al. Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice. J Transl Med. 2015;13(1):28. doi:10.1186/s12967-015-0388-1.
  • Zuluaga Tamayo M, Choudat L, Aid-Launais R, Thibaudeau O, Louedec L, et al. Astaxanthin complexes to attenuate muscle damage after in vivo femoral ischemia-reperfusion. Marine Drugs. 2019;17(6):354. doi:10.3390/md17060354.
  • Curek GD, Cort A, Yucel G, Demir N, Ozturk S, et al. Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion. Toxicology. 2010;267(1–3):147–153. doi:10.1016/j.tox.2009.11.003.