Evaluation of Hepatic Microcirculation by In Vivo Microscopy

REFERENCES

• Almond NE, Wheatley AM. Measurement of hepatic per-fusion in rats by laser Doppler flowmetry. Am J Physiol. 1992;262:G203–G209.
   PubMed Web of Science ®Google Scholar
• Vollmar B, Glasz J, Leiderer R, Post S, Menger MD. Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol. 1994;145:1421–1431.
   PubMed Web of Science ®Google Scholar
• Maass-Moreno R, Rothe CF. Distribution of pressure gradients along hepatic vasculature. Am J Physiol. 1997;41:H2826–H2832.
   Google Scholar
• Spiegel HU, Hauss J, Scho¨ nleben K, Bu¨nte H. Theory and methods of local tissue-pO2 monitoring in experimental angiology. Angiology. 1987;38:1–12.
   Google Scholar
• Uhlmann D, Spiegel HU, Scommotau S, Bremer C. Effect of endothelin receptor antagonist on postischemic hep-atic oxygen supply. Eur Surg Res. 1996;28:59.
   Google Scholar
• Gorey TF. Prediction of intestinal recovery after ischaemic injury due to arterial, venous and mixed arterial and ve-nous occlusions. J Roy Soc Med. 1980;73:631–634.
   Google Scholar
• Carter MS, Fantini GA, Sammartano RJ, Mitsudo S, Silverman DG, Boley SJ. Qualitative and quantitative fluo-rescein fluorescence in determining intestinal viability. Am J Surg. 1984;147:117–123.
   PubMed Web of Science ®Google Scholar
• Horstmann R, Meffert R, Sielhorst K, Spiegel HU, Hohlbach G. Fluorometry for the assessment of tissue vi-ability. J Invest Surg. 1996;9:225.
   Google Scholar
• Vollmar B, Conzen PF, Kerner T, Habazettl H, Vierl M, Waldner H, Peter K. Blood flow and tissue oxygen pres-sures of liver and pancreas in rats: Effects of volatile anes-thetics and of hemorrhage. Anesth Analg. 1992;75:421–430.
   PubMed Web of Science ®Google Scholar
• Barker JH, Anderson GL, Menger MD. Technological De-velopments in the Study of the Microcirculation/Clinicaland Applied Microcirculation Research. Boca Raton: CRC Press; 1995:139–148.
   Google Scholar
• Menger MD, Lehr HA. Scope and perspectives of intravital microscopy—Bridge over from in vitro to in vivo. Immunol Today. 1993;14:519–522.
   Google Scholar
• Uhl E, Stummer W, Beck J, Schu¨rer L, Baethmann A. Leucocyte-edothelium interactions in the early reperfu-sion period after transient ischemia. J Cerebr Blood Flow Metab. 1995;15:134.
   Google Scholar
• Gidday JM, Gonzales ER, Shah AR, Chinwalla AT, Park TS. Inhibition of nitric oxide production increases leukocyte adherence to cerebral venules during reperfusion follow-ing partial ischemia in piglets. J Cerebr Blood Flow Metab. 1995;15:135.
   Google Scholar
• Jones CJH, Kuo L, Davis MJ, DeFily DV, Chilian WM. Role of nitric oxide in the coronary microvascular responses to adenosine and increased metabolic demand. Circulation. 1995;91:1807–1813.
   PubMedGoogle Scholar
• Ku¨bler WM, Kuhnle GEH, Groh J, Goetz AE. Leukocyte kinetics in pulmonary microcirculation: intravital fluores-cence microscopic study. J Appl Physiol. 1994;76:65–71.
   Google Scholar
• Menger MD, Marzi I, Messmer K. In vivo fluorescence mi-croscopy for quantitative analysis of the hepatic microcir-culation in hamsters and rats. Eur Surg Res. 1991;99:158–169.
   Google Scholar
• Kusterer K, Poschmann T, Friedemann A, Enghofer M, Zendler S, Usadel KH. Arterial constriction, ischemia-reperfusion, and leukocyte adherence in acute pancre-atitis. Am J Physiol. 1993;265:G165–G171.
   Google Scholar
• Menger MD, Bonkhoff H, Vollmar B. Ischemia-reperfusion-induced pancreatic microvascular injury—An intravital fluorescence microscopic study in rats. Dig Dis Sci. 1996;41:823–830.
   Google Scholar
• House SD, Lipowsky HH. Leukocyte-endothelium adhe-sion: Microhemodynamics in mesentery of the cat. Mi-crovasc Res. 1987;34:363–379.
   PubMed Web of Science ®Google Scholar
• Granger DN, Benoit JN, Suzuki M, Grisham MB. Leuko-cyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol. 1989;257:G683–G688.
   PubMed Web of Science ®Google Scholar
• Bohlen HG, Gore RW. Preparation of rat intestinal mus-cle and mucosa for quantitative microcirculatory studies. Microvasc Res. 1976;11:103–110.
   Google Scholar
• Zimmerhackl B, Parekh N, Brinkhus H, Steinhausen M. The use of fluorescent labeled erythrocytes for intravital inves-tigation of flow and local hematocrit in glomerular capil-laries in the rat. Int J Microcirc Clin Exp. 1983;2:119–129.
   PubMedGoogle Scholar
• Baatz H, Pleyer U, Thiel HJ, Hammer C. In vivo study of leukocyte-endothelium interaction in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 1995;36:1960–1967.
   Google Scholar
• Lehr HA, Hu¨bner C, Nolte D, Menger MD, Messmer K. Rationale for mediator interplay in oxLDL-induced leukocyte/endothlial cell interactions in vivo. J Lipid Mediat Cell. 1994;10:125–127.
   Google Scholar
• Lehr HA, Leunig M, Menger MD, Nolte D, Messmer K. Technical advances dorsal skinfold chamber technique for intravital microscopy in nude mice. Am J Pathol. 1993;143:1055–1062.
   PubMed Web of Science ®Google Scholar
• Nolte D, Menger MD, Messmer K. Microcirculatory models of ischaemia-reperfusion in skin and striated muscle. Int J Microcirc. 1995;15:9–16.
   PubMedGoogle Scholar
• Kan Z, Ivancev K, Lundersquist A, McCuskey PA, McCuskey RS, Wallace S. In vivo microscopy of hepatic metastases: dynamic observation of tumor cell inva-sion and interaction with Kupffer cells. Hepatology. 1995;21:487–494.
   Google Scholar
• Leunig M, Messmer K. Intravital microscopy in tumor biology: Current status and future perspectives (review). Int J Oncol. 1995;6:413–417.
   Google Scholar
• Baatz H, Steinbauer M, Harris AG, Krombach F. Kinetics of white blood cell staining by intravascular administration of rhodamine 6G. Int J Microcirc. 1995;15:85–91.
   Google Scholar
• Post S, Palma P, Rentsch M, Gonzalez AP, Menger MD. Hepatic reperfusion injury following cold ischemia in the rat: Potentials of quantitative analysis by in vivo fluorescence microscopy. Prog Appl Microcirc. 1993;19:152–166.
   Google Scholar
• Clemens MG, McDonagh PF, Chaudry IH, Baue AE. Hepatic microcirculatory failure after ischemia and reperfusion: Improvement with ATP-MgCl2 treatment. Am J Physiol. 1995;248:H804–H811.
   Google Scholar
• Takei Y, Marzi I, Gao W, Gores GJ, Lemasters JJ, Thurnman RG. Leukocyte adhesion and cell death following ortho-topic liver transplantation in the rat. Transplantation. 1991;51:959–965.
   PubMed Web of Science ®Google Scholar
• Marzi I, Walcher F, Bu¨hren V. Macrophage activation and leukocyte adhesion after liver transplantation. Am J Physiol. 1993;265:G172–G177.
   Google Scholar
• Vollmar B, Glasz J, Post S, Menger MD. Role of micro-circulatory derangements in manifestation of portal triad cross-clamping-induced hepatic reperfusion injury. J Surg Res. 1996;60:49–54.
   PubMedGoogle Scholar
• Bauer C, Marzi I, Bauer M, Fellger H, Larsen R. Interleukin-1 receptor antagonist attenuates leukocyte-endothelial interactions in the liver after hemorrhagic shock in the rat. Crit Care Med. 1995;23:1099–1105.
   Google Scholar
• Spiegel HU, Scommotau S, Uhlmann D, Giersch B. Ef-fect of endothelin receptor antagonist bosentan on postischemic liver microcirculation. Zentralbl Chir. 1996; 121:788–793.
   PubMed Web of Science ®Google Scholar
• Ferguson D, McDonagh PF, Biewer J, Paidas CN, Clemens MG. Spatial relationship between leukocyte accu-mulation and microvascular injury during reperfusion following hepatic ischemia. Int J Microcirc: Clin Exp. 1993;12:45–60.
   Google Scholar
• Post S, Menger MD, Rentsch M, Gonzalez AP, Palma P, Messmer K. New potentials of intravital fluorescence mi-croscopy of the liver. Int J Microcirc Clin Exp. 1992;11:216.
   Google Scholar
• Marzi I, Bauer, C. Mikrozirkulationssto¨ rungen der Leber nach ha¨ morrhagischem Schock. Acta Chir Austriaca. 1994;Suppl. 111:18–20.
   Google Scholar
• Vollmar B, Ru¨cker M, Menger MD. A new method for the intravital microscopic quantifcation of hepatic sinusoidal perfusion failure using the dye bisbenzamide H33342. Microvasc Res. 1996;51:250–259.
   Google Scholar
• Post S, Gonzalez AP, Palma P, Rentsch M, Stiehl A, Menger MD. Assessment of hepatic phagocytic activity by in vivo microscopy after liver transplantation in the rat. Hepatology. 1992;16:803–809.
   PubMed Web of Science ®Google Scholar
• Post S, Menger MD, Rentsch M, Gonzalez AP, Herfarth C, Messmer K. The impact of arterialization on hepatic micro-circulation and leukocyte accumulation after liver trans-plantation in the rat. Transplantation. 1992;54:789–794.
   PubMedGoogle Scholar
• Post S, Palma P, Gonzalez AP, Rentsch M, Menger MD. Microcirculatory events after reperfusion in liver transplantation. Prog Appl Microcirc. 1995;21:43–50.
   Google Scholar
• Lautt WW, Greenway CV, Legare DJ, Weisman H. Local-ization of intrahepatic portal vascular resistance. Am J Physiol. 1986;251:G357–G381.
   Google Scholar
• Vollmar B, Lang G, Menger MD, Messmer K. Hypertonic hydroxyethyl starch restores hepatic microvascular per-fusion in hemorrhagic shock. Am J Physiol. 1994;266:H1927–H1934.
   Google Scholar
• Hoffmann TF, Leiderer R, Waldner H, Messmer K. Bradykinin antagonists HOE-140 and CP-0597 diminish microcirculatory injury after ischaemia-reperfusion of the pancreas in rats. Br J Surg. 1996;189-195.
   Google Scholar
• Koeppel TA, Thies JC, Lehmann T, Gebhard MM, Herfarth C, Otto G, Post S. Improvement of hepatic microhemo-dynamics by N -acetylcysteine after warm ischemia. Eur Surg Res. 1996;28:270–277.
   PubMed Web of Science ®Google Scholar
• Vollmar B, Glasz J, Menger MD, Messmer K. Leuko-cytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venu-lar adherence. Surgery. 1995;117:195–200.
   PubMed Web of Science ®Google Scholar
• Vollmar B, Menger MD, Glasz J, Leiderer R, Messmer K. Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury. Am J Physiol. 1994;267:G786–G793.
   PubMedGoogle Scholar
• Mu¨ller MJ, Friedl HP, Vollmar B, Menger MD. Chir Forum: Xanthin-Oxidase und Superoxid-Radikale vermitteln den mikrovaskula¨ ren Reperfusionsschaden der Leber nach tempora¨ rer Okklusion des Ligamentum hepatoduo-denale. Hierholzer M, Seifert S, Hartel R. Heidelberg: Springer-Verlag; 1995:119–122.
   Google Scholar
• Hansell P, Borgstro¨ m P, Arfors KE. Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. Am J Physiol. 1993;265:H381–H388.
   Google Scholar
• Uhlmann D, Scommotau S, Witzigmann H, Spiegel HU. Exogenous L-arginine protects liver microcirculation from ischemia/reperfusion injury. Eur Surg Res. 1998; 30:175–184.
   Google Scholar
• Bauer M, Marzi I, Ziegenfuß T, Seeck G, Bu¨hren V, Larsen R. Comparative effect of crystalloid and small volume hypertonic hyperoncotic fluid resuscitation on hepatic microcirculation after hemorrhagic shock. Circ Shock. 1993;40:187–193.
   Google Scholar
• Dore M, Korthuis RJ, Granger DN, Entman ML, Smith CW. P-selectin mediates spontaneous leukocyte rolling in vivo. Blood. 1993;82:1308–1316.
   PubMed Web of Science ®Google Scholar
• Steinhoff G, Behrend M, Schrader B, Duijvestijn AM, Wonigeit K. Expression patterns of leukocyte adhesion ligand molecules on human liver endothelia. Am J Pathol. 1993;142:481–488.
   PubMed Web of Science ®Google Scholar
• Zeintl H, Sack FU, Intaglietta M, Messmer K. Computer assisted leukocyte adhesion measurement in intravital microscopy. Int J Microcirc Clin Exp. 1989;8:293–302.
   PubMedGoogle Scholar
• Menger MD, Pelikan S, Steiner D, Messmer K. Microvas-cular ischemia-reperfusion injury in striated muscle: Signifcance of “reflow paradox”. Am J Physiol. 1992;32:H1901–H1906.
   Google Scholar
• Anthuber M, Rihl M, Farkas S, Schildberg FW, Meßmer K. Intravitalmikroskopische Untersuchungen zum Einfluß von Epoprostenol auf den Ischa¨ mie/Reperfusionsschaden nach orthotoper Lebertransplantation in Rattenmodell. Acta Chir Austriaca. 1994;Suppl. 111:21–22.
   Google Scholar
• Lehr HA, Kro¨ ber M, Hu¨bner C, Vajkoczy P, Menger MD, Nolte D, Kohlschu¨tter A, Messmer K. Stimula-tion of leukocyte/endothelium interaction by oxidized low-density lipoprotein in hairless mice—Involvement of CD11b/CD18 adhesion receptor complex. Lab Invest. 1993;68:388–395.
   Google Scholar
• Koo A, Komatsu H. Cells of the Hepatic Sinusoid: Leukocyte Interactions with Sinusoid Endothelial Cells in Ischemic Reperfused Rat Livers. Wisse E, Knook DL, McCuskey RS. Leiden: Kupffer Cell Foundation; 1991:364–366.
   Google Scholar
• Komatsu H, Koo A, Guth PH. Leukocyte flow dynamics in the rat liver microcirculation. Microvasc Res. 1990;40:1–13.
   PubMedGoogle Scholar
• Intaglietta M, Silverman NR, Tompkins WR. Capillary flow velocity measurements in vivo and in situ by television methods. Microvasc Res. 1975;10:165–179.
   PubMed Web of Science ®Google Scholar
• Zhang JX, Pegoli W, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol. 1994;266:G624–G632.
   PubMed Web of Science ®Google Scholar
• Bauer M, Paquette NC, Zhang JX, Bauer I, Pannen BHJ, Kleeberger SR, Clemens MG. Chronic ethanol con-sumption increases hepatic sinusoidal contractile re-sponse to endothelin-1 in the rat. Hepatology. 1995;22:1565–1576.
   PubMedGoogle Scholar
• Vollmar B, Glasz J, Post S, Menger MD. Depressed phagocytic activity of Kupffer cells after warm ischemia-reperfusion of the liver. J Hepatol. 1994;20:301–304.
   Google Scholar
• Hower R, Kiefer B, Marzi I, Bu¨hren V, Harbauer G, Trentz O. Lobular distribution and activation of hepatic macrophages following hemorrhagic shock in the rat. Circ Shock. 1990;31:52.
   Google Scholar
• Zhang JX, Bauer M, Clemens MG. Vessel-and target cell-specifc actions of endothelin-1 and endothelin-3 in rat liver. Am J Physiol. 1995;269:G269–G277.
   PubMed Web of Science ®Google Scholar
• Vollmar B, Glasz J, Senkel A, Menger MD, Messmer K. Role of leukocytes in the initial hepatic microvascular response to endotoxemia. Zentralbl Chir. 1993;118:691–696.
   PubMed Web of Science ®Google Scholar
• Post S, Palma P, Rentsch M, Gonzalez AP, Menger MD. Differential impact of Carolina rinse and University of Wisconsin solution on microcirculation, leukocyte adhesion, Kupffer cell activity and biliary excretion after liver transplantation. Hepatology. 1993;18:1490–1497.
   Google Scholar
• Gawlowski DM, Harding NR, Granger HJ. Leukocyte phagocytosis and alterations in microvascular integrity elicited by FITC-dextran 150 and epi-illumination in the microcirculation of the hamster cheek pouch. Microvasc Res. 1989;37:1–15.
   Google Scholar
• Hansell P, Berger E, Chambers JD, Arfors KE. Influence of acridine tracer dyes on neutrophil function. J Leukoc Biol. 1994;56:464–468.
   Google Scholar
• Massberg S, Enders G, Leiderer R, Eisenmenger S, Vestweber D, Krombach F, Messmer K. Platelet-endothelial cell interactions during ischemia/reperfusion: The role of P-selectin. Blood. 1998;92:507–515.
   PubMed Web of Science ®Google Scholar
• Messmer K, Krombach F. Mikrozirkulationsforschung in der experimentellen Chirurgie. Chirurg. 1998;69:333–338.
   Google Scholar
• Post S, Rentsch M, Palma P, Gonzalez AP, Otto G, Menger MD. Effect of Carolina rinse solution on Kupffer cell activation after reperfusion in rat liver transplantation. Transplant Proc. 1992;24:2703.
   Google Scholar
• Marzi I, Knee J, Bu¨hren V, Menger M, Trenz O. Reduction by superoxide dismutase of leukocyte-endothelial adher-ence after liver transplantation. Surgery. 1992;111:90–97.
   PubMedGoogle Scholar
• Kawano K, Bowers JL, Kruskal JB, Clouse ME. In vivo microscopic assessment of hepatic microcirculation during liver allograft rejection in the rat. Transplantation. 1995;59:1241–1248.
   Google Scholar