SETTING SAFE ACUTE EXPOSURE LIMITS FOR HALON REPLACEMENT CHEMICALS USING PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING

REFERENCES

• Bischoff, K. B., and Brown, R. G. 1966. Drug distribution in mammals. Chem. Eng. Prog. Symp. Ser. 62(66):33–45.
   Google Scholar
• Bois, F. Y., and Paxman, D. G. 1992. An analysis of exposure rate effects for benzene using a physio-logically based pharmacokinetic model. Regul. Toxicol. Pharmacol. 15:122–136.
   PubMed Web of Science ®Google Scholar
• Bois, F. Y., Woodruff, T. J., and Spear, R. C. 1991. Comparison of three physiologically based phar-macokinetic models of benzene disposition. Toxicol. Appl. Pharmaco1.110:79–88.
   Google Scholar
• Brown, R. P., Delp, M. D., Lindstedt, S. L., Rhomberg, L. R., and Beliles, R. P. 1997. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 13: 407–484.
   PubMed Web of Science ®Google Scholar
• Buhler, H. U., DaPrada, M., Haefely, W., and Picotti, G. B. 1978. Plasma adrenaline, noradrenaline and dopamine in man and different animal species. J. PhysioL 276:311–320.
   PubMed Web of Science ®Google Scholar
• Carriere, S., Demassieux, S., Cardinal, J., and LeGrimellec, C. 1983. Release of epinephrine during carotid artery occlusion following vagotomy in dogs. Can.]. Physiol. Pharmacol. 61:495-501. Clewell, H. J., and Jarnot, B. M. 1994. Incorporation of pharmacokinetics in noncancer risk assess- ment: Example with chloropentafluorobenzene. Risk Anal. 14:265–276.
   Google Scholar
• Creech, J. R., Black, R. K., Garrity, B. L., Abbas, R., Dong, L., Williams, R. J., McDougal, J. N., Vinegar, A., and Jepson, G. W. 1995a. Inhalation Uptake and Metabolism of lodohalogenated Compounds, CF3I, C6F131, and C3F7I. Tech. Rep. AUOE-TR-1995-0089, U.S. Air Force, Armstrong Laboratory, Occupational and Environmental Health Directorate, Toxicology Division, Wright-Patterson AFB, OH.
   Google Scholar
• Creech, J. R., Black, R. K., Neurath, S. K., Caracci, M. C., Williams, R. J., Jepson, G. W., and Vinegar, A. 1995b. Inhalation Uptake and Metabolism of Halon 1301 Replacement Candidates, HFC-227ea, HFC-125, and FC-218. Tech. Rep. AUOE-TR-1995-0022. U.S. Air Force, Armstrong Laboratory, Occupational and Environmental Health Directorate, Toxicology Division, Wright-Patterson AFB, OH.
   Google Scholar
• Cronin, W. J. IV, Oswald, E. J., Shelley, M. L., Fisher, J. W., and Flemming, C. D. 1995. A trichloroethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in con-junction with physiologically-based pharmacokinetic modeling. Risk Anal. 15: 555–565.
   Google Scholar
• Davis, N. R., and Mapleson, W. W. 1981. Structure and quantificaticn of a physiological model of the distribution of injected agents and inhaled anesthetics. Br.]. Anaesth. 53:399–405.
   PubMed Web of Science ®Google Scholar
• Dodd, D. E., and Vinegar, A. 1998. Cardiac sensitization testing of the halon replacement candidates trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F71). Drug Chem. Toxicol. 21:137–149.
   PubMed Web of Science ®Google Scholar
• Eger, E. I. 1987. Partition coefficients of 1-653 in human blood, saline, and olive oil. Anesth. Analg. 66:971–973.
   PubMed Web of Science ®Google Scholar
• Farrar, D., Allen, B., Crump, K., and Shipp, A. 1989. Evaluation of uncertainty in input parameters to pharmacokinetic models and the resulting uncertainty in output. Toxicol. Lett. 49:371-385. Hetrick, D. M., Jarabek, A. M., and Travis, C. C. 1991. Sensitivity analysis for physiologically based pharmacokinetic models. Pharmacokinet Biopharmacol. 19:1–20.
   Google Scholar
• Huntingdon Life Sciences Ltd. 1998. HFC 236fa, HFC 227ea, HFC 125 and CF3I. An Inhalation Study to Investigate the Blood Levels of Inhaled Halocarbons in the Beagle Dog. Prepared by Huntingdon Life Sciences Ltd, England. Huntingdon Report IFP 001/984370. Submitted under subcontract to ICF Incorporated, Washington DC, under U.S. EPA contract 68-D5-0147, work assignment 2–09.
   Google Scholar
• Keller-Wood, M. E., Wade, C. E., Shinsako, J., Keil, L. C., Van Loon, G. R., and Dallmann, M. F. 1982. Insulin-induced hypoglycemia in conscious dogs: Effect of maintaining carotid arterial glu-cose levels on the adrenocorticotropin, epinephrine and vasopressin responses. Endocrinology 112:624–632.
   Web of Science ®Google Scholar
• Leggett, R. W., and Williams, L. R. 1995. A proposed blood circulation model for reference man. Health Phys. 69:187–201.
   PubMed Web of Science ®Google Scholar
• Lerman, J., Gregory, G. A., Willis, M. M., Schmidt, B. I., and Eger, E. I. 1985. Age and the solubility of volatile anesthetics in ovine tissues. Anesth. Analg. 64:1097–1100.
   PubMed Web of Science ®Google Scholar
• Lerman, J., Gregory, G. A., Willis, M. M., Schmidt-Bantel, B. I., and Eger, E. I. 1986. Effect of age on the solubility of volatile anesthetics in human tissues. Anesth. Analg. 65: 307–311.
   Google Scholar
• Mullin, L. S., Reinhardt, C. F., and Hemingway, R. E. 1979. Cardiac arrhythmias and blood levels associated with inhalation of Halon 1301. Am. Ind. Hyg. Assoc. J. 40:653–658.
   PubMed Web of Science ®Google Scholar
• Portier, C. J., and Kaplan, N. L. 1989. Variability of safe dose estimates when using complicated models of the carcinogenic process. Fundam. Appl. ToxicoL 13:533–544.
   PubMedGoogle Scholar
• Reinhardt, C. F., Azar, A., Maxfield, M. E., Smith, P. E., Jr., and Mullin, L. S. 1971. Cardiac arrhythmias and aerosol "sniffing." Arch. Environ. Health 22:265–279.
   PubMed Web of Science ®Google Scholar
• Simon, T. W. 1997. Combining physiologically based pharmacokinetic modeling with Monte Carlo simulation to derive an acute inhalation guidance value for trichloroethylene. ReguL Toxicol. Pharmacol. 26:257–270.
   PubMed Web of Science ®Google Scholar
• Spear, R. C., Bois, F. Y., Woodruff, T., Auslander, D., Parker, J., and Selvin, S. 1991. Modeling ben-zene pharmacokinetics across three sets of animal data: Parametric sensitivity and risk implica-tions Risk Anal. 11:641–654.
   PubMed Web of Science ®Google Scholar
• Thomas, R. S., Bigelow, P. L., Keefe, T. J., and Yang, R. S. H. 1996a. Variability in biological expo-sure indices using physiologically based pharmacokinetic modeling and Monte Carlo simulation. Am. Ind. Hyg. Assoc. J. 57:23–32.
   PubMed Web of Science ®Google Scholar
• Thomas, R. S., Lytle, W. E., Keefe, T. J., Constan, A. A., and Yang, R. S. H. 1996b. Incorporating Monte Carlo simulation into physiologically based pharmacokinetic models using advanced con-tinuous simulation language (ACSL): A computational method. Fundam. Appl. ToxicoL 31:19–28.
   PubMedGoogle Scholar
• U. S. Environmental Protection Agency. 1994. SNAP Technical Background Document: Risk Screen on the Use of Substitutes for Class I Ozone-Depleting Substances, Fire Suppression and Explosion Protection (Halon Substitutes). U.S. Environmental Protection Agency, Office of Air and Radiation, Stratospheric Protection Division, Washington, DC.
   Google Scholar
• Vinegar, A., Buttler, G. W., Caracci, M. C., and McCafferty, J. D. 1995. Gas Uptake Kinetics of 1,1,1,2,2,2-Hexafluoropropaie (HFC-236fa) and Identification of Its Potential Metabolites. Tech. Rep. AL/OE-TR-1995-0177, U.S. Air Force, Armstrong Laboratory, Occupational and Environ-mental Health Directorate, Toxicology Division, Wright-Patterson AFB, OH.
   Google Scholar
• Vinegar, A., and Jepson, G. W. 1996. Cardiac sensitization thresholds of halon replacement chem-icals predicted in humans by physiologically-based pharmacokinetic modeling. Risk Anal. 16: 571–579.
   PubMed Web of Science ®Google Scholar
• Vinegar, A., Jepson, G. W., and Overton, J. H. 1998. PBPK modeling of short-term (0 to 5 min) human inhalation exposures to halogenated hydrocarbons. InhaL Toxicol 10:411–429.
   Web of Science ®Google Scholar
• Williams, R. J., Vinegar, A., McDougal, J. N., Jarabek, A. M., and Fisher, J. W. 1996. Rat to human extrapolation of HCFC-123 kinetics deduced from halothane kinetics: A corollary approach to physiologically based pharmacokinetic modeling. Fundam. Appl. Toxicol. 30:55–66.
   PubMedGoogle Scholar
• Yang, R. S. H., El-Masri, H. A., Thomas, R. S., and Constan, A. A. 1995. The use of physiologically-based pharmacokinetic/pharmacodynamic dosimetry models for chemical mixtures. ToxicoL Lett. 82/83:497–504.
   Google Scholar
• Young, M. A., Hintze, T. H., and Vatner, S. F. 1985. Correlation between cardiac performance and plasma catecholamine levels in conscious dogs. Am.]. PhysioL 248:H82—H88.
   Google Scholar