PULMONARY INFLAMMATORY RESPONSE TO INHALED ULTRAFINE PARTICLES IS MODIFIED BY AGE, OZONE EXPOSURE, AND BACTERIAL TOXIN

REFERENCES

• Adamson I. Y., Vincent, R., and Bjarnason, S. G. 1999. Cell injury and interstitial inflammation in rat lung after inhalation of ozone and urban particu lates. Am. J. Respir Cell Mol. Biol. 20(5):1067–1072.
   Google Scholar
• Brand, P., Ruob, K., and Gebhart, J. 1992. Performance of a mobile aerosol spectrometer for an in situ characterization of environmental aerosols in Frankfurt City. Atmos. Environ. 13:2451–2457.
   Web of Science ®Google Scholar
• Dreher, K. L., Jaskot, R. H., Lehmann, J. R., Richards, J. H., McGee, J. K., Ghio, A. J., and Costa, D. L. 1997. Soluble transition metals mediate residual oil fly ash induced lung injury. J. ToxicoL Environ. Health 50(3):285–305.
   Web of Science ®Google Scholar
• Elder, A. C. P., Finkelstein, J., Johnston, C., Gelein, R., and Oberdörster, G. 2000a. Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice. InhaL ToxicoL 12:101–119.
   Web of Science ®Google Scholar
• Elder, A. C. P., Gelein, R., Finkelstein, J. N., Cox, C., and Oberdörster, G. 2000b. Endotoxin priming affects the lung response to ultrafine particles and ozone in young and old rats. InhaL ToxicoL 12\(supp1.1):85–98.
   Google Scholar
• Evans, M. J., Cabral-Anderson, L. J., and Freeman, G. 1977. Effects of NO2 on the lungs of aging rats. II. Cell proliferation. Exp. MoL PathoL 27:366–376.
   Google Scholar
• Gardi, C., Martorana, P. A., de Santi, M. M, van Even, P., and Lungarella, G. 1989. A biochemical and morphological investigation of the early development of genetic emphysema in tight-skin mice. Exp. MoL PathoL 3:398–410.
   Web of Science ®Google Scholar
• Gyetko, M. R. and Toews, G. B. 1993. Immunology of the aging lung. In Pulmonary disease in the elderly patient pp. 379–391. Philadelphia:W. B. Saunders.
   Google Scholar
• Hahn, F. F., Newton, G. J., and Bryant, P. L. 1977. In vitro phagocytosis of respirable-sized monodisperse particles by alveolar macrophages. In Pulmonary macrophages and epithelial cells, C. L. Sanders, R. P. Schneider, G. E. Dagli, and H. A. Ragen. pp. 424–435.
   Google Scholar
• Hamacher, J., Vogel, F., Lichey, J., Kohl, F. V., Diwok, K., Wendel, H., and Lode, H. 1995. Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalized patients—A comparison of meropenem and imipenem/cilastatin. COPD Study Group. J. Antimicrob. Chem other. 36(suppl. A):121–133.
   Google Scholar
• Hatch, G. E., Slade, R., Harris, L. P., McDonnell, W. F., Devlin, R. B., Koren, H. S., Costa, D. L., and McKee, J. 1994. Ozone dose and effect in human and rats. A comparison using oxygen-18 labeling and bronchoalveolar lavage. Am. J. Respir. Crit. Care Med. 150:676–683.
   Web of Science ®Google Scholar
• Hildemann, L. M., Klinedinst, D. B., Klouda, G. A., Currie, L. A., and Cass, G. A. 1994. Sources of urban contemporary aerosol. Environ. Sci. TechnoL 9:1565–1576.
   Web of Science ®Google Scholar
• Hughes, L. S., Cass, G. A., Gone, J., Ames, M., and Olmez, I. 1998. Physical and chemical characterization of atmospheric particles in the Los Angeles area. Environ. Sci. TechnoL 9:1153–1161.
   Web of Science ®Google Scholar
• International Committee on Radiological Protection.1994. Human respiratory tract model for radiological protection. A Report of Committee 2 of the ICRP. Oxford: Pergamon Press.
   Google Scholar
• Johnston, C., Finkelstein, J. N., Gelein, R., and Oberdörster, G. 1998. Pulmonary cytokines and chemokine mRNA levels after inhalation of lipopolysaccharide in C57B V6 mice. ToxicoL Sci. 46: 300–307.
   Google Scholar
• Keil, M., Lungarella, G., Cavarra, E., van Even, P., and Mortorana, P. A. 1996.A scanning electron microscopic investigation of genetic emphysema in tight-skin, pallid, and beige mice, three different C57BL/6J mutants. Lab. Invest. 74(2):353–362.
   PubMed Web of Science ®Google Scholar
• Kielty, C. M., Raghunath, M., Siracusa, L. D., Sherratt, M. J., Peters, R., Shuttleworth, C. A., and Jimenez, S. A. 1998. The tight skin mouse: Demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils. J. Cell Biol. 140(5):1159–1166.
   PubMed Web of Science ®Google Scholar
• Klein, N. C., and Cunha, B. A. 1997. Pasturella multocida pneumonia. Sem. Respir Infect. 1:54–56.
   Google Scholar
• Kodavanti, U. P., Costa, D. L., and Bromberg, P. A. 1998. Rodent models of cardiopulmonary disease: Their potential applicability in studies of air pollutant susceptibility. Environ. Health Perspect. 106\(suppl. 1): 111–130.
   Google Scholar
• Li, X. Y., Gilmour, P. S., Donalson, K., and MacNee, W. 1996. Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro. Thorax51:1216–1222.
   PubMed Web of Science ®Google Scholar
• Mauderly, J. L., Bice, D. E., Cheng, Y. S., Gillett, N. A., Griffith, W. C., Henderson, R. F., Pickrell, J. A., and Wolff, R. K. 1989. Influence of experimenta I pulmonary emphysema on the toxicological effects from inhaled nitrogen dioxide and diesel exhaust, pp. 1–47. Cambridge, MA: Health Effects Institute.
   Google Scholar
• Mauderly, J. L., Bice, D. E., Cheng, Y. S., Gillett, N. A., Griffith, W. C., Henderson, R. F., Pickrell, J. A., and Wolff, R. K. 1990. Influence of preexisting pulmonary emphysema on susceptibility of rats to inhaled diesel exhaust. Am. Rev. Respir. Dis. 141:1333–1341.
   PubMed Web of Science ®Google Scholar
• Montgomery, M. R., Raska-Emery, P., and Balis, J. U. 1987. Age-related differences in pulmonary response to ozone. Biochem. Biophys. Acta 890:271–274.
   Google Scholar
• Mortorana, P. A., Wilkinson, M., van Even, P., and Lungarella, G. 1990. Tsk mice with genetic emphysema. Right ventricular hypertrophy occurs without hypertrophy of muscular pulmonary arteries or muscu-larization of arterioles. Am. Rev. Respir. Dis. 142(2):333–337.
   PubMed Web of Science ®Google Scholar
• Oberdörster, G., Finkelstein, J. N., Johnston, C., Gelein, R., Cox, C., Baggs, R., and Elder, A. 2000. Ultrafine particles as inducers of acute lung injury: Mechanisms and correlation with age and disease. Res. Rep. Health Effects Inst., in press.
   Google Scholar
• Pekkanen, J., Timonen, K. L., Ruuskanen, J., Reponen, A., and Mirme, A. 1997. Effects of ultrafine and fine particles in urban air on peak expiratory flow among children with asthmatic symptoms. Environ. Res. 74:24–33.
   PubMed Web of Science ®Google Scholar
• Perskin, M. H., and Cronstein, B. N. 1992. Age-related changes in neutrophil structure and function. Mech. Ageing Dev. 64:303–313.
   PubMed Web of Science ®Google Scholar
• Pope, C. A. 3rd, Schwartz, J., and Ransom, M. R. 1992. Daily mortality and PM10 pollution in Utah Valley. Arch. Environ. Health 3:211–217.
   Google Scholar
• Schum, M., and Yeh, H. 1980. Theoretical evaluation of aerosol deposition in anatomical models of mammalian lung airways. Bull. Math. Biol. 42:1–15.
   PubMed Web of Science ®Google Scholar
• Schwartz, J., and Dockery, D. W. 1992. Increased mortality in Philadelphia associated with daily air pollution concentrations. Am. Rev. Respir. Dis. 3:600–604.
   Web of Science ®Google Scholar
• Schwartz, J., and Morris, R. 1995. Air pollution and hospital admissions for cardiovasculardisease in Detroit, Michigan. Am. J. EpidemioL 1:23–35.
   Web of Science ®Google Scholar
• Siracusa, L. D., McGrath, R., Ma, Q., Moskow, J. J., Manne, J., Christner, P. J., Buchberg, A. M., and Jimenez, S. A. 1996. A tandem duplication within the fibrillin-1 gene is associated with the tight skin mutation. Genome Res. 6(4):300–313.
   PubMed Web of Science ®Google Scholar
• Snider, G. L., Lucey, E. C., and Stone, P. J. 1986. Animal models of emphysema. Am. Rev. Respir. Dis. 133:149–169.
   PubMed Web of Science ®Google Scholar
• Sweeney, T. D., Brain, J. D., Leavitt, S. A., and Godleski, J. J. 1987. Emphysema alters the deposition pattern of inhaled particles in hamsters. Am. J. Pathol. 128:19–28.
   PubMed Web of Science ®Google Scholar
• Szapiel, S. V., Fulmer, J. D., Hunninghake, G. W., Nelson, N. A., Kawanami, O., Ferrans, V. J., and Crystal, R. G. 1981. Hereditary emphysema in the tight-skin (Tsk/+ ) mouse. Am. Rev. Respir. Dis. 123(6): 680–685.
   PubMed Web of Science ®Google Scholar
• Teramoto, S., Fukuchi, Y., Uejima, Y., Teramoto, K., Ito, H., and Orimo, H. 1994. Age-related changes in the antioxidant screen of the distal lung in mice. Lung 172:223–230.
   PubMed Web of Science ®Google Scholar
• Ulich, T. R., Watson, L. R., Yin, S., Guo, K., Wang, P., Thang, H., and del Castillo, J. 1991a. The intratracheal administration of endotoxin and cytokines. I. Characterization of [PS-induced IL-1 and TNF mRNA expression and the LPS-, IL-1-, and TNF-induced inflammatory infiltrate. Am. J. Pathol. 138(6):1485–1496.
   Web of Science ®Google Scholar
• Ulich, T. R., Yin, S., Guo, K., Yi, E. S., Remick, D., and del Castillo, J. 1991b. Intratracheal injection of endo-toxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Am. J. Pathol. 138(5):1097–1101.
   Web of Science ®Google Scholar
• U.S. Environmental Protection Agency. 1996. Air quality criteria for ozone and related photochemical oxidants, vol. I. EPA/600/P-93/004aF. Washington, DC: U.S. EPA.
   Google Scholar
• Vincent, R., Vu, D., Hatch, G., Poon, R., Dreher, K., Guenette, J., Bjarnason, S., Potvin, M., Norwood, J., and McMullen, E. 1996. Sensitivity of lungs of aging Fisher 344 rats to ozone: Assessment by bronchoalveolar lavage. Am. J. Physiol. 15:L555—L565.
   Google Scholar
• Wenisch, C., Patruta, S., Daxbock, F., Krause, R., and Hörl, W. 2000. Effect of age on human neutrophil function./ Leukocyte Biol. 67:40–45.
   PubMed Web of Science ®Google Scholar
• Yu, C. P., and Xu, G. B. 1987. Predictive models for deposition of inhaled diesel exhaust particles in humans and laboratory species, pp. 1–27. Amherst, NY: Health Effects Institute.
   Google Scholar