Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 13, 2001 - Issue 12
Submit an article Journal homepage
18
Views
3
CrossRef citations to date
0
Altmetric
Research Article

p -ARAMID RFP DO NOT INDUCE CHROMOSOMAL ABERRATIONS IN A STANDARDIZED IN VITRO GENOTOXICITY ASSAY USING HUMAN LYMPHOCYTES

D. B. Warheit DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
,
M. Donner DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
&
H. Murli DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
Pages 1079-1091 | Published online: 01 Oct 2008

  • Blake, T., Castranova, V., Schwegler-Berry, D., Baron, P., Deye, G. J., Li, C., and Jones, W. 1998. Effect of fiber length on glass microfiber cytotoxicity. J. Toxicol. Environ. Health 54:243-259.
  • European Centre for Ecotoxicology and Toxicology of Chemicals. 1996. Toxicology of Man-Made Organic Fibers (MMOF). Tech Rep. No. 69. Brussels: ECETOC.
  • Evans, H. J. 1962. Chromosomal aberrations produced by ionizing radiation. Int. J. Cytol. 13:221-321.
  • Evans, H. J. 1976. Cytological methods for detecting chemical mutagens. In Chemical mutagens, principles and methods for their detection, ed. A. Holaender, Vol. 4, pp. 1-29. New York: Plenum Press.
  • Galloway, S. M., Aardema, M. J., lshidate, M., Jr., Ivett, J. L., Kirkland, D. J., Morita, T., Mosesso, P., and Sofuni, T. 1994. Report from working group on in vitro tests for chromosomal aberrations. [Review]. Mutat. Res. 12:241-61.
  • Hart, G. A., Kathman, L M., and Hesterberg, T. W. 1994. In vitro cytotoxicity of asbestos and manmade vitreous fibers: role of fiber length, diameter and composition. Carcinogenesis 15:971-977.
  • Hesterberg, T. W., Hart, G. A., and Bunn, W. B. 1993. In vitro toxicology of fibers: mechanistic studies and possible use for screening assays. In Fiber toxicology, ed. D. B. Warheit, pp. 139-170. San Diego: Academic Press.
  • IARC. 1996. Mechanisms of carcinogenesis, eds. A. B. Kane, P. Bofetta, R. Saracci, and J. D. Wilbourn. IARC Scientific Publications No. 140, Consensus Report. Lyon: IARC.
  • IARC. 1997. Silica, some silicates, coal dust and para-aramid fibrils. IARC Monogr. Eval. Carcinogen. Risks Hum. 68.
  • Jaurand, M. C. 1997. Mechanisms of fiber-induced genotoxicity. Environ. Health Perspect. 105 (suppl.5):1073-1084.
  • Korkina, L. G., Durnev, A. D., Suslova, T. B., Cheremisina, Z. P., Daugel-Dauge, N. O., and Afanas'ev, L. B. 1992. Oxygen radical-mediated mutagenic effect of asbestos on human lymphocytes: suppression by oxygen radical scavengers. Mutat. Res. 265:245-253.
  • Marsh, J. P., Mossman, B. T., Driscoll, K. E., Schins, R. F., and Borm, P. J. 1994. Effects of aramid, a high strength synthetic fiber, on respiratory cells in vitro. Drug Chem. Toxicol. 17:75-92.
  • Speit, G. 2001. Appropriate in vitro test conditions for genotoxicity testing of fibers, lnhal. Toxicol., in press.
  • VaIerio, F., de Ferrari, M., Ottaggio, M. L., Repetto, E., and Santi, L. 1983. Chromosomal aberrations induced by chrysotile and crocidolite in human lymphocytes in vitro. Mutat. Res. 122:397-402.
  • Wening, J. V., Langendorff, U., Delling, G., Marquardt, H., Hoffmann, M., and Jungbluth, K. H. 1989. Initial results of the biocompatibility, cytotoxicity and genotoxicity of aramid. [German]. Unfallchirurgie 15:215-220.
  • Wening, J. V., Marquardt, H., Katzer, A., Jungbluth, K. H., and Marquardt, H., 1995. Cytotoxicity and mutagenicity of Kevlar: An in vitro evaluation. Biomaterials 16:337-340.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.